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  • 2020-2024  (1,786)
  • 2005-2009
  • 2022  (1,786)
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  • 1
    Online Resource
    Online Resource
    Cardiovascular Signaling in Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Biophysics. ; Cell interaction. ; Biomedical engineering. ; Cardiovascular system. ; Physiology. ; Cardiography. ; Molecular biology. ; Clinical biochemistry. ; Mechanobiological Cell Signaling. ; Biomedical Engineering and Bioengineering. ; Cardiovascular Physiology. ; Cardiography. ; Molecular Biology. ; Medical Biochemistry.
    Description / Table of Contents: Part 1: Cardiac Signaling -- Chapter 1: Calcium-Dependent Signaling in Cardiac Myocytes -- Chapter 2: Organization of Ca2+ Signaling Microdomains in Cardiac Myocytes -- Chapter 3: Stress Kinase Signaling in Cardiac Myocytes -- Chapter 4: Cardiotoxicity and cardiac cell signaling -- Chapter 5: Protein Phosphatase Signaling in Cardiac Myocytes -- Chapter 6: Metabolic Regulation of Mitochondrial Dynamics and Cardiac Function -- Chapter 7: NADPH Oxidase System Mediates Cholesterol Secoaldehyde-Induced Oxidative Stress and Cytotoxicity in H9c2 Cardiomyocytes -- Chapter 8: Lipid Mediators in Cardiovascular Physiology and Disease -- Chapter 9: Cardiac Inflammasome and Arrhythmia -- Chapter 10: Myocardial Fibrosis: Cell Signaling and In Vitro Modeling -- Chapter 11: Neural regulation of cardiac rhythm -- Part 2: Vascular Signaling -- Chapter 12: Mechanisms of lipoproteins and reverse cholesterol transport in atherosclerotic cardiovascular disease -- Chapter 13: Atherosclerotic plaque regression: Future perspective -- Chapter 14: Role of Bioactive Lipid, Phosphatidic Acid in Hypercholesterolemia Drug-induced Myotoxicity – Statin-induced Phospholipase D (PLD) Lipid Signaling in Skeletal Muscle Cells -- Chapter 15: Cell-Cell Communication in the Vascular Endothelium -- Chapter 16: Lysophosphatidic acid regulates endothelial barrier integrity -- Chapter 17: Regulation of Vascular Endothelial Barrier Integrity and Function by Lipid-Derived Mediators -- Chapter 18: Hyperglycemic Oxoaldehyde (Glyoxal)-induced Vascular Endothelial Cell Damage through Oxidative Stress is protected by Thiol Iron Chelator, Dimercaptosuccinic Acid – Role of Iron in Diabetic Vascular Endothelial Dysfunction.
    Abstract: This contributed volume focuses on cardiovascular diseases (CVDs), and explores the ways in which signaling mechanisms at the biochemical, molecular, and cellular levels in the blood vessels (vascular) and heart contribute to the underlying causes of development and progression of the CVDs. This volume covers unique topics such as oxidant signaling in vascular and heart diseases and health, cytoskeletal signaling in vascular health and disease, phospholipase signaling in CVDs, lipid signaling in vascular and myocardial health and diseases, and drug discovery in cellular signaling for cardiovascular diseases. This book assembles the most important discoveries made by leaders on the cellular signaling mechanisms operating behind the development and progression of life-threatening CVDs. It is an extremely useful resource for the investigators in the field of CVDs, and opens the discussion for further discovery of efficient management and effective treatment of the CVDs.
    Type of Medium: Online Resource
    Pages: XVIII, 527 p. 83 illus., 59 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031083099
    URL: https://doi.org/10.1007/978-3-031-08309-9
    DOI: 10.1007/978-3-031-08309-9
    DDC: 571.4
    Language: English
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  • 2
    Online Resource
    Online Resource
    Subcortical Neurosurgery : Open and Parafascicular Channel-Based Approaches for Subcortical and Intraventricular Lesions (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medical sciences. ; Radiology. ; Neurology . ; Health Sciences. ; Radiology. ; Neurology.
    Description / Table of Contents: The subcortical space: anatomy of the subcortical white matter -- Common pathology of the subcortical region -- The ventricular system: Anatomy and common lesions -- Advanced neuro-imaging of the subcortical space -- Advanced neuro-imaging of the human ventricular system -- The evolution of trans-sulcal, channel-based parafascicular surgery -- Open transcortical approaches to subcortical lesions -- Traditional open and neuro-endoscopic approaches to intraventricular pathology -- Trans-sulcal, channel-based parafascicular surgery: Technological considerations and instrumentation -- Standard parafascicular approaches to subcortical regions -- Trans-sulcal, channel-based parafascicular surgery: Basic concepts and a general overview -- Trans-sulcal, channel-based parafascicular surgery for brain metastases -- Trans-sulcal, channel-based parafascicular surgery for gliomas and other primary, intrinsic subcortical tumors -- Trans-sulcal, channel-based parafascicular biopsy techniques -- Trans-sulcal, channel-based parafascicular surgery for intraventricular lesions -- Trans-sulcal, channel-based parafascicular surgery for intracerebral hematoma (ICH) -- Trans-sulcal, channel-based parafascicular surgery for cavernous angiomas and other vascular lesions -- Trans-sulcal, channel-based parafascicular surgery for tumors; Adjunctive measures and techniques -- Case selection and surmounting the learning curve -- Future directions.
    Abstract: This book will be the definitive reference on surgery of the subcortical region. It comprehensively discusses all aspects of treatment of subcortical and intraventricular lesions, including neuroanatomy and neuroimaging of the subcortical space, principles of parafascicular subcortical channel-based surgery, common indications and approaches, and focused chapters for common subcortical lesions. The first section of the reference focuses on the intricate anatomy and neuro-imaging of the subcortical space and ventricular system, with special emphasis on intricate white matter tracts and diffusion tractography imaging. The next section of the book discusses principles of both open and parafascicular, channel-based approaches to subcortical and intraventricular lesions, in addition to workhorse approaches to common subcortical compartments. Finally, specific pathological subcortical lesions that can be commonly addressed via parafascicular channel-based approaches, including brain metastases, gliomas, and intracerebral hemorrhage are addressed. Authored by experts in the field of subcortical neurosurgery, this book was developed to provide a unique, comprehensive text for neurosurgeons, neuro-radiologists, and trainees from a variety of specialties interested in evolving minimally disruptive access and treatment of the subcortical space.
    Type of Medium: Online Resource
    Pages: XII, 257 p. 94 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030951535
    URL: https://doi.org/10.1007/978-3-030-95153-5
    DOI: 10.1007/978-3-030-95153-5
    DDC: 610
    Language: English
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  • 3
    Online Resource
    Online Resource
    The Biological Role of a Virus (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Microbial ecology. ; Evolution (Biology). ; Microbiology. ; Microbial Ecology. ; Evolutionary Biology.
    Description / Table of Contents: PART I. Viral Control of Community Energetics -- Chapter 1. Viral Nature of the Aquatic Ecosystems -- Chapter 2. Life Continues as Viruses Close Land, Water and Atmosphere Nutrient Cycle -- PART II. Understanding the Genetic Partnership Between a Host and Its Viruses -- Chapter 3. Cataloging the Presence of Endogenous Viruses -- Chapter 4. Do the Biological Roles of Endogenous and Lysogenous Viruses Represent Faustian Bargains? -- Chapter 5. Einstein's Capsid: Bacteriophages Solve the Problems of Space and Time for Bacteria with Emergency Dead to Alive Horizontal Gene Transfer (EDA-HGT) -- Chapter 6. Diverse Phage-Encoded Toxins and Their Role in Bacterial Ecology -- Chapter 7. Mycoviruses as Antivirulence Elements of Fungal Pathogens -- PART III. Defending the Health of Its Hosts -- Chapter 8. The Contribution of Viruses to Immune Systems -- Chapter 9. Application of Viruses for Gene Therapy and Vaccine Development -- Chapter 10. Eukaryotic Virus Interactions with Bacteria: Implications for Pathogenesis and Control.
    Abstract: This book answers the question “What is it that viruses do?” by presenting three aspects of viral ecology. The first aspect explains how viruses affect the population diversity and energetics of their host communities. Perhaps the most notable example of this concept is our understanding that primary production within ecosystems often depends upon those viruses which serve as controllers of nutrient recycling, connecting the aquatic and terrestrial realms in ways that can be assessed locally and globally. The second aspect describes genetic partnerships which exist between hosts and their viruses. These include processes termed endogeny and lysogeny by which the host carries at least a partial genomic copy of the virus. Fluidity of these collective genomes is expressed on an evolutionary time scale and the mutual life cycles which they produce represent a forging of shared genomic fate that obligates partnership of the virus and its host. The viral sequences represent a source of potential benefit as well as potential peril for the host and can implement phenotypic changes in the host. Hosts often use those changes as tools. As humans, the most notable example would be that mammals rely upon temporary activation of their endogenous viral genes in order to successfully develop a placenta. The third aspect is defending the health of a host, which relies upon activity in two directions. Hosts often use their captured viral genes to identify and subsequently direct battle against invading viruses. This natural concept has been engineered for combating cancer, is useful for suppressing the detrimental consequences of genetic diseases, and has been developed to create targeted antiviral vaccines. But, the defense has to work in two directions and the host can use other symbiotic microorganisms as protection against its viruses. This book will appeal to a wide readership by providing a broad perspective of viral ecology, and all scientists will find it helpful for gaining a view of fields beyond their specialization.
    Type of Medium: Online Resource
    Pages: XVI, 367 p. 28 illus., 25 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030853952
    Series Statement: Advances in Environmental Microbiology, 9
    URL: https://doi.org/10.1007/978-3-030-85395-2
    DOI: 10.1007/978-3-030-85395-2
    DDC: 579
    Language: English
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  • 4
    Online Resource
    Online Resource
    Macromolecular Protein Complexes IV : Structure and Function (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Proteins . ; Biomolecules. ; Physical biochemistry. ; Macromolecules. ; Cytology. ; Protein Biochemistry. ; Structural Biology. ; Cell Biology.
    Description / Table of Contents: Part 1: Soluble Protein Complexes -- Chapter 1: Fatty Acid Synthase: Structure, Function, and Regulation -- Chapter 2: ATP-binding cassette transporters: Snap-on complexes? -- Chapter 3: The Fork Protection Complex: A regulatory hub at the head of the replisome -- Chapter 4: Ferritin-like Proteins: A Conserved Core for a Myriad of Enzyme Complexes -- Chapter 5: Still no rest for the reductases: Ribonucleotide reductase (RNR) Structure and Function — an update -- Chapter 6: Structure and Dynamics of the Human Multi-tRNA Synthetase Complex -- Chapter 7: On the regulation of mitosis by the kinetochore, a macromolecular complex and organising hub of eukaryotic organisms -- Part 2: Membrane Protein Complexes -- Chapter 8: The conformational dynamics of heterotrimeric G proteins during GPCR-mediated activation -- Chapter 9: Regulation of Lytic Machineries by the FtsEX Complex in the Bacterial Divisome -- Chapter 10 : Structure, Function, and Regulation of the Kainate Receptor -- Chapter 11: Structure, function and variations of the photosystem I-antenna supercomplex from different photosynthetic organisms -- Chapter 12: Structure and Function of Mycobacterial Arabinofuranosyltransferases -- Part 3: Fibrous Protein Complexes -- Chapter 13: Structure and assembly of the bacterial flagellum -- Chapter 14: Actomyosin Complex -- Chapter 15: Structure of motile cilia -- Chapter 16: Segment-Long-Spacing (SLS) and the Polymorphic Structures of Fibrillar Collagen -- Part 4: Virus Protein Complexes -- Chapter 17: Viral Capsid and Polymerase in Reoviridae.
    Abstract: This book covers the latest findings of a wide variety of viral, prokaryotic and eukaryotic macromolecular protein complexes and builds upon the solid macromolecular foundations established by previous volumes of the Subcellular Biochemistry series. Thus, an almost encyclopaedic coverage of the broad field of protein complex structure and function has been established. The 17 interesting chapters included in this book have been organised into four sections: Soluble Protein Complexes, Membrane Protein Complexes, Fibrous Protein Complexes and Viral Protein Complexes. Significant topics present here are: Fatty Acid Synthase, the Fork Protection Complex, Ribonucleotide Reductase, the Kinetochore, G proteins, the FtsEX Complex, the Kainate Receptor, the Photosystem I-antenna, the Mycobacterial Arabinofuranosyltransferases, the the Bacterial Flagellum, the Actomyosin Complex, Motile Cilia, SLS Collagen Polymorphic Structures, and the Reovirus Capsid and Polymerase. Up-dates/expansion of chapter topics present in earlier volumes are now included in chapters here, e.g., those on Ferritin-like proteins and the Multi-tRNA Synthetase. The book is richly illustrated throughout, which is the result of an impressive integration of structural data from X-ray crystallography with that from cryo-electron microscopy. Functional aspects of protein-protein interactions are also given a high priority.
    Type of Medium: Online Resource
    Pages: VIII, 552 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031007934
    Series Statement: Subcellular Biochemistry, 99
    URL: https://doi.org/10.1007/978-3-031-00793-4
    DOI: 10.1007/978-3-031-00793-4
    DDC: 572.6
    Language: English
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  • 5
    Online Resource
    Online Resource
    Nuclear Receptors in Human Health and Disease (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Medicine Research. ; Biology Research. ; Molecular biology. ; Metabolism. ; Genetics. ; Cytology. ; Biomedical Research. ; Molecular Biology. ; Metabolism. ; Genetics and Genomics. ; Cell Biology.
    Description / Table of Contents: Introduction (Moray J Campbell & Charlotte L Bevan) -- Overview (Jason Carroll) -- Part I: Reproduction and Development -- Chapter 1. Nuclear receptors in pregnancy and outcomes: clinical perspective (Luiza Borges Manna & Catherine Williamson) -- Chapter 2. Female Reproductive Systems: hormone dependence and receptor expression (Philippa TK Saunders) -- Chapter 3. Nuclear receptors in ovarian function (Darryl Russell & Doan Thao Dinh) -- Part II: Metabolism -- Chapter 4. Nuclear receptors in energy metabolism (Alina Walth, Stephan Herzig & Maria Rohm) -- Chapter 5. Nuclear Receptors and lipid sensing (James L Thorne and Giorgia Cioccoloni) -- Part III: Central Systems -- Chapter 6. Corticosteroid receptors in Cardiac health and disease (Jessica Ivy, Gillian Gray, Megan Holmes, Martin Denvir, Karen Chapman) -- Chapter 7. Physiological convergence and antagonism between GR and PPARγ in inflammation and metabolism (Marija Dacic, Gayathri Shibu and Inez Rogatsky) -- Chapter 8. Circadian Rhythm and Nuclear Receptors (David W Ray) -- Chapter 9. Vitamin D and gut health (James C Fleet) -- Part IV: Cancer -- Chapter 10. Estrogen Receptor alpha and ESR1 Mutations in Breast Cancer (Jaymin Patel & Rinath Jeselsohn) -- Chapter 11. AR structural variants and prostate cancer (Laura Cato) -- Chapter 12. ERβ and inflammation (Linnea Hases, Amena Archer & Cecilia Williams) -- Chapter 13. Genomic insights into non-steroidal nuclear receptors in prostate and breast cancer (Sajad A Wani & Moray Campbell) -- Part V: New developments in transcriptional control by nuclear receptors -- Chapter 14. Protein condensation in the nuclear receptor family; implications for transcriptional output (Monique Appelman, Elle Hollaar, Jurian Schuijers & Saskia WC van Mil) -- Chapter 15. Prostate cancer epigenetic plasticity and enhancer heterogeneity: molecular causes, consequences and clinical implications (Jeroen Kneppers, Andries M Bergman & Wilbert Zwart) -- Chapter 16. Epigenetic coregulation of androgen receptor signaling (Rayzel Fernandes, Damien A. Leach & Charlotte Bevan) -- Part VI: Clinical Translation -- Chapter 17. Cllnical Translation: Targeting the Estrogen Receptor (Jennifer O. Lauchle & Ciara Metcalfe) -- Chapter 18. Drugging the undruggable: targeting the N-terminal domain of nuclear hormone receptors (Marianne Sadar) -- Chapter 19. Genetic Variation and Mendelian Randomization approaches (Mojgan Yazdanpanah, Nahid Yazdanpanah & Despoina Manousaki) -- Index.
    Abstract: This book addresses and dissects the roles and crosstalk mechanisms for the 48 human nuclear receptors (NR) in human health and disease. After a State-of-the-Art introduction by an undisputed and celebrated field leader to provide an overview of the field and its significance, chapters are organized into six sections. The first three sections discuss NR roles in Reproduction & Development, Metabolism and Central Systems. These present to the reader our current understanding of NR signaling in the development and functioning of the reproductive system; the roles in the regulation of energy metabolism; and how NR signaling is more widely integrated into systemic functions from calcium flux to circadian rhythm. The subsequent three sections dissect how aberrant NR functions drive Cancer; how new insights into Genomic Interaction are helping to reveal how NR disruption drives disease; and finally, how Translational Efforts are exploiting this understanding from developing novel NR ligands to establishing how underlying genetic variation impacts NR function. Within these sections the chapters also illustrate emerging understanding of how the epigenome and non-coding genome combine to regulate NR function and impact dysfunction. Increasingly these insights cross-fertilize over cell and disease boundaries and it is unsurprising that NR are being explored in novel and new arenas such as the context of neurological disorders and depression. Thus, there is wide scope for re-purposing of licensed drugs and development of new NR-targeting therapies for a host of conditions and diseases. This unique book brings together many of the leading figures in NR research from across the globe, to discuss emerging roles and their implications for human health and disease. It summarizes the state of the art and shows signposts for future research to further shape this influential field.
    Type of Medium: Online Resource
    Pages: XII, 346 p. 1 illus. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031118364
    Series Statement: Advances in Experimental Medicine and Biology, 1390
    URL: https://doi.org/10.1007/978-3-031-11836-4
    DOI: 10.1007/978-3-031-11836-4
    DDC: 610.72
    Language: English
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  • 6
    Online Resource
    Online Resource
    Stable Isotopes in Tree Rings : Inferring Physiological, Climatic and Environmental Responses (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Plant physiology. ; Forestry. ; Environment. ; Paleontology . ; Plant Physiology. ; Forestry. ; Environmental Sciences. ; Paleontology.
    Description / Table of Contents: PART I INTRODUCTION: 1. Isotope Dendrochronology: Historical Perspective -- 2. Dendrochronology: Fundamentals and Innovations -- 3. Anatomical, developmental and physiological bases of tree-ring formation in relation to environmental factors -- PART II METHODS: 4. Sample collection and preparation for annual and intra-annual tree-ring isotope chronologies -- 5. Stable isotope signatures of wood, its constituents and methods of cellulose extraction -- 6. Tree-Ring Stable Isotope Measurements: The Role of Quality Assurance and Quality Control to Ensure High Quality Data -- 7. Newer Developments in Tree-Ring Stable Isotope Methods -- PART III: ISOTOPIC FRACTIONATIONS FROM SOURCE TO WOOD: 8. Isotopes – terminology, definitions and properties -- 9. Carbon isotope effects in relation to CO2 assimilation by tree canopies -- 10. Environmental, physiological and biochemical processes determining the oxygen isotope ratio of tree-ring cellulose -- 11. The stable hydrogen isotopic signature: From source water to tree rings -- 12. Nitrogen isotopes in tree rings – Challenges and prospects -- 13. Postphotosynthetic fractionation in leaves, phloem and stem -- PART IV PHYSIOLOGICAL INTERPRETATIONS: 14. Environmental fingerprints in tree-ring stable isotopes: Limits and strengths in mirroring environmental impacts -- 15. Post-photosynthetic carbon, oxygen and hydrogen isotope signal transfer to tree rings – how timing of cell formations and turnover of stored carbohydrates affect intra-annual isotope variations -- 16. Probing tree physiology using the dual-isotope approach -- 17. Intrinsic water-use efficiency derived from stable carbon isotopes of tree-rings -- PART V: ENVIRONMENTAL FACTORS IMPACTING THE ISOTOPIC FRACTIONATION: 18. Spatial and temporal variations in plant source water: O and H isotope ratiosfrom precipitation to xylem water -- 19. Climate signals in stable isotope tree ring records -- 20. Stable isotopes in tree rings of Boreal Forests -- 21. Stable isotopes in tree rings of Mediterranean Forests -- 22. Stable isotopes in tree rings of Tropical forests -- 23. Forest Management and Tree-Ring Isotopes -- 24. Impact of increasing CO2, and air pollutants (NOx, SO2, O3) on the stable isotope ratios in tree rings -- 25. Insect and pathogen influences on tree-ring stable isotopes -- 26. Process-based ecophysiological models of tree-ring stable isotopes.
    Abstract: This Open Access volume highlights how tree ring stable isotopes have been used to address a range of environmental issues from paleoclimatology to forest management, and anthropogenic impacts on forest growth. It will further evaluate weaknesses and strengths of isotope applications in tree rings. In contrast to older tree ring studies, which predominantly applied a pure statistical approach this book will focus on physiological mechanisms that influence isotopic signals and reflect environmental impacts. Focusing on connections between physiological responses and drivers of isotope variation will also clarify why environmental impacts are not linearly reflected in isotope ratios and tree ring widths. This volume will be of interest to any researcher and educator who uses tree rings (and other organic matter proxies) to reconstruct paleoclimate as well as to understand contemporary functional processes and anthropogenic influences on native ecosystems. The use of stable isotopes in biogeochemical studies has expanded greatly in recent years, making this volume a valuable resource to a growing and vibrant community of researchers.
    Type of Medium: Online Resource
    Pages: XXI, 773 p. 106 illus., 76 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030926984
    Series Statement: Tree Physiology ; 8
    URL: https://doi.org/10.1007/978-3-030-92698-4
    DOI: 10.1007/978-3-030-92698-4
    DDC: 571.2
    Language: English
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  • 7
    Online Resource
    Online Resource
    Technologies in Biomedical and Life Sciences Education : Approaches and Evidence of Efficacy for Learning (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Physiology. ; Science Study and teaching. ; Educational tests and measurements. ; Education Research. ; Physiology. ; Science Education. ; Assessment and Testing. ; Educational Research.
    Description / Table of Contents: Part 1: Introduction and Educational Context -- Chapter 1: Introduction: Intentional Innovation in Educational Technology and Media to Promote Students’ Holistic Development -- Chapter 2: Technology, Equity and Inclusion in the Virtual Education Space -- Chapter 3: Institutional Culture of Student Empowerment: Redefining the Roles of Students and Technology -- Chapter 4: From Psychology Laboratory to Student Development: Untangling Momentary Engagement from Longer-term Engagement in Bioscience Education -- Part 2: How Educational Technologies Shape the Classroom Experience -- Chapter 5: Perceptual Learning, Adaptive Learning, and Gamification: Educational Technologies for Pattern Recognition, Problem Solving and Knowledge Retention in Medical Learning -- Chapter 6: The Flipped Classroom: A Guide to Making Evidence-Based Decisions about Implementation -- Chapter 7: Supplementary Videos in the Biosciences: How Stakeholders Can Reinforce Complex Concepts for Self-Directed Learners -- Chapter 8: Aligning assessment goals with the current and future technologies needed to achieve them -- Chapter 9: The Use of Video, Audio and E-portfolios to Provide Feedback -- Chapter 10: Academic Cheating: How Can We Detect and Discourage It? -- Part 3: How Educational Technologies Transcend the Classroom -- Chapter 11: DEBATE PART 1: Attendance and Performance: a New Landscape in the Era of Online Teaching -- Chapter 12: DEBATE PART 2: Lecture Capture, Attendance and Exam Performance in the Biosciences: Exploring Rare Exceptions to the Link Between Attendance and Performance in the Era of Online Teaching -- Chapter 13: Online Science Education at Scale: Open and Distance Learning, MOOCS, and Other Learning Assets for Theory and Practice -- Chapter 14: Social Online Learning: Leveraging Social Media and Web-Based Co-Creation to Drive Learning -- Chapter 15: The Role of Educational Technology on Mitigating the Impact of the COVID-19 Pandemic on Teaching and Learning -- Part 4: The Future and Research -- Chapter 16: The Unpredictable Future of High Fidelity Patient Simulation in Biomedical Science Education: the Price Must Be Right -- Chapter 17: The Future with Extended Reality, Three-dimensional and Advanced Imaging for Molecules, Microscopy and Anatomy -- Chapter 18: The Future of Biomedical and Life Sciences Education: Evidence-based Future Directions.
    Abstract: This contributed volume focuses on understanding the educational strengths and weaknesses of mediated content (including media as a learning supplement), in comparison to traditional face-to-face learning. Each chapter includes research on, and a broad-brush summary of, approaches to combining life sciences education with educational technologies. The chapters are organized into four main sections, each of which focuses on a key question regarding the consequences of incorporating media into education. In this regard, the authors highlight how educational technology is both a bridge and barrier to student access and inclusivity. Further, they address the ongoing discussion as to whether students need to be present for lectures, and on how having agency in their own learning can improve both retention and conceptual understanding. To link the content to current events, the authors also shed light on the impact that the COVID-19 pandemic is having on the continuity of educational programs and on the growing importance of educational technologies. Consequently, the book offers life science educators valuable guidance on the technologies already available, and an outlook on what is yet to come.
    Type of Medium: Online Resource
    Pages: XVI, 580 p. 77 illus., 61 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030956332
    Series Statement: Methods in Physiology,
    URL: https://doi.org/10.1007/978-3-030-95633-2
    DOI: 10.1007/978-3-030-95633-2
    DDC: 571
    Language: English
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  • 8
    Online Resource
    Online Resource
    Pharmacology of Immunosuppression (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Pharmacology. ; Human physiology. ; Immunology. ; Surgery. ; Pharmacology. ; Human Physiology. ; Immunology. ; Surgery.
    Description / Table of Contents: Review of the Pathophysiology of the Alloimmune response -- A Comprehensive Review of Calcineurin Inhibitors Used for Immunosuppression in Cardiac Transplantation -- Anti-proliferative Agents -- Mechanistic Target of Rapamycin (mTOR) Inhibitors -- Corticosteroids -- Induction therapy and antibodies -- Immunosuppression and Heart Transplantation -- Immunosuppression and Lung Transplantation -- Immunosuppression and renal transplant recipients -- Immunosuppression in Rheumatologic and Auto-immune Disease -- Immunosuppression in Bone Marrow Transplantation -- Immunosuppression in Multiple Sclerosis and Other Neurologic Disorders -- Novel immunosuppressive agents for the treatment of organ transplants -- Adverse Effects of Immunosuppression: Infections -- Malignancy: An Adverse Effect of Immunosuppression -- Adverse Effects of Immunosuppression:Nephrotoxicity, Hypertension and Metabolic Disease.
    Abstract: The goal of this book is to provide a guide and detailed review of immunosuppression in terms of molecular mechanisms of action, side effects and clinical trials that validated their utility. This includes their use in solid organ transplantation, bone marrow transplantation and autoimmune diseases and inflammatory diseases. This book is a critical review of these topics and a vital resource.
    Type of Medium: Online Resource
    Pages: VIII, 348 p. 100 illus., 30 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783031051180
    Series Statement: Handbook of Experimental Pharmacology, 272
    URL: https://doi.org/10.1007/978-3-031-05118-0
    DOI: 10.1007/978-3-031-05118-0
    DDC: 615
    Language: English
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  • 9
    Online Resource
    Online Resource
    The Marine Microbiome (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Microbiology. ; Industrial microbiology. ; Microbial ecology. ; Biochemical engineering. ; Microbiology. ; Industrial Microbiology. ; Microbial Ecology. ; Bioprocess Engineering.
    Description / Table of Contents: Chapter 1: A Sea Of Microbes: What’s So Special About Marine Microbiology -- Part I: Diversity And Evolution Of Marine Microorganisms -- Chapter 2: Survival In A Sea Of Gradients: Bacterial And Archaeal Foraging In A Heterogeneous Ocean -- Chapter 3: Marine Cyanobacteria -- Chapter 4: Marine Protists: A Hitchhiker’s Guide To Their Role In The Marine Microbiome -- Chapter 5: Marine Fungi -- Chapter 6: Marine Viruses: Agents Of Chaos, Promoters Of Order -- Chapter 7: Evolutionary Genomics Of Marine Bacteria And Archaea -- Part II: Marine Habitats -- Chapter 8: Towards A Global Perspective Of The Marine Microbiome -- Chapter 9: The Pelagic Light-Dependent Microbiome -- Chapter 10: Microbial Inhabitants Of The Dark Ocean -- Chapter 11: The Subsurface And Oceanic Crust Prokaryotes -- Chapter 12: The Microbiome Of Coastal Sediments -- Chapter 13: Symbiosis In The Ocean Microbiome -- Chapter 14: Marine Extreme Habitats -- Part III: Marine Microbiome From Genomes To Phenomes: Biogeochemical Cycles, Networks, Fluxes, And Interaction -- Chapter 15: Marine Biogeochemical Cycles -- Chapter 16: A Holistic Approach For The Study Of The Role Of Microorganisms In The Marine Ecosystem -- Chapter 17: The Hidden Treasure: Marine Microbiome As Repository Of Bioactive Compounds -- Chapter 18: Ocean Restoration And The Strategic Plan Of The Marine Microbiome. .
    Abstract: This updated and expanded second edition reviews numerous aspects of the marine microbiome and its possible industrial applications. The marine microbiome is the total of microorganisms and viruses in the ocean and seas and in any connected environment, including the seafloor and marine animals and plants. In the first part of the book, diversity, origin and evolution of the marine microorganisms and viruses are discussed. The microbes presented originate from all three domains of life: Bacteria, Archaea, and Eukarya. The second part sheds some light on the different communities: it describes marine habitats and how their inhabitants control biogeochemical cycles. The third part finally examines the microbial ocean as a global system and evaluates methods of utilizing marine microbial resources. Adopting a translational approach, the book connects academic research with industrial applications, making it a fascinating read and valuable resource for microbiologists from both domains.
    Type of Medium: Online Resource
    Pages: XVI, 766 p. 92 illus. in color. , online resource.
    Edition: 2nd ed. 2022.
    ISBN: 9783030903831
    Series Statement: The Microbiomes of Humans, Animals, Plants, and the Environment, 3
    URL: https://doi.org/10.1007/978-3-030-90383-1
    DOI: 10.1007/978-3-030-90383-1
    DDC: 579
    Language: English
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  • 10
    Online Resource
    Online Resource
    Prevention and Treatment of Atherosclerosis : Improving State-of-the-Art Management and Search for Novel Targets (2022)
    Cham :Springer International Publishing :
    Details
    Keywords: Internal medicine. ; Pharmacology. ; Diseases. ; Internal Medicine. ; Pharmacology. ; Internal Medicine. ; Diseases.
    Description / Table of Contents: Diet, Life Style, Smoking -- Blood Pressure Lowering -- Glycemic Control in Diabetes -- LDL-Cholesterol Lowering -- Antithrombotic Therapy (Platelet Inhibition, Anti-coagulation) -- Triglyceride Rich Lipoproteins -- HDL -- Lipoprotein(a) -- Obesity, Non-alcoholic Fatty Liver Disease, and Metabolic Syndrome -- Nutraceuticals / Functional Food -- Adipose Tissue (WAT, BAT) -- Microbiota and Cardiometabolic Disease -- SMCs, Matrix -- Immune Modulation -- NETs and Neutrophils -- Genomic Strategies Towards Identification of Novel Therapeutic Targets -- Non Coding RNAs -- Metabolomics, Lipidomics -- Epigenomics.
    Abstract: This open access book is supported by the European Atherosclerosis Society Association (EAS). This follow-up edition of the well-received Handbook volume 'Atherosclerosis: Diet and Drugs' reflects the state-of-the-art and most recent developments in atherosclerosis research. Outstanding international experts give a comprehensive overview of the field covering topics, such as improving the treatment focusing on established targets, novel drug developments addressing pre-defined targets, hypothesis-based and hypothesis-free approaches to unravel novel targets. .
    Type of Medium: Online Resource
    Pages: X, 538 p. 40 illus., 37 illus. in color. , online resource.
    Edition: 1st ed. 2022.
    ISBN: 9783030860769
    Series Statement: Handbook of Experimental Pharmacology, 270
    URL: https://doi.org/10.1007/978-3-030-86076-9
    DOI: 10.1007/978-3-030-86076-9
    DDC: 616
    Language: English
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