Publication Date:
2004-07-27
Description:
Inherited channelopathies are at the origin of many neurological disorders. Here we report a form of channelopathy that is acquired in experimental temporal lobe epilepsy (TLE), the most common form of epilepsy in adults. The excitability of CA1 pyramidal neuron dendrites was increased in TLE because of decreased availability of A-type potassium ion channels due to transcriptional (loss of channels) and posttranslational (increased channel phosphorylation by extracellular signal-regulated kinase) mechanisms. Kinase inhibition partly reversed dendritic excitability to control levels. Such acquired channelopathy is likely to amplify neuronal activity and may contribute to the initiation and/or propagation of seizures in TLE.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bernard, Christophe -- Anderson, Anne -- Becker, Albert -- Poolos, Nicholas P -- Beck, Heinz -- Johnston, Daniel -- MH44754/MH/NIMH NIH HHS/ -- MH48432/MH/NIMH NIH HHS/ -- NS37444/NS/NINDS NIH HHS/ -- NS39943/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2004 Jul 23;305(5683):532-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. cbernard@inmed.univ-mrs.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15273397" target="_blank"〉PubMed〈/a〉
Keywords:
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine/pharmacology
;
4-Aminopyridine/pharmacology
;
Action Potentials/drug effects
;
Animals
;
Butadienes/pharmacology
;
Dendrites/*physiology
;
Enzyme Inhibitors/pharmacology
;
Epilepsy, Temporal Lobe/*physiopathology
;
Hippocampus/cytology/*physiopathology
;
Male
;
Membrane Potentials
;
Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
;
Nitriles/pharmacology
;
Phosphorylation
;
Pilocarpine/administration & dosage
;
Potassium Channel Blockers/pharmacology
;
Potassium Channels/drug effects/metabolism/*physiology
;
*Potassium Channels, Voltage-Gated
;
Protein Kinase C/antagonists & inhibitors/metabolism
;
Pyramidal Cells/*physiology
;
Rats
;
Rats, Sprague-Dawley
;
Shal Potassium Channels
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
Permalink
