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  • Blackwell Publishing Ltd
  • Springer Nature
  • 2020-2024  (3)
  • 1970-1974  (6)
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  • 1
    Publication Date: 2021-10-29
    Description: The COVID-19 outbreak has caused over three million deaths worldwide. Understanding the pathology of the disease and the factors that drive severe and fatal clinical outcomes is of special relevance. Studying the role of the respiratory microbiota in COVID-19 is especially important as the respiratory microbiota is known to interact with the host immune system, contributing to clinical outcomes in chronic and acute respiratory diseases. Here, we characterized the microbiota in the respiratory tract of patients with mild, severe, or fatal COVID-19, and compared it to healthy controls and patients with non-COVID-19-pneumonia. We comparatively studied the microbial composition, diversity, and microbiota structure between the study groups and correlated the results with clinical data. We found differences in the microbial composition for COVID-19 patients, healthy controls, and non-COVID-19 pneumonia controls. In particular, we detected a high number of potentially opportunistic pathogens associated with severe and fatal levels of the disease. Also, we found higher levels of dysbiosis in the respiratory microbiota of patients with COVID-19 compared to the healthy controls. In addition, we detected differences in diversity structure between the microbiota of patients with mild, severe, and fatal COVID-19, as well as the presence of specific bacteria that correlated with clinical variables associated with increased risk of mortality. In summary, our results demonstrate that increased dysbiosis of the respiratory tract microbiota in patients with COVID-19 along with a continuous loss of microbial complexity structure found in mild to fatal COVID-19 cases may potentially alter clinical outcomes in patients. Taken together, our findings identify the respiratory microbiota as a factor potentially associated with the severity of COVID-19.
    Electronic ISSN: 2045-2322
    Topics: Natural Sciences in General
    Published by Springer Nature
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 6 (1974), S. 0 
    ISSN: 1095-8649
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The haemoglobins and globins of the roach, Rutilus rutilus (L.) and the rudd, Scardinius erythrophthalmus (L.) have been studied by starch gel electrophoresis. At all stages of development studied, the roach and rudd haemoglobins give a similar electrophoretic pattern, the young fish of about 2 cm standard length possessing three separate haemoglobins, of which two bands only persist in the adult. The evolutionary significance of multiple haemoglobins in fishes is briefly discussed.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 39 (1974), S. 0 
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A simple and inexpensive method for enriching tortillas with soy proteins was studied. The method consisted of application of the traditional process for making corn tortillas to whole raw corn-soybean mixtures: lime cooking of a mixture, allowing the cooked mixture to stand overnight in the cooking liquor, washing the mixture with tap water, grinding the cooked mixture into a dough, and making tortillas from the dough. This method of enrichment was found to give tortillas with significantly higher protein content and protein quality than normal un-enriched tortillas. PER and NPU values of tortillas containing 8% and 16% soya were found to be comparable to those obtained with tortillas enriched with soy flour or with amino acids lysine and tryptophane. The presence of soybeans in tortillas so enriched was found to be not significantly detectable by a trained panel, at least up to a soya level of 16%. Toxic factors present in raw soybeans were not detected in enriched tortillas by the urease method, having been apparently inactivated by the tortilla-making process. Enrichment by this method is cheaper than enrichment with soy flour or with amino acids. The method permits uniform introduction of soya proteins within the tortillas, and changes neither food recipes nor eating habits.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    The @journal of eukaryotic microbiology 17 (1970), S. 0 
    ISSN: 1550-7408
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: SYNOPSIS By using the split-pair method autogamy was induced in Stylonychia mytilus Ehrenberg and S. muscorum Kahl, and the process was thoroly studied in the former. The pairs split early in conjugation continued the process as autogamonts and never united again altho they were placed in the same depression slide.The pattern of nuclear behavior during autogamy closely resembles that reported for conjugation. The fusion of pronuclei at metaphase is usually observed, but it occasionally fails and the stationary pronucleus appears to continue its development as a hemicaryon. The macronuclear anlage and the definitive micronuclei differentiate from particular products of the 3rd postgamic division.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 8 (1972), S. 0 
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: . A mathematical model to predict water quality in a surface-groundwater system is under development. This project is being sponsored by the Environmental Protection Agency. The ultimate goal of this study is to obtain cause and effect relationships between pollutant sources and the ensuing concentrations at different locations in a basin. Several programs are used to model the various hydrologic processes occurring in nature, namely: rainfall, runoff, flow in surface bodies of water, infiltration, and groundwater flow. At every time step in the simulation, the water quantity computations for the above hydrologic models are performed first. Subsequently, the results of these computations, typically in the form of flow velocities, are used as input to the water quality calculations. The water quality routines involve the modeling of the associated physical, chemical, and biological processes. In this study, emphasis is being placed on pollution in agricultural areas. Accordingly the Lake Apopka basin in Central Florida is being used as the application site.
    Type of Medium: Electronic Resource
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  • 6
    Publication Date: 2022-02-11
    Description: This paper presents the results of a pilot study about students’ adoption and learning outcomes of 4 MOOCs proposed as a complementary resource for traditional remedial courses on calculus. While the MOOCs were not mandatory, traditional remedial courses were required for those freshmen failing a diagnostic exam. The effects on 589 freshmen students were investigated. The data analysis shows that up to 16 % of the students were active in the MOOCs under study, mostly during the days before taking the diagnostic exam that preceded the traditional face-to-face remedial courses. Trace data about learner actions within the platform were collected as well as the students’ scores. According to a statistical comparison of the students’ exam scores and their interaction behavior with the MOOCs, we observe that active students had more chances of passing the diagnostic exam and skipping the required remedial courses. However, we found no significant differences on the remedial course exam scores between the students that were active in the MOOCs and those that were not. These findings suggest that MOOCs are a good solution to strengthening skills and reviewing concepts, but that more guidance is needed when used as a complement to traditional f2f courses.
    Keywords: LB5-3640 ; adoption ; pilot study ; higher education ; learning outcomes ; remedial courses ; MOOCs
    Language: English
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  • 7
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-02
    Description: This open access book considers a pivotal era in Chinese history from a global perspective. This book’s insight into Chinese and international history offers timely and challenging perspectives on initiatives like “Chinese characteristics”, “The New Silk Road” and “One Belt, One Road” in broad historical context. Global History with Chinese Characteristics analyses the feeble state capacity of Qing China questioning the so-called “High Qing” (shèng qīng 盛清) era’s economic prosperity as the political system was set into a “power paradox” or “supremacy dilemma”. This is a new thesis introduced by the author demonstrating that interventionist states entail weak governance. Macao and Marseille as a new case study aims to compare Mediterranean and South China markets to provide new insights into both modern eras’ rising trade networks, non-official institutions and interventionist impulses of autocratic states such as China’s Qing and Spain’s Bourbon empires.
    Keywords: History of China ; History of Early Modern Europe ; Economic History ; Open Access ; Socioeconomic networks between China and Europe ; bilateral Sino‐European trade relations ; trans‐national communities of Macau and Marseille ; Foreign merchant networks and the Silk Road ; Trade and European and Chinese socio‐cultural habits ; Polycentric approaches to the 18th century Silk Road ; Strategic sites of commerce and consumption ; Asian history ; European history ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCZ Economic history
    Language: English
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  • 8
    Publication Date: 1973-12-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 9
    Publication Date: 1974-04-01
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Springer Nature
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