Publication Date:
1995-03-24
Description:
B cells can exchange gene segments for the constant region of the immunoglobulin heavy chain, altering the class and effector function of the antibodies that they produce. Class switching is directed to distinct classes by cytokines, which induce transcription of the targeted DNA sequences. These transcripts are processed, resulting in spliced "switch" transcripts. Switch recombination can be directed to immunoglobulin G1 (IgG) by the heterologous human metallothionein IIA promoter in mutant mice. Induction of the structurally conserved, spliced switch transcripts is sufficient to target switch recombination to IgG1, whereas transcription alone is not.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lorenz, M -- Jung, S -- Radbruch, A -- New York, N.Y. -- Science. 1995 Mar 24;267(5205):1825-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genetics, University of Cologne, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7892607" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
B-Lymphocytes/immunology
;
Base Sequence
;
Immunoglobulin Class Switching/*genetics
;
Immunoglobulin G/genetics
;
Interleukin-4/physiology
;
Metallothionein/genetics
;
Mice
;
Mice, Inbred BALB C
;
Mice, Inbred C57BL
;
Mice, Mutant Strains
;
Molecular Sequence Data
;
Promoter Regions, Genetic
;
RNA, Messenger/*genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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