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  • Atomic, Molecular and Optical Physics  (2)
  • Pyrido-pyridazine, derivative  (1)
  • Wiley-Blackwell  (3)
  • 2020-2021
  • 1990-1994  (3)
  • 1960-1964
  • 1945-1949
  • 1
    Electronic Resource
    Electronic Resource
    Sur une tentative d'unification des théaories quantiques de la cancérisation par les polyacènes. II: Le rôle de la rèagion K dans le processus d'activation metabolique conduisant au cancérogène ultime. Théorie des régions M, L, et BK (1990)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 38 (1990), S. 487-495 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This study is a unified approach to quantum theories of polyacen carcinogenesis. Part II is on the role of the K-region in metabolic activation process leading to ultimate carcinogen and discusses the M, L, and BK theory. The saturation of the polyacen K-region, or the transformation into a quinoid one, deactivates the carcinogenic process going through a diol epoxyde, which results in Bay-region carbocation. K and B regions must be considered as two interdependent parts of the same structural entity, which may be termed the BK-region. The M, L, and BK theory achieves a complete unification of the Pullman and Jerina and other theories.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560380309
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  • 2
    Electronic Resource
    Electronic Resource
    Sur une tentative d'unification des théaories quantiques de la cancèrisation par les polyacènes: I. Thèorie des règions M, L, et B (1990)
    New York, NY : Wiley-Blackwell
    International Journal of Quantum Chemistry 38 (1990), S. 461-486 
    Details
    ISSN: 0020-7608
    Keywords: Computational Chemistry and Molecular Modeling ; Atomic, Molecular and Optical Physics
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This study is a unified approach to quantum theories of polyacen carcinogenesis. Part I discusses the M, L, and B regions theory. Although the M region of polyacens is much less reactive than is the K region, the chemical reactivity of these two regions parallels each other. Consequently, the K-L Pullman's theory may be reformulated by replacing the K region by the M region. The M-L regions theory improves all the quantum structure-carcinogenic activity relationships obtained previously in the K-L framework. Moreover, it would appear that in these correlations, the most important role is played by nonconcerted electrophilic reactions. We suggest that the M-L modified Pullman's theory and the Bay (B) region theory, proposed by Jerina et al., are related to different steps of the metabolic activation mechanism leading to ultimate carcinogen: the first step for the Pullman's theory and the carbocation step for the theory of the Bay region. We have termed the “M, L and B regions theory” as this unified approach to the problem of polyacens carcinogenesis.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/qua.560380308
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  • 3
    Electronic Resource
    Electronic Resource
    Synthesis of polyfunctionally substituted pyridazines (1990)
    Weinheim : Wiley-Blackwell
    Liebigs Annalen 1990 (1990), S. 293-296 
    Details
    ISSN: 0170-2041
    Keywords: Pyridazine, derivatives ; Pyrazolo-pyridazine, derivative ; Pyrido-pyridazine, derivative ; Isoxazolo-pyridazine, derivative ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The pyridazines 3, 4, 5, and 7 were obtained by reaction of the hydrazone derivatives 2 with several reagents. By treatment of 5 with acetic acid/hydrochloric acid, the pyrazolo[4,3-c]-pyridazine 6 was formed. The pyrido-pyridazine derivatives 8 and 9 were obtained by reaction of 2 and 3 with malononitrile and ethyl cyanoacetate, respectively, and the isoxazolo-pyridazines 11 by reaction of 3a, b with hydroxylamine hydrochloride in ethanolic sodium ethoxide solution. The intermediate 9 was separated by reaction of 3a, b with hydroxylamine hydrochloride in ethanolic sodium acetate solution.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jlac.199019900153
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