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  • Wiley  (32)
  • Nature Publishing Group  (6)
  • Wiley-Blackwell  (6)
  • Frontiers Media
  • ZBW - Deutsche Zentralbibliothek für Wirtschaftswissenschaften, Leibniz-Informationszentrum Wirtschaft Kiel, Hamburg
  • 2020-2024  (2)
  • 2010-2014  (19)
  • 1995-1999  (17)
  • 1980-1984  (7)
Collection
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Publisher
Years
Year
  • 1
    Electronic Resource
    Electronic Resource
    Time-dependent models of single- and double-layer mantle convection (1984)
    [s.l.] : Nature Publishing Group
    Nature 308 (1984), S. 533-535 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Models of mantle convection have been proposed with several different combinations of convecting layers, including convection confined to the upper mantle, convection in separate layers in the upper and lower mantle, and whole-mantle convection2-10. The models of double-layer convection have been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/308533a0
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  • 2
    Electronic Resource
    Electronic Resource
    Hot times in the solar nebula (1995)
    [s.l.] : Nature Publishing Group
    Nature 377 (1995), S. 578-579 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] How hot did it get? That question was on the minds of meteoriticists gathered in Washington DC this September*. While autumn breezes cooled the Mall, scientists meeting deep underground presented convincing evidence that the early solar nebula was considerably hotter than has been thought likely ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/377578a0
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  • 3
    Electronic Resource
    Electronic Resource
    Giants and dwarfs meet in the middle (1996)
    [s.l.] : Nature Publishing Group
    Nature 379 (1996), S. 397-398 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] How massive can a giant planet be? What is the lowest mass for a brown dwarf star? The answers to both of these questions have changed because of observations presented at a recent meeting187th Meeting of the American Astronomical Society, San Antonio, USA, 14-18 January 1996.Geoffrey W. Marcy (San ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/379397a0
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  • 4
    Electronic Resource
    Electronic Resource
    Timing is everything (1995)
    [s.l.] : Nature Publishing Group
    Nature 375 (1995), S. 13-14 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] How long did the earliest phases of planet formation last in the inner Solar System? New measurements of aluminium isotope abundances in primitive meteorites imply that rocky solids were formed in a dusty disk over a period of about 10 million years (Myr). That period of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/375013a0
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  • 5
    Electronic Resource
    Electronic Resource
    Gene regulation: Enhancer elements in immunoglobulin genes (1983)
    [s.l.] : Nature Publishing Group
    Nature 303 (1983), S. 281-282 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] EXPERIMENTS designed to explore the control of antibody production have revealed for the first time the existence of enhancer sequences in eukaryotic genes. Enhancers, until now identified only in viruses, are short regulatory sequences that increase the rate of transcription from many eukaryotic ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/303281a0
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  • 6
    Electronic Resource
    Electronic Resource
    Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cells (1984)
    [s.l.] : Nature Publishing Group
    Nature 311 (1984), S. 752-755 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The two cell lines used in our study, 40E4 and 22D6, were produced by Abelson murine leukaemia virus (A-MuLV) transformation of BALB/c fetal liver at 13-14 and 17-19 days of gestation, respectively. These cell lines produce no detectable immunoglobulin12; they possess DJH rearrangements on both ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/311752a0
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  • 7
    Electronic Resource
    Electronic Resource
    Diastereoselective Synthesis of Cyclododeca-1,6-diallenes ( = cyclododeca-l,2,6,7-tetraenes) (1997)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 80 (1997), S. 414-420 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The synthesis of substituted cyclododeca-1,6-diallenes.( = cyclododeca-1,2,6,7-tetraenes) from cyclododeca-5,11-diyne-1,4-diols is described (Schemes 1 and 3). The ca. 1:1 mixtures of the stereoisomers of the cyclododeca-1,6-diallenes were formed in high yields from the ca. 1:1 diastereoisomer mixtures of the 1,4-disubstituted cyclododeca-5,11-diynes by reactions with Me2CuLi or t-BuMgCl/CuII. In mechanistically relevant experiments with the pure diastereoisomers of 1,4-dimethylcyclododeca-5,11-diyne-1,4-diol, it is demonstrated that the configuration is conserved in these reactions. The first synthesis of a 1-substituted cyclododeca-2,8-diyne bearing only one propargylic leaving group gives access to a mixed 12-membered allen-yne (Scheme 5).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19970800207
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  • 8
    Electronic Resource
    Electronic Resource
    Synthesis and Structure of Functionalized Cyclododecadiynes and -dienes (1996)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 79 (1996), S. 2164-2175 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The cyclododecadiynes 3b-d, 8b-d, and 10b-c with functionalities in two propargylic positions, as well as the monofunctionalized diyne 13b have been prepared from simple open-chain building blocks. In the DMPU ( = N,N'-dimethylpropyleneurea)-assisted ring-closing alkylation of 1,7-diynes, the twelve-membered ring compounds have been prepared in yields of 16-55%. The preparation of the diene-diyne 15 and the cyclododeca-5,11-diyne-1,4-dione 18 are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19960790811
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  • 9
    Electronic Resource
    Electronic Resource
    Use of a Hepta-tyr glycopeptide antibiotic as chiral selector in capillary electrophoresis (1998)
    Weinheim : Wiley-Blackwell
    Electrophoresis 19 (1998), S. 1742-1751 
    Details
    ISSN: 0173-0835
    Keywords: Antibiotics ; Chiral separations ; Enantiomers ; Drugs ; Herbicides ; Capillary electrophoresis ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: A new glycopeptide antibiotic, MDL 63,246 (Hepta-tyr), of the teicoplanin family, has been evaluated in capillary electrophoresis for the resolution of chiral compounds of pharmaceutical and environmental interest. Electrophoretic separations were carried out in a polyacrylamide-coated capillary using the partial filling-counter current mode with aqueous-organic buffers in the pH range 4-6. Experimental parameters affecting resolution, such as antibiotic concentration, buffer pH, organic modifier type and capillary temperature, were studied. The Hepta-tyr antibiotic exhibited a high enantiorecognition capability towards the studied compounds at very low concentrations (1-2 mg/mL). The optimum experimental conditions were achieved by using a buffer at pH 5 containing acetonitrile at 25°C.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150191036
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  • 10
    Electronic Resource
    Electronic Resource
    Sample matrix effects on glycopeptide stability by high performance capillary electrophoresis (1997)
    Weinheim : Wiley-Blackwell
    Electrophoresis 18 (1997), S. 751-756 
    Details
    ISSN: 0173-0835
    Keywords: Glycopeptides ; Matrix ; Stability ; Capillary electrophoresis ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: High performance capillary electrophoresis (CE) of glycoprotein digests frequently reveals extensive microheterogeneity associated with specific protein glycosylation sites. The choice of the sample matrix can influence the electrophoretic migration time, peak shape and resolution, as well as the physical stability of the product glycopeptides. Acetic acid is a frequently employed sample matrix for both capillary electrophoresis and electrospray ionization-mass spectrometry (ESI-MS). Acetic acid appears to enhance the spontaneous hydrolysis of sialic acids from the nonreducing termini of glycopeptides in a time- and concentration-dependent manner, even at 5°C, as evidenced by changes in the electrophoretic mobility and ESI-MS spectra of the resulting glycopeptides. The observed parallel electrophoretic mobility changes for specific glycoforms are consistent with the induction of peptide structure with time. Asialoglycopeptide mobilities were stable in acetic acid. Electrophoretic mobilities can be stabilized with propionic acid sample matrix with no apparent structural changes observed by ESI-MS within 31 h. Migration time reproducibility was in the range of 0.1% relative standard deviation (N = 7) with excellent peak shapes and enhanced glycopeptide resolution.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elps.1150180515
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