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  • Articles  (81)
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  • 2005-2009  (81)
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  • 11
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    Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-02-14
    Description: Mice experiencing repeated aggression develop a long-lasting aversion to social contact, which can be normalized by chronic, but not acute, administration of antidepressant. Using viral-mediated, mesolimbic dopamine pathway-specific knockdown of brain-derived neurotrophic factor (BDNF), we showed that BDNF is required for the development of this experience-dependent social aversion. Gene profiling in the nucleus accumbens indicates that local knockdown of BDNF obliterates most of the effects of repeated aggression on gene expression within this circuit, with similar effects being produced by chronic treatment with antidepressant. These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Berton, Olivier -- McClung, Colleen A -- Dileone, Ralph J -- Krishnan, Vaishnav -- Renthal, William -- Russo, Scott J -- Graham, Danielle -- Tsankova, Nadia M -- Bolanos, Carlos A -- Rios, Maribel -- Monteggia, Lisa M -- Self, David W -- Nestler, Eric J -- New York, N.Y. -- Science. 2006 Feb 10;311(5762):864-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16469931" target="_blank"〉PubMed〈/a〉
    Keywords: Aggression ; Animals ; Antidepressive Agents/pharmacology ; Brain-Derived Neurotrophic Factor/genetics/*physiology ; Depression/physiopathology ; Dominance-Subordination ; Dopamine/*physiology ; Fluoxetine/pharmacology ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Imipramine/pharmacology ; Limbic System/*physiology ; Male ; Mice ; Mice, Inbred C57BL ; Neurons/physiology ; Nucleus Accumbens/*physiology ; Oligonucleotide Array Sequence Analysis ; Proto-Oncogene Proteins c-fos/biosynthesis ; *Social Behavior ; Social Isolation ; *Stress, Psychological ; Ventral Tegmental Area/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 12
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    Exogenous induction of cerebral beta-amyloidogenesis is governed by agent and host (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-09-23
    Description: Protein aggregation is an established pathogenic mechanism in Alzheimer's disease, but little is known about the initiation of this process in vivo. Intracerebral injection of dilute, amyloid-beta (Abeta)-containing brain extracts from humans with Alzheimer's disease or beta-amyloid precursor protein (APP) transgenic mice induced cerebral beta-amyloidosis and associated pathology in APP transgenic mice in a time- and concentration-dependent manner. The seeding activity of brain extracts was reduced or abolished by Abeta immunodepletion, protein denaturation, or by Abeta immunization of the host. The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Abeta strains with varying biological activities reminiscent of prion strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Meyer-Luehmann, Melanie -- Coomaraswamy, Janaky -- Bolmont, Tristan -- Kaeser, Stephan -- Schaefer, Claudia -- Kilger, Ellen -- Neuenschwander, Anton -- Abramowski, Dorothee -- Frey, Peter -- Jaton, Anneliese L -- Vigouret, Jean-Marie -- Paganetti, Paolo -- Walsh, Dominic M -- Mathews, Paul M -- Ghiso, Jorge -- Staufenbiel, Matthias -- Walker, Lary C -- Jucker, Mathias -- NS45357/NS/NINDS NIH HHS/ -- RR-00165/RR/NCRR NIH HHS/ -- Wellcome Trust/United Kingdom -- New York, N.Y. -- Science. 2006 Sep 22;313(5794):1781-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cellular Neurology, Hertie-Institute for Clinical Brain Research, University of Tubingen, D-72076 Tubingen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16990547" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/*administration & dosage/*analysis/chemistry/pharmacology ; Amyloid beta-Protein Precursor/*administration & dosage/pharmacology ; Amyloidosis/*metabolism/pathology ; Animals ; Brain/pathology ; Brain Chemistry ; Brain Diseases/*metabolism/pathology ; Female ; Hippocampus/*chemistry/pathology ; Humans ; Male ; Mice ; Mice, Transgenic ; Protein Denaturation ; Time Factors ; Tissue Extracts
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Debating sexual selection and mating strategies (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pizzari, Tommaso -- Birkhead, Tim R -- Blows, Mark W -- Brooks, Rob -- Buchanan, Katherine L -- Clutton-Brock, Tim H -- Harvey, Paul H -- Hosken, Dave J -- Jennions, Michael D -- Kokko, Hanna -- Kotiaho, Janne S -- Lessells, C M -- Macias-Garcia, Constantino -- Moore, Allen J -- Parker, Geoff A -- Partigridge, Linda -- Pitnick, Scott -- Radwan, Jacek -- Ritchie, Mike -- Sheldon, Ben C -- Simmons, Leigh W -- Snook, Rhonda R -- Stockley, Paula -- Zuk, Marlene -- New York, N.Y. -- Science. 2006 May 5;312(5774):689-97; author reply 689-97.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16680817" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Evolution ; Female ; Male ; Reproduction ; Sex Characteristics ; *Sexual Behavior, Animal ; *Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-09-30
    Description: To pursue a systematic approach to the discovery of functional connections among diseases, genetic perturbation, and drug action, we have created the first installment of a reference collection of gene-expression profiles from cultured human cells treated with bioactive small molecules, together with pattern-matching software to mine these data. We demonstrate that this "Connectivity Map" resource can be used to find connections among small molecules sharing a mechanism of action, chemicals and physiological processes, and diseases and drugs. These results indicate the feasibility of the approach and suggest the value of a large-scale community Connectivity Map project.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lamb, Justin -- Crawford, Emily D -- Peck, David -- Modell, Joshua W -- Blat, Irene C -- Wrobel, Matthew J -- Lerner, Jim -- Brunet, Jean-Philippe -- Subramanian, Aravind -- Ross, Kenneth N -- Reich, Michael -- Hieronymus, Haley -- Wei, Guo -- Armstrong, Scott A -- Haggarty, Stephen J -- Clemons, Paul A -- Wei, Ru -- Carr, Steven A -- Lander, Eric S -- Golub, Todd R -- New York, N.Y. -- Science. 2006 Sep 29;313(5795):1929-35.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Broad Institute of Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA. justin@broad.mit.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17008526" target="_blank"〉PubMed〈/a〉
    Keywords: Alzheimer Disease/drug therapy/genetics ; Cell Line ; Cell Line, Tumor ; *Databases, Factual ; Dexamethasone/pharmacology/therapeutic use ; Drug Evaluation, Preclinical/*methods ; Drug Resistance, Neoplasm ; Enzyme Inhibitors/pharmacology ; Estrogens/pharmacology ; Gene Expression/*drug effects ; *Gene Expression Profiling ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; Histone Deacetylase Inhibitors ; Humans ; Limonins/pharmacology ; Obesity/genetics/physiopathology ; Oligonucleotide Array Sequence Analysis ; Phenothiazines/pharmacology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug ; therapy/genetics/physiopathology ; Sirolimus/pharmacology/therapeutic use ; Software
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Differential targeting of Gbetagamma-subunit signaling with small molecules (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-04-22
    Description: G protein betagamma subunits have potential as a target for therapeutic treatment of a number of diseases. We performed virtual docking of a small-molecule library to a site on Gbetagamma subunits that mediates protein interactions. We hypothesized that differential targeting of this surface could allow for selective modulation of Gbetagamma subunit functions. Several compounds bound to Gbetagamma subunits with affinities from 0.1 to 60 muM and selectively modulated functional Gbetagamma-protein-protein interactions in vitro, chemotactic peptide signaling pathways in HL-60 leukocytes, and opioid receptor-dependent analgesia in vivo. These data demonstrate an approach for modulation of G protein-coupled receptor signaling that may represent an important therapeutic strategy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bonacci, Tabetha M -- Mathews, Jennifer L -- Yuan, Chujun -- Lehmann, David M -- Malik, Sundeep -- Wu, Dianqing -- Font, Jose L -- Bidlack, Jean M -- Smrcka, Alan V -- GM60286/GM/NIGMS NIH HHS/ -- HL-T3207949/HL/NHLBI NIH HHS/ -- HL080706/HL/NHLBI NIH HHS/ -- K05-DA00360/DA/NIDA NIH HHS/ -- R01 CA132317/CA/NCI NIH HHS/ -- R01 GM054597/GM/NIGMS NIH HHS/ -- R01 GM054597-09/GM/NIGMS NIH HHS/ -- R01 HL080706/HL/NHLBI NIH HHS/ -- R01 HL080706-10/HL/NHLBI NIH HHS/ -- R01 HL080706-11/HL/NHLBI NIH HHS/ -- T32DA07232/DA/NIDA NIH HHS/ -- New York, N.Y. -- Science. 2006 Apr 21;312(5772):443-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology and Physiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16627746" target="_blank"〉PubMed〈/a〉
    Keywords: Analgesics/pharmacology ; Animals ; Binding Sites ; Binding, Competitive ; Cell Line ; Computer Simulation ; Cyclohexanes/chemistry/*metabolism/*pharmacology ; Drug Evaluation, Preclinical/*methods ; Enzyme-Linked Immunosorbent Assay ; G-Protein-Coupled Receptor Kinase 2 ; GTP-Binding Protein alpha Subunits/metabolism ; GTP-Binding Protein beta Subunits/chemistry/*metabolism ; GTP-Binding Protein gamma Subunits/chemistry/*metabolism ; HL-60 Cells ; Humans ; Isoenzymes/metabolism ; Mice ; Mice, Inbred ICR ; Mitogen-Activated Protein Kinases/metabolism ; Molecular Structure ; Morphine/pharmacology ; N-Formylmethionine Leucyl-Phenylalanine/metabolism ; Peptide Library ; Peptides/*metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phospholipase C beta ; Protein Binding ; Protein Interaction Mapping ; *Signal Transduction ; Software ; Structure-Activity Relationship ; Type C Phospholipases/metabolism ; Xanthenes/chemistry/*metabolism/*pharmacology ; beta-Adrenergic Receptor Kinases/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 16
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    Retinoid signaling determines germ cell fate in mice (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-04-01
    Description: Germ cells in the mouse embryo can develop as oocytes or spermatogonia, depending on molecular cues that have not been identified. We found that retinoic acid, produced by mesonephroi of both sexes, causes germ cells in the ovary to enter meiosis and initiate oogenesis. Meiosis is retarded in the fetal testis by the action of the retinoid-degrading enzyme CYP26B1, ultimately leading to spermatogenesis. In testes of Cyp26b1-knockout mouse embryos, germ cells enter meiosis precociously, as if in a normal ovary. Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bowles, Josephine -- Knight, Deon -- Smith, Christopher -- Wilhelm, Dagmar -- Richman, Joy -- Mamiya, Satoru -- Yashiro, Kenta -- Chawengsaksophak, Kallayanee -- Wilson, Megan J -- Rossant, Janet -- Hamada, Hiroshi -- Koopman, Peter -- New York, N.Y. -- Science. 2006 Apr 28;312(5773):596-600. Epub 2006 Mar 30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16574820" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cytochrome P-450 Enzyme System/genetics/*metabolism ; Female ; Gene Expression Regulation, Developmental ; Genes, Reporter ; Germ Cells/*physiology ; In Situ Hybridization ; Lac Operon ; Male ; *Meiosis ; Mesonephros/metabolism ; Mice ; Mice, Knockout ; Naphthalenes/pharmacology ; *Oogenesis ; Ovary/embryology/metabolism ; Receptors, Retinoic Acid/antagonists & inhibitors ; Sertoli Cells/enzymology ; Sex Characteristics ; *Signal Transduction ; *Spermatogenesis ; Testis/embryology/metabolism ; Tissue Culture Techniques ; Tretinoin/*metabolism/pharmacology
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Social modulation of pain as evidence for empathy in mice (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-07-01
    Description: Empathy is thought to be unique to higher primates, possibly to humans alone. We report the modulation of pain sensitivity in mice produced solely by exposure to their cagemates, but not to strangers, in pain. Mice tested in dyads and given an identical noxious stimulus displayed increased pain behaviors with statistically greater co-occurrence, effects dependent on visual observation. When familiar mice were given noxious stimuli of different intensities, their pain behavior was influenced by their neighbor's status bidirectionally. Finally, observation of a cagemate in pain altered pain sensitivity of an entirely different modality, suggesting that nociceptive mechanisms in general are sensitized.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Langford, Dale J -- Crager, Sara E -- Shehzad, Zarrar -- Smith, Shad B -- Sotocinal, Susana G -- Levenstadt, Jeremy S -- Chanda, Mona Lisa -- Levitin, Daniel J -- Mogil, Jeffrey S -- New York, N.Y. -- Science. 2006 Jun 30;312(5782):1967-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology and Centre for Research on Pain, McGill University, Montreal, QC H3A 1B1, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16809545" target="_blank"〉PubMed〈/a〉
    Keywords: Altruism ; Animals ; Behavior, Animal ; Cues ; *Empathy ; Female ; Formaldehyde/administration & dosage ; Hot Temperature ; Male ; Mice/*psychology ; Pain/*psychology ; Pain Measurement ; *Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Dynamic nuclear actin assembly by Arp2/3 complex and a baculovirus WASP-like protein (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-10-21
    Description: Diverse bacterial and viral pathogens induce actin polymerization in the cytoplasm of host cells to facilitate infection. Here, we describe a pathogenic mechanism for promoting dynamic actin assembly in the nucleus to enable viral replication. The baculovirus Autographa californica multiple nucleopolyhedrovirus induced nuclear actin polymerization by translocating the host actin-nucleating Arp2/3 complex into the nucleus, where it was activated by p78/83, a viral Wiskott-Aldrich syndrome protein (WASP)-like protein. Nuclear actin assembly by p78/83 and Arp2/3 complex was essential for viral progeny production. Recompartmentalizing dynamic host actin may represent a conserved mode of pathogenesis and reflect viral manipulation of normal functions of nuclear actin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goley, Erin D -- Ohkawa, Taro -- Mancuso, Joel -- Woodruff, Jeffrey B -- D'Alessio, Joseph A -- Cande, W Zacheus -- Volkman, Loy E -- Welch, Matthew D -- AI054693/AI/NIAID NIH HHS/ -- GM59609/GM/NIGMS NIH HHS/ -- R01 GM059609/GM/NIGMS NIH HHS/ -- R01 GM059609-07/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Oct 20;314(5798):464-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17053146" target="_blank"〉PubMed〈/a〉
    Keywords: Actin-Related Protein 2-3 Complex/*metabolism ; Actins/*metabolism ; Animals ; Biopolymers/metabolism ; Cell Line ; Cell Nucleus/*metabolism ; Fluorescence Recovery After Photobleaching ; Moths ; Mutation ; Nucleocapsid/metabolism/ultrastructure ; Nucleopolyhedrovirus/genetics/*physiology ; Transfection ; Viral Proteins/chemistry/genetics/isolation & purification/*metabolism ; Virion/ultrastructure ; Virus Replication ; Wiskott-Aldrich Syndrome Protein/chemistry
    Print ISSN: 0036-8075
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    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 19
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    Selection on gamete recognition proteins depends on sex, density, and genotype frequency (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-04-15
    Description: Gamete recognition proteins can evolve at astonishing rates and lie at the heart of reproductive isolation and speciation in diverse taxa. However, the source of selection driving this evolution remains unknown. We report on how the sperm bindin genotype influences reproductive success under natural conditions. An interaction between genotype frequency and spawning density determines how sperm bindin genotype influences reproductive success. Common genotypes are selected under sperm-limited conditions, whereas rare genotypes are selected under conditions of intense sperm competition and sexual conflict. Variation in the evolutionary rates of bindin may reflect historic differences in sperm availability.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levitan, Don R -- Ferrell, David L -- New York, N.Y. -- Science. 2006 Apr 14;312(5771):267-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Science, Florida State University, Tallahassee, Florida 32306-1100, USA. levitan@bio.fsu.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16614223" target="_blank"〉PubMed〈/a〉
    Keywords: Alleles ; Animals ; *Evolution, Molecular ; Female ; Genotype ; Glycoproteins/*genetics/metabolism ; Male ; Ovum/physiology ; Polymorphism, Genetic ; Receptors, Cell Surface ; Reproduction ; *Selection, Genetic ; Sex Characteristics ; Species Specificity ; Spermatozoa/*physiology ; Strongylocentrotus/*genetics/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 20
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    Chromosomes can congress to the metaphase plate before biorientation (2006)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2006-01-21
    Description: The stable propagation of genetic material during cell division depends on the congression of chromosomes to the spindle equator before the cell initiates anaphase. It is generally assumed that congression requires that chromosomes are connected to the opposite poles of the bipolar spindle ("bioriented"). In mammalian cells, we found that chromosomes can congress before becoming bioriented. By combining the use of reversible chemical inhibitors, live-cell light microscopy, and correlative electron microscopy, we found that monooriented chromosomes could glide toward the spindle equator alongside kinetochore fibers attached to other already bioriented chromosomes. This congression mechanism depended on the kinetochore-associated, plus end-directed microtubule motor CENP-E (kinesin-7).〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768465/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768465/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kapoor, Tarun M -- Lampson, Michael A -- Hergert, Polla -- Cameron, Lisa -- Cimini, Daniela -- Salmon, E D -- McEwen, Bruce F -- Khodjakov, Alexey -- GM06627/GM/NIGMS NIH HHS/ -- GM24364/GM/NIGMS NIH HHS/ -- GM59363/GM/NIGMS NIH HHS/ -- GM65933/GM/NIGMS NIH HHS/ -- R01 GM024364/GM/NIGMS NIH HHS/ -- R01 GM059363/GM/NIGMS NIH HHS/ -- R37 GM024364/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2006 Jan 20;311(5759):388-91.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, NY 10021, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16424343" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aurora Kinases ; Cell Line ; Chromosomal Proteins, Non-Histone/physiology ; Chromosomes, Mammalian/*physiology/ultrastructure ; HeLa Cells ; Humans ; Indoles/pharmacology ; Kinesin/antagonists & inhibitors ; Kinetochores/*physiology/ultrastructure ; Metaphase ; Microscopy, Confocal ; Microscopy, Electron ; Microscopy, Interference ; Microscopy, Video ; Microtubules/*physiology/ultrastructure ; *Mitosis ; Molecular Motor Proteins/physiology ; Movement ; Potoroidae ; Protein-Serine-Threonine Kinases/antagonists & inhibitors/metabolism ; Pyrimidines/pharmacology ; RNA Interference ; RNA, Small Interfering ; Spindle Apparatus/*physiology/ultrastructure ; Sulfonamides/pharmacology ; Thiones/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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