Publication Date:
1983-09-16
Description:
A twofold thickening of capillary basement membranes of rat retinas resulting from dietary galactose was prevented by sorbinil, an inhibitor of aldose reductase. Since the basement membrane thickening was ultrastructurally similar to that typical of diabetic retinopathy, it may indicate changes in vessel permeability and susceptibility to hemorrhage. Galactosemic rats should be useful models for studying basement membrane-related complications of diabetes and for examining the potential biochemical regulation of basement membrane synthesis by aldose reductase inhibitors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robison, W G Jr -- Kador, P F -- Kinoshita, J H -- New York, N.Y. -- Science. 1983 Sep 16;221(4616):1177-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6612330" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Basement Membrane/*pathology
;
Capillaries/pathology
;
Diabetic Retinopathy/etiology
;
Disease Models, Animal
;
Galactosemias/drug therapy/*pathology
;
Imidazoles/*therapeutic use
;
*Imidazolidines
;
Male
;
Rats
;
Rats, Inbred Strains
;
Retinal Vessels/*pathology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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