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Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity (1995)

F. Rieux-Laucat ; F. Le Deist ; C. Hivroz ; [weitere]

American Association for the Advancement of Science (AAAS)

In: Science. 268(5215): 1347-9.

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Publikationsdatum: 1995-06-02

Beschreibung: Fas (also known as Apo1 and CD95) is a cell surface receptor involved in apoptotic cell death. Fas expression and function were analyzed in three children (including two siblings) with a lymphoproliferative syndrome, two of whom also had autoimmune disorders. A large deletion in the gene encoding Fas and no detectable cell surface expression characterized the most affected patient. Clinical manifestations in the two related patients were less severe: Fas-mediated apoptosis was impaired and a deletion within the intracytoplasmic domain was detected. These findings illustrate the crucial regulatory role of Fas and may provide a molecular basis for some autoimmune diseases in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rieux-Laucat, F -- Le Deist, F -- Hivroz, C -- Roberts, I A -- Debatin, K M -- Fischer, A -- de Villartay, J P -- New York, N.Y. -- Science. 1995 Jun 2;268(5215):1347-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut National de la Sante et de la Recherche Medicale (INSERM) U 429, Hopital Necker-Enfants Malades, Paris, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7539157" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Amino Acid Sequence ; Antigens, CD95 ; Antigens, Surface/chemistry/*genetics/physiology ; Apoptosis ; Autoimmune Diseases/*genetics/immunology/pathology ; Base Sequence ; Child ; Female ; *Frameshift Mutation ; Humans ; Infant ; Lymphoproliferative Disorders/*genetics/immunology/pathology ; Male ; Molecular Sequence Data ; Sequence Deletion ; Syndrome ; Thrombocytopenia/genetics/immunology/pathology

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Control of cell fate by a deubiquitinating enzyme encoded by the fat facets gene (1995)

Y. Huang ; R. T. Baker ; J. A. Fischer-Vize

American Association for the Advancement of Science (AAAS)

In: Science. 270(5243): 1828-31.

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Publikationsdatum: 1995-12-15

Beschreibung: Ubiquitin is a highly conserved polypeptide found in all eukaryotes. The major function of ubiquitin is to target proteins for complete or partial degradation by a multisubunit protein complex called the proteasome. Here, the Drosophila fat facets gene, which is required for the appropriate determination of particular cells in the fly eye, was shown to encode a ubiquitin-specific protease (Ubp), an enzyme that cleaves ubiquitin from ubiquitin-protein conjugates. The Fat facets protein (FAF) acts as a regulatory Ubp that prevents degradation of its substrate by the proteasome. Flies bearing fat facets gene mutations were used to show that a Ubp is cell type--and substrate-specific and a regulator of cell fate decisions in a multicellular organism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huang, Y -- Baker, R T -- Fischer-Vize, J A -- New York, N.Y. -- Science. 1995 Dec 15;270(5243):1828-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Zoology, University of Texas, Austin 78712, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8525378" target="_blank"〉PubMed〈/a〉

Schlagwort(e): Amino Acid Sequence ; Animals ; Base Sequence ; *Cell Differentiation/genetics ; Cysteine/metabolism ; Drosophila/embryology/enzymology/genetics ; Endopeptidases/genetics/*metabolism ; Escherichia coli ; Eye/embryology ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Oligodeoxyribonucleotides ; Recombinant Fusion Proteins/genetics/metabolism ; Ubiquitins/*metabolism ; beta-Galactosidase/genetics

Print ISSN: 0036-8075

Digitale ISSN: 1095-9203

Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von American Association for the Advancement of Science (AAAS)

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Reaction of 5,6,7,8-Tetrahydropterin with Iron(III) Acetylacetonate. Detection of Radical Cations by Electrospray Ionization Mass Spectrometry‘Pterin Chemistry’ Part 96, presented at the 10th International Symposium on Chemistry and Biology of Pteridines, held March 21-26, 1993, in Orange Beach, Alabama, USA [1]; Part 94 [2]; Part 95 [3]. (1995)

Schäfer, Andrea ; Hesse, Manfred ; Viscontini, Max ; [weitere]

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 78 (1995), S. 1763-1776

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: The experimental conditions developed for the detection of rather stable radical cations in solution by electrospray-ionization mass spectrometry (ESI-MS) of a FeII complex of 2-amino-5,6,7,8-tetrahydro-5-methylpteridin-4 (3H)-one (1c) are used to observe the formation of the more unstable radical cations formed from 2-amino-5,6,7,8-tetrahydropteridin-4(3H)-one (1a) and tris(pentane-2,4-dionato)iron(III) ([FeIII(acac)3]; 4) and to monitor their oxidation to the corresponding p-quinonoid dihydropterin complexes. These results contribute to the understanding of the important role played by 6β-5,6,7,8-tetrahydro-L-biopterin (1b; a homologue of 1a) together with iron as constituent of some cofactors. The complexes obtained from 1a and iron may be considered, e.g. as a model of the cofactor of the phenylalanine hydroxylase. Moreover, we describe an improved synthesis of 1c.

Zusätzliches Material: 11 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19950780710

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Absolute Rate Constants for the Addition of Benzyl (PhĊH2) and Cumyl (PhĊMe2) Radicals to Alkenes in Solution (1995)

Walbiner, Manfred ; Wu, Jie Qiang ; Fischer, Hanns

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 78 (1995), S. 910-924

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Absolute rate constants and their temperature dependence were determined by time-resolved electron spin resonance for the addition of the radicals PhĊH2 and PhĊMe2 to a variety of alkenes in toluene solution. To vinyl monomers CH2=CXY, PhĊH2 adds at the unsubstituted C-atom with rate constants ranging from 14 M-1S-1 (ethoxyethene) to 6.7 · 103 M-1S-1 (4-vinylpyridine) at 296 K, and the frequency factors are in the narrow range of log (A/M-1S-1) = 8.6 ± 0.3, whereas the activation energy varies with the substituents from ca. 51 kJ/mol to ca. 26 kJ/mol. The rate constants and the activation energies increase both with increasing exothermicity of the reaction and with increasing electron affinity of the alkenes and are mainly controlled by the reaction enthalpy, but are markedly influenced also by nucleophilic polar effects for electron-deficient substrates. For 1,2-disubstituted and trisubstituted alkenes, the rate constants are affected by additional steric substituent effects. To acrylate and styrenes, PhĊMe2 adds with rate constants similar to those of PhĊH2, and the reactivity is controlled by the same factors. A comparison with relative-rate data shows that reaction enthalpy and polar effects also dominate the copolymerization behavior of the styrene propagation radical.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19950780414

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Absolute Rate Constants for the Addition of Cyanomethyl (·CH2CN) and (tert-Butoxy)carbonylmethyl (·CH2CO2C(CH3)3) radicals to alkenes in solution (1995)

Wu, Jie Qiang ; Beranek, Ivan ; Fischer, Hanns

New York, NY : Wiley-Blackwell

Helvetica Chimica Acta 78 (1995), S. 194-214

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ISSN: 0018-019X

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Absolute rate constants and their temperature dependence were determined by time-resolved electron spin resonance for the addition of the radicals ·CH2CN and ·CH2CO2C(CH3)3 to a variety of mono- and 1,1-disubstituted and to selected 1,2- and trisubstituted alkenes in acetonitrile solution. To alkenes CH2=CXY, ·CH2CN adds at the unsubstituted C-atom with rate constants ranging from 3.3·103 M-1S-1 (ethene) to 2.4·106 M-1S-1 (1,1-diphenylethene) at 278 K, and the frequency factors are in the narrow range of log (A/M-1S-1) = 8.7 ± 0.3. ·CH2CO2C(CH3)3 shows a very similar reactivity with rate constants at 296 K ranging from 1.1·104 M-1S-1 (ethene) to 107 M-1S-1 (1,1-diphenylethene) and frequency factors log (A/M-1S-1) = 8.4 ± 0.1. For both radicals, the rate constants and the activation energies for addition to CH2=CXY correlate well with the overall reaction enthalpy. In contrast to the expectation of an electro- or ambiphilic behavior, polar alkene-substituent effects are not clearly expressed, but some deviations from the enthalpy correlations point to a weak electrophilicity of the radicals. The rate constants for the addition to 1,2- and to trisubstituted alkenes reveal additional steric substituent effects. Self-termination rate data for the title radicals and spectral properties of their adducts to the alkenes are also given.

Zusätzliches Material: 12 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/hlca.19950780118

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Karl-Fischer-Reaktion in Dimethylsulfoxid (1995)

Fischer, Wolfgang ; Beil, Stefanie ; Krenn, Karl-Dieter

New York, NY : Wiley-Blackwell

Journal für Praktische Chemie/Chemiker-Zeitung 337 (1995), S. 266-268

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ISSN: 0941-1216

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Karl-Fischer-Reaction in Dimethyl SulfoxideThe water equivalent (titer) of methanolic Karl-Fischer-reagents rises if dimethyl sulfoxide (DMSO) is used as an additional solvent. It is shown that the probable reason for this observation is the formation of iodine by the reaction between DMSO, iodide and sulfur trioxide.

Zusätzliches Material: 2 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/prac.19953370156

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Some reactions of 1,3-Dichloro-2-azoniaallene Salts with heteronucleophiles (1995)

Hamed, A. ; Sedeak, M. ; Ismail, A.-H. ; [weitere]

New York, NY : Wiley-Blackwell

Journal für Praktische Chemie/Chemiker-Zeitung 337 (1995), S. 274-282

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ISSN: 0941-1216

Schlagwort(e): Chemistry ; Organic Chemistry

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: 1,3-Dichloro-2-azoniaallene hexachloroantimonates (1) reacted with H2S to give 1,2,4-dithiazolium salts 2. With hydrazines 1,2,4-triazolium salts (3, 4) were formed. 1,3-Dimethylurea, respectively 1,3-dimethylthiourea or ethyl allophanate, reacted with 1 to afford 2-oxo- or 2-thioxo-1,3,5-triazinium salts (5-7). With diphenylmethaneimines imino substituted 2-azoniaallene salts 8 were produced. From chloroacetonitrile dichloropyrimidines 9, and from the tricyanomethyl anion a hexatriene 10 and a triazine 11 could be prepared. The 1,5-dichloro substituted 2-azoniaallene salts 12 reacted as bifunctional electrophiles with nucleophiles such as benzophenone hydrazone or anilines, to furnish 1,3,5-triazinium salts 14. Against benzohydrazide the allene 12j behaved as trivalent electrophile giving the bicyclic 1,3,5-oxadiazinium salt 13j, the constitution of which has been secured by a crystal structural analysis. The vinyl-2-azoniaallene salt 1i cyclized on heating to the 1,3-thiazinium salts 16, 17. From 17 the triazinium salts 18 were prepared with alcohols.

Zusätzliches Material: 2 Tab.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/prac.19953370158

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