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  • M13 procoat protein  (1)
  • calcium antagonist  (1)
  • 1990-1994  (2)
  • 1935-1939
  • 1990  (2)
  • 1
    Electronic Resource
    Electronic Resource
    Renal effects of the new calcium channel blocking drug isradipine (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 333-335 
    Details
    ISSN: 1432-1041
    Keywords: Isradipine ; renal function ; calcium antagonist ; healthy volunteers ; side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males. Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate, renal plasma flow, renal vascular resistance, and urinary albumin excretion remained constant. There was a marked natriuretic and diuretic effect about 1–3 h after isradipine. Plasma renin activity showed a slight, insignificant increase 1 h after dosing. Uric acid clearance and β2-microglobulin excretion showed no significant changes, despite an increase in sodium clearance, suggesting an additional mechanism of action other than the proximal tubular natriuretic effect of isradipine in normotensive volunteers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315405
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  • 2
    Electronic Resource
    Electronic Resource
    Ribonucleoparticle-independent transport of proteins into mammalian microsomes (1990)
    Springer
    Journal of bioenergetics and biomembranes 22 (1990), S. 711-723 
    Details
    ISSN: 1573-6881
    Keywords: Mammalian endoplasmic reticulum ; prepromelittin ; prepropeptide GLa ; preprocecropin A ; M13 procoat protein ; protein transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract There are at least two different mechanisms for the transport of secretory proteins into the mammalian endoplasmic reticulum. Both mechanisms depend on the presence of a signal peptide on the respective precursor protein and involve a signal peptide receptor on the cis-side and signal peptidase on the trans-side of the membrane. Furthermore, both mechanisms involve a membrane component with a cytoplasmically exposed sulfhydryl. The decisive feature of the precursor protein with respect to which of the two mechanisms is used is the chain length of the polypeptide. The critical size seems to be around 70 amino acid residues (including the signal peptide). The one mechanism is used by precursor proteins larger than about 70 amino acid residues and involves two cytosolic ribonucleoparticles and their receptors on the microsomal surface. The other one is used by small precursor proteins and relies on the mature part within the precursor molecule and a cytosolic ATPase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00786927
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