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  • 1
    Description / Table of Contents: This special issue of Pure and Applied Geophysics is one of two volumes containing an augmented collection of papers originating from the Evison Symposium on Seismogenesis and Earthquake Forecasting held in Wellington, New Zealand, in February 2008. The volumes honor Frank Evison's interest in earthquake generation and forecasting. A biography of Frank Evison and a list of his publications is included, as well as review papers and new research papers in the field. The volume includes papers related to Frank's most abiding interest of precursory earthquake swarms. The research contributions cover a range of current forecasting methods such as the Epidemic-Type Aftershock model, the Every Earthquake a precursor According to Scale model, Pattern Informatics, Reverse Tracing of Precursors, stochastic models of elastic rebound, and methods for handling multiple precursors. The methods considered employ a variety of statistical approaches to using previous seismicity to forecast future earthquakes, including regional and global earthquake likelihood models and alarm-type forecasts. The forecast time-frames of interest range from the short time-frame associated with clustering of aftershocks to the long time-frame associated with recurrence of major earthquakes. A recurring theme is the assessment of forecasting performance, whether by likelihood scores, skill scores, error diagrams, or relative operating characteristic tests. The volume will be useful to students and professional researchers who are interested in the earthquake preparation process and in converting that understanding into forecasts of earthquake occurrence.
    Pages: Online-Ressource (250 Seiten)
    ISBN: 9783034604970
    Language: English
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  • 2
    Description / Table of Contents: This special issue of Pure and Applied Geophysics is the second of two volumes containing an augmented collection of papers originating from the Evison Symposium on Seismogenesis and Earthquake Forecasting held in Wellington, New Zealand, in February 2008. The volumes honor Frank Evison's interest in earthquake generation and forecasting. This volume includes descriptions of earthquake forecasting test centers through the Collaboratory for the Study of Earthquake Predictability (CSEP) program and the first results from the Regional Earthquake Likelihood Model (RELM) experiment in California. Other papers discuss methods of testing predictions, in particular by the use of error diagrams. There is discussion of prediction methodologies using seismicity, including an application of the statistical technique of Hidden Markov Models to identify changes in seismicity and a new technique for identifying precursory quiescence. Several papers employ other data besides seismicity, such as geologically determined faults, calculations of stress changes via Coulomb stress modeling, tomographically determined velocity structure, groundwater, crustal deformation, and comparisons of real earthquakes to synthetic seismicity determined from hypothesized earthquake physics. One paper focuses on the prediction of human casualties in the event that a large earthquake occurs anywhere on the globe. The volume will be useful to students and professional researchers who are interested in the earthquake preparation process and in converting that understanding into forecasts of earthquake occurrence.
    Pages: Online-Ressource (274 Seiten)
    ISBN: 9783034604994
    Language: English
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  • 3
    Keywords: mass movements; landslides
    Description / Table of Contents: Introduction --- Subaqueous mass movements in the context of observations of contemporary slope failure / Joshu J. Mountjoy, Aggeliki Georgiopoulou, Jason Chaytor, Michael A. Clare, Davide Gamboa and Jasper Moernaut / Geological Society, London, Special Publications, 500, 1-12, 26 May 2020, https://doi.org/10.1144/SP500-2019-237 --- Section A: consequences and implications --- Revisiting the tsunamigenic volcanic flank collapse of Fogo Island in the Cape Verdes, offshore West Africa / Rachel Barrett, Elodie Lebas, Ricardo Ramalho, Ingo Klaucke, Steffen Kutterolf, Andreas Klügel, Katja Lindhorst, Felix Gross and Sebastian Krastel / Geological Society, London, Special Publications, 500, 13-26, 13 March 2020, https://doi.org/10.1144/SP500-2019-187 --- The sedimentology and tsunamigenic potential of the Byron submarine landslide off New South Wales, Australia / Kendall C. Mollison, Hannah E. Power, Samantha L. Clarke, Alan T. Baxter, Emily M. Lane and Thomas C. T. Hubble / Geological Society, London, Special Publications, 500, 27-40, 7 April 2020, https://doi.org/10.1144/SP500-2019-160 --- Effects of rotational submarine slump dynamics on tsunami genesis: new insight from idealized models and the 1929 Grand Banks event / T. Zengaffinen, F. Løvholt, G. K. Pedersen and C. B. Harbitz / Geological Society, London, Special Publications, 500, 41-61, 11 May 2020, https://doi.org/10.1144/SP500-2019-201 --- A scenario-based assessment of the tsunami hazard in Palermo, northern Sicily, and the southern Tyrrhenian Sea / Jack Dignan, Aaron Micallef, Christof Mueller, Attilio Sulli, Elisabetta Zizzo and Daniele Spatola / Geological Society, London, Special Publications, 500, 63-80, 31 March 2020, https://doi.org/10.1144/SP500-2019-181 --- A workflow for the rapid assessment of the landslide-tsunami hazard in peri-alpine lakes / Michael Strupler, Flavio S. Anselmetti, Michael Hilbe, Katrina Kremer and Stefan Wiemer / Geological Society, London, Special Publications, 500, 81-95, 18 March 2020, https://doi.org/10.1144/SP500-2019-166 --- Towards a national-scale assessment of the subaqueous mass movement hazard in Canada / D. Gwyn Lintern, Jessica Rutherford, Philip R. Hill, Calvin Campbell and Alexandre Normandeau / Geological Society, London, Special Publications, 500, 97-113, 11 May 2020, https://doi.org/10.1144/SP500-2019-206 --- Structural constraints on the subduction of mass-transport deposits in convergent margins / Jacob Geersen, Andrea Festa and Francesca Remitti / Geological Society, London, Special Publications, 500, 115-128, 13 March 2020, https://doi.org/10.1144/SP500-2019-174 --- Evaluating the sealing potential of young and thin mass-transport deposits: Lake Villarrica, Chile / Jasper Moernaut, Gauvain Wiemer, Achim Kopf and Michael Strasser / Geological Society, London, Special Publications, 500, 129-146, 13 March 2020, https://doi.org/10.1144/SP500-2019-155 --- Influence of mass transport deposit (MTD) surface topography on deep-water deposition: an example from a predominantly fine-grained continental margin, New Zealand / Suzanne Bull, Greg H. Browne, Malcolm J. Arnot and Lorna J. Strachan / Geological Society, London, Special Publications, 500, 147-171, 28 April 2020, https://doi.org/10.1144/SP500-2019-192 --- Section B: initiation, triggers and preconditioning --- A multi-disciplinary investigation of the AFEN Slide: the relationship between contourites and submarine landslides / Ricarda Gatter, Michael A. Clare, James E. Hunt, Millie Watts, B. N. Madhusudhan, Peter J. Talling and Katrin Huhn / Geological Society, London, Special Publications, 500, 173-193, 28 April 2020, https://doi.org/10.1144/SP500-2019-184 --- Indonesian Throughflow as a preconditioning mechanism for submarine landslides in the Makassar Strait / Rachel E. Brackenridge, Uisdean Nicholson, Benyamin Sapiie, Dorrik Stow and Dave R. Tappin / Geological Society, London, Special Publications, 500, 195-217, 1 April 2020, https://doi.org/10.1144/SP500-2019-171 --- Morphological signature of gully development by rapid slide retrogression in a layered coarse-grained delta foreslope / Jacques Locat, Ali Azizian, Jim Stronach, Aurélien Hospital, Chris Young, Dominique Turmel and Andrew Bevan / Geological Society, London, Special Publications, 500, 219-234, 13 March 2020, https://doi.org/10.1144/SP500-2019-159 --- Morphology and spatio-temporal distribution of lacustrine mass-transport deposits in Wörthersee, Eastern Alps, Austria / Christoph Daxer, Maddalena Sammartini, Ariana Molenaar, Thomas Piechl, Michael Strasser and Jasper Moernaut / Geological Society, London, Special Publications, 500, 235-254, 19 March 2020, https://doi.org/10.1144/SP500-2019-179 --- A numerical investigation of excess pore pressures and continental slope stability in response to ice-sheet dynamics / Morelia Urlaub, Isabel Kratzke and Berit Oline Hjelstuen / Geological Society, London, Special Publications, 500, 255-266, 13 March 2020, https://doi.org/10.1144/SP500-2019-185 --- Impact of sea-level fluctuations on the sedimentation patterns of the SE African margin: implications for slope instability / Aaron Micallef, Aggeliki Georgiopoulou, Andrew Green and Vittorio Maselli / Geological Society, London, Special Publications, 500, 267-276, 13 March 2020, https://doi.org/10.1144/SP500-2019-172 --- Geomechanical behaviour of gassy soils and implications for submarine slope stability: a literature analysis / P. Kaminski, M. Urlaub, J. Grabe and C. Berndt / Geological Society, London, Special Publications, 500, 277-288, 13 March 2020, https://doi.org/10.1144/SP500-2019-149 --- From gravity cores to overpressure history: the importance of measured sediment physical properties in hydrogeological models / Davide Mencaroni, Jaume Llopart, Roger Urgeles, Sara Lafuerza, Eulàlia Gràcia, Anne Le Friant and Morelia Urlaub / Geological Society, London, Special Publications, 500, 289-300, 22 May 2020, https://doi.org/10.1144/SP500-2019-176 --- The influence of clay content on submarine slope failure: insights from laboratory experiments and numerical models / M. M. W. Silver and B. Dugan / Geological Society, London, Special Publications, 500, 301-309, 26 March 2020, https://doi.org/10.1144/SP500-2019-186 --- Subduction of an extinct rift and its role in the formation of submarine landslides in NW South America / Carlos A. Vargas, Gustavo A. Gutiérrez and Gustavo A. Sarmiento / Geological Society, London, Special Publications, 500, 311-322, 12 May 2020, https://doi.org/10.1144/SP500-2019-189 --- Section C: characterization and regional controls --- Mass wasting on Alpha Ridge in the Arctic Ocean: new insights from multibeam bathymetry and sub-bottom profiler data / Kai Boggild, David C. Mosher, Paola Travaglini, Catalina Gebhardt and Larry Mayer / Geological Society, London, Special Publications, 500, 323-340, 13 May 2020, https://doi.org/10.1144/SP500-2019-196 --- The Last Glacial Maximum Balearic Abyssal Plain megabed revisited / Antonio Cattaneo, Shray Badhani, Cristina Caradonna, Massimo Bellucci, Estelle Leroux, Nathalie Babonneau, Sébastien Garziglia, Jeffrey Poort, Grigorii G. Akhmanov, Germain Bayon, Bernard Dennielou, Gwenäel Jouet, Sébastien Migeon, Marina Rabineau, Laurence Droz and Michael Clare / Geological Society, London, Special Publications, 500, 341-357, 14 May 2020, https://doi.org/10.1144/SP500-2019-188 --- Integrated geophysical, sedimentological and geotechnical investigation of submarine landslides in the Gulf of Lions (Western Mediterranean) / Shray Badhani, Antonio Cattaneo, Stefano Collico, Roger Urgeles, Bernard Dennielou, Estelle Leroux, Florent Colin, Sebastien Garziglia, Marina Rabineau and Laurence Droz / Geological Society, London, Special Publications, 500, 359-376, 14 May 2020, https://doi.org/10.1144/SP500-2019-175 --- Characterization of recent deep-sea debrites in the eastern Mediterranean based on foraminiferal taphonomy / Oded Katz, Leeron Ashkenazi, Shani Sultan-Levi, Sigal Abramovich, Ahuva Almogi-Labin and Orit Hyams-Kaphzan / Geological Society, London, Special Publications, 500, 377-391, 11 May 2020, https://doi.org/10.1144/SP500-2019-170 --- Widespread mass-wasting processes off NE Sicily (Italy): insights from morpho-bathymetric analysis / Daniele Casalbore, Romano Clementucci, Alessandro Bosman, Francesco Latino Chiocci, Eleonora Martorelli and Domenico Ridente / Geological Society, London, Special Publications, 500, 393-403, 15 May 2020, https://doi.org/10.1144/SP500-2019-195 --- Geomorphology and event-stratigraphy of recent mass-movement processes in Lake Hallstatt (UNESCO World Heritage Cultural Landscape, Austria) / Michael Strasser, T. Berberich, S. Fabbri, M. Hilbe, J-J. S. Huang, S. Lauterbach, M. Ortler, H. Rechschreiter, A. Brauer, F. Anselmetti and K. Kowarik / Geological Society, London, Special Publications, 500, 405-426, 31 March 2020, https://doi.org/10.1144/SP500-2019-178 --- Slope stability hazard in a fjord environment: Douglas Channel, Canada / Cooper D. Stacey, D. Gwyn Lintern, John Shaw and Kim W. Conway / Geological Society, London, Special Publications, 500, 427-451, 20 May 2020, https://doi.org/10.1144/SP500-2019-191 --- Submarine canyons, slope failures and mass transport processes in southern Cascadia / Jenna C. Hill, Janet T. Watt, Daniel S. Brothers and Jared W. Kluesner / Geological Society, London, Special Publications, 500, 453-475, 20 May 2020, https://doi.org/10.1144/SP500-2019-169 --- Tectonic and geomorphic controls on the distribution of submarine landslides across active and passive margins, eastern New Zealand / S. J. Watson, J. J. Mountjoy and G. J. Crutchley / Geological Society, London, Special Publications, 500, 477-494, 13 March 2020, https://doi.org/10.1144/SP500-2019-165 --- Geological and tectonic controls on morphometrics of submarine landslides of the Spanish margins / Ricardo León, Roger Urgeles, Raul Pérez-López, Emilio Payo, Amanda Vázquez-Izquierdo, Carmen Julia Giménez-Moreno and David Casas / Geological Society, London, Special Publications, 500, 495-513, 20 May 2020, https://doi.org/10.1144/SP500-2019-153 --- Section D: mobility and kinematics --- Megaclasts within mass-transport deposits: their origin, characteristics and effect on substrates and succeeding flows / Jefferson Nwoko, Ian Kane and Mads Huuse / Geological Society, London, Special Publications, 500, 515-530, 31 March 2020, https://doi.org/10.1144/SP500-2019-146 --- Line length balancing to evaluate multi-phase submarine landslide development: an example from the Storegga Slide, Norway / Suzanne Bull and Joseph A. Cartwright / Geological Society, London, Special Publications, 500, 531-549, 23 March 2020, https://doi.org/10.1144/SP500-2019-168 --- A new depositional model for the Tuaheni Landslide Complex, Hikurangi Margin, New Zealand / Benjamin Couvin, Aggeliki Georgiopoulou, Joshu J. Mountjoy, Lawrence Amy, Gareth J. Crutchley, Morgane Brunet, Sebastian Cardona, Felix Gross, Christoph Böttner, Sebastian Krastel and Ingo Pecher / Geological Society, London, Special Publications, 500, 551-566, 19 May 2020, https://doi.org/10.1144/SP500-2019-180 --- Mass transport deposits in the Donegal Barra Fan and their association with British–Irish Ice Sheet dynamics / Srikumar Roy, Aggeliki Georgiopoulou, Sara Benetti and Fabio Sacchetti / Geological Society, London, Special Publications, 500, 567-586, 18 March 2020, https://doi.org/10.1144/SP500-2019-177 --- Short- and long-term movement of mudflows of the Mississippi River Delta Front and their known and potential impacts on oil and gas infrastructure / Jason D. Chaytor, Wayne E. Baldwin, Samuel J. Bentley, Melanie Damour, Douglas Jones, Jillian Maloney, Michael D. Miner, Jeff Obelcz and Kehui Xu / Geological Society, London, Special Publications, 500, 587-604, 26 March 2020, https://doi.org/10.1144/SP500-2019-183 --- Lessons learned from the monitoring of turbidity currents and guidance for future platform designs / Michael Clare, D. Gwyn Lintern, Kurt Rosenberger, John E. Hughes Clarke, Charles Paull, Roberto Gwiazda, Matthieu J. B. Cartigny, Peter J. Talling, Daniel Perara, Jingping Xu, Daniel Parsons, Ricardo Silva Jacinto and Ronan Apprioual / Geological Society, London, Special Publications, 500, 605-634, 22 May 2020, https://doi.org/10.1144/SP500-2019-173
    Pages: Online-Ressource (VII, 639 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 9781786204776
    Language: English
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  • 4
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Neuroscience.
    Description / Table of Contents: 1. Translational Neuroscience of Speech and Language Disorders: State of the Art. -2. Translational Neuroscience of Aphasia and Adult Language Rehabilitation. -3. Treatment and intervention approaches for the improvement of language abilities in neurodegenerative diseases -- 4. Neural and Genetic Mechanisms of Dyslexia -- 5. The role of memory systems in neurodevelopmental disorders of language -- 6. Transcranial direct current stimulation (tDCS) and Language/Speech: Can patients benefit from a combined therapeutic approach? -- 7. Transcranial Magnetic Stimulation in Aphasia Rehabilitation -- 8. The Cerebellum: A Therapeutic Target in Treating Speech and Language Disorders -- 9. Navigated rTMS for Mapping the Language Network in Preoperative Settings: Current Status and Future Prospects -- 10. Presurgical Language fMRI in Epilepsy: An Introduction -- 11. Lesion-symptom mapping in speech and language disorders: a translational perspective.
    Abstract: This edited volume provides the first presentation of the state-of-the-art in the application of modern Neuroscience research in predicting, preventing and alleviating the negative sequelae of neurodevelopmental, acquired, or neurodegenerative conditions on speech and language. It brings together contributions from several leading experts in a markedly broad range of disciplines, including Speech and Language Therapy, Neuropsychology and Neurology, but also Neurosurgery, Neuroimaging and Neurostimulation, as well as Engineering and Genetics.
    Type of Medium: Online Resource
    Pages: XVII, 290 p. 18 illus., 8 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030356873
    Series Statement: Contemporary Clinical Neuroscience,
    DDC: 612.8
    Language: English
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  • 5
    Keywords: Cancer. ; Oncology. ; Medicine Research. ; Biology Research. ; Cancer Biology. ; Oncology. ; Biomedical Research.
    Description / Table of Contents: Section 1: Historical Background -- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover -- Chapter 2: gene cloning/overview -- Chapter 3: gene cloning/melanoma metastasis -- Chapter 4: gene cloning/cancer/immune system -- Chapter 5: heparin/HS modifying enzymes -- Section 2: Crystal Structure/substrate specificity/gene regulation -- Chapter 6: crystal structure -- Chapter 7: molecular dynamics, KKDC peptide -- Chapter 8: Biochemistry/active site -- Chapter 9: substrate specificity -- Chapter 10: gene regulation, promoter/Egr1/methylation -- Chapter 11: SNPs -- polymorphism -- Chapter 12: Splice variants -- Section 3: Cell & tumor biology (general functions & mode of action) -- Chapter 13: Exosomes/heparan sulfate/heparanse -- Chapter 14: Exosomes/drug resistance -- Chapter 15: Nuclear heparanse/transcriptional activity -- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy -- Chapter 17: Heparan sulfate/stem cells/inflammation -- Chapter 18: Danger signals/HS/platelet heparanse -- Chapter 19: Heparanse/Intergrins/Melanoma -- Section 3: Immune Cells/Immnuno-Modulation -- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity -- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies -- Chapter 24: NK Cells -- Section 4: Cancer (heparanse in specific types of cancer) -- Chapter 25: Myeloma, inhbition, drug resistance -- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation -- Chapter 27: Brain Metastasis/MIR-1258 -- Chapter 28: Gastric cancer/immunization -- Chapter 29: Head and Neck Cancer -- Chapter 30: Glioma -- Chapter 31: Sarcoma -- Section 5: Inhibitors/clinical trails/cancer -- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG -- Chapter 33: PG series/biology/Tumor models and clinical trial -- Chapter 34:Chemically modified heparins/Heparin mimetics -- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases -- Chapter 36: IBD/inflammation and cancer/diabetes/obesity -- Chapter 37: Immune Diabetes -- Chapter 38 Inflammation, Sepsis/Amyloidosis -- Chapter 39: Kidney dysfunction -- Chapter 40: Fibrosis -- Chapter 41: Viral infection -- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy -- Chapter 43: Eye research -- Chapter 44: atheroscelerosis, nuclear localization -- Chapter 45: Yona Nadir (coagulation/tissue factor) -- Section 7: Heparanse-2 (Hpa2) -- Chapter 46: Hpa2 gene cloning -- Chapter 47: UFS -- urofacial syndrome/peripheral neuropathy -- Chapter 48: Hpa2: tumor suppressor.
    Abstract: Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase’s multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
    Type of Medium: Online Resource
    Pages: XVIII, 885 p. 168 illus., 107 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030345211
    Series Statement: Advances in Experimental Medicine and Biology, 1221
    DDC: 571.978
    Language: English
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  • 6
    Keywords: Cytology. ; Neurosciences. ; Immunology. ; Medicine Research. ; Biology Research. ; Cancer. ; Cell Biology. ; Neuroscience. ; Immunology. ; Biomedical Research. ; Cancer Biology.
    Description / Table of Contents: Part I. Cancer -- Ubiquitin-Regulated Cell Proliferation and Cancer -- Ubiquitin, SUMO, and Nedd8 as Therapeutic Targets in Cancer -- The Proteasome System in Health and Disease -- Proteostasis Dysregulation in Pancreatic Cancer -- Divergent Modulation of Proteostasis in Prostate Cancer -- Resistance to the Proteasome Inhibitors: Lessons from Multiple Myeloma and Mantle Cell Lymphoma -- Part II. Neurodegeneration -- Altered Proteostasis in Neurodegenerative Tauopathies -- The Ubiquitin System in Alzheimer’s Disease -- The Interplay Between Proteostasis Systems and Parkinson’s Disease -- Machado–Joseph Disease: A Stress Combating Deubiquitylating Enzyme Changing Sides -- Part III. Infection, Inflammation and Developmental Disorders -- SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends -- The Role of Proteostasis in the Regulation of Cardiac Intercellular Communication -- By the Tips of Your Cilia: Ciliogenesis in the Retina and the Ubiquitin-Proteasome System -- TRIM E3 Ubiquitin Ligases in Rare Genetic Disorders -- Part IV. Diet -- We Are What We Eat: Ubiquitin–Proteasome System (UPS) Modulation Through Dietary Products.
    Abstract: This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.
    Type of Medium: Online Resource
    Pages: XII, 348 p. 42 illus., 24 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030382667
    Series Statement: Advances in Experimental Medicine and Biology, 1233
    DDC: 571.6
    Language: English
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  • 7
    Online Resource
    Online Resource
    Cham :Springer International Publishing :
    Keywords: Neurosciences. ; Endocrine glands. ; Neuroscience. ; Endocrine System.
    Description / Table of Contents: Photoperiodism and Circannual Timing: Introduction and Historical Perspective.-The Pars Tuberalis and Seasonal Timing -- Tanycytes and Their Pivotal Role in Seasonal Physiological Adaptations -- Epigenetic Mechanisms in Developmental and Seasonal Programs -- Plasticity of Neuroendocrine Mechanisms Regulating Seasonal Reproduction in Sheep -- Clocks and Calendrars in Birds -- Calendar Timing in Teleost Fish -- Action of Light on the Neuroendocrine Axis -- Seasons, Clocks, and Mood -- Photoperiodic Modulation of Clock Gene Expression in the SCN -- Circadian Timekeeping in the Suprachiasmatic Nucleus: Genes, Neurotransmitters, Neurons and Astrocytes. .
    Abstract: This book explores how daily and seasonal rhythmicity is generated, how these rhythms are synchronised by our environment, and how they regulate the neuroendocrine systems that impact our physiology and behaviour. The constraints of surviving in a seasonal environment have shaped human evolution and migration, have shaped our societies and cultures, and continue to influence our everyday lives, health and wellbeing. Identifying the mechanisms whereby seasonal rhythmicity is generated and regulates the brain and body is not only important for understanding the natural world and relevant to animal production, it also offers many insights into the human condition. Each chapter is written by an international expert in the field of chronobiology. A historical perspective on how research into photoperiodism and rhythmicity progressed is initially provided, but the main focus of this book is on the remarkable studies in the last few decades that have unravelled the molecular and cellular machinery underpinning circadian and circannual timing. Topics covered include the role of melatonin in communicating seasonal information to the brain and pituitary gland, the neuroanatomical pathways in mammals, birds and fish by which changes in photoperiod reach the hypothalamus, the role of glial cells (tanycytes) and thyroid hormone in seasonal rhythmicity, neuroplasticity across seasons, effects of changing day length on mood, regulation of “clock“ gene expression, and the role of the suprachiasmatic nucleus. This book will appeal to all students and researchers who wish to learn about current and past research on daily and seasonal rhythmicity. This is the tenth volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley) that aims to illustrate highest standards and encourage the use of the latest technologies in basic and clinical research and hopes to provide inspiration for further exploration into the exciting field of neuroendocrinology. .
    Type of Medium: Online Resource
    Pages: XII, 244 p. 64 illus., 58 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030556433
    Series Statement: Masterclass in Neuroendocrinology, 10
    DDC: 612.8
    Language: English
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  • 8
    Keywords: Ecology . ; Biotic communities. ; Pollution. ; Water. ; Hydrology. ; Ecology. ; Ecosystems. ; Pollution. ; Water.
    Abstract: This book is the final installation in a three-volume series synthesizing 30 years of mercury research in the Florida Everglades. The first part of this book evaluates the occurrence of trends in both biota mercury concentrations and atmospheric mercury deposition. Through both empirical and deterministic analyses, the likely drivers of biota trends are identified. These analyses help lay the predicate for devising an overall strategy to mitigate and manage the Everglades mercury problem. The book concludes with a model analysis of the likely benefits and uncertainty attendant with implementing the leading candidate strategy for best reducing the Everglades mercury problem.
    Type of Medium: Online Resource
    Pages: XV, 164 p. 78 illus., 72 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030556358
    DDC: 577
    Language: English
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  • 9
    Keywords: Environmental management. ; Operations research. ; Environmental health. ; Environmental monitoring. ; Environmental Management. ; Operations Research and Decision Theory. ; Environmental Health. ; Environmental Monitoring.
    Description / Table of Contents: The Classic Challenge of Good Decision Making -- About Expertise Problems: Decision Making Challenges in a Contentious Environment -- Actors and Experts in the Decision Making Process -- Critical Challenges and Difficulties in Safety, Security, Environment and Health: Why are we often so bad at managing SSEH Problems?- Ethics and Analytics as Key Drivers of Good Decisions -- Solving Problems in SSEH: The Use of Decision Support Tools -- Decision Making, ELECTRE, and SSEH -- Navigating Decisions in a 21st Century World -- References.
    Abstract: This book explores the challenges that confront leaders in government and industry when making decisions in the areas of environmental health and safety. Today, decision making demands transparency, robustness, and resiliency. However thoughtfully they are devised, decisions made by governments and enterprises can often trigger immediate, passionate public response. Expertise Under Scrutiny shows how leaders can establish organizational decision making processes that yield valid, workable choices even in fast-changing and uncertain conditions. The first part of the book examines the organizational decision making process, describing the often-contentious environment in which important environmental health and safety decisions are made, and received. The authors review the roles of actors and experts in the decision making process. The book goes on to address such topics as: · The roles of actors and experts in the decision making process · Ethics and analytics as drivers of good decisions · Why managing problems in safety, security, environment, and health Part II offers an outline for adopting a formal decision support structure, including the use of decision support tools. It includes a chapter devoted to ELECTRE (ELimination and Choice Expressing Reality), a multi-criteria decision analysis system. The book concludes with an insightful appraisal and analysis of the expertise, structure and resources needed for navigating well-supported, risk-informed decisions in our 21st Century world. Expertise Under Scrutiny benefits a broad audience of students, academics, researchers, and working professionals in management and related disciplines, especially in the field of environmental health and safety.
    Type of Medium: Online Resource
    Pages: XVI, 168 p. 45 illus., 32 illus. in color. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030205324
    Series Statement: Risk, Systems and Decisions,
    DDC: 333.7
    Language: English
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  • 10
    Keywords: Geotechnical engineering. ; Energy policy. ; Energy and state. ; Electric power production. ; Power resources. ; Geotechnical Engineering and Applied Earth Sciences. ; Energy Policy, Economics and Management. ; Electrical Power Engineering. ; Mechanical Power Engineering. ; Natural Resource and Energy Economics.
    Description / Table of Contents: The effects of the forecasting time frame on forecast performance and forecast performance requirements -- Further development of the long-term forecasting methodology for the energy sector -- Methods of projecting price and demand for energy commodities -- Assessment and factoring in of conditions and barriers that limit the projection range of the prospective development of the engery sector -- Quantitative assessment of strategic threats and energy security indicatiors.
    Abstract: This book covers available approaches to improving the performance and impact of long-term projections of the national energy sector development. In turn, it introduces an original multi-stage approach to narrowing down the uncertainty range of the input data and resulting projections. Its unique contribution is that it limits the scope for each of the projection timeframe segments step-by-step. This is done in the course of iterative calculations, which employ dedicated methods and other tools to elucidate and solve top-priority problems specific to each time segment. In closing, the book provides a detailed treatment of two essential research problems: 1) long-term forecasting for regional energy markets, and 2) the quantitative assessment of a) the barriers that are likely to hinder energy sector development and b) strategic-level energy security threats.
    Type of Medium: Online Resource
    Pages: XVI, 98 p. , online resource.
    Edition: 1st ed. 2020.
    ISBN: 9783030305338
    Series Statement: Springer Geophysics,
    DDC: 624.151
    Language: English
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