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  • Calcium
  • Gas chromatography
  • Wheat
  • bioavailability
  • Springer  (8)
  • American Chemical Society
  • Nature Publishing Group
  • 1985-1989  (8)
  • 1980-1984
  • 1970-1974
  • 1988  (8)
Collection
Keywords
Publisher
  • Springer  (8)
  • American Chemical Society
  • Nature Publishing Group
  • Wiley-Blackwell  (2)
Years
  • 1985-1989  (8)
  • 1980-1984
  • 1970-1974
Year
  • 1
    Electronic Resource
    Electronic Resource
    The production of haploid wheat plants from wheat x maize crosses (1988)
    Springer
    Theoretical and applied genetics 76 (1988), S. 393-397 
    Details
    ISSN: 1432-2242
    Keywords: Wheat ; Maize ; Wide-crosses ; Embryo culture ; Haploids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Hybrid embryos from hexaploid wheat x maize crosses rapidly lose the maize chromosomes to produce haploid wheat embryos. Such embryos almost always aborted when left to develop on the plant, and only 1 was recovered from 2440 florets (0.17% of the expected number). Embryos had greater viability in spikelet culture, 47 (26.5% of the expected number) being recovered from 706 ovaries. Thirty-two of these embryos germinated to give green plants, 31 of which were haploid (21 wheat chromosomes) and 1 of which was euploid (42 wheat chromosomes). Spikelet culture enabled 17.1% of the expected number of embryos to be recovered as haploid plants, a 100-fold improvement on allowing embryos to develop in vivo. Ten haploid plants of ‘Chinese Spring’ (kr1, kr2), 13 plants of ‘Chinese Spring (Hope 5A)’ (kr1, Kr2), and 8 of ‘Hope’ (Kr1, Kr2) were recovered. The potential of wheat x maize crosses for wheat haploid production and for gene transfer from maize to wheat is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265339
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  • 2
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of xamoterol after intravenous and oral administration to volunteers (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 469-473 
    Details
    ISSN: 1432-1041
    Keywords: xamoterol ; cardiac failure ; beta1-adrenoceptor partial agonist ; pharmacokinetics ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of xamoterol, a β-adrenoceptor partial agonist under clinical evaluation for the treatment of mild to moderate heart failure, have been studied in 12 healthy male subjects. They received 14 mg i.v. and oral doses of 50 and 200 mg as a tablet and 200 mg as a solution in a 4 way cross-over design. After i.v. dosing the elimination half-life was 7.7 h, the total body clearance was 224 ml·min−1 and the volume of distribution at steady-state (Vss) was 48 l. Sixty-two percent of the dose was recovered unchanged in urine. After oral doses, the absolute bioavailability of xamoterol was shown to be 5% irrespective of whether the dose was administered as a tablet or solution. Peak plasma concentrations occurred at about 2 h for the tablet dose and slightly earlier (1.4 h) for the solution. Peak plasma concentration, AUC and urinary recovery of unchanged drug increased in proportion to dose. The apparent elimination half-life after oral doses (16 h) was significantly longer than that observed after an intravenous dose. Despite the low bioavailability, the degree of inter-subject variability of oral bioavailability was small probably indicating that the controlling factor is the hydrophilic nature of the molecule rather than extensive first pass metabolism or poor dissolution of xamoterol from the tablet formulation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01046704
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  • 3
    Electronic Resource
    Electronic Resource
    Doxazosin in patients with hypertension (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 21-24 
    Details
    ISSN: 1432-1041
    Keywords: doxazosin ; hypertension ; alpha-adrenergic blockade ; bioavailability ; pharmacokinetics ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The antihypertensive effects and steady-state pharmacokinetics of doxazosin, as well as the bioequivalence of four dosage forms, were studied in 25 hypertensive patients. For an 8 mg daily dose mean Cmax at steady-state for all patients was 108 ng/ml; the mean tmax was 1.8 h. The mean terminal elimination half-life was 22 h. The four tablets containing 1, 2, 4, or 8 mg of doxazosin were bioequivalent in delivering the 8 mg dose. In patients with mild to moderate hypertension, 26-day treatment with doxazosin resulted in blood pressure reduction of 10/7 mm Hg in the supine and 13/18 mm Hg in the standing position. Adverse effects were generally mild and of brief duration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00555502
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of ketorolac tromethamine in humans after intravenous, intramuscular and oral administration (1988)
    Springer
    European journal of clinical pharmacology 35 (1988), S. 423-425 
    Details
    ISSN: 1432-1041
    Keywords: ketorolac tromethamine ; non-narcotic analgesic ; pharmacokinetics ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of ketorolac tromethamine, a potent non-narcotic analgesic agent used for relief of moderate to severe pain, has been studied in 15 healthy volunteers who received single 10 mg doses intravenously (i.v.), intramuscularly (i.m.) and orally (p.o.) in a three-way cross-over design. The kinetics of i.v. ketorolac were characterized by a terminal half-life of 5.09 h, a small plasma clearance (CL = 0.35 ml·min−1·kg−1) and a small tissue distribution (Vss=0.111·kg−1, Vβ=0.17 l·kg−1; mean (SD). Following i.m. and p.o. administration, peak levels of approximately 0.8 µg/ml were rapidly attained (tmax = 0.8 and 0.9 h, respectively) and the systemic bioavailability was essentially complete.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00561376
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  • 5
    Electronic Resource
    Electronic Resource
    Location of β-amylase sequences in wheat and its relatives (1988)
    Springer
    Theoretical and applied genetics 75 (1988), S. 286-290 
    Details
    ISSN: 1432-2242
    Keywords: RFLP ; Wheat ; Aegilops ; Rye ; β-Amylase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary A β-amylase cDNA clone isolated from barley has been used to locate β-amylase encoding sequences on wheat, rye, and Aegilops umbellulata chromosomes by hybridisation to restriction endonuclease digested DNA obtained from wheat aneuploid and wheat-alien addition lines. Structural genes were identified on homoeologous group 4 and 5 chromosomes, confirming the results of isozyme studies. In addition, a further set of structural genes was found on homoeologous group 2 chromosomes. It is proposed that there are two homoeoallelic series, β-Amy-1 on group 4 or 5 chromosomes, and β-Amy-2 on group 2 chromosomes. Evidence is presented that each locus contains one or two β-amylase structural genes, and it is suggested that the large number of isozymes seen upon IEF are due to post-translational modifications.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303966
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  • 6
    Electronic Resource
    Electronic Resource
    The use of activated (S)-(+)-naproxen for the gas chromatographic resolution of some amino acid methyl esters (1988)
    Springer
    Chromatographia 25 (1988), S. 925-927 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; (S)-(+)-Naproxen ; Amino acid methyl esters ; Resolution of diasteroisomers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A GC method has been elaborated for the separation of enantiomers of some amino acid methyl esters after derivatization with activated (S)-(+)-naproxen. Nine amino acid ester paris were completely resolvede in a single run on a fused silica capillary column.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02311433
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  • 7
    Electronic Resource
    Electronic Resource
    Micropacked column gas chromatography with vapour of organic substance as the mobile phase (1988)
    Springer
    Chromatographia 25 (1988), S. 993-998 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; HPLC system ; Micropacked column ; Organic mobile phase ; UV detection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Retention behaviours of aromatic hydrocarbons were examined by using the vapour of an organic substance as the mobile phase and silica gel as the stationary phase. Gas chromatographic separation of aromatic hydrocarbons was demonstrated by using a system comprising a liquid chromatographic (LC) pump, a micropacked column for LC, a column oven and a UV detector.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02259418
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  • 8
    Electronic Resource
    Electronic Resource
    Comparative evaluation of retention of hydrocarbons present in the C5-petroleum fraction on methylsilicone and squalane phases (1988)
    Springer
    Chromatographia 25 (1988), S. 177-180 
    Details
    ISSN: 1612-1112
    Keywords: Gas chromatography ; Retention index ; Hydrocarbons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The retention of hydrocarbons present in the C5 pyrolysis fraction of gasolines on the stationary phases squalane and methylsilicone oil JXR at 30, 40 and 50°C was investigated by capillary gas chromatography. The unified retention indices of the hydrocarbons were also calculated on squalane. The retention indices obtained on these two phases were interrelated and the quantitative relationship with the structure of the solutes was studied. Equations based on the unified retention indices calculated on squalane and some selected structural elements of the solutes permit the calculation of their retention on methylsilicone with sufficient accuracy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02316441
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