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  • Life and Medical Sciences  (135)
  • Analytical Chemistry and Spectroscopy  (128)
  • ASTROPHYSICS  (112)
  • Humans  (106)
  • Electronic structure and strongly correlated systems
  • Lunar and Planetary Science and Exploration
  • 2015-2019
  • 1985-1989  (481)
  • 1988  (481)
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  • 2015-2019
  • 1985-1989  (481)
Year
  • 11
    Electronic Resource
    Electronic Resource
    Static coating of phenyl and biphenyl polysiloxane stationary phases on small-diameter capillary columns (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 113-118 
    Details
    ISSN: 0935-6304
    Keywords: Static coating ; Biphenyl polysiloxane ; Capillary columns ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Static coating of phenyl and biphenyl polysiloxane stationary phases on 50 μm i.d. open tubular capillaries was studied. The influence of coating solvents and coating temperatures on the viscosities and surface tensions of the polymer stationary phases and their coating solutions was determined. A measure of the Rayleigh instability paralled the observed coating efficiencies.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110129
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  • 12
    Electronic Resource
    Electronic Resource
    GC/MS characterization of urinary metabolites of doxylamine succinate: Identification of the aglycones formed from intestinal microflora metabolism of the polar glucuronide metabolites (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 517-520 
    Details
    ISSN: 0935-6304
    Keywords: Capillary GC ; Mass spectrometry ; GC/MS ; Doxylamine metabolites ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: This study describes the use of high performance liquid chromatography (HPLC) and capillary gas chromatography/mass spectrometry (GC/MS) in the characterization of polar glucuronide conjugates of doxylamine and their subsequent aglycones following deconjugation. Rat urinary extracts which contained doxylamine and both nonconjugated and conjugated doxylamine metabolites, were examined by HPLC before and after incubation with rat intestinal microflora. The subsequent deconjugated urinary metabolites and the nonconjugated products remaining in the urinary extracts were then isolated, acetylated, and assayed by GC/MS. Incubation with the intestinal microflora indicated that anaerobic bacteria were capable of effecting hydrolytic cleavage of these polar O-glucuronide metabolites of doxylamine and its demethylated products to their subsequent aglycones. GC/MS analysis was performed using a fused silica DB-5 GC column and was utilized for the identification of these deconjugated metabolites.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110704
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  • 13
    Electronic Resource
    Electronic Resource
    Novel fused silica capillary columns: Surface modification through controlled doping of the preform-tube (1988)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 11 (1988), S. 395-400 
    Details
    ISSN: 0935-6304
    Keywords: Gas chromatography (GC) ; Fused silica ; Column technology ; Surface modification ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method has been developed for fabricating fused silica capillary columns which have specific surface properties but still retain the excellent strength, flexibility, and resilience of pure fused silica. By using the Modified Chemical Vapor Deposition process (MCVD), typically used for the production of optical fiber lightguides, inorganic dopants such as Al, Nd, Ge, and P can be introduced into the preform-tube by MCVD. Doped columns have a wide range of specific surface properties, and columns with undoped fused silica prepared by MCVD are more chemically inert and less acidic than columns prepared by conventional methods. This paper describes the method for fabricating capillaries and the initial studies to characterize them.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240110507
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  • 14
    Electronic Resource
    Electronic Resource
    Gene expression and tumor cell escape from host effector mechanisms in murine large cell lymphomaPresented at the ICN/UCLA Symposium “Tumor Progression and Metastasis,” Keystone, April 6-12, 1987. (1988)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 36 (1988), S. 393-403 
    Details
    ISSN: 0730-2312
    Keywords: tumor metastasis ; viral antigens ; macrophage cytostasis ; differential gene expression ; mitochondrial genes ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Using in vivo selection methods, we obtained metastatic sublines of the murine RAW 117 large cell lymphoma that form multiple liver metastases. The highly metastatic subline RAW117-H10 has a low number of gp70 molecules expressed at the cell surface and low cytostatic sensitivity to activated syngeneic macrophages. This subline was infected with endogenous RNA tumor virus isolated from a high virus-expressing RAW117-P subline of low metastatic potential. After superinfection the H10 subline gradually increased its expression of cell surface gp70 and showed enhanced sensitivity to macrophage-mediated cytostasis, suggesting that gp70 might be involved in host macrophage-mediated surveillance. Culture of RAW117-P and H10 cells in media conditioned by activated macrophages indicated that parental cells are severely growth inhibited in a dose dependent fashion while H10 cells showed almost no effect. Examination of differentially expressed genes in the highly metastatic RAW117-H10 cells by analysis of RNA blots indicated that a mitochondrial gene was expressed at a level that was ∼ 10 times higher in H10 cells than in parental cells. This gene was identified as ND5, which codes for a subunit of NADH dehydrogenase (complex I of the mitochondrial electron transport chain); this complex is the target for an activated macrophage-released cytostatic factor. Among other possibilities, the results are consistent with the suggestion that highly metastatic RAW 117 cells may escape macrophage surveillance by decreasing the synthesis of specific cell-surface receptors for cytostatic molecules and increasing the synthesis of specific cellular targets for such molecules.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240360408
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  • 15
    Electronic Resource
    Electronic Resource
    Obtaining structural information of perfluoro-1,3-dimethyladamantane from collisionally activated decomposition mass spectra (1988)
    New York, NY : Wiley-Blackwell
    Rapid Communications in Mass Spectrometry 2 (1988), S. 204-206 
    Details
    ISSN: 0951-4198
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Cyclic, high molecular weight perfluorocarbons (PFC's) are very electronegative, and can be detected by methane negative ion chemical ionization (NICI); however only molecular ions are detected. Electron ionization (EI) of PFC's, on the other hand, yields little or no molecular ion but very intense low mass fragment ions such as CF3+ (m/z 69), C3F5+ (m/z 131) and C4F7+ (m/z 181), which are not structurally characteristic. High-energy collisionally activated decomposition (CAD) of positive, molecular ions of perfluoro-1,3-dimethyladamantane yields important structural information by providing more intense high mass fragment ions. Fragments of the following formulae and abundances (in brackets): C5F11+ (100), C11F17+ (73), C7F9+ (67), C8F11+ (43), C4F7+ (26), C7F8+. (18), and CF3+ (14) are detected by this method.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/rcm.1290021005
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  • 16
    Electronic Resource
    Electronic Resource
    Spermiogenesis in the red-ear turtle (Pseudemys scripta) and the domestic fowl (Gallus domesticus): A study of cytoplasmic events including cell volume changes and cytoplasmic elimination (1988)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 198 (1988), S. 95-118 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Nuclear and cytoplasmic volume changes as well as the elimination of residual spermatid cytoplasm were investigated in the red-ear turtle (Pseudemys scripta) and the rooster (Gallus domesticus). Nuclei of newly formed spermatids which were originally centrally located became eccentrically located within the cell in both species. Shortly thereafter the nuclear pole of the spermatid was found situated within deep crypts of a Sertoli cell. The cytoplasm of elongating spermatids was displaced along the nonacrosomal region of the nucleus and the proximal flagellum. In both species sheetlike Sertoli cell processes indented spermatid cytoplasm adjacent to the nucleus and appeared to segregate small packets of the cytoplasm. In the turtle, these packets of cytoplasm were separated from the spermatid. In both the turtle and rooster, a portion of the spermatid cytoplasm was displaced forward over the acrosomal region of the spermatid to resemble a hood. As spermatids were transported to the seminiferous tubular lumen, cytoplasmic lobes which projected forward of the spermatid head were formed by preferential flow of cytoplasm into one aspect of the cytoplasmic hood. In both species, at sperm release the cytoplasmic lobe was disengaged from the spermatid head to form a large residual body that was internalized and degraded within the Sertoli cell. Medium-sized cytoplasmic lobes were pinched from the head and neck region of the turtle and rooster spermatids, respectively. In the turtle, small-sized mitochondrial-rich cytoplasmic fragments budded from the caudal head and midpiece of the spermatids and were phagocytosed by the Sertoli cell. Thus, cytoplasmic elimination occurred through (1) segregation of cytoplasmic packets by Sertoli penetrating processes (turtle), (2) elimination of large and medium-sized residual bodies from the head (turtle and bird), and (3) budding of small mitochondrial-rich cytoplasmic fragments from the region of the midpiece (turtle). In the turtle a 79% reduction in total cell volume occurred during spermiogenesis which was the result of an 84% cytoplasmic reduction and a 78% nuclear reduction. During spermiogenesis, the rooster lost 97% of its total cell volume due to a 97% cytoplasmic volume change and a 96% nuclear volume change.
    Additional Material: 31 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051980110
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  • 17
    Electronic Resource
    Electronic Resource
    Spermiogenesis in the bluegill (Lepomis macrochirus): A study of cytoplasmic events including cell volume changes and cytoplasmic elimination (1988)
    New York, NY : Wiley-Blackwell
    Journal of Morphology 198 (1988), S. 165-177 
    Details
    ISSN: 0362-2525
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The process involved in the reduction of both nuclear and cytoplasmic volume was investigated in the bluegill (Lepomis macrochirus), a teleost fish. Young spermatids contained centrally positioned nuclei which, with time, moved toward the cell surface to become eccentrically positioned. Chromatin condensation was initiated from a region near the implantation fossa, whereas at the opposite pole of the nucleus an area sparse in heterochromatin (clear area) was noted. The nuclear membrane lying adjacent to the clear area dissolved and subsequently reformed, yielding a nucleus with a reduced volume. During this process, packets of cytoplasm surrounded by a double membrane were formed along the future midpiece. The packets of cytoplasm migrated toward the cell surface, protruded from the surface, and were extruded into the spermatocyst lumen. These structures, termed residual bodies, were subsequently endocytosed, accumulated into large phagocytic vocuoles, and eventually degraded by the nearby Sertoli cell. When the spermatocyst ruptured, spermatozoa containing sparse cytoplasm were released into the excurrent duct system. During spermiogenesis, both the nuclear and cytoplasmic volumes decreased substantially (80%, 92% respectively) leading to an overall 87% reduction in total cell volume.
    Additional Material: 19 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jmor.1051980204
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  • 18
    Electronic Resource
    Electronic Resource
    Rainbow trout has two genes for growth hormone (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Molecular Reproduction and Development 1 (1988), S. 11-17 
    Details
    ISSN: 1040-452X
    Keywords: GH1 ; GH2 ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology
    Notes: We report the primary structures of two mRNA species (GH1 and GH2), each predicted from the cloned cDNA and genomic gene sequences, that encode growth hormone in rainbow trout (Salmo gairdneri). Both GH1 and GH2 mRNA contain open reading frames comprising 630 nucleotides and encode 210 amino acid residues, of which 11 are variant. The translated regions of mRNA are flanked by a short 5′-untranslated sequence, which is highly conserved, and a relatively long 3′-untranslated sequence, which is highly divergent. The differences at the 3′-untranslated regions suggest that the GH1 and GH2 mRNA originate from different loci. RNA blot analysis of trout pituitary RNA using an oligonucleotide probe specific for the GH2 sequence indicates that the cloned gene is expressed. The GH1 and GH2 mRNA likely are transcribed from two distinct loci, which were duplicated during tetraploidization of the salmonid genome between 50 and 100 million years ago.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrd.1080010104
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  • 19
    Electronic Resource
    Electronic Resource
    Cesium ion liquid secondary ion mass spectrometry of membrane-bound glycoproteins: Structural and topological considerations of acetylcholine receptor from Torpedo californica (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 16 (1988), S. 25-30 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We report mass mapping of a large (270 kD) multisubunit membrane bound glycoprotein, nicotinic acetylcholine receptor from Torpedo californica, using enzymic digests of the affinity purified whole receptor and cesium ion liquid secondary ion mass spectrometry. Peptides, glycopeptides and derivatized N-linked oligosaccharides were isolated by HPLC and identified by LSIMS. We have shown that mass spectrometric sensitivity is improved a hundred-fold through use of computer-controlled mass window stepping of an electro-optical multichannel array detection system on a LSIMS double focusing mass spectrometer. This new method permitted determination of the complete fragmentation pattern of Man8N2-ABEE using only 5 picomoles of sample.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200160105
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  • 20
    Electronic Resource
    Electronic Resource
    Effects of phorbol ester on mitogen and orthovanadate stimulated responses of cultured human fibroblasts (1988)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Cellular Physiology 134 (1988), S. 220-228 
    Details
    ISSN: 0021-9541
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Mitogen c stimulation of quiescent human fibroblasts (HSWP) with serum or a mixture of growth factors (consisting of vasopressin, bradykinin, EGF, and insulin) stimulates the release of inositol phosphates, mobilization of intracellular Ca, activation of Na/H exchange and subsequent incorporation of [3H]-thymidine. We have determined previously that pretreatment with the tumor-promoting phorbol ester 12-0-tetradecanoyl-phorbol-13-acetate (TPA) inhibits mitogen-stimulated Na influx in HSWP cells. We report herein that TPA pretreatment also substantially inhibits the mitogen-stimulated release of inositol phosphates in HSWP cells. Half maximal inhibition of mitogen-stimulated inositol phosphate release occurs at 1-2 nM TPA. Treatment of cells with TPA alone has no effect on inositol phosphate release. The effect of TPA pretreatment on inositol phosphate release induced by individual growth factors has also been determined. Orthovanadate, reported by Cassel et al. (1984) to increase Na/H exchange in A431 cells, has been demonstrated to stimulate both Na influx and inositol phosphate release in HSWP cells. TPA pretreatment also inhibits both orthovanadate-stimulated inositol phosphate release and Na influx. In addition, Orthovanadate was determined to increase intra-cellular Ca activity by mobilizing intracellular calcium stores, as determined with the fluorescent intracellular calcium probe fura-2. TPA pretreatment blocks orthovanadate stimulated mobilization of intracellular Ca stores. It appears clear that in HSWP cells pretreatment of cells with phorbol ester is capable of artificially desensitizing the early cellular responses to mitogenic stimuli (growth factors, orthovanadate) by blocking the signal transduction mechanism involved at a point prior to the release of inositol phosphates. We hypothesize that in HSWP cells the normal desensitization of both inositol phosphate release and Na/H exchange is mediated via activation of protein kinase C subsequent to the stimulus-mediated activation of phospholipase C and release of protein kinase C activator diacylglycerol. However it is interesting to note that TPA-mediated inhibition of these early responses in HSWP cells does not inhibit their ability to be stimulated to incorporate [3H]-thymidine. These results are contrasted with those obtained in WI-38 cells. A cell-type in which (1) orthovanadate does not stimulate inositol phosphate release, (2) TPA has minimal or no inhibitory effect on early growth factor induced cellular responses (i.e., inositol phosphate release, intracellular Ca mobilization, activation of Na/H exchange), (3) TPA stimulates Na/H exchanger activity, without activating inositol phosphate release, and (4) TPA promotes (unlike in HSWP cells) the incorporation of [3H]-thymidine.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcp.1041340207
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