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  • Bread-making quality  (1)
  • Cholesterol 7-alpha-Hydroxylase/metabolism  (1)
  • Clifford Dobell  (1)
  • 2020-2024
  • 2000-2004  (3)
  • 1985-1989
  • 1
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    Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-09-01
    Description: Several nuclear hormone receptors involved in lipid metabolism form obligate heterodimers with retinoid X receptors (RXRs) and are activated by RXR agonists such as rexinoids. Animals treated with rexinoids exhibited marked changes in cholesterol balance, including inhibition of cholesterol absorption and repressed bile acid synthesis. Studies with receptor-selective agonists revealed that oxysterol receptors (LXRs) and the bile acid receptor (FXR) are the RXR heterodimeric partners that mediate these effects by regulating expression of the reverse cholesterol transporter, ABC1, and the rate-limiting enzyme of bile acid synthesis, CYP7A1, respectively. Thus, these RXR heterodimers serve as key regulators of cholesterol homeostasis by governing reverse cholesterol transport from peripheral tissues, bile acid synthesis in liver, and cholesterol absorption in intestine.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Repa, J J -- Turley, S D -- Lobaccaro, J A -- Medina, J -- Li, L -- Lustig, K -- Shan, B -- Heyman, R A -- Dietschy, J M -- Mangelsdorf, D J -- R37 HL 09610/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2000 Sep 1;289(5484):1524-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute and Department of Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9050, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10968783" target="_blank"〉PubMed〈/a〉
    Keywords: ATP Binding Cassette Transporter 1 ; ATP-Binding Cassette Transporters/genetics/*metabolism ; Animals ; Bile Acids and Salts/biosynthesis ; Biological Transport/drug effects ; Cholesterol/*metabolism ; Cholesterol 7-alpha-Hydroxylase/metabolism ; Cholesterol, Dietary/administration & dosage ; Cricetinae ; DNA-Binding Proteins/metabolism ; Dimerization ; Gene Expression Regulation/drug effects ; Glycoproteins/genetics/*metabolism ; Homeostasis/drug effects ; Intestinal Absorption/*drug effects ; Intestine, Small/*metabolism ; Ligands ; Liver/*metabolism ; Macrophages, Peritoneal/metabolism ; Male ; Mesocricetus ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Orphan Nuclear Receptors ; *Receptors, Cytoplasmic and Nuclear ; Receptors, Retinoic Acid/agonists/genetics/*metabolism ; Receptors, Thyroid Hormone/agonists/genetics/metabolism ; Retinoid X Receptors ; Transcription Factors/agonists/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Sex, Death, and Evolution in Proto- and Metazoa, 1876–1913 (2000)
    Springer
    Journal of the history of biology 33 (2000), S. 221-246 
    Details
    ISSN: 1573-0387
    Keywords: August Weismann ; ciliates ; Clifford Dobell ; cytology ; death ; Emile Maupas ; evolution ; Herbert Spencer Jennings ; Otto Bütschli ; Paramecium ; rejuvenescence ; sex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , History
    Notes: Abstract In the period 1875–1920, a debate about the generality and applicability of evolutionary theory to all organisms was motivated by work on unicellular ciliates like Paramecium because of their peculiar nuclear dualism and life cycles. The French cytologist Emile Maupas and the German zoologist August Weismann argued in the 1880s about the evolutionary origins and functions of sex (which in the ciliates is not linked to reproduction), and death (which appeared to be the inevitable fate of lineages denied sexual conjugation), an argument rooted in the question of whether the ciliates and their processes where homologous to other cellular organisms. In the beginning of the twentieth century, this question of homology came to be less important as the ciliates were used by the British protozoologist Clifford Dobell and the American zoologist Herbert Spencer Jennings to study evolutionary processes in general rather than problems of development and cytology. For them, homology mattered less than analogy. This story illustrates two partially distinct problems in evolutionary biology: first, the question of whether all living things have common features and origins; and second, whether their history and current nature can be described by identical mechanisms. Where Maupas (contra Weismann) made the ciliates qualitatively the same as all other organisms in order to create a cohesive evolutionary theory for biology, Jennings and Dobell made them qualitatively different in order to achieve the same end.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1004740325150
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  • 3
    Electronic Resource
    Electronic Resource
    Silencing of HMW glutenins in transgenic wheat expressing extra HMW subunits (2000)
    Springer
    Theoretical and applied genetics 100 (2000), S. 319-327 
    Details
    ISSN: 1432-2242
    Keywords: Key words Transgenic wheat ; HMW glutenins ; Gene silencing ; Bread-making quality
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Wheat HMW glutenin subunit genes 1Ax1 and 1Dx5 were introduced, and either expressed or overexpressed, into a commercial wheat cultivar that already expresses five subunits. Six independent transgenic events were obtained and characterized by SDS-PAGE and Southern analysis. The 1Dx5 gene was overexpressed in two events without changes in the other endosperm proteins. Overexpression of 1Dx5 increased the contribution of HMW glutenin subunits to total protein up to 22%. Two events express the 1Ax1 subunit transgene with associated silencing of the 1Ax2* endogenous subunit. In the SDS-PAGE one of them shows a new HMW glutenin band of an apparent Mr lower than that of the 1Dx5 subunit. Southern analysis of the four events confirmed transformation and suggest that the transgenes are present in a low copy number. Silencing of all the HMW glutenin subunits was observed in two different events of transgenic wheat expressing the 1Ax1 subunit transgene and overexpressing the Dx5 gene. Transgenes and expression patterns were stably transmitted to the progenies in all the events except one where in some of the segregating T2 seeds the silencing of all HMW glutenin subunits was reverted associated with a drastic lost of transgenes from a high to a low copy number. The revertant T2 seeds expressed the five endogenous subunits plus the 1Ax1 transgene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220050042
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