Publication Date:
1982-11-26
Description:
The action of desipramine on the norepinephrine-sensitive adenylate cyclase system and the density of beta-adrenergic receptors in rat cortex was studied after selective lesioning of serotonergic neurons with 5,7-dihydroxytryptamine. In animals with lesions desipramine failed to reduce the density of beta-adrenoceptors but decreased the response of adenosine 3',5'-monophosphate to isoproterenol and norepinephrine to the same degree as in animals without lesions. The results demonstrate a functional linkage between serotonergic and noradrenergic systems in the rat cortex, with beta-adrenergic receptors and neurohormonal sensitivity of the adenosine 3',5'-monophosphate-generating system being under separate regulatory control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Janowsky, A -- Okada, F -- Manier, D H -- Applegate, C D -- Sulser, F -- Steranka, L R -- New York, N.Y. -- Science. 1982 Nov 26;218(4575):900-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291152" target="_blank"〉PubMed〈/a〉
Keywords:
Adenylyl Cyclases/*metabolism
;
Animals
;
Cerebral Cortex/*physiology
;
Cyclic AMP/biosynthesis
;
Desipramine/pharmacology
;
Male
;
Rats
;
Receptors, Adrenergic/*physiology
;
Receptors, Adrenergic, beta/*physiology
;
Serotonin/*physiology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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