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  • Humans  (1)
  • Chemistry
  • LUNAR AND PLANETARY EXPLORATION
  • tyrosine kinase
  • 1985-1989  (3)
  • 1987  (3)
  • 1
    Electronic Resource
    Electronic Resource
    Phosphorylation of glycolytic and gluconeogenic enzymes by the insulin receptor kinase (1987)
    New York, N.Y. : Wiley-Blackwell
    Journal of Cellular Biochemistry 33 (1987), S. 15-26 
    Details
    ISSN: 0730-2312
    Keywords: phosphorylation ; insulin receptor ; tyrosine kinase ; phosphofructokinase ; glycolysis ; Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Various glycolytic and gluconeogenic enzymes were tested as substrates for the insulin receptor kinase. Phosphofructokinase and phosphoglycerate mutase were found to be the best substrates. Phosphorylation of these enzymes was rapid, stimulated 2- to 6-fold by 10-7 M insulin and occurred exclusively on tyrosine residues. Enolase, fructose 1,6-bisphosphatase, lactate dehydrogenases in decreasing order, were also subject to insulin-stimulated phosphorylation but to a smaller extent than that for phpsphofructokinase or phosphoglycerate mutase.The phosphorylation of phosphofructokinase was studied most extensively since phosphofructokinase is known to catalyze a rate-limiting step in glycolosis. The apparent Km of the insulin receptor for phosphofructokinase was 0.1 μM, which is within the physiologic range of concentration of this enzyme in most cells. Tyrosine phosphorylation of phosphofructokinase paralleled autophosphorylation of the β-subunit of the insulin receptor with respect to time course, insulin dose response (half maximal effect between 10-9 and 10-8 M insulin), and cation requirement (Mn2+ 〉 Mg2+ 〉 〉 Ca2+). Further study will be required to determine whether the tyrosine phosphorylation of phosphofructokinase plays a role in insulin-stimulated increases in glycolytic flux.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jcb.240330103
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Human aging: usual and successful (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-07-10
    Description: Research in aging has emphasized average age-related losses and neglected the substantial heterogeneity of older persons. The effects of the aging process itself have been exaggerated, and the modifying effects of diet, exercise, personal habits, and psychosocial factors underestimated. Within the category of normal aging, a distinction can be made between usual aging, in which extrinsic factors heighten the effects of aging alone, and successful aging, in which extrinsic factors play a neutral or positive role. Research on the risks associated with usual aging and strategies to modify them should help elucidate how a transition from usual to successful aging can be facilitated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rowe, J W -- Kahn, R L -- New York, N.Y. -- Science. 1987 Jul 10;237(4811):143-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3299702" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Aged, 80 and over ; *Aging/metabolism/physiology/psychology ; Carbohydrate Metabolism ; Cognition ; Cross-Sectional Studies ; Grief ; Health Promotion ; Health Services for the Aged ; Humans ; Longitudinal Studies ; Osteoporosis/physiopathology ; Patient Acceptance of Health Care ; Reference Values ; Social Support ; Volition
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 3
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    Cratering and obliteration history of the south polar region of Mars (1987)
    In:  CASI
    Details
    Publication Date: 2013-08-31
    Description: Results are presented from a comprehensive analysis of crater size frequency distributions compiled from Viking Orbiter images of Martian south polar terrains. Depositional histories for the various terrain units are modelled based on deviations of cumulative crater size frequency plots from an assumed production function. Stratigraphic and morphologic data obtained from visual examination of Viking images are also used, primarily to corroborate inferences concerning ages and obliteration histories derived from the crater data.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: NASA, Washington, Reports of Planetary Geology and Geophysics Program, 1986; p 418-419
    Format: application/pdf
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    NASA TECHNICAL REPORTS
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