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  • ASTROPHYSICS  (206)
  • Life and Medical Sciences  (181)
  • Lunar and Planetary Science and Exploration  (115)
  • 2010-2014  (99)
  • 1990-1994  (403)
  • 1920-1924
  • 2014  (99)
  • 1993  (403)
Collection
Keywords
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  • 2010-2014  (99)
  • 1990-1994  (403)
  • 1920-1924
Year
  • 1
    Electronic Resource
    Electronic Resource
    Microscopy in solid state science (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Microscopy Research and Technique 24 (1993), S. 299-315 
    Details
    ISSN: 1059-910X
    Keywords: STEM ; PEELS ; HAADFI ; Nanolithography ; Super-resolution ; STM ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Natural Sciences in General
    Notes: The Microstructural Physics group at the Cavendish Laboratory is actively involved in a considerable number of research projects which cover a broad range of materials science. In this paper, we describe briefly several such projects, with particular emphasis given to the application of parallel-detection electron energy loss spectroscopy (PEELS) on a scanning transmission electron microscope (STEM) to the analysis of materials such as stainless steels, catalysts, and high temperature superconductors. In addition, we describe a number of related projects that are currently being carried out in the group, particularly those which utilise and develop novel STEM imaging and analytical techniques. © 1993 Wiley-Liss, Inc.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jemt.1070240404
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  • 2
    Electronic Resource
    Electronic Resource
    Nuclear protein redistribution in heat-shocked cells (1993)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 154 (1993), S. 402-409 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: An increase was observed in the total protein mass of nuclei isolated from Chinese hamster ovary cells heated at 45°C or 45.5°C. An increase in the fractional recovery of DNA polymerase α and β, and of DNA topoisomerase activity coincided with this increase in the protein mass of nuclei from heated cells. Nuclear protein mass which was soluble in 2.0 M NaCl decreased 0.5 fold, while DNA-associated and nuclear matrix-associated protein mass increased 2.2 and 3.4 fold, respectively. The results indicate that the increase in nuclear protein mass observed in nuclei from heated cells is due in part to an increased binding, or precipitation, of nuclear proteins onto the cell's DNA and nuclear matrix. © 1993 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041540224
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  • 3
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    STARDUST - A simulation experiment of cosmic dust analogues production in microgravity conditions (1993)
    In:  Other Sources
    Details
    Publication Date: 2011-08-24
    Description: The condensation of solid materials from the vapor phase is important in several scientific fields such as chemical vapor deposition, air pollution and the formation of refractory cosmic dust around stars. Conventional studies of refractory grain formation, using high temperature furnace and shock tube techniques, are restricted to short time scales and suffer from buoyancy induced convection that limit their accuracy. In order to simulate more accurately the condensation of refractory grains near stars and to investigate the advantages of performing condensation studies in microgravity conditions, an experimental investigation was undertaken. This work reports the experimental equipment currently used. The results from the first flight series and particle aggregation modelling efforts are presented briefly.
    Keywords: ASTROPHYSICS
    Type: Microgravity Science and Technology (ISSN 0938-0108); 6; 2; p. 123-130.
    Format: text
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  • 4
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    (abstract) Galileo NIMS Thermal Observations of Asteroid 951 Gaspra (1993)
    In:  Other Sources
    Details
    Publication Date: 2018-06-08
    Description: The Near Infrared Mapping Spectrometer (NIMS) onboard the Galileo spacecraft performed spectral and thermal imaging of asteroid 951 Gaspra during the spacecraft flyby on October 29, 1991. Measurements of the hemispherically averaged temperature on Gaspra as the spacecraft approached the asteroid will also be reported. Differences resulting from other choices for thermophysical parameters in the model will be explored. Similar measurements are currently being planned for the Galileo encounter with asteroid 243 Ida, which will occur in late August of 1993.
    Keywords: Lunar and Planetary Science and Exploration
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  • 5
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    Diamond thermoluminescence properties of different chondrites (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-01-25
    Description: It was found that thermoluminescence (TL) glows of diamonds depend on the origin of diamonds and the chondrite metamorphism degree. The investigation of TL of diamonds was continued and the results for diamonds from Murchison CM2, Krymka LL3.0, Kainsaz CO3, and Abee E4 were considered. The diamonds synthesized by CVD-process (samples 133, 159) and by detonation from soot (DDS-B14-89) were also analyzed for comparison. Before the TL measuring samples were annealed at approximately 350 C for a few seconds and then irradiated by gamma-rays of Cs-137 up to dose approximately 200 krad. TL-measurements were performed in the air atmosphere on the standard equipment. TL data for samples are shown. TL glow for some diamonds are also presented.
    Keywords: ASTROPHYSICS
    Type: Lunar and Planetary Inst., Twenty-fourth Lunar and Planetary Science Conference. Part 1: A-F; p 479-480
    Format: text
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    NASA TECHNICAL REPORTS
  • 6
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    Global Inventory and Characterization of Pyroclastic Deposits on Mercury: New Insights into Pyroclastic Activity from MESSENGER Orbital Data (2014)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: We present new observations of pyroclastic deposits on the surface of Mercury from data acquired during the orbital phase of the MErcury Surface, Space ENvironment, GEochemistry, and Ranging (MESSENGER) mission. The global analysis of pyroclastic deposits brings the total number of such identified features from 40 to 51. Some 90% of pyroclastic deposits are found within impact craters. The locations of most pyroclastic deposits appear to be unrelated to regional smooth plains deposits, except some deposits cluster around the margins of smooth plains, similar to the relation between many lunar pyroclastic deposits and lunar maria. A survey of the degradation state of the impact craters that host pyroclastic deposits suggests that pyroclastic activity occurred on Mercury over a prolonged interval. Measurements of surface reflectance by MESSENGER indicate that the pyroclastic deposits are spectrally distinct from their surrounding terrain, with higher reflectance values, redder (i.e., steeper) spectral slopes, and a downturn at wavelengths shorter than approximately 400nm (i.e., in the near-ultraviolet region of the spectrum). Three possible causes for these distinctive characteristics include differences in transition metal content, physical properties (e.g., grain size), or degree of space weathering from average surface material on Mercury. The strength of the near-ultraviolet downturn varies among spectra of pyroclastic deposits and is correlated with reflectance at visible wavelengths. We suggest that this interdeposit variability in reflectance spectra is the result of either variable amounts of mixing of the pyroclastic deposits with underlying material or inherent differences in chemical and physical properties among pyroclastic deposits.
    Keywords: Lunar and Planetary Science and Exploration
    Type: GSFC-E-DAA-TN21209 , Geophysical Research Letters (ISSN 0094-8276); 119; 3; 635–658
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  • 7
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    Mercury's Weather-Beaten Surface: Understanding Mercury in the Context of Lunar and Asteroidal Space Weathering Studies (2014)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Mercury's regolith, derived from the crustal bedrock, has been altered by a set of space weathering processes. Before we can interpret crustal composition, it is necessary to understand the nature of these surface alterations. The processes that space weather the surface are the same as those that form Mercury's exosphere (micrometeoroid flux and solar wind interactions) and are moderated by the local space environment and the presence of a global magnetic field. To comprehend how space weathering acts on Mercury's regolith, an understanding is needed of how contributing processes act as an interactive system. As no direct information (e.g., from returned samples) is available about how the system of space weathering affects Mercury's regolith, we use as a basis for comparison the current understanding of these same processes on lunar and asteroidal regoliths as well as laboratory simulations. These comparisons suggest that Mercury's regolith is overturned more frequently (though the characteristic surface time for a grain is unknown even relative to the lunar case), more than an order of magnitude more melt and vapor per unit time and unit area is produced by impact processes than on the Moon (creating a higher glass content via grain coatings and agglutinates), the degree of surface irradiation is comparable to or greater than that on the Moon, and photon irradiation is up to an order of magnitude greater (creating amorphous grain rims, chemically reducing the upper layers of grains to produce nanometer scale particles of metallic iron, and depleting surface grains in volatile elements and alkali metals). The processes that chemically reduce the surface and produce nanometer-scale particles on Mercury are suggested to be more effective than similar processes on the Moon. Estimated abundances of nanometer-scale particles can account for Mercury's dark surface relative to that of the Moon without requiring macroscopic grains of opaque minerals. The presence of nanometer-scale particles may also account for Mercury's relatively featureless visible-near-infrared reflectance spectra. Characteristics of material returned from asteroid 25143 Itokawa demonstrate that this nanometer-scale material need not be pure iron, raising the possibility that the nanometer-scale material on Mercury may have a composition different from iron metal [such as (Fe,Mg)S]. The expected depletion of volatiles and particularly alkali metals from solar-wind interaction processes are inconsistent with the detection of sodium, potassium, and sulfur within the regolith. One plausible explanation invokes a larger fine fraction (grain size less than 45 micron) and more radiation-damaged grains than in the lunar surface material to create a regolith that is a more efficient reservoir for these volatiles. By this view the volatile elements detected are present not only within the grain structures, but also as adsorbates within the regolith and deposits on the surfaces of the regolith grains. The comparisons with findings from the Moon and asteroids provide a basis for predicting how compositional modifications induced by space weathering have affected Mercury's surface composition.
    Keywords: Lunar and Planetary Science and Exploration
    Type: GSFC-E-DAA-TN16346 , Space Science Reviews; 181; 4-Jan; 121-214
    Format: application/pdf
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  • 8
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    EGRET observations of active galactic nuclei - 0836 + 710, 0454 - 234, 0804 + 499, 0906 + 430, 1510-089, and 2356 + 196 (1993)
    In:  Other Sources
    Details
    Publication Date: 2019-07-13
    Description: The Energetic Gamma Ray Experiment Telescope (EGRET) on the Compton Gamma Ray Observatory observed high-energy gamma rays (50 - 2000 MeV) from quasar 0836 + 710 (z = 2.16) during observations in 1992 January, near the time of an optical fare (von Linde et al., 1993). The gamma-ray spectrum can be fitted with a power law with photon number index 2.4 +/- 0.2. EGRET identifies quasars 0454 - 234, 0804 + 499, 0906 + 430, 1510 - 089, and 2356 + 196 at a statistical significance of between 4 and 5 standard deviations.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 415; 1; p. L13-L16.
    Format: text
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  • 9
    Electronic Resource
    Electronic Resource
    Regulation of prolactin receptor expression by the tumour promoting phorbol ester 12-O-tetradecanoylphorbol-13-acetate in human breast cancer cells (1993)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 52 (1993), S. 47-56 
    Details
    ISSN: 0730-2312
    Keywords: prolactin receptor ; phorbol ester ; human breast cancer ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: In both the normal and malignant human breast, cellular sensitivity to the proliferative and differentiative activities of the lactogenic hormones is conferred by expression of the prolactin receptor (PRLR). The PRLR is regulated by steroid hormones; however, recent findings have suggested that PRLR may also be regulated by protein kinase C. To examine this possibility we have studied the effect of various modulators of PKC activity on PRLR binding activity and gene expression in five PRLR positive human breast cancer cell lines. Treatment with 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumour promoter and modulator of PKC activity, decreased PRLR binding activity in all cell lines examined. In MCF-7 cells, 10 nM TPA caused a 70% loss of PRLR mRNA after 12 h, paralleled 3 h later by a comparable loss of cell surface PRLR. Mezerein, a non-phorbol ester modulator of PKC activity and 1,2-dioctanoyl-sn-glycerol, a permeant analogue of the endogenous activator of PKC, also reduced PRLR binding activity, and gene expression in a time- and concentration-dependent manner. Cycloheximide failed to abrogate the TPA-induced decline in PRLR mRNA levels, indicating that this process was not dependent upon continuing protein synthesis. No change in the stability of PRLR mRNA was observed during 24 h of TPA treatment and TPA reduced the rate of PRLR gene transcription within 3 h of treatment. These results demonstrate that modulators of PKC activity reduce PRLR binding activity and gene expression, implicating this signal transduction pathway in PRLR regulation.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240520108
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  • 10
    Electronic Resource
    Electronic Resource
    1,25-Dihydroxyvitamin D3 increases type 1 interleukin-1 receptor expression in a murine T cell line (1993)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 52 (1993), S. 159-170 
    Details
    ISSN: 0730-2312
    Keywords: Northern analysis ; vitamin D receptor ; metabolite specificity ; immune regulation ; cellular proliferation ; MTT assay ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The biologically active metabolite of vitamin D3, 1,25 (OH)2 D3, exerts important immunoregulatory effects in addition to being a central mediator of calcium/phosphate metabolism. Utilizing an interleukin 1 responsive murine T cell line and 125I-interleukin 1α, we show that 1,25 (OH)2 D3 (5,50 nM) enhanced 125I-interleukin 1α binding up to almost 2-fold over control. This 1,25 (OH)2 D3 effect occurred in a dose-dependent manner and was detectable after 24 h but not before 7 h of culture. Scatchard analysis of 125I-interleukin 1α binding data demonstrated that 1,25 (OH)2 D3 enhanced interleukin 1 receptor number without a significant change in affinity. The biologically less potent metabolite of vitamin D3, 25 (OH) D3, also augmented 125I-interleukin 1α binding but at steroid levels 2-3 log orders greater than 1,25 (OH)2 D3. This observation, combined with the presence of high-affinity 3H-1,25 (OH)2 D3 receptors (88 sites/cell, K = 0.45 nM) in cytosolic extracts, strongly suggests that the nuclear vitamin D receptor mediates this steroid's effect on interleukin 1 receptor expression. Based on the capacity of an anti-type 1 interleukin 1 receptor monoclonal antibody (35F5) to block 1,25 (OH)2 D3-enhanced 125I-interleukin 1α binding, we conclude that this steroid augments type 1 interleukin 1 receptor expression. When combined with interleukin 1, a cytokine that also impacts MD10 interleukin 1 receptor expression, 1,25 (OH)2 D3 enhanced interleukin 1 receptor expression. Northern blots hybridized with a 32P-type 1 interleukin 1 receptor cDNA probe show that 1,25 (OH)2 D3 enhanced type 1 interleukin 1 receptor steady state mRNA levels. Functionally, 1,25 (OH)2 D3 pretreatment augmented the MD10 proliferative response to suboptimal levels of interleukin 1 (〈 100 fM interleukin 1α). These findings further support 1,25 (OH)2 D3's role as an immunoregulatory molecule and provides a possible mechanism by which this steroid could potentiate certain immune activities.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240520208
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