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Renal effects of the new calcium channel blocking drug isradipine

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Summary

The acute effect of a single oral dose of isradipine 5 mg on blood pressure, renal haemodynamics, electrolyte excretion and plasma renin activity was studied in 10 healthy males.

Isradipine did not produce a significant change in systolic or diastolic blood pressure, and glomerular filtration rate, renal plasma flow, renal vascular resistance, and urinary albumin excretion remained constant. There was a marked natriuretic and diuretic effect about 1–3 h after isradipine. Plasma renin activity showed a slight, insignificant increase 1 h after dosing. Uric acid clearance and β2-microglobulin excretion showed no significant changes, despite an increase in sodium clearance, suggesting an additional mechanism of action other than the proximal tubular natriuretic effect of isradipine in normotensive volunteers.

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References

  1. Bauer JH, Reams G (1987) Short- and long-term effects of calcium entry blockers on the kidney. Am J Cardiol 59: 66A-71A

    Google Scholar 

  2. Winer N, Thys-Jacobs S, Kumar R, Davidson WD, Grayson M, Harris C, Walker D, Itskovitz H, Gonasum L (1987) Evaluation of isradipine (PN 200-110) in mild to moderate hypertension. Clin Pharmacol Ther 42: 442–448

    Google Scholar 

  3. Nelson EB, Pool JL, Taylor AA (1986) Antihypertensive activity of isradipine in humans: A new dihydropyridine calcium channel antagonist. Clin Pharmacol Ther 40: 694–697

    Google Scholar 

  4. Handler CE, Rosenthal E, Tsagadopoulos D, Najm Y (1988) Comparison of isradipine and nifedipine in chronic stable angina. Int J Cardiol 18: 15–26

    Google Scholar 

  5. Mauser M, Voelker W, Ickrath O, Karsch KR (1989) Myocardial properties of the new dihydropyridine calcium antagonist isradipine compared to nifedipine with or without additional beta blockade in coronary artery disease. Am J Cardiol 63: 40–44

    Google Scholar 

  6. Krusell LR, Jespersen LT, Schmitz A, Thomsen K, Lederballe Pedersen O (1987) Repetitive natriuresis and blood pressure. Long-term calcium entry blockade with isradipine. Hypertension 10: 577–581

    Google Scholar 

  7. Lederballe Pederson O, Krusell LR, Sihm I, Jespersen LT, Thomsen K (1989) Long-term effects of isradipine on blood pressure and renal function. Am J Med 86 [Suppl 4A]: 15–18

    Google Scholar 

  8. Persson B, Andersson OK, Wysocki M, Hedner T, Aurell M (1989) Renal and hemodynamic effects of isradipine in essential hypertension. Am J. Med 86 [Suppl 4A]: 60–64

    Google Scholar 

  9. Rupoli L, Fruscio M, Gradnik R, Chianca R, Leonetti G, Zanchetti A (1989) Cardiovascular and renal effects of single administration of three different doses of isradipine in hypertensive patients. Am J Med 86 [Suppl 4A]: 65–66

    Google Scholar 

  10. Lederballe Pedersen O, Christensen NJ, Ramsch KD (1980) Comparison of acute effects of nifedipine in normotensive and hypertensive man. J Cardiovasc Pharmacol 2: 357–366

    Google Scholar 

  11. Chellingsworth MC, Willis JV, Broadfoot Jack D, Kendall MJ (1988) Pharmacokinetics and pharmacodynamics of isradipine (PN 200-110) in young and elderly patients. Am J Med 84 [Suppl 3B]: 72–79

    Google Scholar 

  12. Tse FLS, Jaffe JM (1987) Pharmacokinetics of PN 200-110 (isradipine), a new calcium antagonist, after oral administration in man. Eur J Clin Pharmacol 32: 361–365

    Google Scholar 

  13. Krusell LR, Christensen CK, Lederballe Pedersen O (1987) Acute natriuretic effect of nifedipine in hypertensive patients and normotensive controls — a proximal tubular effect? Eur J Clin Pharmacol 32: 121–126

    Google Scholar 

  14. Leonetti G, Zanchetti A (1987) Effects of calcium antagonists on renal hemodynamics and water and sodium excretion in hypertensive patients. J Cardiovasc Pharmacol 10 [Suppl 5]: 93–97

    Google Scholar 

  15. De Leeuw PW, Birkenhäger WH (1987) Renal blood flow in essential hypertension. J Cardiovasc Pharmacol 10 [Suppl 5]: 10–13

    Google Scholar 

  16. Bauer JH, Reams GP (1989) Do calcium antagonists protect the human hypertensive kidney? Am J Hypertension 2: 173S-178S

    Google Scholar 

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Krämer, B.K., Häussler, M., Ress, K.M. et al. Renal effects of the new calcium channel blocking drug isradipine. Eur J Clin Pharmacol 39, 333–335 (1990). https://doi.org/10.1007/BF00315405

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  • DOI: https://doi.org/10.1007/BF00315405

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