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  • ASTROPHYSICS  (146)
  • Animals  (130)
  • CHEMISTRY
  • STRUCTURAL MECHANICS
  • 1980-1984  (308)
  • 1970-1974
  • 1960-1964
  • 1984  (308)
  • 1
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    Interferon-beta-related DNA is dispersed in the human genome (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-23
    Description: Interferon-beta 1 (IFN-beta 1) complementary DNA was used as a hybridization probe to isolate human genomic DNA clones lambda B3 and lambda B4 from a human genomic DNA library. Blot-hybridization procedures and partial nucleotide sequencing revealed that lambda B3 is related to IFN-beta 1 (and more distantly to IFN-alpha 1). Analyses of DNA obtained from a panel of human-rodent somatic cell hybrids that were probed with DNA derived from lambda B3 showed that lambda B3 is on human chromosome 2. Similar experiments indicated that lambda B4 is not on human chromosomes 2, 5, or 9. The finding that DNA related to the IFN-beta 1 gene (and IFN-alpha 1 gene) is dispersed in the human genome raises new questions about the origins of the interferon genes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sagar, A D -- Sehgal, P B -- May, L T -- Inouye, M -- Slate, D L -- Shulman, L -- Ruddle, F H -- AI-16262/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 23;223(4642):1312-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6546621" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromosome Mapping ; Chromosomes, Human/*analysis ; Chromosomes, Human, 1-3 ; Chromosomes, Human, 4-5 ; Chromosomes, Human, 6-12 and X ; Cloning, Molecular ; Cricetinae ; DNA/*analysis ; *Genes ; Humans ; Hybrid Cells ; Interferon Type I/*genetics ; Mice ; Nucleic Acid Hybridization
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Molecular Clouds Within 100 Pc (1984)
    In:  CASI
    Details
    Publication Date: 2014-09-16
    Description: Observations at the 2.6 mm line of CO reveal the presence of a large number of molecular clouds at high galactic latitude. If the velocity dispersion of the clouds is a measure of their scale height, the mean distance of the ensemble detected is 100 pc. The clouds are unusual in that either they are not gravitationally bound or they are very deficient in CO relative to molecular hydrogen. These clouds represent a heretofore unrecognized component of the local interstellar medium. If they are pervasive in the Milky Way, they probably represent the small molecular cloud component of the interstellar medium.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center Local Interstellar Medium, No. 81; p 231-234
    Format: text
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    NASA TECHNICAL REPORTS
  • 3
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    Evidence for cholinergic neurites in senile plaques (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-21
    Description: In the neocortices and amygdalae of young and aged macaques, cholinergic axons were identified by means of a monoclonal antibody to bovine choline acetyltransferase. Many fine, linear, immunoreactive profiles were seen in these animals. In the older animals, some cholinergic axons showed multifocal enlargements along their course. In some instances, neurites with choline acetyltransferase immunoreactivity were associated with deposits of amyloid (visualized with thioflavin T fluorescence). The appearance of these amyloid-associated abnormal cholinergic processes was similar to that of neurites in senile plaques, as shown by conventional silver impregnation techniques. Cholinergic systems thus give rise to some of the neurites within senile plaques.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kitt, C A -- Price, D L -- Struble, R G -- Cork, L C -- Wainer, B H -- Becher, M W -- Mobley, W C -- NS 07179/NS/NINDS NIH HHS/ -- NS 10580/NS/NINDS NIH HHS/ -- NS 15721/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1984 Dec 21;226(4681):1443-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505701" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Amygdala/enzymology/*pathology ; Amyloid/analysis ; Animals ; Antibodies, Monoclonal ; Axons/enzymology ; Cerebral Cortex/enzymology/*pathology ; Choline O-Acetyltransferase/analysis ; Female ; Humans ; Macaca mulatta ; Male ; Nerve Endings/enzymology ; Parasympathetic Nervous System/enzymology/*pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Isolation and culture of a tetraploid subpopulation of smooth muscle cells from the normal rat aorta (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-11-02
    Description: Smooth muscle cells with 4C (double diploid) DNA content have been found in major arteries. The proportion of 4C cells increases with normal aging and with hypertension. These cells may represent a state of arrest at the G2 phase of the cell cycle or may be examples of true tetraploidy. Flow cytometric cell sorting was used to isolate 4C smooth muscle cells from the rat aorta, and the cells were cultured. Flow cytometry, Feulgen microdensitometry, and karyotyping of the progeny of the 4C cells established the presence of true tetraploid cells. These findings demonstrate the presence of reproductively viable tetraploid cells in a normal mammalian tissue.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, I D -- Rosen, E M -- Shapiro, H M -- Zoller, L C -- Myrick, K -- Levenson, S E -- Christenson, L -- 5-P01-CA-12662/CA/NCI NIH HHS/ -- AG00599/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 1984 Nov 2;226(4674):559-61.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6494901" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aorta, Thoracic/analysis/*cytology ; Cells, Cultured ; DNA/analysis ; Flow Cytometry ; Humans ; Karyotyping ; Muscle, Smooth, Vascular/analysis/*cytology ; *Polyploidy ; Rats ; Rats, Inbred Strains
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Transmission of simian acquired immunodeficiency syndrome (SAIDS) with blood or filtered plasma (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-06
    Description: Simian acquired immunodeficiency syndrome (SAIDS), a disease clinically and pathologically similar to acquired immunodeficiency syndrome in humans, was transmitted from diseased rhesus monkeys (Macaca mulatta) to normal monkeys by inoculation with heparinized whole blood or plasma that had been passed through filters of 0.45 micrometer pore size. This suggests that the causative agent is small and most probably a virus. No viruses, however, were isolated by standard cell culture techniques from the blood or filtered plasma which caused SAIDS. Both cellular and humoral immunity were markedly depressed in animals with advanced SAIDS.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gravell, M -- London, W T -- Houff, S A -- Madden, D L -- Dalakas, M C -- Sever, J L -- Osborn, K G -- Maul, D H -- Henrickson, R V -- Marx, P A -- RR00169/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 6;223(4631):74-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6318315" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/blood/immunology/*transmission ; Animals ; Blood/microbiology ; Cytomegalovirus/isolation & purification ; Filtration ; Immunoglobulins/analysis ; Lymphatic System/pathology ; Lymphocyte Activation ; Macaca mulatta ; *Plasma/microbiology ; Retroviridae/isolation & purification ; Viruses/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Activation of pontine cholinergic sites implicated in unconsciousness following cerebral concussion in the cat (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-01-20
    Description: Low levels of cerebral concussion in the cat produce reversible behavioral suppression presumably associated with unconsciousness. This injury is also associated with increased rates of glucose utilization in regions within the dorsomedial pontine tegmentum. Microinjection of carbachol into these regions produced behavioral suppression resembling that following concussion. These data, together with previously published observations on cholinergic responses to brain injury, suggest that concussive unconsciousness may be attributable in part to activation of cholinergic pontine sites.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hayes, R L -- Pechura, C M -- Katayama, Y -- Povlishock, J T -- Giebel, M L -- Becker, D P -- NS 12587/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1984 Jan 20;223(4633):301-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6701514" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Atropine/pharmacology ; Brain Concussion/*physiopathology ; Carbachol/pharmacology ; Cats ; Cholinergic Fibers/*physiopathology ; Deoxyglucose/metabolism ; Pons/metabolism/*physiopathology ; Tetracaine/pharmacology ; Unconsciousness/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Simian AIDS: isolation of a type D retrovirus and transmission of the disease (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-03-09
    Description: A type D retrovirus related to but distinct from Mason-Pfizer monkey virus was isolated in vitro from the blood of two rhesus monkeys (Macaca mulatta) with simian acquired immunodeficiency syndrome (SAIDS). Three juvenile rhesus monkeys that were injected intravenously with tissue culture fluids containing this virus developed SAIDS after 2 to 4 weeks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Marx, P A -- Maul, D H -- Osborn, K G -- Lerche, N W -- Moody, P -- Lowenstine, L J -- Henrickson, R V -- Arthur, L O -- Gilden, R V -- Gravell, M -- AI20573-01/AI/NIAID NIH HHS/ -- N01-CO-23910/CO/NCI NIH HHS/ -- RR00169/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1984 Mar 9;223(4640):1083-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695196" target="_blank"〉PubMed〈/a〉
    Keywords: Acquired Immunodeficiency Syndrome/microbiology/transmission/*veterinary ; Animals ; Antigens, Viral/immunology ; Disease Models, Animal ; Female ; Macaca/*microbiology ; Macaca mulatta/*microbiology ; Male ; Retroviridae/immunology/*isolation & purification/ultrastructure ; Viral Core Proteins ; Viral Envelope Proteins/immunology ; Viral Proteins/immunology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Control of extracellular potassium levels by retinal glial cell K+ siphoning (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-09-14
    Description: Efflux of K+ from dissociated salamander Muller cells was measured with ion-selective microelectrodes. When the distal end of an isolated cell was exposed to high concentrations of extracellular K+, efflux occurred primarily from the endfoot, a cell process previously shown to contain most of the K+ conductance of the cell membrane. Computer simulations of K+ dynamics in the retina indicate that shunting ions through the Muller cell endfoot process is more effective in clearing local increases in extracellular K+ from the retina than is diffusion through extracellular space.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693189/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693189/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Newman, E A -- Frambach, D A -- Odette, L L -- EY04077/EY/NEI NIH HHS/ -- EY05630/EY/NEI NIH HHS/ -- R01 EY004077/EY/NEI NIH HHS/ -- R01 EY004077-19/EY/NEI NIH HHS/ -- New York, N.Y. -- Science. 1984 Sep 14;225(4667):1174-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6474173" target="_blank"〉PubMed〈/a〉
    Keywords: Ambystoma ; Animals ; Extracellular Space/*metabolism ; Microelectrodes ; Neuroglia/*metabolism ; Potassium/*metabolism ; Retina/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Morphine analgesia potentiated but tolerance not affected by active immunization against cholecystokinin (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-12-07
    Description: Administration of cholecystokinin was recently found to attenuate opiate analgesia. In the present study, the role of endogenous cholecystokinin in opiate analgesia was examined. Endogenously released cholecystokinin was sequestered by antibodies to cholecystokinin developed in response to an active immunization procedure. Morphine analgesia was potentiated and prolonged in rats immunized against cholecystokinin. The rate of development of morphine tolerance, however, was not affected by the antibodies. Endogenous cholecystokinin appears to function as a short-term modulator of opiate action.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Faris, P L -- McLaughlin, C L -- Baile, C A -- Olney, J W -- Komisaruk, B R -- ES-07066/ES/NIEHS NIH HHS/ -- MH-38894/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1984 Dec 7;226(4679):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6505689" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies ; Cholecystokinin/immunology/*physiology ; *Drug Tolerance ; Immunization ; Male ; Morphine/*pharmacology ; Pain/*physiology ; Rats ; Rats, Inbred Strains ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Antigenic similarity between cells transformed by ultraviolet radiation in vitro and in vivo (1984)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1984-02-10
    Description: Cells of the 10T 1/2 mouse fibroblast line transformed in vitro by ultraviolet radiation are antigenically similar to those from skin cancers produced in mice by repeated exposure to ultraviolet radiation. Both types of tumor cells grew preferentially in ultraviolet-irradiated syngeneic mice relative to untreated animals, and both were recognized by ultraviolet radiation-induced tumor-specific suppressor lymphocytes. These properties were not shared by 10T 1/2 cells transformed in vitro by x-rays or 3-methylcholanthrene.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fisher, M S -- Kripke, M L -- Chan, G L -- CA-09078/CA/NCI NIH HHS/ -- CA-11751/CA/NCI NIH HHS/ -- N01-CO-23909/CO/NCI NIH HHS/ -- New York, N.Y. -- Science. 1984 Feb 10;223(4636):593-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6695169" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/*analysis ; Carcinogens ; Cell Line ; *Cell Transformation, Neoplastic ; Cells, Cultured ; Mice ; Mice, Inbred C3H ; Neoplasm Transplantation ; Transplantation, Isogeneic ; *Ultraviolet Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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