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Optical Resolution Photoacoustic Microscopy of Ovary and Fallopian Tube (2019)

Rao, Bin ; Leng, Xiandong ; Zeng, Yifeng ; [weitere]

Springer Nature

In: Scientific Reports. 2019; 9(1): 14306. Published 2019 Oct 04. doi: 10.1038/s41598-019-50743-7.

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Publikationsdatum: 2019-10-04

Beschreibung: Ovarian cancer is the leading cause of death among gynecological cancers, but is poorly amenable to preoperative diagnosis. In this study, we investigate the feasibility of “optical biopsy,” using high-optical-resolution photoacoustic microscopy (OR-PAM) to quantify the microvasculature of ovarian and fallopian tube tissue. The technique is demonstrated using excised human ovary and fallopian tube specimens imaged immediately after surgery. Quantitative parameters are derived using Amira software. The parameters include three-dimensional vascular segment count, total volume and length, which are associated with tumor angiogenesis. Qualitative results of OR-PAM demonstrate that malignant ovarian tissue has larger and more tortuous blood vessels as well as smaller vessels of different sizes, while benign and normal ovarian tissue has smaller vessels of uniform size. Quantitative analysis shows that malignant ovaries have greater tumor vessel volume, length and number of segments, as compared with benign and normal ovaries. The vascular pattern of benign fallopian tube is different than that of benign ovarian tissue. Our initial results demonstrate the potential of OR-PAM as an imaging tool for fast assessment of ovarian tissue and fallopian tube and could avoid unnecessary surgery if the risk of the examined ovary is extremely low.

Digitale ISSN: 2045-2322

Thema: Allgemeine Naturwissenschaft

Publiziert von Springer Nature

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Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer (2016)

Khaled Ali; Dalya R. Soond; Roberto Piñeiro; Thorsten Hagemann; Wayne Pearce; Ee Lyn Lim; Hicham Bouabe; Cheryl L. Scudamore; Timothy Hancox; Heather Maecker; Lori Friedman; Martin Turner; Klaus Okkenhaug; Bart Vanhaesebroeck

Springer Nature

In: Nature

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Publikationsdatum: 2016-07-28

Beschreibung: Corrigendum: Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer Nature 535, 7613 (2016). doi:10.1038/nature17641 Authors: Khaled Ali, Dalya R. Soond, Roberto Piñeiro, Thorsten Hagemann, Wayne Pearce, Ee Lyn Lim, Hicham Bouabe, Cheryl L. Scudamore, Timothy Hancox, Heather Maecker, Lori Friedman, Martin Turner, Klaus Okkenhaug & Bart Vanhaesebroeck Nature510, 407–411 (2014); doi:10.1038/nature13444Queen Mary University London notified Nature and University College London that there is reason to question the provenance of the data for Fig. 5b, d, e of this Letter (Fig. 5a, c

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Structure and properties of complex hydride perovskite materials (2014)

Pascal Schouwink; Morten B. Ley; Antoine Tissot; Hans Hagemann; Torben R. JensenĽubomír Smrčok; Radovan Černý

Springer Nature

In: Nature Communications

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Publikationsdatum: 2014-12-12

Beschreibung: Article Complex metal hydrides are of interest for applications such as hydrogen storage, solid-state phosphors and solid electrolytes. Here the authors present the synthesis and properties of 30 complex hydride compounds with a perovskite crystal structure, based on the BH4 − anion and new synthesis protocols involving rare-earth elements. Nature Communications doi: 10.1038/ncomms6706 Authors: Pascal Schouwink, Morten B. Ley, Antoine Tissot, Hans Hagemann, Torben R. Jensen, Ľubomír Smrčok, Radovan Černý

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Genomic encoding of transcriptional burst kinetics (2019)

Anton J. M. Larsson, Per Johnsson, Michael Hagemann-Jensen, Leonard Hartmanis, Omid R. Faridani, Björn Reinius, Åsa Segerstolpe, Chloe M. Rivera, Bing Ren, Rickard Sandberg

Springer Nature

In: Nature

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Publikationsdatum: 2019

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

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ADAM8 as a drug target in pancreatic cancer (2015)

Uwe Schlomann; Garrit Koller; Catharina Conrad; Taheera Ferdous; Panagiota Golfi; Adolfo Molejon Garcia; Sabrina Höfling; Maddy Parsons; Patricia Costa; Robin Soper; Maud Bossard; Thorsten Hagemann; Rozita Roshani; Norbert Sewald; Randal R. Ketchem; Marcia L. Moss; Fred H. Rasmussen; Miles A. Miller; Douglas A. Lauffenburger; David A. Tuveson; Christopher Nimsky; Jörg W. Bartsch

Springer Nature

In: Nature Communications

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Publikationsdatum: 2015-01-30

Beschreibung: Article Expression of ADAM8, a metalloprotease disintegrin, correlates with worse prognosis in pancreatic adenocarcinoma (PDAC). Here Schlomann et al . show that ADAM8 promotes PDAC invasiveness, and develop a peptide inhibitor that blocks ADAM8 function and impedes PDAC progression in mouse models. Nature Communications doi: 10.1038/ncomms7175 Authors: Uwe Schlomann, Garrit Koller, Catharina Conrad, Taheera Ferdous, Panagiota Golfi, Adolfo Molejon Garcia, Sabrina Höfling, Maddy Parsons, Patricia Costa, Robin Soper, Maud Bossard, Thorsten Hagemann, Rozita Roshani, Norbert Sewald, Randal R. Ketchem, Marcia L. Moss, Fred H. Rasmussen, Miles A. Miller, Douglas A. Lauffenburger, David A. Tuveson, Christopher Nimsky, Jörg W. Bartsch

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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Nitric oxide mediates glial-induced neurodegeneration in Alexander disease (2015)

Liqun Wang; Tracy L. Hagemann; Hermann Kalwa; Thomas Michel; Albee Messing; Mel B. Feany

Springer Nature

In: Nature Communications

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Publikationsdatum: 2015-11-28

Beschreibung: Article Alexander disease is a rare neurological disorder caused by mutations in GFAP, yet it is unclear how glial disruptions lead to neural death. Here, Wang et al . identify a mechanism by which glial-derived nitric oxide leads to neuronal degeneration in fly and mouse models of the disease. Nature Communications doi: 10.1038/ncomms9966 Authors: Liqun Wang, Tracy L. Hagemann, Hermann Kalwa, Thomas Michel, Albee Messing, Mel B. Feany

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

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Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis (2014)

Silvia Batista; Eleni Maniati; Louise E. Reynolds; Bernardo Tavora; Delphine M. Lees; Isabelle Fernandez; George Elia; Oriol Casanovas; Cristina Lo Celso; Thorsten Hagemann; Kairbaan Hodivala-Dilke

Springer Nature

In: Nature Communications

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Publikationsdatum: 2014-10-03

Beschreibung: Article Focal adhesion kinase (FAK) is frequently overexpressed in solid tumours. Here Batista et al. show that loss of FAK skews hematopoietic progenitors toward myeloid differentiation and promotes metastases, warning against the use of FAK inhibitors in anticancer therapies. Nature Communications doi: 10.1038/ncomms6054 Authors: Silvia Batista, Eleni Maniati, Louise E. Reynolds, Bernardo Tavora, Delphine M. Lees, Isabelle Fernandez, George Elia, Oriol Casanovas, Cristina Lo Celso, Thorsten Hagemann, Kairbaan Hodivala-Dilke

Digitale ISSN: 2041-1723

Thema: Biologie , Chemie und Pharmazie , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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