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  • seaweed  (13)
  • Nitrogen fixation  (9)
  • bioavailability  (6)
  • Bone
  • Springer  (31)
  • 1980-1984  (31)
  • 1984  (31)
Sammlung
Schlagwörter
Verlag/Herausgeber
  • Springer  (31)
Erscheinungszeitraum
  • 1980-1984  (31)
Jahr
  • 1
    Digitale Medien
    Digitale Medien
    Can strains give adequate information for adaptive bone remodeling? (1984)
    Springer
    Calcified tissue international 36 (1984), S. S118 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Strain ; Remodeling ; Adaptation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary For bone to remodel adaptively, the cells responsible should follow some algorithm. Nine different loading situations and structures are discussed. It seems that either algorithm must be extremely complex, or cells in different structures must follow different algorithms.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02406144
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Failure to detect an amorphous calcium-phosphate solid phase in bone mineral: A radial distribution function study (1984)
    Springer
    Calcified tissue international 36 (1984), S. 291-301 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Mineral ; Amorphous calcium phosphate ; X-ray diffraction ; Radial distribution function
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary X-ray diffraction radial distribution function analysis was used to determine if a significant amount of an amorphous solid phase of calcium phosphate exists in bone, and if so, whether the amount varies as a function of age and maturation. Unfractionated cortical bone from embryonic and posthatch chicks of various ages and a low-density fraction of embryonic bone were studied. No evidence was found for the presence of an amorphous solid phase of calcium phosphate in any of the samples studied, including the recently deposited bone mineral of the low density fraction of embryonic bone. As little as 12.5% of synthetic amorphous calcium phosphate (ACP) added to bone was readily detected by the radial distribution function technique used. The results clearly indicate that the concept that ACP is the initial solid mineral phase deposited in bone, and the major mineral constituent of young bone is no longer tenable. The concept does not provide an accurate description of the nature of the initial bone mineral deposited, or the changes that occur with maturation, nor can it acount for the compositional and X-ray diffraction changes that the mineral component undergoes during maturation and aging.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02405333
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    What should bones be designed to do? (1984)
    Springer
    Calcified tissue international 36 (1984), S. S7 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Mechanical function
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The variety of different mechanical functions required of whole bones is discussed. Often, the design optimizing the structure for one function is not optimal for another function.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02406127
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Bioequivalence studies in humans of indomethacin capsules marketed in India (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 261-264 
    Details
    ISSN: 1432-1041
    Schlagwort(e): indomethacin capsules ; bioequivalence ; volunteers ; pharmacokinetics ; statistical significance ; bioavailability ; comparative bioequivalence
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Two, separate 6×6 Latin square cross-over bioequivalence studies were performed in adult male volunteers using 10 different indomethacin capsule preparations marketed in India together with the pure drug powder as the standard. The products were evaluated with respect to plasma level at various times up to 8 h following administration of a 50 mg (2 × 25 mg) dose. Plasma samples were analysed by a fluorimetric method. Various pharmacokinetic parameters were calculated according to a two compartment model. Statistical evaluation of the data employed analysis of variance for a cross-over design (ANOVA) and Duncan's multiple range test to ascertain the significance of differences between the products. Of the 10 products studied, two were found to be bioinequivalent.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00630296
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Bioavailability of amiodarone (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 533-534 
    Details
    ISSN: 1432-1041
    Schlagwort(e): amiodarone ; bioavailability ; clearance estimation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542153
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of oral and rectal flurbiprofen in children (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 367-369 
    Details
    ISSN: 1432-1041
    Schlagwort(e): flurbiprofen ; syrup ; suppository ; kinetics ; children ; bioavailability
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Eight subjects, aged 6–12 years and weighing 18.8–36.7 kg, received single doses of flurbiprofen 50 or 75 mg (corresponding to 1.4–2.7 mg/kg) as syrup and suppository in a Latin square design. Half-life (2.7–3.2 h), elimination constant (0.22–0.26 h−1), area under the plasma level curve (72.4–77.3 µg·h·ml−1) and time to reach the concentration peak (1–0.75 h) were similar after the syrup and suppository. Flurbiprofen showed equivalent bioavailability after oral and rectal administration and the same pharmacokinetic profile was confirmed in children as observed in adults.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542178
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and bioavailability of digitoxin by a specific assay (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 85-89 
    Details
    ISSN: 1432-1041
    Schlagwort(e): digitoxin ; radioimmunoassay ; pharmacokinetics ; bioavailability ; digitoxin metabolites
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 days. After oral administration, the elimination half-life was 5.8 days. The bioavailability was 81.5% using the specific assay. Using a non-specific, direct serum digitoxin radioimmunoassay the bioavailability was 98.0%. Assay of aqueous fractions from extracted serum samples indicated higher levels of water-soluble metabolites following oral compared to intravenous digitoxin administration. These findings suggest that previously reported values for digitoxin bioavailability using non-specific methods may be falsely elevated due to the presence of digitoxin metabolites in serum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02395212
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Pharmacokinetics and bioavailability of digitoxin by a specific assay (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 85-89 
    Details
    ISSN: 1432-1041
    Schlagwort(e): digitoxin ; radioimmunoassay ; pharmacokinetics ; bioavailability ; digitoxin metabolites
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 days. After oral administration, the elimination half-life was 5.8 days. The bioavailability was 81.5% using the specific assay. Using a non-specific, direct serum digitoxin radioimmunoassay the bioavailability was 98.0%. Assay of aqueous fractions from extracted serum samples indicated higher levels of water-soluble metabolites following oral compared to intravenous digitoxin administration. These findings suggest that previously reported values for digitoxin bioavailability using non-specific methods may be falsely elevated due to the presence of digitoxin metabolites in serum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00553160
    Standort Signatur Erwartet Verfügbarkeit
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    Artikel (Nationallizenzen)
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  • 9
    Digitale Medien
    Digitale Medien
    Organisation of nodulation and nitrogen fixation genes on a Rhizobium trifolii symbiotic plasmid (1984)
    Springer
    Archives of microbiology 139 (1984), S. 151-157 
    Details
    ISSN: 1432-072X
    Schlagwort(e): Rhizobium trifolii ; Symbiosis ; Nodulation ; Nitrogen fixation ; Symbiotic genes ; Reiterated sequences ; Plasmid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A Rhizobium trifolii symbiotic plasmid specific gene library was constructed and the physical organisation of regions homologous to nifHDK, nifA and nod genes was determined. These symbiotic gene regions were localised to u 25 kb region on the sym-plasmid, pPN1. In addition four copies of a reiterated sequence were identified on this plasmid, with one copy adjacent to nifH. No rearrangement of these reiterated sequences was observed between R. trifolii bacterial and bacteroid DNA. Analysis of a deletion derivative of pPN1 showed that these sequences were spread over a 110 kb region to the left of nifA.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00401991
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered (1984)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 12 (1984), S. 575-586 
    Details
    ISSN: 1573-8744
    Schlagwort(e): hydrochlorothiazide ; triamterene ; hydroxytriamterene sulfate ; pharmacokinetics ; bioavailability ; renal clearance ; interaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie
    Notizen: Abstract Hydrochlorothiazide, triamterene, and hydroxytriamterene sulfate were monitored in the plasma and urine of 24 healthy young men taking single doses of a liquid preparation containing both hydrochlorothiazide and triameterene, liquid preparations containing either of these drugs alone, and a combination tablet recently formulated with a dose ratio of hydrochlorothiazide: triamterene (1∶1,5) found to give optimal potassium-sparing effect. In contradiction to a recent publication, no interaction between the drugs affecting the bioavailability or renal clearance of either could be demonstrated. The previous report of drug-drug interaction probably arose from formulationrelated problems with bioavailability from the two capsule and two tablet products which had been studied. A well-formulated hydrochlorothiazide-triamterene combination tablet promotes plasma concentrations and urinary excretion of hydrochlorothiazide, triamterene, and hydroxytriamterene sulfate which are virtually identical to those seen after either a combination liquid dosage form or simple liquid forms containing only one of the two drugs.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01059553
    Standort Signatur Erwartet Verfügbarkeit
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