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  • 2020-2024  (74)
  • 2000-2004
  • 1965-1969
  • 2020  (74)
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  • 1
    Online Resource
    Online Resource
    Neuroinflammation and Schizophrenia (2020)
    Cham :Springer International Publishing :
    Details
    Keywords: Neurosciences. ; Immunology. ; Psychiatry. ; Neuroscience. ; Immunology. ; Psychiatry.
    Description / Table of Contents: Preface -- A Brief History of Immunological Research into Psychosis and Pathways for Immune Influence of the Brain.-Basic Concept of Microglia Biology and Neuroinflammation in Relation to Psychiatry -- Epidemiological Studies of Prenatal and Childhood Infection and Schizophrenia -- Schizophrenia, Cytokines and Other Systemic Inflammatory Mediators [to include oxidative stress and lymphocyte alterations] -- Association between Schizophrenia, Microbial Infection and Microbiota -- Autoantibodies and psychosis -- Effect of Infection on Cognition in Schizophrenia and Healthy People -- Role of Infection, Autoimmunity, Atopic Disorders and the Immune System in Schizophrenia: Evidence from Epidemiological and Genetic Studies -- Microglial Activation and Psychotic Disorders: Evidence from Pre-clinical and Clinical Studies -- Early-Life Adversity, Systemic Inflammation, and Co-Morbid Physical and Psychiatric Illnesses of Adult Life -- Inflammation, Antipsychotic Drugs and Evidence for Effectiveness of Anti-inflammatory Agents in Schizophrenia.
    Abstract: This book provides a comprehensive summary of the cutting edge scientific evidence regarding the role of immune system in the pathogenesis and treatment of schizophrenia and related psychotic disorders. It illustrates the role of inflammation and immunity in schizophrenia drawing on both basic science and clinical research. The chapters provide up-to-date summaries of immunological risk factors for schizophrenia and related psychotic disorders, and underlying mechanisms as informed by neuroimaging, genetic, clinical and animal experimental studies. In addition, the book will illuminate the scope for immunological treatment for schizophrenia. .
    Type of Medium: Online Resource
    Pages: X, 244 p. 10 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030391416
    Series Statement: Current Topics in Behavioral Neurosciences, 44
    URL: https://doi.org/10.1007/978-3-030-39141-6
    DOI: 10.1007/978-3-030-39141-6
    DDC: 612.8
    Language: English
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  • 2
    Online Resource
    Online Resource
    Planetary Accounting : Quantifying How to Live Within Planetary Limits at Different Scales of Human Activity (2020)
    Singapore :Springer Nature Singapore :
    Details
    Keywords: Sustainability. ; Physical geography. ; Economic development. ; Energy policy. ; Energy and state. ; Environmental management. ; Sustainability. ; Earth System Sciences. ; Development Studies. ; Energy Policy, Economics and Management. ; Environmental Management.
    Description / Table of Contents: Part 1: Introduction -- Chapter 1: The science of anthropogenic climate change -- Chapter 2: The Holocene, the Anthropocene, and the Planetary Boundaries -- Chapter 3: Managing the Earth System – Why we Need a Poly-Scalar Approach -- Chapter 4: Environmental Accounting, Absolute Limits, and Systemic Change -- Chapter 5: Resolving the Disconnect between Earth System Science, Management Theory, and Environmental Accounting -- Part 2: Developing Planetary Quotes -- Chapter 6: Translating the Planetary Boundaries into Planetary Quotas -- Chapter 7: A Planetary Quota for Carbon Dioxide.-Chapter 8: A Quota for Agricultural GHG Emissions (Methane and Nitrous Oxide) -- Chapter 9: A Quota for Forestland -- Chapter 10: A Quota for Ozone Depleting Substances -- Chapter 11: A Quota for Aerosols -- Chapter 12: A Quota for Water -- Chapter 13: A Quota for Nitrogen -- Chapter 14: The Phosphorus Quota -- Chapter 15: The Biodiversity Quota -- Chapter 16: The Imperishable Waste Quota. Part 3: The planetary Accounting Framework -- Chapter 17: The Planetary Accounting Framework.
    Abstract: This book presents a novel way to enable people, regardless of their scale of influence, to take responsibility for global environmental problems including climate change. It introduces a new framework called Planetary Accounting, which allows the Planetary Boundaries, non-negotiable limits for the environment, to be translated into limits for human activity. It shows how such limits can be broken down into chunks that can be managed at different levels (from individual and community, to business and sector levels, to cities and regions), and at any level of government. The book begins by summarising the science of climate change and introducing the notion of the Anthropocene – the “human age”. It highlights the importance of returning to and remaining within the Planetary Boundaries but shows that we can’t realistically do so unless we have a new approach to environmental accounting. The book then outlines how Planetary Accounting furnishes this new approach by combining sustainability science, change theory, and environmental accounting to create a scalable framework for environmental management that encourages systemic and individual change. The details of the science of and our human contribution to ten critical human pressures are then presented, and the book concludes with a guide for those seeking to apply Planetary Accounting in practice. Planetary Accounting could form the scientific underpinning of behaviour change programs, guide the development of policy and regulations, and provide both the basis for environmental laws, and the foundation of future global environmental agreements. It has been 50 years since the first views from space showed a blue planet alone in our solar system. This book is an historic opportunity to provide humanity for the first time with sufficient information to begin implementing Planetary Accounting. .
    Type of Medium: Online Resource
    Pages: XIV, 278 p. 1 illus. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9789811514432
    URL: https://doi.org/10.1007/978-981-15-1443-2
    DOI: 10.1007/978-981-15-1443-2
    DDC: 304.2
    Language: English
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  • 3
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    Factors controlling plankton community production, export flux, and particulate matter stoichiometry in the coastal upwelling system off Peru (2020)
    Copernicus Publications (EGU)
    Details
    Publication Date: 2023-02-08
    Description: Eastern boundary upwelling systems (EBUS) are among the most productive marine ecosystems on Earth. The production of organic material is fueled by upwelling of nutrient-rich deep waters and high incident light at the sea surface. However, biotic and abiotic factors can modify surface production and related biogeochemical processes. Determining these factors is important because EBUS are considered hotspots of climate change, and reliable predictions of their future functioning requires understanding of the mechanisms driving the biogeochemical cycles therein. In this field experiment, we used in situ mesocosms as tools to improve our mechanistic understanding of processes controlling organic matter cycling in the coastal Peruvian upwelling system. Eight mesocosms, each with a volume of ∼55 m3, were deployed for 50 d ∼6 km off Callao (12∘ S) during austral summer 2017, coinciding with a coastal El Niño phase. After mesocosm deployment, we collected subsurface waters at two different locations in the regional oxygen minimum zone (OMZ) and injected these into four mesocosms (mixing ratio ≈1.5 : 1 mesocosm: OMZ water). The focus of this paper is on temporal developments of organic matter production, export, and stoichiometry in the individual mesocosms. The mesocosm phytoplankton communities were initially dominated by diatoms but shifted towards a pronounced dominance of the mixotrophic dinoflagellate (Akashiwo sanguinea) when inorganic nitrogen was exhausted in surface layers. The community shift coincided with a short-term increase in production during the A. sanguinea bloom, which left a pronounced imprint on organic matter C : N : P stoichiometry. However, C, N, and P export fluxes did not increase because A. sanguinea persisted in the water column and did not sink out during the experiment. Accordingly, export fluxes during the study were decoupled from surface production and sustained by the remaining plankton community. Overall, biogeochemical pools and fluxes were surprisingly constant for most of the experiment. We explain this constancy by light limitation through self-shading by phytoplankton and by inorganic nitrogen limitation which constrained phytoplankton growth. Thus, gain and loss processes remained balanced and there were few opportunities for blooms, which represents an event where the system becomes unbalanced. Overall, our mesocosm study revealed some key links between ecological and biogeochemical processes for one of the most economically important regions in the oceans.
    Type: Article , PeerReviewed
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  • 4
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    KOSMOS 2017 Peru mesocosm study: overview data (2020)
    PANGAEA
    Details
    Publication Date: 2024-04-20
    Description: Eastern boundary upwelling systems (EBUS) are among the most productive marine ecosystems on Earth. The production of organic material is fueled by upwelling of nutrient-rich deep waters and high incident light at the sea surface. However, biotic and abiotic factors can mod- ify surface production and related biogeochemical processes. Determining these factors is important because EBUS are considered hotspots of climate change, and reliable predic- tions of their future functioning requires understanding of the mechanisms driving the biogeochemical cycles therein. In this field experiment, we used in situ mesocosms as tools to improve our mechanistic understanding of processes con- trolling organic matter cycling in the coastal Peruvian up- welling system. Eight mesocosms, each with a volume of ∼ 55 m3, were deployed for 50 d ∼ 6 km off Callao (12◦ S) during austral summer 2017, coinciding with a coastal El Niño phase. After mesocosm deployment, we collected sub- surface waters at two different locations in the regional oxy- gen minimum zone (OMZ) and injected these into four meso- cosms (mixing ratio ≈ 1.5 : 1 mesocosm: OMZ water). The focus of this paper is on temporal developments of organic matter production, export, and stoichiometry in the indi- vidual mesocosms. The mesocosm phytoplankton commu- nities were initially dominated by diatoms but shifted to- wards a pronounced dominance of the mixotrophic dinoflag- ellate (Akashiwo sanguinea) when inorganic nitrogen was exhausted in surface layers. The community shift coincided with a short-term increase in production during the A. san- guinea bloom, which left a pronounced imprint on organic matter C : N : P stoichiometry. However, C, N, and P export fluxes did not increase because A. sanguinea persisted in the water column and did not sink out during the experiment. Accordingly, export fluxes during the study were decou- pled from surface production and sustained by the remain- ing plankton community. Overall, biogeochemical pools and fluxes were surprisingly constant for most of the experiment. We explain this constancy by light limitation through self- shading by phytoplankton and by inorganic nitrogen limita- tion which constrained phytoplankton growth. Thus, gain and loss processes remained balanced and there were few oppor- tunities for blooms, which represents an event where the sys- tem becomes unbalanced. Overall, our mesocosm study re- vealed some key links between ecological and biogeochem- ical processes for one of the most economically important regions in the oceans.
    Keywords: Binary Object; Binary Object (File Size); Binary Object (Media Type); Climate - Biogeochemistry Interactions in the Tropical Ocean; KOSMOS_2017; KOSMOS_2017_Peru; KOSMOS Peru; MESO; Mesocosm experiment; SFB754
    Type: Dataset
    Format: text/tab-separated-values, 11 data points
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    DATA PANGAEA
  • 5
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    Habitat light sets the boundaries for the rapid evolution of cichlid fish vision, while sexual selection can tune it within those limits (2020)
    Wiley
    Details
    Publication Date: 2023-02-08
    Description: Cichlid fishes’ famous diversity in body coloration is accompanied by a highly diverse and complex visual system. Although cichlids possess an unusually high number of seven cone opsin genes, they express only a subset of these during their ontogeny, accounting for their astonishing interspecific variation in visual sensitivities. Much of this diversity is thought to have been shaped by natural selection as cichlids inhabit a variety of habitats with distinct light environments. Also, sexual selection might have contributed to the observed visual diversity, and sexual dimorphism in coloration potentially co‐evolved with sexual dimorphism in opsin expression. We investigated sex‐specific opsin expression of several cichlids from Africa and the Neotropics and collected and integrated datasets on sex‐specific body coloration, species‐specific visual sensitivities, lens transmission and habitat light properties for some of them. We comparatively analyzed this wide range of molecular and ecological data, illustrating how integrative approaches can address specific questions on the factors and mechanisms driving diversification, and the evolution of cichlid vision in particular. We found that both sexes expressed opsins at the same levels ‐ even in sexually dimorphic cichlid species – which argues against coevolution of sexual dichromatism and differences in sex‐specific visual sensitivity. Rather, a combination of environmental light properties and body coloration shaped the diversity in spectral sensitivities among cichlids. We conclude that although cichlids are particularly colorful and diverse and often sexually dimorphic, it would appear that natural rather than sexual selection is a more powerful force driving visual diversity in this hyper‐diverse lineage.
    Type: Article , PeerReviewed
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  • 6
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    Diving into divergence: Differentiation in swimming performances, physiology and gene expression between locally‐adapted sympatric cichlid fishes (2020)
    Wiley
    Details
    Publication Date: 2023-02-08
    Description: Sympatric speciation occurs without geographical barriers and is thought to often be driven by ecological specialization of individuals that eventually diverge genetically and phenotypically. Distinct morphologies between sympatric populations occupying different niches have been interpreted as such differentiating adaptive phenotypes, yet differences in performance and thus likely adaptiveness between them were rarely tested. Here, we investigated if divergent body shapes of two sympatric crater lake cichlid species from Nicaragua, one being a shore‐associated (benthic) species while the other prefers the open water zones (limnetic), affect cruising (Ucrit) and sprinting (Usprint) swimming abilities ‐ performances particularly relevant to their respective lifestyles. Furthermore, we investigated species differences in oxygen consumption (MO2) across different swimming speeds and compare gene expression in gills and white muscle at rest and during exercise. We found a superior cruising ability in the limnetic Amphilophus zaliosus compared to the benthic A. astorquii, while sprinting was not different, suggesting that their distinct morphologies affect swimming performance. Increased cruising swimming ability in A. zaliosus was linked to a higher oxygen demand during activity (but not rest), indicating different metabolic rates during exercise ‐ a hypothesis supported by coinciding gene expression patterns of gill transcriptomes. We identified differentially expressed genes linked to swimming physiology, regulation of swimming behaviour and oxygen intake. A combination of physiological and morphological differences may thus underlie adaptations to these species’ distinct niches. This complex ecological specialization likely resulted in morphological and physiological trade‐offs that contributed to the rapid establishment and maintenance of divergence with gene flow.
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  • 7
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    Genomic and genetic sequence information of strains assigned to the genus Rhodopseudomonas reveal the great heterogeneity of the group and identify strain Rhodopseudomonas palustris DSM 123T as the authentic type strain of this species (2020)
    Microbiology Society
    Details
    Publication Date: 2023-02-08
    Description: The genus Rhodopseudomonas , containing purple nonsulfur photosynthetic Proteobacteria, has a number of strains that belong to different species, although many of them are collectively called Rhodopseudomonas palustris . The type species R. palustris and closely related species are the focus of this paper. The comparison of available genome sequences indicate that the following Rhodopseudomonas species are well recognized: R. palustris (strains ATH 2.1.6T=DSM 123T=NBRC 100419T and BisB5), Rhodopseudomonas rutila (strains R1T, DSM 126, CGA009, ATH 2.1.37, Eli 1980, ATCC 17001 and TIE1), Rhodopseudomonas pentothenatexigens JA575T and Rhodopseudomonas faecalis JCM 11668T. Other strains for which genome sequences are available are distinct from these four species. Evidence is presented that R. palustris strain ATH 2.1.6T–KCM as obtained directly from the van Niel collection by one of us (T.E.M.) is identical to the DSMZ deposit DSM 123T of ATH 2.1.6T, but not to the deposit at ATCC 17001. The amino acid sequences of the cytochromes C2 and C556 from R. palustris strain ATH 2.1.6T–KCM are in complete agreement with the translated genome sequences of R. palustris DSM 123T. In addition, the 16S rRNA gene sequence of R. palustris NBRC 100419T completely matches that of strain DSM 123T. In conclusion, the type strain of R. palustris ATH 2.1.6T is correctly represented by DSM 123T and NBRC 100419T. However, the deposit at ATCC 17001 has properties that do not conform with properties of authentic R. palustris , but rather indicate that this is a strain of R. rutila . The previously suggested assignment of the type strain of R. palustris DSM 123T to the new species R. pseudopalustris was incorrect because strain DSM 123T is the authentic type strain of R. palustris .
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  • 8
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    Experimental parasite infection causes genome-wide changes in DNA methylation (2020)
    Oxford University Press
    Details
    Publication Date: 2023-02-08
    Description: Parasites are arguably among the strongest drivers of natural selection, constraining hosts to evolve resistance and tolerance mechanisms. Although, the genetic basis of adaptation to parasite infection has been widely studied, little is known about how epigenetic changes contribute to parasite resistance and eventually, adaptation. Here, we investigated the role of host DNA methylation modifications to respond to parasite infections. In a controlled infection experiment, we used the three-spined stickleback fish, a model species for host-parasite studies, and their nematode parasite Camallanus lacustris. We showed that the levels of DNA methylation are higher in infected fish. Results furthermore suggest correlations between DNA methylation and shifts in key fitness and immune traits between infected and control fish, including respiratory burst and functional trans-generational traits such as the concentration of motile sperm. We revealed that genes associated with metabolic, developmental and regulatory processes (cell death and apoptosis) were differentially methylated between infected and control fish. Interestingly, genes such as the neuropeptide FF receptor 2 and the integrin alpha 1 as well as molecular pathways including the Th1 and Th2 cell differentiation were hypermethylated in infected fish, suggesting parasite-mediated repression mechanisms of immune responses. Altogether, we demonstrate that parasite infection contributes to genome-wide DNA methylation modifications. Our study brings novel insights into the evolution of vertebrate immunity and suggests that epigenetic mechanisms are complementary to genetic responses against parasite-mediated selection.
    Type: Article , PeerReviewed
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  • 9
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    A genomic cluster containing novel and conserved genes is associated with cichlid fish dental developmental convergence (2020)
    Oxford University Press
    Details
    Publication Date: 2023-02-08
    Description: The two toothed jaws of cichlid fishes provide textbook examples of convergent evolution. Tooth phenotypes such as enlarged molar-like teeth used to process hard-shelled molluscs have evolved numerous times independently during cichlid diversification. While the ecological benefit of molar-like teeth to crush prey is known, it is unclear whether the same molecular mechanisms underlie these convergent traits. To identify genes involved in the evolution and development of enlarged cichlid teeth, we performed RNA-seq on the serially homologous toothed oral and pharyngeal jaws as well as the fourth toothless gill arch of Astatoreochromis alluaudi. We identified 27 genes that are highly upregulated on both tooth-bearing jaws compared to the toothless gill arch. Most of these genes have never been reported to play a role in tooth formation. Two of these genes (unk, rpfA) are not found in other vertebrate genomes but are present in all cichlid genomes. They also cluster genomically with two other highly expressed tooth genes (odam, scpp5) that exhibit conserved expression during vertebrate odontogenesis. Unk and rpfA were confirmed via in situ hybridization to be expressed in developing teeth of Astatotilapia burtoni. We then examined expression of the cluster's four genes in six evolutionarily independent and phylogenetically disparate cichlid species pairs each with a large- and a small-toothed species. Odam and unk commonly and scpp5 and rpfA always showed higher expression in larger-toothed cichlid jaws. Convergent trophic adaptations across cichlid diversity are associated with the repeated developmental deployment of this genomic cluster containing conserved and novel cichlid-specific genes.
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  • 10
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    Two different epigenetic information channels in wild three-spined sticklebacks are involved in salinity adaptation (2020)
    AAAS (American Association for the Advancement of Science)
    Details
    Publication Date: 2023-03-09
    Description: Epigenetic inheritance has been proposed to contribute to adaptation and acclimation via two information channels: (i) inducible epigenetic marks that enable transgenerational plasticity and (ii) noninducible epigenetic marks resulting from random epimutations shaped by selection. We studied both postulated channels by sequencing methylomes and genomes of Baltic three-spined sticklebacks ( Gasterosteus aculeatus ) along a salinity cline. Wild populations differing in salinity tolerance revealed differential methylation (pop-DMS) at genes enriched for osmoregulatory processes. A two-generation experiment demonstrated that 62% of these pop-DMS were noninducible by salinity manipulation, suggesting that they are the result of either direct selection or associated genomic divergence at cis- or trans-regulatory sites. Two-thirds of the remaining inducible pop-DMS increased in similarity to patterns detected in wild populations from corresponding salinities. The level of similarity accentuated over consecutive generations, indicating a mechanism of transgenerational plasticity. While we can attribute natural DNA methylation patterns to the two information channels, their interplay with genomic variation in salinity adaptation is still unresolved.
    Type: Article , PeerReviewed
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