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  • GEOPHYSICS  (8)
  • Humans  (6)
  • 2005-2009
  • 1990-1994  (14)
  • 1940-1944
  • 1930-1934
  • 1992  (7)
  • 1990  (7)
  • 1
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    Expression of T cell antigen receptor heterodimers in a lipid-linked form (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-08-10
    Description: The interaction of the T cell receptor for antigen (TCR) with its antigen-major histocompatibility complex ligand is difficult to study because both are cell surface multimers. The TCR consists of two chains (alpha and beta) that are complexed to the five or more nonpolymorphic CD3 polypeptides. A soluble form of the TCR was engineered by replacing the carboxyl termini of alpha and beta with signal sequences from lipid-linked proteins, making them susceptible to enzymatic cleavage. In this manner, TCR heterodimers can be expressed independently of the CD3 polypeptides and in significant quantities (0.5 milligram per week). This technique seems generalizable to biochemical and structural studies of many other cell surface molecules as well.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lin, A Y -- Devaux, B -- Green, A -- Sagerstrom, C -- Elliott, J F -- Davis, M M -- New York, N.Y. -- Science. 1990 Aug 10;249(4969):677-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Stanford University School of Medicine, CA 94305-5402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1696397" target="_blank"〉PubMed〈/a〉
    Keywords: Alkaline Phosphatase/genetics ; Amino Acid Sequence ; Animals ; Antigens, CD3 ; Antigens, CD55 ; Antigens, Differentiation, T-Lymphocyte/genetics ; Cell Line ; Complement Inactivator Proteins/genetics ; Female ; Humans ; Macromolecular Substances ; Membrane Proteins/genetics ; Molecular Sequence Data ; Placenta/enzymology ; Pregnancy ; Protein Sorting Signals/genetics ; Receptors, Antigen, T-Cell/*genetics ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
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    Smokers: black and white (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-07-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schneiderman, M -- Davis, D L -- Wagener, D K -- New York, N.Y. -- Science. 1990 Jul 20;249(4966):228-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2374921" target="_blank"〉PubMed〈/a〉
    Keywords: African Americans ; European Continental Ancestry Group ; Female ; Humans ; Lung Neoplasms/mortality ; Male ; Prevalence ; Smoking/*epidemiology ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-05-25
    Description: Tumor necrosis factor alpha and beta (TNF-alpha and TNF-beta) bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA clone encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-alpha. The encoded receptor was also able to bind TNF-beta. The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Smith, C A -- Davis, T -- Anderson, D -- Solam, L -- Beckmann, M P -- Jerzy, R -- Dower, S K -- Cosman, D -- Goodwin, R G -- New York, N.Y. -- Science. 1990 May 25;248(4958):1019-23.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunex Corporation, Seattle, WA 98101.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2160731" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Blotting, Northern ; Cloning, Molecular ; DNA/genetics ; Humans ; Membrane Proteins/genetics ; Molecular Sequence Data ; Multigene Family ; Receptors, Cell Surface/*genetics ; Receptors, Tumor Necrosis Factor ; Tumor Necrosis Factor-alpha/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The human genome and other initiatives (1990)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1990-07-27
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, B D -- New York, N.Y. -- Science. 1990 Jul 27;249(4967):342-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Harvard Medical School, Boston, MA 02115.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2377887" target="_blank"〉PubMed〈/a〉
    Keywords: Budgets ; *Human Genome Project/economics ; Humans ; National Institutes of Health (U.S.) ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Invariant chain peptides in most HLA-DR molecules of an antigen-processing mutant (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-12-11
    Description: Class II major histocompatibility complexes bind peptides in an endosome-like compartment. When the class II null cell line 721.174 was transfected with class II DR3 genes, DR molecules were produced in normal amounts. However, the DR molecules were abnormally conformed and unstable because deletion of an antigen-processing gene had impaired intracellular formation of most class II-peptide complexes. Yet, 70 percent of the DR molecules still bore peptides, 80 percent of which were 21- to 24-amino acid fragments of the class II-associated invariant chain. These peptides were rare on DR3 from control cells. Thus, a defect in the main antigen-processing pathway revealed a process in which DR molecules bind long peptides derived from proteins present in the same compartment.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sette, A -- Ceman, S -- Kubo, R T -- Sakaguchi, K -- Appella, E -- Hunt, D F -- Davis, T A -- Michel, H -- Shabanowitz, J -- Rudersdorf, R -- AI15486/AI/NIAID NIH HHS/ -- AI18634/AI/NIAID NIH HHS/ -- GM37537/GM/NIGMS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1992 Dec 11;258(5089):1801-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Genetics, University of Wisconsin, Madison 53706.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1465617" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Binding Sites ; Cell Line ; Gene Deletion ; *Genes, MHC Class II ; HLA-DR Antigens/*genetics/*metabolism ; HLA-DR3 Antigen/*genetics/metabolism ; Humans ; Kinetics ; Macromolecular Substances ; Molecular Sequence Data ; Peptides/*metabolism ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    The insanity defense and mental illness (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-04-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sabshin, M -- Pincus, H A -- Davis, W -- New York, N.Y. -- Science. 1992 Apr 17;256(5055):292-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1566074" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Insanity Defense ; Mental Disorders/*diagnosis
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    A compressed marine data set for geomagnetic field modeling (1990)
    In:  Other Sources
    Details
    Publication Date: 2011-08-19
    Description: Some 13 million scalar magnetic field data points that have been collected from the world's ocean areas reside in the collection of the National Geophysical Data Center. In order to derive a suitable data set for modeling the geomagnetic field of the earth, each ship track is divided into 220 km segments. The distribution of the reduced data in position, time and local time is discussed. The along-track filtering process described has proved to be an effective method of condensing large numbers of shipborne magnetic data into a manageable and meaningful data set for field modeling. This process also provides the benefits of smoothing short-wavelength crystal anomalies, discarding data recorded during magnetically noisy periods, and assigning reasonable error estimates to be utilized in the least squares modeling.
    Keywords: GEOPHYSICS
    Type: Journal of Geomagnetism and Geoelectricity (ISSN 0022-1392); 42; 9, 19
    Format: text
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    NASA TECHNICAL REPORTS
  • 8
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    Reduction of Marine Magnetic Data for Modeling the Main Field of the Earth (1992)
    In:  CASI
    Details
    Publication Date: 2014-09-25
    Description: The marine data set archived at the National Geophysical Data Center (NGDC) consists of shipborne surveys conducted by various institutes worldwide. This data set spans four decades (1953, 1958, 1960-1987), and contains almost 13 million total intensity observations. These are often less than 1 km apart. These typically measure seafloor spreading anomalies with amplitudes of several hundred nanotesla (nT) which, since they originate in the crust, interfere with main field modeling. The source for these short wavelength features are confined within the magnetic crust (i.e., sources above the Curie isotherm). The main field, on the other hand, is of much longer wavelengths and originates within the earth's core. It is desirable to extract the long wavelength information from the marine data set for use in modeling the main field. This can be accomplished by averaging the data along the track. In addition, those data which are measured during periods of magnetic disturbance can be identified and eliminated. Thus, it should be possible to create a data set which has worldwide data distribution, spans several decades, is not contaminated with short wavelengths of the crustal field or with magnetic storm noise, and which is limited enough in size to be manageable for the main field modeling. The along track filtering described above has proved to be an effective means of condensing large numbers of shipborne magnetic data into a manageable and meaningful data set for main field modeling. Its simplicity and ability to adequately handle varying spatial and sampling constraints has outweighed consideration of more sophisticated approaches. This filtering technique also provides the benefits of smoothing out short wavelength crustal anomalies, discarding data recorded during magnetically noisy periods, and assigning reasonable error estimates to be used in the least square modeling. A useful data set now exists which spans 1953-1987.
    Keywords: GEOPHYSICS
    Type: NASA. Goddard Space Flight Center, Types and Characteristics of Data for Geomagnetic Field Modeling; p 149-202
    Format: text
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    NASA TECHNICAL REPORTS
  • 9
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    Material transport in laser-heated diamond anvil cell melting experiments (1992)
    In:  Other Sources
    Details
    Publication Date: 2019-07-12
    Description: A previously undocumented effect in the laser-heated diamond anvil cell, namely, the transport of molten species through the sample chamber, over distances large compared to the laser beam diameter, is presented. This effect is exploited to determine the melting behavior of high-pressure silicate assemblages of olivine composition. At pressures where beta-spinel is the phase melted, relative strengths of partitioning can be estimated for the incompatible elements studied. Iron was found to partition into the melt from beta-spinel less strongly than calcium, and slightly more strongly than manganese. At higher pressures, where a silicate perovskite/magnesiowuestite assemblage is melted, it is determined that silicate perovskite is the liquidus phase, with iron-rich magnesiowuestite accumulating at the end of the laser-melted stripe.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters (ISSN 0094-8276); 19; 10 M
    Format: text
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  • 10
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    Studies of regional and global tectonics and the rotation of the earth using very-long-baseline interferometry (1992)
    In:  CASI
    Details
    Publication Date: 2019-07-13
    Description: Work is continuing on the study of atmospheric gradients. We include a preprint entitled 'The effect of turbulence on atmospheric gradient parameters determined from ground-based radiometric and space geodetic measurements'. Work has begun on a study of solid Earth tidal deformations using the VLBI data set. We have examined deformations at the semi-diurnal tidal period using the IRIS data set.
    Keywords: GEOPHYSICS
    Type: NASA-CR-191902 , NAS 1.26:192902
    Format: application/pdf
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