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  • United States  (65)
  • American Association for the Advancement of Science (AAAS)  (65)
  • Springer Nature
  • 2000-2004  (65)
  • 1995-1999
  • 1980-1984
  • 1970-1974
  • 1940-1944
  • 2002  (65)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (65)
  • Springer Nature
Years
  • 2000-2004  (65)
  • 1995-1999
  • 1980-1984
  • 1970-1974
  • 1940-1944
Year
  • 1
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    No major schizophrenia locus detected on chromosome 1q in a large multicenter sample (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-04-27
    Description: Reports of substantial evidence for genetic linkage of schizophrenia to chromosome 1q were evaluated by genotyping 16 DNA markers across 107 centimorgans of this chromosome in a multicenter sample of 779 informative schizophrenia pedigrees. No significant evidence was observed for such linkage, nor for heterogeneity in allele sharing among the eight individual samples. Separate analyses of European-origin families, recessive models of inheritance, and families with larger numbers of affected cases also failed to produce significant evidence for linkage. If schizophrenia susceptibility genes are present on chromosome 1q, their population-wide genetic effects are likely to be small.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Levinson, Douglas F -- Holmans, Peter A -- Laurent, Claudine -- Riley, Brien -- Pulver, Ann E -- Gejman, Pablo V -- Schwab, Sibylle G -- Williams, Nigel M -- Owen, Michael J -- Wildenauer, Dieter B -- Sanders, Alan R -- Nestadt, Gerald -- Mowry, Bryan J -- Wormley, Brandon -- Bauche, Stephanie -- Soubigou, Stephane -- Ribble, Robert -- Nertney, Deborah A -- Liang, Kung Yee -- Martinolich, Laura -- Maier, Wolfgang -- Norton, Nadine -- Williams, Hywel -- Albus, Margot -- Carpenter, Eric B -- DeMarchi, Nicola -- Ewen-White, Kelly R -- Walsh, Dermot -- Jay, Maurice -- Deleuze, Jean-Francois -- O'Neill, F Anthony -- Papadimitriou, George -- Weilbaecher, Ann -- Lerer, Bernard -- O'Donovan, Michael C -- Dikeos, Dimitris -- Silverman, Jeremy M -- Kendler, Kenneth S -- Mallet, Jacques -- Crowe, Raymond R -- Walters, Marilyn -- G9309834/Medical Research Council/United Kingdom -- G9810900/Medical Research Council/United Kingdom -- K24-MH64197/MH/NIMH NIH HHS/ -- KO2-01207/PHS HHS/ -- MH 41953/MH/NIMH NIH HHS/ -- MH 45390/MH/NIMH NIH HHS/ -- MH 52537/MH/NIMH NIH HHS/ -- MH61602/MH/NIMH NIH HHS/ -- R01-MH57314/MH/NIMH NIH HHS/ -- U01 MH46289/MH/NIMH NIH HHS/ -- U01 MH46318/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 2002 Apr 26;296(5568):739-41.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. dfl@mail.med.upenn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11976456" target="_blank"〉PubMed〈/a〉
    Keywords: Africa ; Alleles ; Australia ; Canada ; Chromosomes, Human, Pair 1/*genetics ; Europe ; Female ; Genes, Recessive ; *Genetic Linkage ; *Genetic Predisposition to Disease ; Genotype ; Humans ; Lod Score ; Male ; Microsatellite Repeats ; Pedigree ; Schizophrenia/ethnology/*genetics ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Mechanisms of adaptation in a predator-prey arms race: TTX-resistant sodium channels (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-08-24
    Description: Populations of the garter snake Thamnophis sirtalis have evolved geographically variable resistance to tetrodotoxin (TTX) in a coevolutionary arms race with their toxic prey, newts of the genus Taricha. Here, we identify a physiological mechanism, the expression of TTX-resistant sodium channels in skeletal muscle, responsible for adaptive diversification in whole-animal resistance. Both individual and population differences in the ability of skeletal muscle fibers to function in the presence of TTX correlate closely with whole-animal measures of TTX resistance. Demonstration of individual variation in an essential physiological function responsible for the adaptive differences among populations is a step toward linking the selective consequences of coevolutionary interactions to geographic and phylogenetic patterns of diversity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Geffeney, Shana -- Brodie, Edmund D Jr -- Ruben, Peter C -- Brodie, Edmund D 3rd -- New York, N.Y. -- Science. 2002 Aug 23;297(5585):1336-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, Utah State University, Logan, UT 84322, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12193784" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Adaptation, Physiological ; Animals ; *Biological Evolution ; Colubridae/*physiology ; Drug Resistance ; Linear Models ; Locomotion/drug effects ; Muscle Fibers, Skeletal/drug effects/physiology ; Muscle, Skeletal/drug effects/*physiology ; Neuromuscular Junction/drug effects/physiology ; Predatory Behavior ; *Salamandridae/metabolism ; Skin/chemistry ; Sodium Channels/*drug effects/physiology ; Tetrodotoxin/*toxicity ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Advice without dissent (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michaels, David -- Bingham, Eula -- Boden, Les -- Clapp, Richard -- Goldman, Lynn R -- Hoppin, Polly -- Krimsky, Sheldon -- Monforton, Celeste -- Ozonoff, David -- Robbins, Anthony -- New York, N.Y. -- Science. 2002 Oct 25;298(5594):703.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12399550" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Biomedical Research ; Environmental Health ; *Federal Government ; Genetic Testing ; Politics ; *Science ; United States ; United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Harmful moratorium on stem cell research (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-09-21
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowley, Janet D -- Blackburn, Elizabeth -- Gazzaniga, Michael S -- Foster, Daniel W -- New York, N.Y. -- Science. 2002 Sep 20;297(5589):1957.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12242409" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Advisory Committees ; Embryo, Mammalian/*cytology ; Ethics Committees, Research ; Financing, Government ; Humans ; National Institutes of Health (U.S.) ; *Research ; Research Support as Topic ; *Stem Cells ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Space science. Science emerges from shadows of China's space program (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-06-08
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Normile, Dennis -- Yimin, Ding -- New York, N.Y. -- Science. 2002 Jun 7;296(5574):1788-91.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12052934" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chick Embryo ; China ; Environmental Monitoring ; International Cooperation ; Mutation ; *Research ; Seeds/genetics/growth & development/physiology ; *Space Flight ; *Spacecraft ; United States ; Weightlessness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    Homeland security. New agency contains strong science arm (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-11-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Malakoff, David -- New York, N.Y. -- Science. 2002 Nov 22;298(5598):1534.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12446877" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioterrorism ; Financing, Government ; Government Agencies/economics/legislation & jurisprudence/*organization & ; administration ; National Institutes of Health (U.S.) ; Research/*organization & administration ; Research Support as Topic ; Security Measures/economics/legislation & jurisprudence/*organization & ; administration ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    Collaborating on public health issues (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-05-28
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ozonoff, David -- Robbins, Anthony -- New York, N.Y. -- Science. 2002 May 24;296(5572):1400.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12030273" target="_blank"〉PubMed〈/a〉
    Keywords: New England ; *Public Health/manpower ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Planetary science. And an icy patch at Mars's south pole (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-12-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mackenzie, Dana -- New York, N.Y. -- Science. 2002 Dec 6;298(5600):1866-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12471229" target="_blank"〉PubMed〈/a〉
    Keywords: Climate ; Dry Ice ; Extraterrestrial Environment ; *Ice ; *Mars ; Space Flight ; United States ; United States National Aeronautics and Space Administration ; Water
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Unpopular opinions need not apply (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-11-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Loomis, Dana -- New York, N.Y. -- Science. 2002 Nov 15;298(5597):1335-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12436979" target="_blank"〉PubMed〈/a〉
    Keywords: *Advisory Committees ; Federal Government ; Human Engineering ; *National Institute for Occupational Safety and Health (U.S.) ; Peer Review, Research ; *Politics ; Public Policy ; Research Support as Topic ; United States ; *United States Dept. of Health and Human Services
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Beauty and the beast (2002)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2002-03-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennedy, Donald -- New York, N.Y. -- Science. 2002 Mar 1;295(5560):1601.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11872803" target="_blank"〉PubMed〈/a〉
    Keywords: Bacterial Vaccines ; *Biological Warfare ; *Botulinum Toxins, Type A/administration & dosage/therapeutic use ; Clostridium botulinum/immunology ; *Cosmetic Techniques ; *Drug Approval ; Humans ; *Public Health ; United States ; United States Food and Drug Administration
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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