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  • Animals  (5)
  • American Association for the Advancement of Science (AAAS)  (5)
  • National Academy of Sciences
  • Springer Nature
  • 2020-2024
  • 2005-2009  (5)
  • 1960-1964
  • 2009  (5)
Collection
Keywords
Publisher
Years
  • 2020-2024
  • 2005-2009  (5)
  • 1960-1964
Year
  • 1
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    A gene necessary for reproductive suppression in termites (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-05-09
    Description: A major transition in evolution is the origin of a division between reproduction and work among individuals. Nowhere is this divide more striking than in social insects, where workers rarely produce offspring even though they are often capable of reproduction should the queen or king die. The molecular mechanisms that control worker reproduction remain largely unknown. We used a combination of behavioral assays and RNA interference (RNAi) to identify a gene required for the reproductive division of labor between the queen and the workers.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Korb, Judith -- Weil, Tobias -- Hoffmann, Katharina -- Foster, Kevin R -- Rehli, Michael -- New York, N.Y. -- Science. 2009 May 8;324(5928):758. doi: 10.1126/science.1170660.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Behavioral Biology, University of Osnabrueck, Barbarastrasse 11, D-49076 Osnabrueck, Germany. judith.korb@biologie.uni-osnabrueck.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19423819" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Behavior, Animal ; Evolution, Molecular ; Female ; *Genes ; Glycoside Hydrolases/*genetics/*metabolism ; Isoptera/enzymology/*genetics/*physiology ; RNA Interference ; Reproduction/genetics ; Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Conserve livestock genetic resources, too (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-10-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boettcher, Paul J -- Hoffmann, Irene -- New York, N.Y. -- Science. 2009 Oct 16;326(5951):365. doi: 10.1126/science.326_365b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Animal Production and Health Division, Food and Agriculture Organization of the United Nations, Rome, 00153, Italy. paul.boettcher@fao.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19833942" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Domestic/*genetics ; Biodiversity ; *Biological Specimen Banks ; Conservation of Natural Resources ; Extinction, Biological ; *Genes
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-02-14
    Description: Deposition of the amyloid-beta peptide is a pathological hallmark of Alzheimer's disease. A high-throughput functional genomics screen identified G protein-coupled receptor 3 (GPR3), a constitutively active orphan G protein-coupled receptor, as a modulator of amyloid-beta production. Overexpression of GPR3 stimulated amyloid-beta production, whereas genetic ablation of GPR3 prevented accumulation of the amyloid-beta peptide in vitro and in an Alzheimer's disease mouse model. GPR3 expression led to increased formation and cell-surface localization of the mature gamma-secretase complex in the absence of an effect on Notch processing. GPR3 is highly expressed in areas of the normal human brain implicated in Alzheimer's disease and is elevated in the sporadic Alzheimer's disease brain. Thus, GPR3 represents a potential therapeutic target for the treatment of Alzheimer's disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Thathiah, Amantha -- Spittaels, Kurt -- Hoffmann, Marcel -- Staes, Mik -- Cohen, Adrian -- Horre, Katrien -- Vanbrabant, Mieke -- Coun, Frea -- Baekelandt, Veerle -- Delacourte, Andre -- Fischer, David F -- Pollet, Dirk -- De Strooper, Bart -- Merchiers, Pascal -- New York, N.Y. -- Science. 2009 Feb 13;323(5916):946-51. doi: 10.1126/science.1160649.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Developmental Genetics, Vlaams Institute for Biotechnology, Center for Human Genetics, Catholic University of Leuven, Herestraat 49, 3000 Leuven, Belgium.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19213921" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Amyloid Precursor Protein Secretases/metabolism ; Amyloid beta-Peptides/*biosynthesis ; Animals ; Cell Line ; Cell Line, Tumor ; Cells, Cultured ; Female ; Humans ; Male ; Mice ; Middle Aged ; Neurons/*metabolism ; Protein Structure, Tertiary ; Receptors, G-Protein-Coupled/*metabolism ; Receptors, Notch/metabolism ; Signal Transduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Fundamental evolutionary limits in ecological traits drive Drosophila species distributions (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-09-05
    Description: Species that are habitat specialists make up much of biodiversity, but the evolutionary factors that limit their distributions have rarely been considered. We show that in Drosophila, narrow and wide ranges of desiccation and cold resistance are closely associated with the distributions of specialist and generalist species, respectively. Furthermore, our data show that narrowly distributed tropical species consistently have low means and low genetic variation for these traits as compared with those of widely distributed species after phylogenetic correction. These results are unrelated to levels of neutral variation. Thus, specialist species may simply lack genetic variation in key traits, limiting their ability to adapt to conditions beyond their current range. We predict that such species are likely to be constrained in their evolutionary responses to future climate changes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kellermann, Vanessa -- van Heerwaarden, Belinda -- Sgro, Carla M -- Hoffmann, Ary A -- New York, N.Y. -- Science. 2009 Sep 4;325(5945):1244-6. doi: 10.1126/science.1175443.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Centre for Environmental Stress and Adaptation Research, Department of Genetics, University of Melbourne, Parkville, Melbourne 3010, Australia. vanessa.kellermann@biology.au.dk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19729654" target="_blank"〉PubMed〈/a〉
    Keywords: *Adaptation, Physiological ; Animals ; *Biological Evolution ; *Climatic Processes ; Cold Temperature ; Dehydration ; Drosophila/anatomy & histology/*genetics/*physiology ; *Ecosystem ; *Genetic Variation ; Phylogeny ; Selection, Genetic ; Species Specificity ; Tropical Climate ; Wings, Animal/anatomy & histology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Livestock genomics in developing countries (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-06-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boettcher, Paul J -- Hoffmann, Irene -- New York, N.Y. -- Science. 2009 Jun 19;324(5934):1515. doi: 10.1126/science.324_1515b.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Animal Production and Health Division, Food and Agriculture Organization of the United Nations, Rome 00153, Italy. paul.boettcher@fao.org〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19541976" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Animals ; Breeding ; Cattle/*genetics ; *Developing Countries ; Environment ; Genetic Variation ; *Genomics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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