ISSN:
1573-8221
Keywords:
chronic myeloid leukemia
;
blast crisis
;
myeloblasts
;
antimyeloblastic serum
;
cytotoxic reaction
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract An antimyeloblastic immune serum (AMS) was prepared by immunizing horses with white blood cells (WBC) from a patient with chronic myeloid leukemia (CML) in the blast crisis stage. The serum was exhausted in relation to antibodies against red and white blood cells of healthy donors. The AMS continued to have a cytotoxic action on blast cells from the blood of 20 of the 42 patients with CML in the blast crisis stage. The AMS did not react with WBC from the blood of patients with CML in the chronic phase or from patients with other forms of leukemia. Morphological observations indicate that the above-mentioned immune serum cam be used to identify antigen associated with myeloblasts from the blood of patients with CML in the blast crisis stage.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00798896
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