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  • FLUID MECHANICS AND HEAT TRANSFER  (7)
  • Molecular Sequence Data  (3)
  • 2020-2022
  • 2005-2009
  • 1990-1994  (10)
  • 1990  (10)
  • 1
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    Expression of T cell antigen receptor heterodimers in a lipid-linked form (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-10
    Description: The interaction of the T cell receptor for antigen (TCR) with its antigen-major histocompatibility complex ligand is difficult to study because both are cell surface multimers. The TCR consists of two chains (alpha and beta) that are complexed to the five or more nonpolymorphic CD3 polypeptides. A soluble form of the TCR was engineered by replacing the carboxyl termini of alpha and beta with signal sequences from lipid-linked proteins, making them susceptible to enzymatic cleavage. In this manner, TCR heterodimers can be expressed independently of the CD3 polypeptides and in significant quantities (0.5 milligram per week). This technique seems generalizable to biochemical and structural studies of many other cell surface molecules as well.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, A Y -- Devaux, B -- Green, A -- Sagerstrom, C -- Elliott, J F -- Davis, M M -- New York, N.Y. -- Science. 1990 Aug 10;249(4969):677-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305-5402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1696397" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaline Phosphatase/genetics ; Amino Acid Sequence ; Animals ; Antigens, CD3 ; Antigens, CD55 ; Antigens, Differentiation, T-Lymphocyte/genetics ; Cell Line ; Complement Inactivator Proteins/genetics ; Female ; Humans ; Macromolecular Substances ; Membrane Proteins/genetics ; Molecular Sequence Data ; Placenta/enzymology ; Pregnancy ; Protein Sorting Signals/genetics ; Receptors, Antigen, T-Cell/*genetics ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46 (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-03-02
    Description: Cold-sensitive mutations in the SPB genes (spb1-spb7) of Saccharomyces cerevisiae suppress the inhibition of translation initiation resulting from deletion of the poly(A)-binding protein gene (PAB1). The SPB4 protein belongs to a family of adenosine triphosphate (ATP)-dependent RNA helicases. The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits the deletion of PAB1. These data suggest that mutations affecting different steps of 60S subunit formation can allow PAB-independent translation, and they indicate that further characterization of the spb mutations could lend insight into the biogenesis of the ribosome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sachs, A B -- Davis, R W -- R37 GM 21891/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1990 Mar 2;247(4946):1077-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Stanford Medical Center, CA 94305.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2408148" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Base Sequence ; Carrier Proteins/genetics/metabolism ; DEAD-box RNA Helicases ; Molecular Sequence Data ; Mutation ; Poly(A)-Binding Proteins ; *Protein Biosynthesis ; RNA Nucleotidyltransferases/genetics/*metabolism ; RNA Processing, Post-Transcriptional ; RNA, Fungal/genetics/metabolism ; RNA, Ribosomal/genetics/*metabolism ; Ribosomal Proteins/genetics/*metabolism ; Ribosomes/*metabolism ; Saccharomyces cerevisiae/enzymology/*genetics ; *Saccharomyces cerevisiae Proteins ; Sequence Homology, Nucleic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-05-25
    Description: Tumor necrosis factor alpha and beta (TNF-alpha and TNF-beta) bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA clone encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-alpha. The encoded receptor was also able to bind TNF-beta. The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, C A -- Davis, T -- Anderson, D -- Solam, L -- Beckmann, M P -- Jerzy, R -- Dower, S K -- Cosman, D -- Goodwin, R G -- New York, N.Y. -- Science. 1990 May 25;248(4958):1019-23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunex Corporation, Seattle, WA 98101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2160731" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Blotting, Northern ; Cloning, Molecular ; DNA/genetics ; Humans ; Membrane Proteins/genetics ; Molecular Sequence Data ; Multigene Family ; Receptors, Cell Surface/*genetics ; Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Long-wave morphological instabilities in the directional solidification of a dilute binary mixture (1990)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Long-wave instabilities in a directionally-solidified binary mixture may occur in several limits. Sivashinsky (1983) identified a small-segregation-coefficient limit and obtained a weakly nonlinear evolution equation governing subcritical two-dimensional bifurcation. Brattkus and Davis (1988) identified a near-absolute-stability limit and obtained a strongly nonlinear evolution equation governing supercritical two-dimensional bifurcation. The present investigation identifies a third strongly nonlinear evolution equation, arising in the small-segregation-coefficient, large-surface-energy limit. This equation links both of the former and describes the change from the sub- to super-critical bifurcations. This study sets the previous long-wave analyses into a logical framework.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: SIAM Journal on Applied Mathematics (ISSN 0036-1399); 50; 420-436
    Format: text
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  • 5
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    Hydrodynamic interactions in directional solidification (1990)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: A binary liquid undergoes unidirectional solidification. The one-dimensional steady state is susceptible to morphological instability that causes the solid/liquid interface to change from a planar state to a cellular pattern. This paper examines the effects on this transition of volume-change convection, buoyancy-driven convection or forced flows. It emphasizes how flows alter stability limits, create scale and pattern changes in morphology, and create, through coupling, new instabilities. Emphasis is placed on the physical mechanisms of the interactions.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Fluid Mechanics (ISSN 0022-1120); 212; 241-262
    Format: text
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  • 6
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    Long-wave interactions in morphological and convective instabilities (1990)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: A binary liquid that undergoes directional solidification is susceptible to morphological and solutal-convective instabilities that cause the solid/liquid interface to change from a planar to a cellular state. This paper gives derivations for those long-wave evolution equations that describe the weak couplings between convection and interface morphology and gives some analytical results obtainable from these.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: IMA Journal of Applied Mathematics (ISSN 0272-4960); 45; 3, 19; 267-285
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  • 7
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    Experimental investigation of turbulent flow through a circular-to-rectangular transition duct (1990)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: An incompressible, turbulent, swirl-free flow through a circular-to-rectangular transition duct was studied experimentally. The cross-sectional geometry all along the duct was defined using the equation of a superellipse. The three mean velocity components and the six Reynolds stress components were measured at two axial stations downstream from the transition. It is shown that a secondary flow vortex pair which develops along the duct sidewalls significantly distorts the mean and turbulence fields. At the duct exit, the flow is not in local equilibrium, but recovers to local equilibrium conditions in the rectangular extension duct. Analysis demonstrates that conventional wall functions are not applicable at all streamwise locations in the duct.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AIAA PAPER 90-1505
    Format: text
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  • 8
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    Unsteady analysis of hot streak migration in a turbine stage (1990)
    In:  Other Sources
    Details
    Publication Date: 2019-06-28
    Description: Two- and three-dimensional Navier-Stokes analyses are used to predict unsteady viscous rotor-stator interacting flow in the presence of a combustor hot streak. Predicted results are presented for a two-dimensional three-stator/four-rotor, a two-dimensional one-stator/one-rotor, and a three-dimensional one-stator/one-rotor simulation of hot streak migration through a turbine stage. Comparison of these results with experimental data demonstrates the capability of the three-dimensional procedure to capture most of the flow physics associated with hot streak migration including the effects of combustor hot streaks on turbine rotor surface temperatures. It is noted that blade count ratio has little effect on predicted time-averaged surface pressure and temperature distributions, but a substantial effect on the unsteady flow characteristics. It is shown that high-temperature hot streak fluid accumulates on the pressure surface of the rotor blades, resulting in a high time-averaged surface temperature 'hot spots'.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: AIAA PAPER 90-2354
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  • 9
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    On the buoyancy-driven motion of a drop towards a rigid surface or a deformable interface (1990)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: The deformation of a viscous drop, driven by buoyancy toward a solid surface or a deformable interface, is analyzed in the asymptotic limit of small Bond number, for which the deformation becomes important only when the drop is close to the solid surface or interface. Lubrication theory is used to describe the flow in the thin gap between the drop and the solid surface or interface, and boundary-integral theory is used in the fluid phases on either side of the gap. The evolution of the drop shape is traced from a relatively undeformed state until a dimple is formed and a long-time quasi-steady-state pattern is established. A wide range of drop to suspending phase viscosity ratios is examined. It is shown that a dimple is always formed, independently of the viscosity ratio, and that the long-time thinning rates take simple forms as inverse fractional powers of time.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: Journal of Fluid Mechanics (ISSN 0022-1120); 217; 547-573
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  • 10
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    Experimental investigation of a single flush-mounted hypermixing nozzle (1990)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: The results of an experimental wind tunnel investigation of a circular supersonic jet (m sub j = 3.47) injected at a 10 degree angle into a supersonic freestream. The jet penetrates a boundary layer, which has a thickness approximately the same as the jet nozzle exit diameter. Measurements were made for nominal freestream Mach numbers of 1.6, 2.0, 2.5, and 3.0. Three jet total pressures were run at each freestream Mach number, resulting in twelve separate operating conditions. Mean data accumulated by means of static and total pressure probe instrumentation are presented at two axial stations: seven jet nozzle diameters upstream and 15 jet nozzle diameters downstream from where the centerline of the nozzle intersects the wind tunnel wall. For one condition at each freestream Mach number, the jet air was seeded with a hydrocarbon trace gas and the flow was sampled at the downstream measurement plane to quantify the mean mixing of the two streams. Surface oil flow visualization was also used to investigate the flow interaction. All results are for air-to-air mixing. The measurements indicate the presence of two pairs contra-rotating vortices. One pair follows the jet trajectory and tends to split the jet into two streams. A smaller pair, rotating in an opposite sense, develops in the near wall region. Reported results include Mach number and volume fraction distributions in the cross plane, as well as jet penetration and mixing efficiency.
    Keywords: FLUID MECHANICS AND HEAT TRANSFER
    Type: NASA-TM-103726 , E-5960 , NAS 1.15:103726 , AIAA PAPER 90-5240 , Second International Aerospace Planes Conference; Oct 29, 1990 - Oct 31, 1990; Orlando, FL; United States
    Format: application/pdf
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