ALBERT

Description: Estimates of extinction risk for Amazonian plant and animal species are rare and not often incorporated into land-use policy and conservation planning. We overlay spatial distribution models with historical and projected deforestation to show that at least 36% and up to 57% of all Amazonian tree species are likely to qualify as globally threatened under International Union for Conservation of Nature (IUCN) Red List criteria. If confirmed, these results would increase the number of threatened plant species on Earth by 22%. We show that the trends observed in Amazonia apply to trees throughout the tropics, and we predict that most of the world’s 〉40,000 tropical tree species now qualify as globally threatened. A gap analysis suggests that existing Amazonian protected areas and indigenous territories will protect viable populations of most threatened species if these areas suffer no further degradation, highlighting the key roles that protected areas, indigenous peoples, and improved governance can play in preventing large-scale extinctions in the tropics in this century.

Description: Critical measurements for understanding accretion and the dust/gas ratio in the solar nebula, where planets were forming 4.5 billion years ago, are being obtained by the GIADA (Grain Impact Analyser and Dust Accumulator) experiment on the European Space Agency's Rosetta spacecraft orbiting comet 67P/Churyumov-Gerasimenko. Between 3.6 and 3.4 astronomical units inbound, GIADA and OSIRIS (Optical, Spectroscopic, and Infrared Remote Imaging System) detected 35 outflowing grains of mass 10(-10) to 10(-7) kilograms, and 48 grains of mass 10(-5) to 10(-2) kilograms, respectively. Combined with gas data from the MIRO (Microwave Instrument for the Rosetta Orbiter) and ROSINA (Rosetta Orbiter Spectrometer for Ion and Neutral Analysis) instruments, we find a dust/gas mass ratio of 4 +/- 2 averaged over the sunlit nucleus surface. A cloud of larger grains also encircles the nucleus in bound orbits from the previous perihelion. The largest orbiting clumps are meter-sized, confirming the dust/gas ratio of 3 inferred at perihelion from models of dust comae and trails.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rotundi, Alessandra -- Sierks, Holger -- Della Corte, Vincenzo -- Fulle, Marco -- Gutierrez, Pedro J -- Lara, Luisa -- Barbieri, Cesare -- Lamy, Philippe L -- Rodrigo, Rafael -- Koschny, Detlef -- Rickman, Hans -- Keller, Horst Uwe -- Lopez-Moreno, Jose J -- Accolla, Mario -- Agarwal, Jessica -- A'Hearn, Michael F -- Altobelli, Nicolas -- Angrilli, Francesco -- Barucci, M Antonietta -- Bertaux, Jean-Loup -- Bertini, Ivano -- Bodewits, Dennis -- Bussoletti, Ezio -- Colangeli, Luigi -- Cosi, Massimo -- Cremonese, Gabriele -- Crifo, Jean-Francois -- Da Deppo, Vania -- Davidsson, Bjorn -- Debei, Stefano -- De Cecco, Mariolino -- Esposito, Francesca -- Ferrari, Marco -- Fornasier, Sonia -- Giovane, Frank -- Gustafson, Bo -- Green, Simon F -- Groussin, Olivier -- Grun, Eberhard -- Guttler, Carsten -- Herranz, Miguel L -- Hviid, Stubbe F -- Ip, Wing -- Ivanovski, Stavro -- Jeronimo, Jose M -- Jorda, Laurent -- Knollenberg, Joerg -- Kramm, Rainer -- Kuhrt, Ekkehard -- Kuppers, Michael -- Lazzarin, Monica -- Leese, Mark R -- Lopez-Jimenez, Antonio C -- Lucarelli, Francesca -- Lowry, Stephen C -- Marzari, Francesco -- Epifani, Elena Mazzotta -- McDonnell, J Anthony M -- Mennella, Vito -- Michalik, Harald -- Molina, Antonio -- Morales, Rafael -- Moreno, Fernando -- Mottola, Stefano -- Naletto, Giampiero -- Oklay, Nilda -- Ortiz, Jose L -- Palomba, Ernesto -- Palumbo, Pasquale -- Perrin, Jean-Marie -- Rodriguez, Julio -- Sabau, Lola -- Snodgrass, Colin -- Sordini, Roberto -- Thomas, Nicolas -- Tubiana, Cecilia -- Vincent, Jean-Baptiste -- Weissman, Paul -- Wenzel, Klaus-Peter -- Zakharov, Vladimir -- Zarnecki, John C -- New York, N.Y. -- Science. 2015 Jan 23;347(6220):aaa3905. doi: 10.1126/science.aaa3905.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Istituto di Astrofisica e Planetologia Spaziali, Istituto Nazionale di Astrofisica (INAF), Via Fosso del Cavaliere, 100, 0133 Rome, Italy. Universita degli Studi di Napoli "Parthenope," Dipartimento di Scienze e Tecnologie, CDN IC4, 80143 Naples, Italy. rotundi@uniparthenope.it. ; Max-Planck-Institut fur Sonnensystemforschung, Justus-von-Liebig-Weg, 3, 37077 Gottingen, Germany. ; Istituto di Astrofisica e Planetologia Spaziali, Istituto Nazionale di Astrofisica (INAF), Via Fosso del Cavaliere, 100, 0133 Rome, Italy. ; Osservatorio Astronomico, INAF, Via Tiepolo 11, 34143 Trieste, Italy. ; Instituto de Astrofisica de Andalucia, Consejo Superior de Investigaciones Cientificas (CSIC), P.O. Box 3008, 18080 Granada, Spain. ; Department of Physics and Astronomy, Padova University, Vicolo dell'Osservatorio 3, 35122 Padova, Italy. ; Laboratoire d'Astrophysique de Marseille, UMR 7326, CNRS and Aix-Marseille Universite, 13388 Marseille, France. ; Centro de Astrobiologia (Instituto Nacional de Tecnica Aerospacial-CSIC), 28691 Villanueva de la Canada, Madrid, Spain. International Space Science Institute, Hallerstrasse 6, CH-3012 Bern, Switzerland. ; Scientific Support Office, European Space Agency, 2201 Noordwijk, Netherlands. ; Department of Physics and Astronomy, Uppsala University, Box 516, 75120 Uppsala, Sweden. Polish Academy of Sciences Space Research Center, Bartycka 18A, PL-00716 Warszawa, Poland. ; Institute for Geophysics and Extraterrestrial Physics, Technische Universitat Braunschweig, Braunschweig 38106, Germany. ; Istituto di Astrofisica e Planetologia Spaziali, Istituto Nazionale di Astrofisica (INAF), Via Fosso del Cavaliere, 100, 0133 Rome, Italy. Universita degli Studi di Napoli "Parthenope," Dipartimento di Scienze e Tecnologie, CDN IC4, 80143 Naples, Italy. ; Department of Astronomy, University of Maryland, College Park, MD 20742-2421, USA. ; European Space Agency (ESA)-European Space Astronomy Center (ESAC), Camino Bajo del Castillo, s/n, 28692 Villanueva de la Canada, Madrid, Spagna. ; Department of Mechanical Engineering, University of Padova, via Venezia 1, 35131 Padova, Italy. ; Laboratoire d'Etudes Spatiales et d'Instrumentation en Astrophysique, Observatoire de Paris, CNRS, Universite Paris 06, Universite Paris-Diderot, 5 place Johannes Janssen, 92195 Meudon, France. ; Laboratoire Atmospheres, Milieux, Observations Spatiales, CNRS/Universite de Versailles Saint-Quentin-en-Yvelines/Institut Pierre-Simon Laplace, 11 boulevard d'Alembert, 78280 Guyancourt, France. ; University of Padova, Centro Interdipartimentale di Studi e Attivita Spaziali (CISAS), via Venezia 15, 35100 Padova, Italy. ; Universita degli Studi di Napoli "Parthenope," Dipartimento di Scienze e Tecnologie, CDN IC4, 80143 Naples, Italy. ; ESA, European Space Research and Technology Centre (ESTEC), Keplerlaan 1, 2201 AZ Noordwijk, Netherlands. ; Selex-ES, Via Albert Einstein, 35, 50013 Campi Bisenzio, Firenze, Italy. ; Osservatorio Astronomico di Padova, INAF, Vicolo dell'Osservatorio 5, 35122 Padova, Italy. ; Consiglio Nazionale delle Ricerche-Istituto di Fotonica e Nanotecnologie-Unita Operativa di Supporto Padova LUXOR, via Trasea 7, 35131 Padova, Italy. ; Department of Physics and Astronomy, Uppsala University, Box 516, 75120 Uppsala, Sweden. ; Universita di Trento, via Mesiano, 77, 38100 Trento, Italy. ; Osservatorio Astronomico di Capodimonte, INAF, Salita Moiariello, 16, 80133 Naples, Italy. ; Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; University of Florida, Gainesville, FL 32611, USA. ; Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK. ; Max-Planck-Institut fuer Kernphysik, Saupfercheckweg 1, 69117 Heidelberg, Germany. ; Institute of Planetary Research, Deutsches Zentrum fur Luft- und Raumfahrt (DLR), Rutherfordstrasse 2, 12489 Berlin, Germany. ; Institute for Space Science, National Central University, 300 Chung Da Road, 32054 Chung-Li, Taiwan. ; The University of Kent, School of Physical Sciences, Canterbury, Kent CT2 7NZ, UK. ; Department of Physics, University of Padova, 35131 Padova, Italy. ; Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK. The University of Kent, School of Physical Sciences, Canterbury, Kent CT2 7NZ, UK. Unispacekent, Canterbury CT2 8EF, UK. ; Institut fur Datentechnik und Kommunikationsnetze, 38106 Braunschweig, Germany. ; Departamento de Fisica Aplicada, Universidad de Granada, Facultad de Ciencias, Avenida Severo Ochoa, s/n, 18071 Granada, Spain. ; Department of Information Engineering, Padova University, via Gradenigo 6, 35131 Padova, Italy. ; Laboratoire Atmospheres, Milieux, Observations Spatiales, CNRS/Universite de Versailles Saint-Quentin-en-Yvelines/Institut Pierre-Simon Laplace, 11 boulevard d'Alembert, 78280 Guyancourt, France. Observatoire de Haute Provence OSU Pytheas UMS 2244 CNRS-AMU, 04870 Saint Michel l'Observatoire, France. ; Instituto Nacional de Tecnica Aeroespacial, Carretera de Ajalvir, p.k. 4, 28850 Torrejon de Ardoz, Madrid, Spain. ; Max-Planck-Institut fur Sonnensystemforschung, Justus-von-Liebig-Weg, 3, 37077 Gottingen, Germany. Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK. ; Physikalisches Institut, Sidlerstrasse 5, University of Bern, 3012 Bern, Switzerland. ; Planetary Science Section, Jet Propulsion Laboratory, 4800 Oak Grove Drive, Pasadena, CA 91109, USA. ; International Space Science Institute, Hallerstrasse 6, CH-3012 Bern, Switzerland. Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25613898" target="_blank"〉PubMed〈/a〉

Description: Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380271/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380271/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Neafsey, Daniel E -- Waterhouse, Robert M -- Abai, Mohammad R -- Aganezov, Sergey S -- Alekseyev, Max A -- Allen, James E -- Amon, James -- Arca, Bruno -- Arensburger, Peter -- Artemov, Gleb -- Assour, Lauren A -- Basseri, Hamidreza -- Berlin, Aaron -- Birren, Bruce W -- Blandin, Stephanie A -- Brockman, Andrew I -- Burkot, Thomas R -- Burt, Austin -- Chan, Clara S -- Chauve, Cedric -- Chiu, Joanna C -- Christensen, Mikkel -- Costantini, Carlo -- Davidson, Victoria L M -- Deligianni, Elena -- Dottorini, Tania -- Dritsou, Vicky -- Gabriel, Stacey B -- Guelbeogo, Wamdaogo M -- Hall, Andrew B -- Han, Mira V -- Hlaing, Thaung -- Hughes, Daniel S T -- Jenkins, Adam M -- Jiang, Xiaofang -- Jungreis, Irwin -- Kakani, Evdoxia G -- Kamali, Maryam -- Kemppainen, Petri -- Kennedy, Ryan C -- Kirmitzoglou, Ioannis K -- Koekemoer, Lizette L -- Laban, Njoroge -- Langridge, Nicholas -- Lawniczak, Mara K N -- Lirakis, Manolis -- Lobo, Neil F -- Lowy, Ernesto -- MacCallum, Robert M -- Mao, Chunhong -- Maslen, Gareth -- Mbogo, Charles -- McCarthy, Jenny -- Michel, Kristin -- Mitchell, Sara N -- Moore, Wendy -- Murphy, Katherine A -- Naumenko, Anastasia N -- Nolan, Tony -- Novoa, Eva M -- O'Loughlin, Samantha -- Oringanje, Chioma -- Oshaghi, Mohammad A -- Pakpour, Nazzy -- Papathanos, Philippos A -- Peery, Ashley N -- Povelones, Michael -- Prakash, Anil -- Price, David P -- Rajaraman, Ashok -- Reimer, Lisa J -- Rinker, David C -- Rokas, Antonis -- Russell, Tanya L -- Sagnon, N'Fale -- Sharakhova, Maria V -- Shea, Terrance -- Simao, Felipe A -- Simard, Frederic -- Slotman, Michel A -- Somboon, Pradya -- Stegniy, Vladimir -- Struchiner, Claudio J -- Thomas, Gregg W C -- Tojo, Marta -- Topalis, Pantelis -- Tubio, Jose M C -- Unger, Maria F -- Vontas, John -- Walton, Catherine -- Wilding, Craig S -- Willis, Judith H -- Wu, Yi-Chieh -- Yan, Guiyun -- Zdobnov, Evgeny M -- Zhou, Xiaofan -- Catteruccia, Flaminia -- Christophides, George K -- Collins, Frank H -- Cornman, Robert S -- Crisanti, Andrea -- Donnelly, Martin J -- Emrich, Scott J -- Fontaine, Michael C -- Gelbart, William -- Hahn, Matthew W -- Hansen, Immo A -- Howell, Paul I -- Kafatos, Fotis C -- Kellis, Manolis -- Lawson, Daniel -- Louis, Christos -- Luckhart, Shirley -- Muskavitch, Marc A T -- Ribeiro, Jose M -- Riehle, Michael A -- Sharakhov, Igor V -- Tu, Zhijian -- Zwiebel, Laurence J -- Besansky, Nora J -- 092654/Wellcome Trust/United Kingdom -- R01 AI050243/AI/NIAID NIH HHS/ -- R01 AI063508/AI/NIAID NIH HHS/ -- R01 AI073745/AI/NIAID NIH HHS/ -- R01 AI076584/AI/NIAID NIH HHS/ -- R01 AI080799/AI/NIAID NIH HHS/ -- R01 AI104956/AI/NIAID NIH HHS/ -- R21 AI101459/AI/NIAID NIH HHS/ -- R56 AI107263/AI/NIAID NIH HHS/ -- SC1 AI109055/AI/NIAID NIH HHS/ -- U19 AI089686/AI/NIAID NIH HHS/ -- U19 AI110818/AI/NIAID NIH HHS/ -- U41 HG007234/HG/NHGRI NIH HHS/ -- U54 HG003067/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2015 Jan 2;347(6217):1258522. doi: 10.1126/science.1258522. Epub 2014 Nov 27.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. neafsey@broadinstitute.org nbesansk@nd.edu. ; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Department of Genetic Medicine and Development, University of Geneva Medical School, Rue Michel-Servet 1, 1211 Geneva, Switzerland. Swiss Institute of Bioinformatics, Rue Michel-Servet 1, 1211 Geneva, Switzerland. ; Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran. ; George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA. ; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. ; National Vector Borne Disease Control Programme, Ministry of Health, Tafea Province, Vanuatu. ; Department of Public Health and Infectious Diseases, Division of Parasitology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy. ; Department of Biological Sciences, California State Polytechnic-Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA. ; Tomsk State University, 36 Lenina Avenue, Tomsk, Russia. ; Department of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA. ; Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. ; Inserm, U963, F-67084 Strasbourg, France. CNRS, UPR9022, IBMC, F-67084 Strasbourg, France. ; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. ; Faculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia. ; Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK. ; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. ; Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada. ; Department of Entomology and Nematology, One Shields Avenue, University of California-Davis, Davis, CA 95616, USA. ; Institut de Recherche pour le Developpement, Unites Mixtes de Recherche Maladies Infectieuses et Vecteurs Ecologie, Genetique, Evolution et Controle, 911, Avenue Agropolis, BP 64501 Montpellier, France. ; Division of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA. ; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece. ; Centre of Functional Genomics, University of Perugia, Perugia, Italy. ; Genomics Platform, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. ; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso. ; Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; School of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA. ; Department of Medical Research, No. 5 Ziwaka Road, Dagon Township, Yangon 11191, Myanmar. ; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA. ; Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA. ; Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Universita degli Studi di Perugia, Perugia, Italy. ; Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; Computational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK. ; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA. ; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Bioinformatics Research Laboratory, Department of Biological Sciences, New Campus, University of Cyprus, CY 1678 Nicosia, Cyprus. ; Wits Research Institute for Malaria, Faculty of Health Sciences, and Vector Control Reference Unit, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham 2131, Johannesburg, South Africa. ; National Museums of Kenya, P.O. Box 40658-00100, Nairobi, Kenya. ; Department of Biology, University of Crete, 700 13 Heraklion, Greece. ; Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA. ; Virginia Bioinformatics Institute, 1015 Life Science Circle, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; Kenya Medical Research Institute-Wellcome Trust Research Programme, Centre for Geographic Medicine Research - Coast, P.O. Box 230-80108, Kilifi, Kenya. ; Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA. ; Department of Entomology, 1140 East South Campus Drive, Forbes 410, University of Arizona, Tucson, AZ 85721, USA. ; Department of Medical Microbiology and Immunology, School of Medicine, University of California Davis, One Shields Avenue, Davis, CA 95616, USA. ; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Centre of Functional Genomics, University of Perugia, Perugia, Italy. ; Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, 3800 Spruce Street, Philadelphia, PA 19104, USA. ; Regional Medical Research Centre NE, Indian Council of Medical Research, P.O. Box 105, Dibrugarh-786 001, Assam, India. ; Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA. Molecular Biology Program, New Mexico State University, Las Cruces, NM 88003, USA. ; Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. ; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA. ; Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN 37235, USA. Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA. ; Department of Genetic Medicine and Development, University of Geneva Medical School, Rue Michel-Servet 1, 1211 Geneva, Switzerland. Swiss Institute of Bioinformatics, Rue Michel-Servet 1, 1211 Geneva, Switzerland. ; Department of Entomology, Texas A&M University, College Station, TX 77807, USA. ; Department of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand. ; Fundacao Oswaldo Cruz, Avenida Brasil 4365, RJ Brazil. Instituto de Medicina Social, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil. ; School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA. ; Department of Physiology, School of Medicine, Center for Research in Molecular Medicine and Chronic Diseases, Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Santiago de Compostela, A Coruna, Spain. ; Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, CB10 1SA, UK. ; School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool L3 3AF, UK. ; Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA. ; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Department of Computer Science, Harvey Mudd College, Claremont, CA 91711, USA. ; Program in Public Health, College of Health Sciences, University of California, Irvine, Hewitt Hall, Irvine, CA 92697, USA. ; Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA. ; Department of Vector Biology, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Malaria Programme, Wellcome Trust Sanger Institute, Cambridge CB10 1SJ, UK. ; Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA. Centre of Evolutionary and Ecological Studies (Marine Evolution and Conservation group), University of Groningen, Nijenborgh 7, NL-9747 AG Groningen, Netherlands. ; Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA. ; Department of Biology, Indiana University, Bloomington, IN 47405, USA. School of Informatics and Computing, Indiana University, Bloomington, IN 47405, USA. ; Centers for Disease Control and Prevention, 1600 Clifton Road NE MSG49, Atlanta, GA 30329, USA. ; Department of Biology, University of Crete, 700 13 Heraklion, Greece. Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece. Centre of Functional Genomics, University of Perugia, Perugia, Italy. ; Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA. Biogen Idec, 14 Cambridge Center, Cambridge, MA 02142, USA. ; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, 12735 Twinbrook Parkway, Rockville, MD 20852, USA. ; Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. ; Departments of Biological Sciences and Pharmacology, Institutes for Chemical Biology, Genetics and Global Health, Vanderbilt University and Medical Center, Nashville, TN 37235, USA. ; Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA. neafsey@broadinstitute.org nbesansk@nd.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25554792" target="_blank"〉PubMed〈/a〉

Description: Images of comet 67P/Churyumov-Gerasimenko acquired by the OSIRIS (Optical, Spectroscopic and Infrared Remote Imaging System) imaging system onboard the European Space Agency's Rosetta spacecraft at scales of better than 0.8 meter per pixel show a wide variety of different structures and textures. The data show the importance of airfall, surface dust transport, mass wasting, and insolation weathering for cometary surface evolution, and they offer some support for subsurface fluidization models and mass loss through the ejection of large chunks of material.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thomas, Nicolas -- Sierks, Holger -- Barbieri, Cesare -- Lamy, Philippe L -- Rodrigo, Rafael -- Rickman, Hans -- Koschny, Detlef -- Keller, Horst Uwe -- Agarwal, Jessica -- A'Hearn, Michael F -- Angrilli, Francesco -- Auger, Anne-Therese -- Barucci, M Antonella -- Bertaux, Jean-Loup -- Bertini, Ivano -- Besse, Sebastien -- Bodewits, Dennis -- Cremonese, Gabriele -- Da Deppo, Vania -- Davidsson, Bjorn -- De Cecco, Mariolino -- Debei, Stefano -- El-Maarry, Mohamed Ramy -- Ferri, Francesca -- Fornasier, Sonia -- Fulle, Marco -- Giacomini, Lorenza -- Groussin, Olivier -- Gutierrez, Pedro J -- Guttler, Carsten -- Hviid, Stubbe F -- Ip, Wing-Huen -- Jorda, Laurent -- Knollenberg, Jorg -- Kramm, J-Rainer -- Kuhrt, Ekkehard -- Kuppers, Michael -- La Forgia, Fiorangela -- Lara, Luisa M -- Lazzarin, Monica -- Lopez Moreno, Jose J -- Magrin, Sara -- Marchi, Simone -- Marzari, Francesco -- Massironi, Matteo -- Michalik, Harald -- Moissl, Richard -- Mottola, Stefano -- Naletto, Giampiero -- Oklay, Nilda -- Pajola, Maurizio -- Pommerol, Antoine -- Preusker, Frank -- Sabau, Lola -- Scholten, Frank -- Snodgrass, Colin -- Tubiana, Cecilia -- Vincent, Jean-Baptiste -- Wenzel, Klaus-Peter -- New York, N.Y. -- Science. 2015 Jan 23;347(6220):aaa0440. doi: 10.1126/science.aaa0440.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Physikalisches Institut, Sidlerstrasse 5, University of Bern, 3012, Bern, Switzerland. nicolas.thomas@space.unibe.ch. ; Max-Planck-Institut fur Sonnensystemforschung, Justus-von-Liebig-Weg, 3, 37077, Gottingen, Germany. ; Department of Physics and Astronomy, University of Padova, Vicolo dell'Osservatorio 3, 35122 Padova, Italy. ; Laboratoire d'Astrophysique de Marseille, UMR 7326, CNRS, and Aix Marseille Universite, 38 Rue Frederic Joliot-Curie, 13388 Marseille Cedex 13, France. ; International Space Science Institute, Hallerstrasse 6, 3012 Bern, Switzerland, and Centro de Astrobiologia, Consejo Superior de Investigaciones Cientificas - Instituto Nacional de Tecnica Aeroespacial, 28850 Torrejon de Ardoz, Madrid, Spain. ; Department of Physics and Astronomy, Uppsala University, Box 516, SE-75120 Uppsala, Sweden, and Polish Academy of Sciences Space Research Center, Bartycka 18A, PL-00716 Warszawa, Poland. ; Scientific Support Office, European Space Agency, 2201, Noordwijk, Netherlands. ; Institute for Geophysics and Extraterrestrial Physics, Technische Universitat Braunschweig, 38106, Braunschweig, Germany. Deutsches Zentrum fur Luft- und Raumfahrt (DLR), Institut fur Planetenforschung, Asteroiden und Kometen, Rutherfordstrasse 2, 12489 Berlin, Germany. ; Department of Astronomy, University of Maryland, College Park, MD 20742-2421, USA. ; Department of Industrial Engineering, University of Padova, via Venezia 1, 35131 Padova, Italy. ; Aix Marseille Universite, CNRS, Laboratoire d'Astrophysique de Marseille, UMR 7326, 38 rue Frederic Joliot-Curie, 13388 Marseille, France. ; Laboratoire d'Etudes Spatiales et d'Instrumentation en Astrophysique, Observatoire de Paris, CNRS, Universite Paris 06, Universite Paris-Diderot, 5 Place J. Janssen, 92195, Meudon, France. ; Laboratoire Atmospheres, Milieux, Observations Spatiales, CNRS/UVSQ/IPSL, 11 Boulevard d'Alembert, 78280, Guyancourt, France. ; Centro di Ateneo di Studi ed Attivita Spaziali, "Giuseppe Colombo" (CISAS), University of Padova, Via Venezia 15, 35131 Padova, Italy. ; Istituto Nazionale di Astrofisica, Osservatorio Astronomico di Padova, Vicolo dell'Osservatorio 5, 35122 Padova, Italy. ; CNR-IFN UOS Padova LUXOR, Via Trasea, 7, 35131 Padova, Italy. ; Department of Physics and Astronomy, Uppsala University, 75120 Uppsala, Sweden. ; UNITN, Universita di Trento, Via Mesiano, 77, 38100 Trento, Italy. ; Physikalisches Institut, Sidlerstrasse 5, University of Bern, 3012, Bern, Switzerland. ; INAF, Osservatorio Astronomico, Via Tiepolo 11, 34014 Trieste, Italy. ; Dipartimento di Geoscienze, University of Padova, via G. Gradenigo 6, 35131 Padova, Italy. ; Instituto de Astrofisica de Andalucia (CSIC), c/ Glorieta de la Astronomia s/n, 18008 Granada, Spain. ; Deutsches Zentrum fur Luft- und Raumfahrt (DLR), Institut fur Planetenforschung, Asteroiden und Kometen, Rutherfordstrasse 2, 12489 Berlin, Germany. Max-Planck-Institut fur Sonnensystemforschung, Justus-von-Liebig-Weg, 3, 37077, Gottingen, Germany. ; National Central University, Graduate Institute of Astronomy, 300 Chung-Da Road, Chung-Li 32054, Taiwan. ; Laboratoire d'Astrophysique de Marseille, 38 Rue de Frederic Joliot-Curie, 13388 Marseille Cedex 13, France. ; Deutsches Zentrum fur Luft- und Raumfahrt (DLR), Institut fur Planetenforschung, Asteroiden und Kometen, Rutherfordstrasse 2, 12489 Berlin, Germany. ; Science Operations Department, European Space Astronomy Centre/European Space Agency, Post Office Box 78, 28691 Villanueva de la Canada, Madrid, Spain. ; Solar System Exploration Research Virtual Institute, Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302, USA. ; Dipartimento di Geoscienze, University of Padova, via G. Gradenigo 6, 35131 Padova, Italy. Centro di Ateneo di Studi ed Attivita Spaziali, "Giuseppe Colombo" (CISAS), University of Padova, Via Venezia 15, 35131 Padova, Italy. ; Institut fur Datentechnik und Kommunikationsnetze der Technische Universitat Braunschweig, Hans-Sommer-Strasse 66, 38106 Braunschweig, Germany. ; University of Padova, Department of Information Engineering, Via Gradenigo 6/B, 35131 Padova, Italy. CNR-IFN UOS Padova LUXOR, Via Trasea, 7, 35131 Padova, Italy. Centro di Ateneo di Studi ed Attivita Spaziali, "Giuseppe Colombo" (CISAS), University of Padova, Via Venezia 15, 35131 Padova, Italy. ; Instituto Nacional de Tecnica Aeroespacial, Carretera de Ajalvir, 28850 Torrejon de Ardoz (Madrid), Spain. ; Planetary and Space Sciences, Department of Physical Sciences, The Open University, Milton Keynes MK7 6AA, UK. Max-Planck-Institut fur Sonnensystemforschung, Justus-von-Liebig-Weg, 3, 37077, Gottingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25613893" target="_blank"〉PubMed〈/a〉

Description: Species interaction networks are shaped by abiotic and biotic factors. Here, as part of the Tara Oceans project, we studied the photic zone interactome using environmental factors and organismal abundance profiles and found that environmental factors are incomplete predictors of community structure. We found associations across plankton functional types and phylogenetic groups to be nonrandomly distributed on the network and driven by both local and global patterns. We identified interactions among grazers, primary producers, viruses, and (mainly parasitic) symbionts and validated network-generated hypotheses using microscopy to confirm symbiotic relationships. We have thus provided a resource to support further research on ocean food webs and integrating biological components into ocean models.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lima-Mendez, Gipsi -- Faust, Karoline -- Henry, Nicolas -- Decelle, Johan -- Colin, Sebastien -- Carcillo, Fabrizio -- Chaffron, Samuel -- Ignacio-Espinosa, J Cesar -- Roux, Simon -- Vincent, Flora -- Bittner, Lucie -- Darzi, Youssef -- Wang, Jun -- Audic, Stephane -- Berline, Leo -- Bontempi, Gianluca -- Cabello, Ana M -- Coppola, Laurent -- Cornejo-Castillo, Francisco M -- d'Ovidio, Francesco -- De Meester, Luc -- Ferrera, Isabel -- Garet-Delmas, Marie-Jose -- Guidi, Lionel -- Lara, Elena -- Pesant, Stephane -- Royo-Llonch, Marta -- Salazar, Guillem -- Sanchez, Pablo -- Sebastian, Marta -- Souffreau, Caroline -- Dimier, Celine -- Picheral, Marc -- Searson, Sarah -- Kandels-Lewis, Stefanie -- Tara Oceans coordinators -- Gorsky, Gabriel -- Not, Fabrice -- Ogata, Hiroyuki -- Speich, Sabrina -- Stemmann, Lars -- Weissenbach, Jean -- Wincker, Patrick -- Acinas, Silvia G -- Sunagawa, Shinichi -- Bork, Peer -- Sullivan, Matthew B -- Karsenti, Eric -- Bowler, Chris -- de Vargas, Colomban -- Raes, Jeroen -- New York, N.Y. -- Science. 2015 May 22;348(6237):1262073. doi: 10.1126/science.1262073.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, Rega Institute KU Leuven, Herestraat 49, 3000 Leuven, Belgium. VIB Center for the Biology of Disease, VIB, Herestraat 49, 3000 Leuven, Belgium. Department of Applied Biological Sciences (DBIT) Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. ; Station Biologique de Roscoff, CNRS, UMR 7144, Place Georges Teissier, 29680 Roscoff, France. Sorbonne Universites, Universite Pierre et Marie Curie (UPMC) Universite Paris 06, UMR 7144, Station Biologique de Roscoff, Place Georges Teissier, 29680 Roscoff, France. ; Station Biologique de Roscoff, CNRS, UMR 7144, Place Georges Teissier, 29680 Roscoff, France. Sorbonne Universites, Universite Pierre et Marie Curie (UPMC) Universite Paris 06, UMR 7144, Station Biologique de Roscoff, Place Georges Teissier, 29680 Roscoff, France. Ecole Normale Superieure, Institut de Biologie de l'ENS (IBENS), Inserm U1024, CNRS UMR 8197, Paris, F-75005 France. ; Department of Microbiology and Immunology, Rega Institute KU Leuven, Herestraat 49, 3000 Leuven, Belgium. VIB Center for the Biology of Disease, VIB, Herestraat 49, 3000 Leuven, Belgium. Department of Applied Biological Sciences (DBIT) Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. Interuniversity Institute of Bioinformatics in Brussels (IB), ULB Machine Learning Group, Computer Science Department, Universite Libre de Bruxelles (ULB), Brussels, Belgium. ; Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 85721, USA. ; VIB Center for the Biology of Disease, VIB, Herestraat 49, 3000 Leuven, Belgium. Ecole Normale Superieure, Institut de Biologie de l'ENS (IBENS), Inserm U1024, CNRS UMR 8197, Paris, F-75005 France. ; Station Biologique de Roscoff, CNRS, UMR 7144, Place Georges Teissier, 29680 Roscoff, France. Sorbonne Universites, Universite Pierre et Marie Curie (UPMC) Universite Paris 06, UMR 7144, Station Biologique de Roscoff, Place Georges Teissier, 29680 Roscoff, France. Ecole Normale Superieure, Institut de Biologie de l'ENS (IBENS), Inserm U1024, CNRS UMR 8197, Paris, F-75005 France. Institut de Biologie Paris-Seine, CNRS FR3631, F-75005, Paris, France. ; VIB Center for the Biology of Disease, VIB, Herestraat 49, 3000 Leuven, Belgium. Department of Applied Biological Sciences (DBIT) Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. ; Department of Microbiology and Immunology, Rega Institute KU Leuven, Herestraat 49, 3000 Leuven, Belgium. VIB Center for the Biology of Disease, VIB, Herestraat 49, 3000 Leuven, Belgium. ; CNRS, UMR 7093, Laboratoire d'Oceanographie de Villefranche (LOV), Observatoire Oceanologique, F-06230 Villefranche-sur-mer, France. Sorbonne Universites, UPMC Paris 06, UMR 7093, Laboratoire d'Oceanographie de Villefranche (LOV), Observatoire Oceanologique, F-06230 Villefranche-sur-mer, France. ; Interuniversity Institute of Bioinformatics in Brussels (IB), ULB Machine Learning Group, Computer Science Department, Universite Libre de Bruxelles (ULB), Brussels, Belgium. ; Department of Marine Biology and Oceanography, Institute of Marine Sciences (ICM)-Consejo Superior de Investigaciones Cientificas (CSIC), Pg. Maritim de la Barceloneta, 37-49, Barcelona E08003, Spain. ; Sorbonne Universites, UPMC, Universite Paris 06, CNRS-Institut pour la Recherche et le Developpement-Museum National d'Histoire Naturelle, Laboratoire d'Oceanographie et du Climat: Experimentations et Approches Numeriques (LOCEAN) Laboratory, 4 Place Jussieu, 75005, Paris, France. ; KU Leuven, Laboratory of Aquatic Ecology, Evolution and Conservation, Charles Deberiotstraat 32, 3000 Leuven. ; PANGAEA, Data Publisher for Earth and Environmental Science, University of Bremen, Hochschulring 18, 28359 Bremen, Germany. MARUM, Center for Marine Environmental Sciences, University of Bremen, Hochschulring 18, 28359 Bremen, Germany. ; Structural and Computational Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Directors' Research, European Molecular Biology Laboratory, Heidelberg, Germany. ; Institute for Chemical Research, Kyoto University, Gokasho, Uji, 611-0011 Kyoto, Japan. ; Department of Geosciences, Laboratoire de Meteorologie Dynamique (LMD), Ecole Normale Superieure, 24 rue Lhomond, 75231 Paris Cedex 05, France. Laboratoire de Physique des Ocean, Universite de Bretagne Occidentale (UBO)-Institut Universaire Europeen de la Mer (IUEM), Palce Copernic, 29820 Polouzane, France. ; Commissariat a l'Energie Atomique (CEA), Genoscope, 2 rue Gaston Cremieux, 91000 Evry, France. CNRS, UMR 8030, 2 rue Gaston Cremieux, 91000 Evry, France. Universite d'Evry, UMR 8030, CP5706 Evry, France. ; Structural and Computational Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. ; Structural and Computational Biology, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany. Max-Delbruck-Centre for Molecular Medicine, 13092 Berlin, Germany. ; Ecole Normale Superieure, Institut de Biologie de l'ENS (IBENS), Inserm U1024, CNRS UMR 8197, Paris, F-75005 France. Directors' Research, European Molecular Biology Laboratory, Heidelberg, Germany. jeroen.raes@vib-kuleuven.be vargas@sb-roscoff.fr cbowler@biologie.ens.fr karsenti@embl.de. ; Ecole Normale Superieure, Institut de Biologie de l'ENS (IBENS), Inserm U1024, CNRS UMR 8197, Paris, F-75005 France. jeroen.raes@vib-kuleuven.be vargas@sb-roscoff.fr cbowler@biologie.ens.fr karsenti@embl.de. ; Station Biologique de Roscoff, CNRS, UMR 7144, Place Georges Teissier, 29680 Roscoff, France. Sorbonne Universites, Universite Pierre et Marie Curie (UPMC) Universite Paris 06, UMR 7144, Station Biologique de Roscoff, Place Georges Teissier, 29680 Roscoff, France. jeroen.raes@vib-kuleuven.be vargas@sb-roscoff.fr cbowler@biologie.ens.fr karsenti@embl.de. ; Department of Microbiology and Immunology, Rega Institute KU Leuven, Herestraat 49, 3000 Leuven, Belgium. VIB Center for the Biology of Disease, VIB, Herestraat 49, 3000 Leuven, Belgium. Department of Applied Biological Sciences (DBIT) Vrije Universiteit Brussel, Pleinlaan 2, 1050 Brussels, Belgium. jeroen.raes@vib-kuleuven.be vargas@sb-roscoff.fr cbowler@biologie.ens.fr karsenti@embl.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25999517" target="_blank"〉PubMed〈/a〉

Description: Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease with no effective treatment. We report the results of a moderate-scale sequencing study aimed at increasing the number of genes known to contribute to predisposition for ALS. We performed whole-exome sequencing of 2869 ALS patients and 6405 controls. Several known ALS genes were found to be associated, and TBK1 (the gene encoding TANK-binding kinase 1) was identified as an ALS gene. TBK1 is known to bind to and phosphorylate a number of proteins involved in innate immunity and autophagy, including optineurin (OPTN) and p62 (SQSTM1/sequestosome), both of which have also been implicated in ALS. These observations reveal a key role of the autophagic pathway in ALS and suggest specific targets for therapeutic intervention.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437632/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437632/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cirulli, Elizabeth T -- Lasseigne, Brittany N -- Petrovski, Slave -- Sapp, Peter C -- Dion, Patrick A -- Leblond, Claire S -- Couthouis, Julien -- Lu, Yi-Fan -- Wang, Quanli -- Krueger, Brian J -- Ren, Zhong -- Keebler, Jonathan -- Han, Yujun -- Levy, Shawn E -- Boone, Braden E -- Wimbish, Jack R -- Waite, Lindsay L -- Jones, Angela L -- Carulli, John P -- Day-Williams, Aaron G -- Staropoli, John F -- Xin, Winnie W -- Chesi, Alessandra -- Raphael, Alya R -- McKenna-Yasek, Diane -- Cady, Janet -- Vianney de Jong, J M B -- Kenna, Kevin P -- Smith, Bradley N -- Topp, Simon -- Miller, Jack -- Gkazi, Athina -- FALS Sequencing Consortium -- Al-Chalabi, Ammar -- van den Berg, Leonard H -- Veldink, Jan -- Silani, Vincenzo -- Ticozzi, Nicola -- Shaw, Christopher E -- Baloh, Robert H -- Appel, Stanley -- Simpson, Ericka -- Lagier-Tourenne, Clotilde -- Pulst, Stefan M -- Gibson, Summer -- Trojanowski, John Q -- Elman, Lauren -- McCluskey, Leo -- Grossman, Murray -- Shneider, Neil A -- Chung, Wendy K -- Ravits, John M -- Glass, Jonathan D -- Sims, Katherine B -- Van Deerlin, Vivianna M -- Maniatis, Tom -- Hayes, Sebastian D -- Ordureau, Alban -- Swarup, Sharan -- Landers, John -- Baas, Frank -- Allen, Andrew S -- Bedlack, Richard S -- Harper, J Wade -- Gitler, Aaron D -- Rouleau, Guy A -- Brown, Robert -- Harms, Matthew B -- Cooper, Gregory M -- Harris, Tim -- Myers, Richard M -- Goldstein, David B -- 089701/Wellcome Trust/United Kingdom -- K08 NS075094/NS/NINDS NIH HHS/ -- P01 AG017586/AG/NIA NIH HHS/ -- P01 AG032953/AG/NIA NIH HHS/ -- P50 AG025688/AG/NIA NIH HHS/ -- R37 NS033123/NS/NINDS NIH HHS/ -- R37 NS083524/NS/NINDS NIH HHS/ -- T32 GM007754/GM/NIGMS NIH HHS/ -- TL1 TR001066/TR/NCATS NIH HHS/ -- UL1 TR001067/TR/NCATS NIH HHS/ -- New York, N.Y. -- Science. 2015 Mar 27;347(6229):1436-41. doi: 10.1126/science.aaa3650. Epub 2015 Feb 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Applied Genomics and Precision Medicine, Duke University School of Medicine, Durham, NC 27708, USA. ; HudsonAlpha Institute for Biotechnology, Huntsville, AL 35806, USA. ; Institute for Genomic Medicine, Columbia University, New York, NY 10032, USA. ; Department of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA. ; Montreal Neurological Institute, Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada. ; Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. ; Duke University School of Medicine, Durham, NC 27708, USA. ; Biogen Idec, Cambridge, MA 02142, USA. ; Neurogenetics DNA Diagnostic Laboratory, Center for Human Genetics Research, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA. ; Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA. ; Department of Genome Analysis, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, Netherlands. ; Academic Unit of Neurology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Republic of Ireland. ; Department of Basic and Clinical Neuroscience, King's College London, Institute of Psychiatry, Psychology and Neuroscience, London SE5 8AF, UK. ; Department of Neurology, Brain Center Rudolf Magnus, University Medical Centre Utrecht, 3508 GA Utrecht, Netherlands. ; Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan 20149, Italy, and Department of Pathophysiology and Transplantation, Dino Ferrari Center, Universita degli Studi di Milano, Milan 20122, Italy. ; Cedars Sinai Medical Center, Los Angeles, CA 90048, USA. ; Houston Methodist Hospital, Houston, TX 77030, USA, and Weill Cornell Medical College of Cornell University, New York, NY 10065, USA. ; Ludwig Institute for Cancer Research and Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA. ; Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA. ; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Neurology, Penn ALS Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Neurology, Penn Frontotemporal Degeneration Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA. ; Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA. ; Department of Pediatrics and Medicine, Columbia University, New York, NY 10032, USA. ; Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA. ; Department of Neurology, Emory University, Atlanta, GA 30322, USA. ; Department of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10027, USA. ; Biogen Idec, Cambridge, MA 02142, USA. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. ; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. ; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27708, USA. ; Duke ALS Clinic and Durham VA Medical Center, Durham, NC 27708, USA. ; Biogen Idec, Cambridge, MA 02142, USA. tim.harris@biogenidec.com.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25700176" target="_blank"〉PubMed〈/a〉