Summary
The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males.
Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate, renal plasma flow, renal vascular resistance, and urinary albumin excretion remained constant. There was a marked natriuretic and diuretic effect about 1–3 h after isradipine. Plasma renin activity showed a slight, insignificant increase 1 h after dosing. Uric acid clearance and β2-microglobulin excretion showed no significant changes, despite an increase in sodium clearance, suggesting an additional mechanism of action other than the proximal tubular natriuretic effect of isradipine in normotensive volunteers.
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Krämer, B.K., Häussler, M., Ress, K.M. et al. Renal effects of the new calcium channel blocking drug isradipine. Eur J Clin Pharmacol 39, 333–335 (1990). https://doi.org/10.1007/BF00315405
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DOI: https://doi.org/10.1007/BF00315405