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  • Adult
  • American Association for the Advancement of Science (AAAS)  (12)
  • Elsevier
  • 2000-2004  (12)
  • 1980-1984
  • 1975-1979
  • 1940-1944
  • 2002  (12)
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Verlag/Herausgeber
  • American Association for the Advancement of Science (AAAS)  (12)
  • Elsevier
Erscheinungszeitraum
  • 2000-2004  (12)
  • 1980-1984
  • 1975-1979
  • 1940-1944
Jahr
  • 1
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    Biomarkers of caloric restriction may predict longevity in humans (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-08-06
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roth, George S -- Lane, Mark A -- Ingram, Donald K -- Mattison, Julie A -- Elahi, Dariush -- Tobin, Jordan D -- Muller, Denis -- Metter, E Jeffrey -- New York, N.Y. -- Science. 2002 Aug 2;297(5582):811.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉National Institute on Aging, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12161648" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Aged ; Aged, 80 and over ; Aging/blood ; Animals ; Biomarkers/blood ; *Body Temperature ; Dehydroepiandrosterone Sulfate/*blood ; Diet ; Energy Intake/*physiology ; Humans ; Insulin/*blood ; Life Expectancy ; Longevity/*physiology ; Longitudinal Studies ; Macaca mulatta/*blood/*physiology ; Male ; Middle Aged
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Serotonin transporter genetic variation and the response of the human amygdala (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-07-20
    Beschreibung: A functional polymorphism in the promoter region of the human serotonin transporter gene (SLC6A4) has been associated with several dimensions of neuroticism and psychopathology, especially anxiety traits, but the predictive value of this genotype against these complex behaviors has been inconsistent. Serotonin [5- hydroxytryptamine, (5-HT)] function influences normal fear as well as pathological anxiety, behaviors critically dependent on the amygdala in animal models and in clinical studies. We now report that individuals with one or two copies of the short allele of the serotonin transporter (5-HTT) promoter polymorphism, which has been associated with reduced 5-HTT expression and function and increased fear and anxiety-related behaviors, exhibit greater amygdala neuronal activity, as assessed by BOLD functional magnetic resonance imaging, in response to fearful stimuli compared with individuals homozygous for the long allele. These results demonstrate genetically driven variation in the response of brain regions underlying human emotional behavior and suggest that differential excitability of the amygdala to emotional stimuli may contribute to the increased fear and anxiety typically associated with the short SLC6A4 allele.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hariri, Ahmad R -- Mattay, Venkata S -- Tessitore, Alessandro -- Kolachana, Bhaskar -- Fera, Francesco -- Goldman, David -- Egan, Michael F -- Weinberger, Daniel R -- New York, N.Y. -- Science. 2002 Jul 19;297(5580):400-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12130784" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Alleles ; Amygdala/*physiology ; Carrier Proteins/*genetics/physiology ; Cohort Studies ; Facial Expression ; *Fear ; Female ; Functional Laterality ; *Genetic Variation ; Genotype ; Humans ; Magnetic Resonance Imaging ; Male ; Membrane Glycoproteins/*genetics/physiology ; *Membrane Transport Proteins ; *Nerve Tissue Proteins ; Personality ; Polymorphism, Genetic ; *Promoter Regions, Genetic ; Serotonin/*metabolism ; Serotonin Plasma Membrane Transport Proteins ; Sex Characteristics
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-09-21
    Beschreibung: We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites. This led to regression of the patients' metastatic melanoma as well as to the onset of autoimmune melanocyte destruction. This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus-related acquired immunodeficiency syndrome and other infectious diseases.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764179/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1764179/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dudley, Mark E -- Wunderlich, John R -- Robbins, Paul F -- Yang, James C -- Hwu, Patrick -- Schwartzentruber, Douglas J -- Topalian, Suzanne L -- Sherry, Richard -- Restifo, Nicholas P -- Hubicki, Amy M -- Robinson, Michael R -- Raffeld, Mark -- Duray, Paul -- Seipp, Claudia A -- Rogers-Freezer, Linda -- Morton, Kathleen E -- Mavroukakis, Sharon A -- White, Donald E -- Rosenberg, Steven A -- Z01 BC010763-01/Intramural NIH HHS/ -- Z99 CA999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):850-4. Epub 2002 Sep 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20902, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242449" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Antigens, Neoplasm ; *Autoimmunity ; CD8-Positive T-Lymphocytes/immunology ; Clone Cells ; Cytokines/secretion ; Female ; HLA-A2 Antigen/immunology ; Histocompatibility Antigens Class I/immunology ; Histocompatibility Antigens Class II/immunology ; Humans ; *Immunotherapy, Adoptive ; Interleukin-2/therapeutic use ; Lymphocyte Count ; Lymphocyte Depletion ; Lymphocytes, Tumor-Infiltrating/*immunology ; MART-1 Antigen ; Male ; Melanocytes/immunology ; Melanoma/*immunology/pathology/secondary/*therapy ; Middle Aged ; Neoplasm Proteins/immunology ; Receptors, Antigen, T-Cell, alpha-beta/immunology ; T-Lymphocytes/*immunology ; Treatment Outcome
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Harmful moratorium on stem cell research (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-09-21
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowley, Janet D -- Blackburn, Elizabeth -- Gazzaniga, Michael S -- Foster, Daniel W -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):1957.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242409" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Advisory Committees ; Embryo, Mammalian/*cytology ; Ethics Committees, Research ; Financing, Government ; Humans ; National Institutes of Health (U.S.) ; *Research ; Research Support as Topic ; *Stem Cells ; United States
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    Adult-onset primary open-angle glaucoma caused by mutations in optineurin (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-02-09
    Beschreibung: Primary open-angle glaucoma (POAG) affects 33 million individuals worldwide and is a leading cause of blindness. In a study of 54 families with autosomal dominantly inherited adult-onset POAG, we identified the causative gene on chromosome 10p14 and designated it OPTN (for "optineurin"). Sequence alterations in OPTN were found in 16.7% of families with hereditary POAG, including individuals with normal intraocular pressure. The OPTN gene codes for a conserved 66-kilodalton protein of unknown function that has been implicated in the tumor necrosis factor-alpha signaling pathway and that interacts with diverse proteins including Huntingtin, Ras-associated protein RAB8, and transcription factor IIIA. Optineurin is expressed in trabecular meshwork, nonpigmented ciliary epithelium, retina, and brain, and we speculate that it plays a neuroprotective role.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rezaie, Tayebeh -- Child, Anne -- Hitchings, Roger -- Brice, Glen -- Miller, Lauri -- Coca-Prados, Miguel -- Heon, Elise -- Krupin, Theodore -- Ritch, Robert -- Kreutzer, Donald -- Crick, R Pitts -- Sarfarazi, Mansoor -- EY-09947/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 2002 Feb 8;295(5557):1077-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Molecular Ophthalmic Genetics Laboratory, Surgical Research Center, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11834836" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Alternative Splicing ; Amino Acid Sequence ; Brain/metabolism ; Chromosome Mapping ; Chromosomes, Human, Pair 10/genetics ; Ciliary Body/metabolism ; Exons ; Eye Proteins/analysis/chemistry/*genetics/physiology ; Female ; Glaucoma, Open-Angle/*genetics ; Golgi Apparatus/chemistry ; Heterozygote ; Humans ; Intraocular Pressure ; Male ; Middle Aged ; *Mutation ; *Mutation, Missense ; Nerve Tissue Proteins/analysis/chemistry/*genetics/physiology ; Ocular Hypertension/genetics ; Pedigree ; Polymorphism, Single-Stranded Conformational ; Retina/metabolism ; Trabecular Meshwork/metabolism ; *Transcription Factor TFIIIA ; Zinc Fingers
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    The cortical topography of tonal structures underlying Western music (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-12-14
    Beschreibung: Western tonal music relies on a formal geometric structure that determines distance relationships within a harmonic or tonal space. In functional magnetic resonance imaging experiments, we identified an area in the rostromedial prefrontal cortex that tracks activation in tonal space. Different voxels in this area exhibited selectivity for different keys. Within the same set of consistently activated voxels, the topography of tonality selectivity rearranged itself across scanning sessions. The tonality structure was thus maintained as a dynamic topography in cortical areas known to be at a nexus of cognitive, affective, and mnemonic processing.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janata, Petr -- Birk, Jeffrey L -- Van Horn, John D -- Leman, Marc -- Tillmann, Barbara -- Bharucha, Jamshed J -- P50 NS17778-18/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2167-70.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth Brain Imaging Center, Dartmouth College, Hanover, NH 03755, USA. petr.janata@dartmouth.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481131" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Auditory Cortex/anatomy & histology/physiology ; *Auditory Perception ; Brain/anatomy & histology/*physiology ; Brain Mapping ; Female ; Functional Laterality ; Humans ; Magnetic Resonance Imaging ; Male ; Memory ; Mental Processes ; Middle Aged ; Models, Neurological ; *Music ; Nerve Net/anatomy & histology/physiology ; Neural Networks (Computer) ; Pitch Perception ; Prefrontal Cortex/anatomy & histology/*physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-12-03
    Beschreibung: A 4-base pair deletion in the neuronal serine protease neurotrypsin gene was associated with autosomal recessive nonsyndromic mental retardation (MR). In situ hybridization experiments on human fetal brains showed that neurotrypsin was highly expressed in brain structures involved in learning and memory. Immuno-electron microscopy on adult human brain sections revealed that neurotrypsin is located in presynaptic nerve endings, particularly over the presynaptic membrane lining the synaptic cleft. These findings suggest that neurotrypsin-mediated proteolysis is required for normal synaptic function and suggest potential insights into the pathophysiological bases of mental retardation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Molinari, Florence -- Rio, Marlene -- Meskenaite, Virginia -- Encha-Razavi, Ferechte -- Auge, Joelle -- Bacq, Delphine -- Briault, Sylvain -- Vekemans, Michel -- Munnich, Arnold -- Attie-Bitach, Tania -- Sonderegger, Peter -- Colleaux, Laurence -- New York, N.Y. -- Science. 2002 Nov 29;298(5599):1779-81.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Unite de Recherches sur les Handicaps Genetiques de l'Enfant, INSERM U-393, et Departement de Genetique, Hopital Necker-Enfants Malades, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12459588" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adolescent ; Adult ; Brain/embryology/*metabolism ; Female ; Fetus/metabolism ; Gene Expression ; Genes, Recessive ; Humans ; Immunohistochemistry ; Intellectual Disability/*genetics/metabolism ; Male ; Microsatellite Repeats ; Microscopy, Immunoelectron ; Pedigree ; *Sequence Deletion ; Serine Endopeptidases/chemistry/*genetics/metabolism ; Spinal Cord/embryology/metabolism ; Synapses/*metabolism/ultrastructure ; Synaptic Membranes/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    Another unmet public health need (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-05-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Baker, Susan P -- Baker, Timothy D -- New York, N.Y. -- Science. 2002 May 17;296(5571):1237.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12025831" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Accidents, Traffic/statistics & numerical data ; Adult ; Cause of Death ; Child ; Child, Preschool ; Humans ; *Public Health ; *Wounds and Injuries/epidemiology/mortality
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    Improving the health of the global poor (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-03-16
    Beschreibung: We analyzed the technical basis for a major global program to reduce disease among the poor. Effective interventions exist against the few diseases which most account for excess mortality among the poor. Achieving high coverage of effective interventions requires a well-functioning health system, as well as overcoming a set of financial and nonfinancial constraints. The annual incremental cost would be between $40 billion and $52 billion by 2015 in 83 low-income and sub-Saharan African countries. Such a program is feasible and would avoid millions of child, maternal, and adult deaths annually in poor countries.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jha, Prabhat -- Mills, Anne -- Hanson, Kara -- Kumaranayake, Lilani -- Conteh, Lesong -- Kurowski, Christoph -- Nguyen, Son Nam -- Cruz, Valeria Oliveira -- Ranson, Kent -- Vaz, Lara M E -- Yu, Shengchao -- Morton, Oliver -- Sachs, Jeffrey D -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2036-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉World Health Organization (WHO), Geneva 01220, Switzerland. jhap@who.int〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896266" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Child ; *Delivery of Health Care/economics ; Female ; *Global Health ; Government ; Health Care Costs ; *Health Expenditures ; Health Services Accessibility ; *Health Status ; Humans ; Immunization Programs/economics ; *Medically Underserved Area ; *Poverty ; Pregnancy ; Preventive Health Services/economics ; Public Policy
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
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    What's new, pussycat? On talking to babies and animals (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2002-05-25
    Beschreibung: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Burnham, Denis -- Kitamura, Christine -- Vollmer-Conna, Ute -- New York, N.Y. -- Science. 2002 May 24;296(5572):1435.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MARCS Auditory Laboratories, University of Western Sydney, Post Office Box 1797, Sydney, 1797, Australia. d.burnham@uws.edu.au〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12029126" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adult ; Animals ; *Animals, Domestic ; Cats ; Dogs ; Humans ; Infant ; *Mother-Child Relations ; *Mothers ; *Phonetics ; *Speech ; *Speech Acoustics ; Verbal Behavior
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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