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  • bioavailability  (6)
  • NDE  (5)
  • Springer  (11)
  • Oxford University Press
  • Springer Nature
  • Wiley
  • 2005-2009
  • 1980-1984  (11)
  • 1965-1969
  • 1984  (11)
Collection
Keywords
Publisher
  • Springer  (11)
  • Oxford University Press
  • Springer Nature
  • Wiley
Years
  • 2005-2009
  • 1980-1984  (11)
  • 1965-1969
Year
  • 1
    Electronic Resource
    Electronic Resource
    Ultrasonic reflection from a stressed interface (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 3-12 
    Details
    ISSN: 1573-4862
    Keywords: Ultrasonic ; stress measurements ; interfacial stress ; NiTi ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract In seeking to develop an NDE technique for verifying the serviceability of NiTi couplers for plumbing unions, it was found that the reflection coefficient for a normally incident ultrasonic wave correlated with the stress level at the NiTi-tubing interface. Current theory pertaining to interface reflection is not complete but, even at present status, there is semiquantitative accord between theoretical predictions and normalized data for reflection coefficient versus stress level. These results are at fixed frequency and with comparable surface roughness. Variation of either frequency or surface roughness further affects the reflection coefficient. Current studies are being pursued to define this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711095
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  • 2
    Electronic Resource
    Electronic Resource
    Bioequivalence studies in humans of indomethacin capsules marketed in India (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 261-264 
    Details
    ISSN: 1432-1041
    Keywords: indomethacin capsules ; bioequivalence ; volunteers ; pharmacokinetics ; statistical significance ; bioavailability ; comparative bioequivalence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Two, separate 6×6 Latin square cross-over bioequivalence studies were performed in adult male volunteers using 10 different indomethacin capsule preparations marketed in India together with the pure drug powder as the standard. The products were evaluated with respect to plasma level at various times up to 8 h following administration of a 50 mg (2 × 25 mg) dose. Plasma samples were analysed by a fluorimetric method. Various pharmacokinetic parameters were calculated according to a two compartment model. Statistical evaluation of the data employed analysis of variance for a cross-over design (ANOVA) and Duncan's multiple range test to ascertain the significance of differences between the products. Of the 10 products studied, two were found to be bioinequivalent.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00630296
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  • 3
    Electronic Resource
    Electronic Resource
    Bioavailability of amiodarone (1984)
    Springer
    European journal of clinical pharmacology 26 (1984), S. 533-534 
    Details
    ISSN: 1432-1041
    Keywords: amiodarone ; bioavailability ; clearance estimation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542153
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  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of oral and rectal flurbiprofen in children (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 367-369 
    Details
    ISSN: 1432-1041
    Keywords: flurbiprofen ; syrup ; suppository ; kinetics ; children ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Eight subjects, aged 6–12 years and weighing 18.8–36.7 kg, received single doses of flurbiprofen 50 or 75 mg (corresponding to 1.4–2.7 mg/kg) as syrup and suppository in a Latin square design. Half-life (2.7–3.2 h), elimination constant (0.22–0.26 h−1), area under the plasma level curve (72.4–77.3 µg·h·ml−1) and time to reach the concentration peak (1–0.75 h) were similar after the syrup and suppository. Flurbiprofen showed equivalent bioavailability after oral and rectal administration and the same pharmacokinetic profile was confirmed in children as observed in adults.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542178
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  • 5
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and bioavailability of digitoxin by a specific assay (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 85-89 
    Details
    ISSN: 1432-1041
    Keywords: digitoxin ; radioimmunoassay ; pharmacokinetics ; bioavailability ; digitoxin metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 days. After oral administration, the elimination half-life was 5.8 days. The bioavailability was 81.5% using the specific assay. Using a non-specific, direct serum digitoxin radioimmunoassay the bioavailability was 98.0%. Assay of aqueous fractions from extracted serum samples indicated higher levels of water-soluble metabolites following oral compared to intravenous digitoxin administration. These findings suggest that previously reported values for digitoxin bioavailability using non-specific methods may be falsely elevated due to the presence of digitoxin metabolites in serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02395212
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  • 6
    Electronic Resource
    Electronic Resource
    Pharmacokinetics and bioavailability of digitoxin by a specific assay (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 85-89 
    Details
    ISSN: 1432-1041
    Keywords: digitoxin ; radioimmunoassay ; pharmacokinetics ; bioavailability ; digitoxin metabolites
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics and bioavailability of digitoxin were examined in six normal human subjects using an assay that separates digitoxin from its metabolites. After intravenous administration, the mean systemic clearance was 2.44 ml/min; the volume of distribution was 0.47 l/kg; and the elimination half-life was 6.5 days. After oral administration, the elimination half-life was 5.8 days. The bioavailability was 81.5% using the specific assay. Using a non-specific, direct serum digitoxin radioimmunoassay the bioavailability was 98.0%. Assay of aqueous fractions from extracted serum samples indicated higher levels of water-soluble metabolites following oral compared to intravenous digitoxin administration. These findings suggest that previously reported values for digitoxin bioavailability using non-specific methods may be falsely elevated due to the presence of digitoxin metabolites in serum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00553160
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  • 7
    Electronic Resource
    Electronic Resource
    Some computational considerations in eddy-current NDE (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 39-42 
    Details
    ISSN: 1573-4862
    Keywords: Eddy current ; computer analysis ; numerical methods ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Theoretical calculations of eddy-current phenomena often involve the numerical evaluation of various integral expressions. A discussion of some of the possible evaluation methods and of the factors to be considered in choosing a method is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00711099
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  • 8
    Electronic Resource
    Electronic Resource
    The radiographic edge scattering distortion (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 75-88 
    Details
    ISSN: 1573-4862
    Keywords: object scattering ; edge scattering ; knife edge ; neutron radiography ; buildup factor ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract Previously described scattering based edge distortions in optical density scans obtained from a neutron radiographic knife-edge image have been here confirmed using analog Monte Carlo simulation. In an attempt to estimate the effects of additional object scatter on such artifacts, the effect on the edge response of diffusely incident neutrons has been determined both empirically and by Monte Carlo simulation. The diffuse neutron incidence has been found to diminish the relative magnitude of the distortion, offering explanation for the infrequent observation of the corresponding edge scattering halo artifacts. The potential of this edge distortion as a diagnostic indicator of the buildup factor in radiography is suggested and examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566399
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  • 9
    Electronic Resource
    Electronic Resource
    Separation and characterization of stress levels and texture in metal sheet and plate: I. Principles and preliminary experiment (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 157-163 
    Details
    ISSN: 1573-4862
    Keywords: Residual Stress ; ultrasonics ; metals ; EMATs ; NDE
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract An approach is proposed for obtaining separate measures of stress anisotropy and texture in metal sheet or plate. The approach is based on the propagation characteristics ofSH n modes of ultrasonic waves. Experimental work has established that differences betweenSH 0 modes with orthogonal directions of propagation provide a measure of stress anisotropy that is insensitive to texture, with the restriction that the pseudosymmetry of the polycrystalline matrix of the sheet or plate is orthorhombic or higher. In the present work, it is argued that the differences between elastic constants associated with orthogonal directions of propagation of higher order modes should provide a meaningful measure of texture. The only requirement is that the texture be sufficiently well developed so that the following inequality is obeyed: ∣C′44−C′55∣〉0.002 $$\bar C$$ with $$\bar C$$ =1/2 (C′44+C′55). HereC′44 andC′55 are the effective shear moduli for planes normal to the sheet or plate surface and at right angles to each other. They are measurable by observing the differences between the phase velocities of theSH 0 and theSH n〉0 modes in the principal directions. By using Electromagnetic Acoustic Transducers (EMATs), the phase velocities can be deduced from the frequencies at which an SH mode of fixed wavelength is optimally excited. This approach has the advantage of being independent of specimen geometry and dimensions other than thickness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566221
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  • 10
    Electronic Resource
    Electronic Resource
    The interaction of ultrasound with contacting asperities: Applications to crack closure and fatigue crack growth (1984)
    Springer
    Journal of nondestructive evaluation 4 (1984), S. 203-212 
    Details
    ISSN: 1573-4862
    Keywords: Acoustic diffraction ; acoustic transmission ; asperity contact ; crack closure ; fatigue cracks ; mode conversion ; NDE ; stress intensity factor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Mathematics
    Notes: Abstract The partial contact of two rough fatigue crack surfaces leads to transmission, reflection, diffraction, and mode conversion of an acoustic signal at those contacts. This paper reviews recent experimental and theoretical efforts to understand and quantify such contact on actual fatigue cracks in greater detail. It is shown that the size and density of individual contacts, or asperities, can be estimated from acoustic measurements. Furthermore, it is shown that this information is useful to provide the static stress across a partially closed crack as well as the “effective” stress intensity range which activates fatigue crack propagation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566225
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