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  • Articles  (27)
  • Springer  (24)
  • American Association for the Advancement of Science  (3)
  • 1995-1999  (12)
  • 1990-1994  (15)
  • 1940-1944
  • 1905-1909
  • 1997  (12)
  • 1992  (15)
Collection
  • Articles  (27)
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  • 1995-1999  (12)
  • 1990-1994  (15)
  • 1940-1944
  • 1905-1909
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Journal
Topic
  • 1
    Electronic Resource
    Electronic Resource
    Cooking Oil: A Home Fire Hazard in Alberta, Canada (1997)
    Springer
    Fire technology 33 (1997), S. 140-166 
    Details
    ISSN: 1572-8099
    Keywords: Canada ; Alberta ; cooking equipment ; cooking oil ; fire injuries ; smoke point ; flash point ; fire hazard ; fire statistics ; prevention
    Source: Springer Online Journal Archives 1860-2000
    Topics: Architecture, Civil Engineering, Surveying
    Notes: Abstract This paper begins with a brief statistical analysis to establish the significant contribution of cooking equipment fires to fire losses and injuries in Canadian homes. Due to lack of comprehensive fire loss data for Canadian homes, further analysis is focused on Alberta data. The most frequent ignition scenario, based on a top-down analysis of Alberta home fires, was the ignition of overheated cooking oil in pots, deep-fat fryers, or pans heated on stove tops. These fires also accounted for the majority of home fire injuries. Fire characteristics of cooking oils, which point to the importance of maintaining oil temperatures below their flash points, and thermostatically controlled deep-fat fryers as the best available solution to the problem are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1015395001403
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  • 2
    Electronic Resource
    Electronic Resource
    The urate oxidase gene of Drosophila pseudoobscura and Drosophila melanogaster: Evolutionary changes of sequence and regulation (1992)
    Springer
    Journal of molecular evolution 34 (1992), S. 62-77 
    Details
    ISSN: 1432-1432
    Keywords: Urate oxidase ; Drosophila pseudoobscura ; Drosophila melanogaster ; Nucleotide sequence ; Evolutionary comparison ; Gene regulation ; Malpighian tubules
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The urate oxidase (UO) transcription unit of Drosophila pseudoobscura was cloned, sequenced, and compared to the UO transcription unit from Drosophila melanogaster. In both species the UO coding region is divided into two exons of approximately equal size. The deduced D. pseudoobscura and D. melanogaster UO peptides have 346 and 352 amino acid residues, respectively. The nucleotide sequences of the D. pseudoobscura and D. melanogaster UO protein-coding regions are 82.2% identical whereas the deduced amino acid sequences are 87.6% identical with 42 amino acid changes, 33 of which occur in the first exon. Although the UO gene is expressed exclusively within the cells of the Malpighian tubules in both of these species, the temporal patterns of UO gene activity during development are markedly different. UO enzyme activity, UO protein, and UO mRNA are found in the third instar larva and adult of D. melanogaster but only in the adult stage of D. pseudoobscura. The intronic sequences and the extragenic 5′ and 3′ flanking regions of the D. pseudoobscura and D. melanogaster UO genes are highly divergent with the exception of eight small islands of conserved sequence along 772 by 5′ of the UO protein-coding region. These islands of conserved sequence are possible UO cis-acting regulatory elements as they reside along the 5′ flanking DNA of the D. melanogaster UO gene that is capable of conferring a wild-type D. melanogaster pattern of UO regulation on a UO-lacZ fusion gene.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00163853
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of in situ post-deposition annealing on the formation of α-In2Se3 thin films grown by elemental evaporation (1992)
    Springer
    Applied physics 54 (1992), S. 293-299 
    Details
    ISSN: 1432-0630
    Keywords: 68.55 ; 73.60F ; 78.65J ; 81.15E
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Stoichiometric polycrystalline In2Se3 thin films have been grown by elemental evaporation on both glass and quartz substrates. The compositions are examined by DAN fluorimetry and X-ray photoelectron spectroscopy (XPS). Structure of the films are characterized by X-ray diffraction. The structure of this α-form of thin films have been determined to be hexagonal. Optimization of the preparative conditions employed for elemental evaporation, helped in preparing monophasic films by the suppression of other phases to a very minor extent. Influence of annealing conditions on the stoichiometry of the films are investigated in detail.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00323853
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  • 4
    Electronic Resource
    Electronic Resource
    29Si NMR investigations on oligosilane dendrimers (1997)
    Springer
    Fresenius' journal of analytical chemistry 357 (1997), S. 503-504 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Starting with the high functionalized trisilane SiClMe(SiCl2Me)2 and tetrasilane SiMe(SiCl2Me)3 several octa- and decasilane dendrimers containing directly neighboured branchings were prepared. In these compounds the 29Si NMR chemical shifts of the different silyl groups are shifted towards lower field compared with those of analogous groups in tetra- or hexasilanes. This observation is a helpful tool for the characterization of further dendritic oligomers by 29Si NMR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050201
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  • 5
    Electronic Resource
    Electronic Resource
    Characterization of chemically modified silica by infrared and solid state nuclear magnetic resonance spectroscopy (1997)
    Springer
    Fresenius' journal of analytical chemistry 358 (1997), S. 240-241 
    Details
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Silica modified with benzene was investigated by infrared and solid state 13C cross-polarization magic angle spinning nuclear magnetic resonance spectroscopy (13C CP MAS NMR). Whereas infrared spectroscopy did not allow to distinguish between phenyl and polyphenyl groups, this was possible by solid state nuclear magnetic resonance spectroscopy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002160050394
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  • 6
    Electronic Resource
    Electronic Resource
    Genomic organization and chromosomal location of the human gene encoding the B-lymphocyte activation antigen B7 (1992)
    Springer
    Immunogenetics 36 (1992), S. 175-181 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The human B lymphocyte activation antigen B7 provides regulatory signals for T lymphocytes as a consequence of binding to its ligands CD28 and CTLA-4. The cDNA for B7 has previously been isolated and predicted to encode a type I membrane protein. The predicted polypeptide has a secretory signal peptide followed by two contiguous Ig-like domains, a hydrophobic transmembrane region and a short cytoplasmic tail. Here we report the exon-intron genomic organization of human B7 and the chromosomal location. The gene has six exons that span approximately 32 kilobases of DNA. Exon 1 is not translated and the second exon contains the initiation ATG codon and encodes a predicted signal peptide. This gene structure is characteristic for several eukaryotic genes with tissue-specific expression. The third and fourth exons correspond to two Ig-like domains whereas the fifth and sixth exons encode respectively the trans-membrane portion and the cytoplasmic tail. This close relationship between exons and functional domains is a characteristic feature of genes of the Ig superfamily. Cell surface expression of the B7 gene product has previously been mapped to human chromosome 12 by antibody reactivity with the B7-specific monoclonal antibody BB-1. We here demonstrate that theB7 gene is located to theq21-qter region of chromosome 3 by DNA blot analysis of human × rodent somatic cell hybrids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00661094
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  • 7
    Electronic Resource
    Electronic Resource
    Reduction of conductance-based neuron models (1992)
    Springer
    Biological cybernetics 66 (1992), S. 381-387 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract We present a scheme for systematically reducing the number of differential equations required for biophysically realistic neuron models. The techniques are general, are designed to be applicable to a large set of such models and retain in the reduced system as high a degree of fidelity to the original system as possible. As examples, we provide reductions of the Hodgkin-Huxley system and the A-current model of Connor et al. (1977).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00197717
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  • 8
    Electronic Resource
    Electronic Resource
    A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-γ in myeloid cells (1992)
    Springer
    Immunogenetics 36 (1992), S. 369-376 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A cluster of at lest six interferon-γ (IFNγ)-inducible genes designated Ifi201-204 and located on mouse chromosome 1 has recently been described. Here , we report a human IFN-γ-inducible gene, IFI 16, which has nucleotide sequence similarity with portions of two of the mouse genes, Ifi202 and Ifi204. A full-length cDNA clone derived from IFI 16 [2.709 kilobases (kb)] contained a single open reading frame of 2.187 kb which encoded a putative polypeptide of 729 amino acids and a predicted non-glycosylated M r of 80020. IFI 16 mRNA was found to be constitutively expressed in lymphoid cells and in cell lines of both the T and B lineages. By contrast, the mRNA was not expresed by the cell lines HL-60, U937, and K562, which represent early stages of myeloid development, but was strongly inducible in HL-60 and U937 with IFN-γ. The IFI 16 protein demonstrated a putative domain structure with patchy similarity to the proteins expressed from gene Ifi202 and Ifi204. The mouse and human proteins each contain two analogous ≈200 amino acid domains which are imperfect copies, but IFI 16 demonstrated additional unique regions, including a Lys-rich N-terminal portion and a “spacer” region between the reiterated domains, analogous to spacer regions in the CD5 and CD8α molecules. Using a panel of inter-species somatic cell hybrid cell lines, IFI 16 was localized to the chromosomal region 1q12→1qter, a region systenic between mouse an man. DNA blotting indicated that, in contrast to the mouse, IFI 16 is present as a single copy gene in the human genome. The authors are pleased to make the cDNA clones described in this paper available to interested investigators.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00218044
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  • 9
    Electronic Resource
    Electronic Resource
    Post-receptor defect accounts for phosphorylase hypersensitivity in cultured diabetic cardiomyocytes (1992)
    Springer
    Molecular and cellular biochemistry 117 (1992), S. 63-70 
    Details
    ISSN: 1573-4919
    Keywords: glycogen phosphorylase ; alloxan-diabetes ; cardiomyocytes ; G-protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The basis for the hypersensitive response of glycogen phosphorylase to epinephrine stimulation was investigated in adult rat cardiomyocytes isolated from normal and alloxan-diabetic animals. To assess potential G-protein involvement in the response, normal and diabetic derived myocytes were incubated with either cholera or pertussis toxin prior to hormonal stimulation. Pretreatment of cardiomyocytes with cholera toxin resulted in a potentiated response to epinephrine stimulation whereas pertussis toxin did not affect the activation of this signaling pathway. To determine if the enhanced response of phosphorylase activation resulted from an alteration in adenylate cyclase activation, the cells were challenged with forskolin. After 3 hr in primary culture, diabetic cardiomyocytes exhibited a hypersensitive response to forskolin stimulation relative to normal cells. However, after 24 hr in culture, both normal and diabetic myocytes responded identically to forskolin challenge. The present data suggest that a cholera toxin sensitive G-protein mediates the hypersensitive response of glycogen phosphorylase to catecholamine stimulation in diabetic cardiomyocytes and this response which is present in alloxan-diabetic cells and is induced in vitro in normal cardiomyocytes is primarily due to a defect at a post-receptor site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00230411
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  • 10
    Electronic Resource
    Electronic Resource
    Molecular analysis of the plant gene encoding cytosolic phosphoglucose isomerase (1992)
    Springer
    Plant molecular biology 19 (1992), S. 745-757 
    Details
    ISSN: 1573-5028
    Keywords: Clarkia lewisii ; exons ; gene structure ; isozymes ; phosphoglucose isomerase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The gene encoding a cytosolic isozyme of phosphoglucose isomerase (PGI, EC 5.3.1.9) was isolated from Clarkia lewisii, a wild flower native to California, and the structure and sequence of the entire coding region determined. PGI catalyzes an essential step in glycolysis and carbohydrate biosynthesis in plants. Spanning about 6 kb, the gene has 23 exons and 22 introns, the highest number yet reported in plants. The exons range in size from 43 to 156 nt and encode a protein of 569 amino acids. The protein is about 44–46% identical to the inferred protein sequences of pig, Escherichia coli and Saccharomyces cerevisiae. All of the introns are bordered with the consensus 5′-GT...AG-3′ dinucleotides. The longest intron includes a large stem-loop structure bounded by a perfect 9 nt direct repeat. We cloned the PGI gene from a genomic library prepared from a single plant of known PGI genotype. The locus and allele of the clone were identified by matching restriction fragments to fragments from genetically defined genomic DNAs by Southern hybridization.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00027071
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