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  • 1
    Keywords: Zoology. ; Plant diseases. ; Forestry. ; Geology. ; Zoology. ; Plant Pathology. ; Forestry. ; Geology.
    Description / Table of Contents: Section I: Introduction to Forest Entomology -- 1. Introduction to and the Importance of Insects -- 2. Form and Function -- 3. Forest Arthropod Biodiversity -- 4. Insect Ecology -- 5. Forest Insect Population Dynamics -- 6. Forest Insect -Natural Enemy Interactions -- 7. Forest Insect-Plant Interactions -- 8. Insects and Forest Succession. Section II: Categories of Insects that Damage Trees -- 9. Foliage Feeders -- 10. Bark Beetles -- 11. Ambrosia Beetles -- 12. Woodborers in Forest Stands -- 13. Sap-sucking Forest Pests -- 14. Gall Formers -- 15. Tip, Shoot, Root and Regeneration Pests -- 16. Insects of Reproductive Structures -- Section III: Management of Forest Insect Pests -- 17. IPM: the Forest Context -- 18. Spatial Dynamics of Forest Insects -- 19. Monitoring and Surveillance of Forest Insects -- 20. Silviculture -- Section IV: Future Prospects -- 21. Forest Health in the Anthropocene -- 22. Climate Change and Forest Insect Pests -- 23. Forest Insect Invasions and their Management.
    Abstract: This open access book will provide an introduction to forest entomology, the principles and techniques of forest insect pest management, the different forest insect guilds/feeding groups, and relevant forest insect pest management case studies. In addition to covering 30% of the earth, forest ecosystems provide numerous timber and non-timber products that affect our daily lives and recreational opportunities, habitat for diverse animal communities, watershed protection, play critical roles in the water cycle, and mitigate soil erosion and global warming. In addition to being the most abundant organisms in forest ecosystems, insects perform numerous functions in forests, many of which are beneficial and critical to forest health. Conversely, some insects damage and/or kill trees and reduce the capacity of forests to provide desired ecosystem services. The target audience of this book is upper-level undergraduate and graduate students and professionals interested in forest health and entomology.
    Type of Medium: Online Resource
    Pages: XII, 810 p. 149 illus., 119 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031115530
    DDC: 590
    Language: English
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  • 2
    Keywords: Virology. ; Medicine Research. ; Biology Research. ; Life sciences. ; Virology. ; Biomedical Research. ; Life Sciences.
    Description / Table of Contents: 1. The Quest for Excellence and the Challenge of Gender Equality in Arbovirology: A Celebration of Women’s Contributions to the Field -- 2. Serendipity and Arboviruses -- 3. The Tapestry of Life: Weaving an Arbovirologist -- 4. Arbovirus and Viral Hemorrhagic Fevers Research Inception in Central and West Africa -- 5. From Bwamba to the Present: The Changing Forest of Arbovirology -- 6. Fighting Dengue, Chikungunya and Japanese Encephalitis -- 7. Chronicles of Hantaviruses: Foundations of Epidemiology and Ecology -- 8. Yellow Fever and Other Viruses in West Africa -- 9. The “Golden Age” of Arbovirology, 1950-1969 -- 10. Twenty-Seven Years of Field Studies on Dengue and Aedes Aegypti in Latin America -- 11. 50 Years of Medical Entomology: Miscellaneous Interesting Findings -- 12. Remembrances of Virology Past -- 13. An Overview of Arbovirology in São Paulo State, Southeastern Brazil: Highlighting the Virus Research Center in Ribeirão Preto City -- 14. An Unplanned Career in Arbovirology.
    Abstract: These books bring together a panel of expert arbovirologists who recall the history of arbovirology from very personal perspectives. In these timely volumes, the authors describe seminal moments in their experiences in the field and how they integrated these findings with lab studies to further clarify the ecology and epidemiology of diverse arboviruses. Authors identify the most pressing questions that remain to be answered, providing a basis for current research and a stimulus to engage those entering the field. Over the last 20 years a generational gap has developed between the giants of arbovirus research and discovery and the new generation. This gap developed due to an ebbing of training and investment in passing the scepter to the next generation, leading to a lack of continuity among the generations that threatens to derail the rich history of virus discovery, field epidemiology and understanding of the richness of diversity that surrounds us. This lack of continuity may have immediate and disastrous consequences for public health when yet to be discovered arboviruses emerge. The purpose of these books is to bridge this gap by providing a historical context for the work being done today and provide continuity between the generations. To this end, the books provide a narrative of the thrill of scientific discovery and excitement of field adventures and lab studies of that generation -- essential reading for every arbovirologist, and highly recommended for all virologists and public health officials, as well as those students considering future research options. Volume I consists of the personal reflections of arbovirologists who played a significant role in the advancement of arbovirology across the globe. Volume II transitions to descriptions of region-specific and virus family-specific perspectives of arbovirology, as well as recollections of the early events of molecular advances and pathogenesis studies.
    Type of Medium: Online Resource
    Pages: XX, 542 p. 258 illus., 200 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031219993
    DDC: 579.2
    Language: English
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  • 3
    Keywords: Cardiovascular system. ; Physiology. ; Biomedical engineering. ; Heart Surgery. ; Cardiology. ; Cardiovascular Physiology. ; Biomedical Engineering and Bioengineering. ; Cardiac Surgery. ; Cardiology.
    Description / Table of Contents: ANATOMY, PHYSIOLOGY, CONGENITAL DEFECTS, and DISEASE. - The anatomy and function of the atrioventricular valves -- The anatomy and function of the semilunar valves -- Congenital heart defects that include cardiac valve abnormalities -- Acquired valve disease and processes -- Complex repair of CHD requiring conduits OR valve replacement outside of the ROSS procedure -- VALVE REPAIR AND REPLACEMENT -- Heart valve disease -- History of heart valve repair -- The Ross Procedure -- The Use of Echocardiographic imaging of Valves -- Advanced 3D imaging (CT and MRI) and transcatheter valve repair/ implantation -- Transcatheter mitral repair and replacement -- Percutaneous pulmonary valve implantation: the first transcatheter valve -- Transcatheter aortic valve implantation -- Post TAVR PCI -- Complex Procedures in TAV, SAV, HARPOON, BASILICA w/ case studies -- Tissue engineered heart valves -- New trends for valve replacement like the Ozaki procedure -- Post-operative management of valves: On-X valve in post anticoagulation management -- TESTING, REGULATORY and TRAINING ISSUES -- In vitro testing of heart valve substitutes -- Numerical methods for design and evaluation of prosthetic heart valves -- Animal models for cardiac valve research -- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies -- Successful development and regulatory approval of replacement cardiac valves -- Clinical trial requirements for cardiac valves -- Virtual Prototyping and 3D Printing For Simulation -- Computational Modeling, Validation, Verification and Uncertainty: Device simulation in Valvular Anatomies -- Procedural Training and Education: Mixed Realities.
    Abstract: This state-of-the-art handbook is dedicated to cardiac valve anatomy, models for testing and research methods, clinical trials; and clinical needs and applications. In this new edition, chapters are updated with the latest research in addition to new chapters on complex repair of CHD requiring conduits, new trends for valve replacement like the Ozaki procedure, as well as complex procedures in TAV, SAV, HARPOON, and BASILICA, with case studies for each type of procedure. This volume serves as a helpful reference for patients, educators, students, device designers and developers, clinical study specialists, clinicians, and other associated healthcare providers.
    Type of Medium: Online Resource
    Pages: XVII, 615 p. 252 illus., 206 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031255410
    DDC: 573.1
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuropsychology. ; Clinical psychology. ; Psychiatry. ; Neuroscience. ; Neuropsychology. ; Clinical Psychology. ; Psychiatry.
    Description / Table of Contents: Preface -- PART 1: To fear or not -- Disambiguating fear as an emotional state vs. threat detection. Molecular and Neural circuits of fear extinction. Psychological and theoretical elements on the concept of fear extinction. Neural circuit of fear extinction: psychophysiology -- PART 2: Individual differences in fear extinction -- The impact of sex differences and sex hormones on fear extinction. Impact of sleep on fear extinction. Impact of stress and exercise on fear extinction. Intersect between the intrinsic and extrinsic factors that modulate fear extinction -- PART 3: Psychopathology -- Fear extinction and its relevance to psychopathology. Developmental fear and its extinction imaging. Fear extinction and adult psychopathology -- Part 4: Therapeutics and neuromodulations of fear extinction -- Exposure therapy and other behavioral therapeutics targeting fear extinction circuits. Novel pharmacotherapeutics targeting fear extinction circuits. Reconsolidation and its link and impact on fear extinction. Technological advances in exposure therapy: virtual and augmented reality. Novel approaches using neurostimulation targeting fear extinction.
    Abstract: This book aims to provide the reader a neuroscientific understanding surrounding a very simple question: how do we learn not to fear? Exploring answers to this question is very important for two reasons. First, learning about the neural mechanisms of fear extinction is of relevance to everyone’s life - it is such a basic yet relevant question to our daily experiences. Therefore, understanding brain mechanisms of fear and its regulation is essential from a basic neuroscience point of view. Second, excessive fear and the inability to regulate its expression is one of the hallmarks of fear-, anxiety-, trauma-, and stressor-related psychopathologies. And as such, learning about how fear is acquired, stored, expressed, and regulated could help advance our understanding of the etiology of psychopathology, the maintenance of symptoms pertaining to failure to regulate fear, and could help us develop novel therapeutics to equip providers and patients with the tools to better quell their fears. The contributions contained in this book are provided by experts in the fields of basic and clinical neuroscience, experimental and clinical psychology, and neuropsychiatry. The contributions are organized to start the reader with basic definitions of how we define fear, how we study its neural circuits at the molecular and cellular levels, how to study human behavior and the brain using state-of-the art experimental and statistical tools, to how much fear contributes to psychopathology. This volume ends with current advances aimed to enhance the capacity to extinguish fear; a clinical result that would aid in the treatment of multiple psychiatric disorders, followed by a discussion on future directions of this highly important and relevant field.
    Type of Medium: Online Resource
    Pages: VIII, 387 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031430053
    Series Statement: Current Topics in Behavioral Neurosciences, 64
    DDC: 612.8
    Language: English
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  • 5
    Keywords: Anatomy. ; Medical education. ; Virtual reality. ; Augmented reality. ; Anatomy. ; Medical Education. ; Virtual and Augmented Reality.
    Description / Table of Contents: Part I. Communicating Visualisation -- Chapter 1. Science Communication and Biomedical Visualization – Two Sides of the Same Coin -- Chapter 2. Putting the Cart Before the Horse? Developing a Blended Anatomy Curriculum Supplemented by Cadaveric Anatomy -- Part II. Innovating Visualisation -- Chapter 3. The Third Dimension: 3D Printed Replicas and Other Alternatives to Cadaver-Based Learning -- Chapter 4. Evaluating a Photogrammetry-based Video for Undergraduate Anatomy Education -- Chapter 5. Virtual Microscopy Goes Global: The Images Are Virtual and the Problems Are Real -- Chapter 6. Online, Interactive, Digital Visualisation Resources That Enhance Histology Education -- Chapter 7. Leading Transformation in Medical Education Through Extended Reality -- Chapter 8. Visualisation Approaches in Technology-Enhanced Medical Simulation Learning: Current Evidence and Future Directions -- Chapter 9. Visualisation through Participatory/Interactive Theatre for the Health Sciences.
    Abstract: When studying medicine, healthcare, and medical sciences disciplines, learners are frequently required to visualise and understand complex three-dimensional concepts. Consequently, it is important that appropriate modalities are used to support their learning. Recently, educators have turned to new and existing digital visualisation approaches when adapting to pandemic-era challenges and when delivering blended post-pandemic teaching. This book focuses on a range of key themes in anatomical and clinically oriented education that can be enhanced through visual understanding of the spatial three-dimensional arrangement and structure of human patients. The opening chapters describe important digital adaptations for the dissemination of biomedical education to the public and to learners. These topics are followed by reviews and reports of specific modern visualisation technologies for supporting anatomical, biomedical sciences, and clinical education. Examples include 3D printing, 3D digital models, virtual histology, extended reality, and digital simulation. This book will be of interest to academics, educators, and communities aiming to modernise and innovate their teaching. Additionally, this book will appeal to clinical teachers and allied healthcare professionals who are responsible for the training and development of colleagues, and those wishing to communicate effectively to a range of audiences using multimodal digital approaches.
    Type of Medium: Online Resource
    Pages: X, 203 p. 64 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031303791
    Series Statement: Advances in Experimental Medicine and Biology, 1421
    DDC: 611
    Language: English
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  • 6
    Keywords: Neurosciences. ; Neuroanatomy. ; Neurophysiology. ; Developmental neurobiology. ; Cognitive neuroscience. ; Neuroscience. ; Neuroanatomy. ; Neurophysiology. ; Development of the Nervous System. ; Cognitive Neuroscience.
    Abstract: This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.
    Type of Medium: Online Resource
    Pages: XIV, 742 p. 182 illus., 127 illus. in color. , online resource.
    Edition: 2nd ed. 2023.
    ISBN: 9783031150708
    DDC: 612.8
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Geotechnical engineering. ; Surfaces (Technology). ; Thin films. ; Fluid mechanics. ; Condensed matter. ; Soft condensed matter. ; Geotechnical Engineering and Applied Earth Sciences. ; Surfaces, Interfaces and Thin Film. ; Engineering Fluid Dynamics. ; Phase Transitions and Multiphase Systems. ; Soft and Granular Matter.
    Description / Table of Contents: Introduction -- Electrospun Fibrous Mats -- Tailored Electrospun Gas Diffusion Layers With a Graded Pore Structure for Polymer Electrolyte Membrane Fuel Cells -- Dispersed Nanostructured Thin Film (Dnstf) Catalyst -- Electrochemical Actuation of a Nanoporous Polypyrrole Hybrid Material -- Laser-Excited Elastic Guided Waves Reveal the Complex Mechanics of Nanoporous Silicon -- Sample Layout Aiding Efficient Scans of Heterogeneous Sheet-Like Materials -- Protective Porous Media - The Pore & Fiber Structure of Face Masks -- Individual Fibers in Nonwoven are Identified with Artificial Intelligence -- Mechanism of Imperfect Atomic Layer Deposition in Porous Materials -- Mass Transport in Conformally Coated Porous Materials -- Optical Microfabrication of Porous Films -- Bicontinuous Porosity by Spinodal Phase Separation -- Nucleation and Crystal Growth on the Secondary Substrate -- Double-Porosity in Soil -- Boreal Mosses and Lichens -- The Gorgonian Octocoral Eunicella Cavolinii Forms a Porous Biological Material with Outstanding Material Properties -- Foraminifer -- Trovants: The “Living” Stones of Romania Formed as High Porosity Spherical Sandstone Concretions Developed Around a Fossil -- The Complex Pore Spaces of Our Brain: A Challenge and Opportunity for Computer Simulations -- Scaling and Resolution Effect of an Andesite Sample -- Length-Scale Dependence of Pore Space Topology -- Microstructure of Crushable Expanded Clay Aggregates -- Reticulated Rutile -- Mineral Map of Rotliegendes -- Boise Brown -- North Netherlands Gas Reservoir -- Fib-Sem Images From a Cathode Material: Unfiltered and Filtered (Curtaining Filter) -- Vesicles and Fractures in Volcanic Ash -- A View of the Internal Pore Structure of a Volcanic Rock: Xaltipan Ignimbrite -- In Situ Microtomography of the Tensile Fracture and Fragmentation of Porphyry Copper Ores -- Fractured Porous Media: A Cretaceous Carbonate Outcrop Sample -- Fracture Network in a Shale Cube Hydraulically Fractured in the Laboratory -- Geological Carbon Storage at the University of Bergen, Norway.
    Abstract: Graphical depictions of abstract concepts have played a major role in the formulation and communication of ideas since prehistoric times. The invention of photography in the nineteenth century and more recent advances in visualization techniques have catalyzed an enormous wealth of insights into every field of science and engineering by extending our senses far beyond our natural sensorial capabilities. The field of porous media has also benefited enormously from these developments in visualization techniques. Indeed, improvements in these techniques have led to the better morphological characterization of porous media and an enhanced understanding of the assorted physical processes, such as mass transport, capillarity, swelling, and fracturing, that can occur at the pore level. These observations, in turn, have led to superior usage practices for existing porous materials and the design of new products with porous media. Therefore, this bilingual English-Spanish album is aimed at providing a collection of state‐of‐the‐art visualizations of the diverse aspects of porous media that will serve as a reference in education and research. To cover all these aspects properly, the album is organized into seven thematic parts. Each part includes a collection of chapters with images accompanied by a brief English-Spanish description of the novelty of the observation, the visualization technique used, and the phenomenological insights gained. Las representaciones gráficas de conceptos abstractos han jugado un papel importante en la formulación y comunicación de ideas desde tiempos prehistóricos. La invención de la fotografía en el siglo XIX y los avances más recientes en las técnicas de visualización han catalizado una enorme riqueza de conocimientos en todos los campos de la ciencia y la ingeniería al extender nuestros sentidos mucho más allá de nuestras capacidades sensoriales naturales. El campo de los medios porosos también se ha beneficiado enormemente de estos avances en las técnicas de visualización. De hecho, las mejoras en estas técnicas han llevado a una mejor caracterización morfológica de los medios porosos y una mejor comprensión de los diversos procesos físicos, como el transporte de masa, la capilaridad, la hinchazón y la fractura, que pueden ocurrir a nivel de poro. Estas observaciones, a su vez, han llevado a mejores prácticas de uso para los materiales porosos existentes y al diseño de nuevos productos con medios porosos. Por lo tanto, este álbum bilingüe inglés y español tiene como objetivo proporcionar una colección de visualizaciones del estado del arte de los diversos aspectos de los medios porosos que servirán como referencia en la educación y la investigación. Para cubrir adecuadamente todos estos aspectos, el álbum está organizado en siete partes temáticas. Cada parte incluye una colección de capítulos con imágenes acompañadas de una breve descripción en inglés y español de la originalidad de la observación, la técnica de visualización utilizada y los conocimientos fenomenológicos obtenidos.
    Type of Medium: Online Resource
    Pages: XV, 145 p. 119 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031238000
    DDC: 624.151
    Language: English
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  • 8
    Keywords: Nanotechnology. ; Biomaterials. ; Biology Technique. ; Agriculture. ; Biotechnology. ; Molecular biology. ; Nanotechnology. ; Plant Materials. ; Biological Techniques. ; Agriculture. ; Biotechnology. ; Molecular Biology.
    Description / Table of Contents: Preface -- 1. Nano-Biofortification: Finding an Alternative Approach -- 2. Soil ecosystem services and environmental health -- 3. Malnutrition and human health -- 4. Nano-Biofortification: an environmental health overview -- 5. Phytomedicine and medicinal plants -- 6. Role of phytomedicines and medicinal plants in bacterial and viral diseases -- 7. Plant-based diets and cardiovascular health -- 8. Nano-Biofortified crop plants with selenium for human health -- 9. Biofortified crop plants with iodine for human health -- 10. Nano-Biofortified crop plants with copper for human health -- 11. Nano-Biofortified crop plants with zinc for human health -- 12. Nano-Biofortified crop plants with iron for human health -- 13. Plant leaf protein concentrate for human health -- 14. Plant secondary metabolites and human health -- 15. Plant nano-remediation and human health -- 16. Plant nano-nutrition management for human health -- 17. Physiological functions of plant nano-nutrients in human health -- 18. Nanofertilizers in Agriculture -- 19. Biofortification to Improve Micronutrient-Dense Plants -- 20. Nano-Biofortification of vegetables for nutritive values and qualitative traits -- Bibliography -- Index.
    Abstract: Nanotechnology has shown great potential to alleviate increasing pressure to meet food needs for our increasing human population, Novel agricultural innovations are required to enhance the health of edible crops and per unit area yield without impacting the associated environment in a negative way. Recent advancements in nanotechnology-based agricultural solutions have proven to help overcome the problems in agriculture that are associated with run-off of essential fertilizers from agricultural soils, low nutrient accumulation by crops, as well as to control insects, pests, and seasonal biotic factors, treatment of wastewater used for irrigation, plant uptake of xenobiotics (heavy metals, pesticides, industrial chemicals, drugs, and so on) that may be present in contaminated soils. Additionally, the consumption of such food crops may result in malnourishment and plant-mediated transfer of toxic substances among humans especially in underprivileged and rural populations. Agents to stimulate plant growth include various types of nanomaterials such as carbon nanotubes, metal, and metal-oxide nanoparticles. Applications of particular nutrients or elements in crop plants can be shown to aid human nourishment (either by directly inducing its uptake or indirectly through enhancing the intracellular levels of other associated elements that ultimately boost the synthesis of the desired nutrient in plants). It is also important to consider the competence and fate of nanomaterials in soil ecosystems. The entry route of nanomaterials into the environment includes both natural and anthropogenic sources. In order to achieve sustainable and safe use of nanotechnological products in agriculture, similar environmental conditions must be simulated on lab scale with the careful selection of organisms related to agriculture. Thus, emphasis should be placed on the judicial use of nano-enabled products without compromising the sustainability of the environment and human health. This comprehensive book highlights recent field research as well as contributions from academicians in the lab. This book addresses the major aspects related to nanotechnology, biofortification of crops, and human and environmental health.
    Type of Medium: Online Resource
    Pages: XII, 349 p. 57 illus., 54 illus. in color. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031351471
    Series Statement: Sustainable Plant Nutrition in a Changing World,
    DDC: 620.5
    Language: English
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  • 9
    Keywords: Neurosciences. ; Immunology. ; Ophthalmology. ; Neuroscience. ; Immunology. ; Ophthalmology.
    Description / Table of Contents: High Resolution Imaging Mass Spectrometry of Human Donor Eye: Photoreceptor Cells and Basal Laminar Deposits of Age-related Macular Degeneration -- The non-canonical role of Complement Factor H in Retinal Pigment Epithelium (RPE) cells and implications for Age-related Macular Degeneration -- Macular Pigment Carotenoids and Bisretinoid A2E -- Disturbed matrix metalloproteinases activity in age-related macular degeneraton -- Current views on Chr10q26 contribuiton to age-related macular degeneration -- Untargeted lipidomic profiling of aged human retina with and without age-related macular degeneration (AMD) -- Decoding Race and Age-Relation Macular Degeneration: GPR 143 Activity is the Key -- Peroxisome proliferator-activated receptor gamma coactivator 1 alpha ( PGC-1x): a transcriptional regulator at the interface of aging and age-related macular degeneration? -- Regulation of ABCA1 by miR-33 and miR-34a in the aging eye -- The role of gene expression regulation on genetic risk of Age-related Macular Degeneration -- Elastin layer in Bruch's membrane as a target for immunizatio or tolerization to modulate patthology in the mouse model of somke-induced ocular injury -- Repuprosing drugs for treatment of age-relation macular degeneration -- Extracellular Vesicle RNA Contents as Biomarkers for Ocular Diseases -- Proteomics of retinal extracellular vesicles: a reviw inot an unexplored mechanism in retinal health and AMD pathogenesis -- Prime Editing Strategy to Instally the PRHP2 c.828+1G A mutations -- Analysis of CRB1 Pathogenic Variants Correctable with CRISPR Base and Prime Editing -- Generation of an Avian Myeloblastosis Virus (AMV) Reverse Transcriptase Prime Editor -- Pre-existing neutralizing antibodies against different adeno-associated virus serotypes in humans and large animal models for gene therapy -- Optimization of Capillary-based Western Blotting for MYO7A -- AAV Serotypes and Their Suitability for Retinal Gene Therapy -- Gene Augmentation ofautosomal dominant CRX-associated retinopathies -- Txnip gene therapy of retinitis pigmentosa improves cone health Factors affecting readthrough of natural versus premature termination codons -- Integrating Computational Approaches to Predict the Effect of Genetic Variants on Protein Stability in Retinal Degenerative Disease -- Network biology and medcine to resuce: Applications for retinal disease mechanisms and therapy -- Non-sydromic Retinal Degeneration Caused by Pathogenic Variants in Joubert Syndrome Genes -- Exonic variants that affect splicing- an opportunity for "hidden" mutations causing inherited retinal diseases -- Enhanced S-cone Syndrome, a Mini-Review -- The role of microglia in Inherited Retinal Diseases -- CD68: potential contributor to inflammation and RPE cell dystrophy -- Gene Expression of Clusterin, Tissue Inhibitor of Metalloproteinase-1, and Their receptors in Retinal Pigment Epithelial Cells and Muller Glial Cells is Modulated by Inflammatory Stresses -- Axonal Transport Defects in Retinal Ganglion Cells -- Connexins biology in the pathophysiology of retinal diseases -- Role of Nuclear NAD +in Retinal Homeostasis -- Retinal pigmented epithelium-derived ectopic norrin does not promote intraretinal angiogenesis in transgenic mice -- Caveolin-1 Muller glia exist as heat-resistant,high molecular weight complexes -- Role of VLC-PUFAs in Retinal and Macular Degeneration -- Ocular amyloid , condensates, and aggregates - higher order protein assemblies participate in both retinal degeneration and function -- Photoreceptor ion channels in signaling and disease -- The role of peripherin-2 /ROM1 complexes in photoreceptor outer segment disc morphogenesis -- Human mutations in Arl3, a small GTPase involved inlipidated cargo delibery to the cilia cause retinatl dystropthy -- Genotype-Phenotype Association in ABCA4-Associated Retinopathy -- Retinal pathoconnectomics: A Window into Neurodegeneration -- The role of Ceramide in Inherited Retinal Disease Pathology -- Extracelluar Matix: the Unexplored Aspects of Retinal Pathologies and Regeneration -- Role of TFEB in diseases assocaited with lysosomal dysfunction -- Retinoic acid receptor -related oprhan receptors (RORs) in eye development and disease -- A novel mouse model for Late-Onset Retinal Degeneration (L-ORD) devekios RPE abnormalities due to the loss of C1qtnf5/Ctrp5 -- Comparison of mouse models of autosomal dominant retinitis pigmentosa due to P23H muations of Rhodopsin -- Compensatory Cone-Mediated Mechanisms in Inherited Retinal Degeneration Mouse Models: A Functional and Gene Expression Analsyis -- Inhibition of Ryanodine Receptor 1 Reduces Endoplasmic Reticulum (ER) Sress and Promotes ER Protein Degradation in Cyclic Nucleotide-gated Channel Deficiency -- Mouse choroid proteome revisited: foucs on aging -- Morphological and functional comparison of mice models for retinitis pigmentosa -- Current Advancements in Mouse Models of Retinal Disease -- Single-cell Itrnacriptomic Profiling of Muller Glia in the rd10 Retina -- Methods for in vivo characterization of proteostatis in the mouse retina -- Absence or PRCD leads to dysregulation in lipie Homeostatis resulting in disorganizationof photorecptor outer segment structure -- Expansion Microscopy of Mouse Photoreceptro Cilia -- Rod photorecptor specific ablation of Metformin target, AMPK, in preclinical model of autosomal recessvie retinitis pigmentosa -- TLR2 is highly overexpressed in retinal myeloid cells in the rd10 mouse model of retinitis pigmentosa -- Environmental light has an essentail effrect on the diseasae expression in a dominant RPE65 mutation -- Microglia Preserve Visual Function in A Mouse Model of Retinitis Pigmentosa with Rhodopsin-P23H Mutant -- Measuring the release of lactate from wild-type and rd1 mouse retina -- Aerobic glycolysis in photorecptors supports energy demand in the absence of mitochondrial coupling -- Redox Status in Retinitis Pigmentosa -- Perspectives on retinal dolichol metabolism and visual deficits in dolichol metalbolism-associated inherited disorders -- Retinal metabolic profile on IMPG2 deficiency mice with subretinal lesions -- Glutathione-coating of liposomes enhances the delivery of hydrophillic cargo to the inner nuclear layer in retinal cultures -- Modification of Mueller glial cell fate and proliferation with the use of small molecules -- A potential neuroprotective role for pyruvate kinase 2 in retinal degeneration -- Critical role of VEGF as a direct regulator of photorecptor function -- Lysine Ubiquitylation Drives Rhodopsin Protein Turnover -- In-silico prediction of MYO!C Rhodopsin Interactions and its Significance in Protein Localization and Visual Function -- A ciliary branched actin netowrk drives photoreceptor disc morphogenesis -- Revisiting the daily timing of POS phagocytosis -- Inhibition of Bacterial Peoptidoglycan Cytopahty by Retina Pigment Epithelial PGRP2 Amidase -- Understanding ischemic retinopathies: the role of Succinate and its recpto^T mutation -- Inducing neural regeneratio nfrom glia using proneural bHLH transcription factors.
    Abstract: This book contains the proceedings of the XIX International Symposium on Retinal Degeneration. A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. These retinal degeneration symposia are known by most as the “best” and “most important” meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. We anticipate that the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.
    Type of Medium: Online Resource
    Pages: XIX, 588 p. 1 illus. , online resource.
    Edition: 1st ed. 2023.
    ISBN: 9783031276811
    Series Statement: Advances in Experimental Medicine and Biology, 1415
    DDC: 612.8
    Language: English
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  • 10
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    American Meteorological Society
    In:  EPIC3Bulletin of the American Meteorological Society, American Meteorological Society, 104(9), pp. s1-s10, ISSN: 0003-0007
    Publication Date: 2024-05-08
    Description: 〈jats:title〉Abstract〈/jats:title〉 〈jats:p〉—J. BLUNDEN, T. BOYER, AND E. BARTOW-GILLIES〈/jats:p〉 〈jats:p〉Earth’s global climate system is vast, complex, and intricately interrelated. Many areas are influenced by global-scale phenomena, including the “triple dip” La Niña conditions that prevailed in the eastern Pacific Ocean nearly continuously from mid-2020 through all of 2022; by regional phenomena such as the positive winter and summer North Atlantic Oscillation that impacted weather in parts the Northern Hemisphere and the negative Indian Ocean dipole that impacted weather in parts of the Southern Hemisphere; and by more localized systems such as high-pressure heat domes that caused extreme heat in different areas of the world. Underlying all these natural short-term variabilities are long-term climate trends due to continuous increases since the beginning of the Industrial Revolution in the atmospheric concentrations of Earth’s major greenhouse gases.〈/jats:p〉 〈jats:p〉In 2022, the annual global average carbon dioxide concentration in the atmosphere rose to 417.1±0.1 ppm, which is 50% greater than the pre-industrial level. Global mean tropospheric methane abundance was 165% higher than its pre-industrial level, and nitrous oxide was 24% higher. All three gases set new record-high atmospheric concentration levels in 2022.〈/jats:p〉 〈jats:p〉Sea-surface temperature patterns in the tropical Pacific characteristic of La Niña and attendant atmospheric patterns tend to mitigate atmospheric heat gain at the global scale, but the annual global surface temperature across land and oceans was still among the six highest in records dating as far back as the mid-1800s. It was the warmest La Niña year on record. Many areas observed record or near-record heat. Europe as a whole observed its second-warmest year on record, with sixteen individual countries observing record warmth at the national scale. Records were shattered across the continent during the summer months as heatwaves plagued the region. On 18 July, 104 stations in France broke their all-time records. One day later, England recorded a temperature of 40°C for the first time ever. China experienced its second-warmest year and warmest summer on record. In the Southern Hemisphere, the average temperature across New Zealand reached a record high for the second year in a row. While Australia’s annual temperature was slightly below the 1991–2020 average, Onslow Airport in Western Australia reached 50.7°C on 13 January, equaling Australia's highest temperature on record.〈/jats:p〉 〈jats:p〉While fewer in number and locations than record-high temperatures, record cold was also observed during the year. Southern Africa had its coldest August on record, with minimum temperatures as much as 5°C below normal over Angola, western Zambia, and northern Namibia. Cold outbreaks in the first half of December led to many record-low daily minimum temperature records in eastern Australia.〈/jats:p〉 〈jats:p〉The effects of rising temperatures and extreme heat were apparent across the Northern Hemisphere, where snow-cover extent by June 2022 was the third smallest in the 56-year record, and the seasonal duration of lake ice cover was the fourth shortest since 1980. More frequent and intense heatwaves contributed to the second-greatest average mass balance loss for Alpine glaciers around the world since the start of the record in 1970. Glaciers in the Swiss Alps lost a record 6% of their volume. In South America, the combination of drought and heat left many central Andean glaciers snow free by mid-summer in early 2022; glacial ice has a much lower albedo than snow, leading to accelerated heating of the glacier. Across the global cryosphere, permafrost temperatures continued to reach record highs at many high-latitude and mountain locations.〈/jats:p〉 〈jats:p〉In the high northern latitudes, the annual surface-air temperature across the Arctic was the fifth highest in the 123-year record. The seasonal Arctic minimum sea-ice extent, typically reached in September, was the 11th-smallest in the 43-year record; however, the amount of multiyear ice—ice that survives at least one summer melt season—remaining in the Arctic continued to decline. Since 2012, the Arctic has been nearly devoid of ice more than four years old.〈/jats:p〉 〈jats:p〉In Antarctica, an unusually large amount of snow and ice fell over the continent in 2022 due to several landfalling atmospheric rivers, which contributed to the highest annual surface mass balance, 15% to 16% above the 1991–2020 normal, since the start of two reanalyses records dating to 1980. It was the second-warmest year on record for all five of the long-term staffed weather stations on the Antarctic Peninsula. In East Antarctica, a heatwave event led to a new all-time record-high temperature of −9.4°C—44°C above the March average—on 18 March at Dome C. This was followed by the collapse of the critically unstable Conger Ice Shelf. More than 100 daily low sea-ice extent and sea-ice area records were set in 2022, including two new all-time annual record lows in net sea-ice extent and area in February.〈/jats:p〉 〈jats:p〉Across the world’s oceans, global mean sea level was record high for the 11th consecutive year, reaching 101.2 mm above the 1993 average when satellite altimetry measurements began, an increase of 3.3±0.7 over 2021. Globally-averaged ocean heat content was also record high in 2022, while the global sea-surface temperature was the sixth highest on record, equal with 2018. Approximately 58% of the ocean surface experienced at least one marine heatwave in 2022. In the Bay of Plenty, New Zealand’s longest continuous marine heatwave was recorded.〈/jats:p〉 〈jats:p〉A total of 85 named tropical storms were observed during the Northern and Southern Hemisphere storm seasons, close to the 1991–2020 average of 87. There were three Category 5 tropical cyclones across the globe—two in the western North Pacific and one in the North Atlantic. This was the fewest Category 5 storms globally since 2017. Globally, the accumulated cyclone energy was the lowest since reliable records began in 1981. Regardless, some storms caused massive damage. In the North Atlantic, Hurricane Fiona became the most intense and most destructive tropical or post-tropical cyclone in Atlantic Canada’s history, while major Hurricane Ian killed more than 100 people and became the third costliest disaster in the United States, causing damage estimated at $113 billion U.S. dollars. In the South Indian Ocean, Tropical Cyclone Batsirai dropped 2044 mm of rain at Commerson Crater in Réunion. The storm also impacted Madagascar, where 121 fatalities were reported.〈/jats:p〉 〈jats:p〉As is typical, some areas around the world were notably dry in 2022 and some were notably wet. In August, record high areas of land across the globe (6.2%) were experiencing extreme drought. Overall, 29% of land experienced moderate or worse categories of drought during the year. The largest drought footprint in the contiguous United States since 2012 (63%) was observed in late October. The record-breaking megadrought of central Chile continued in its 13th consecutive year, and 80-year record-low river levels in northern Argentina and Paraguay disrupted fluvial transport. In China, the Yangtze River reached record-low values. Much of equatorial eastern Africa had five consecutive below-normal rainy seasons by the end of 2022, with some areas receiving record-low precipitation totals for the year. This ongoing 2.5-year drought is the most extensive and persistent drought event in decades, and led to crop failure, millions of livestock deaths, water scarcity, and inflated prices for staple food items.〈/jats:p〉 〈jats:p〉In South Asia, Pakistan received around three times its normal volume of monsoon precipitation in August, with some regions receiving up to eight times their expected monthly totals. Resulting floods affected over 30 million people, caused over 1700 fatalities, led to major crop and property losses, and was recorded as one of the world’s costliest natural disasters of all time. Near Rio de Janeiro, Brazil, Petrópolis received 530 mm in 24 hours on 15 February, about 2.5 times the monthly February average, leading to the worst disaster in the city since 1931 with over 230 fatalities.〈/jats:p〉 〈jats:p〉On 14–15 January, the Hunga Tonga-Hunga Ha'apai submarine volcano in the South Pacific erupted multiple times. The injection of water into the atmosphere was unprecedented in both magnitude—far exceeding any previous values in the 17-year satellite record—and altitude as it penetrated into the mesosphere. The amount of water injected into the stratosphere is estimated to be 146±5 Terragrams, or ∼10% of the total amount in the stratosphere. It may take several years for the water plume to dissipate, and it is currently unknown whether this eruption will have any long-term climate effect.〈/jats:p〉
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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