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  • Animals  (124)
  • Organic Chemistry  (44)
  • 1980-1984  (168)
  • 1960-1964
  • 1930-1934
  • 1981  (168)
  • 1
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    Cloned viral protein vaccine for foot-and-mouth disease: responses in cattle and swine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-12-04
    Beschreibung: A DNA sequence coding for the immunogenic capsid protein VP3 of foot-and-mouth disease virus A12, prepared from the virion RNA, was ligated to a plasmid designed to express a chimeric protein from the Escherichia coli tryptophan promoter-operator system. When Escherichia coli transformed with this plasmid was grown in tryptophan-depleted media, approximately 17 percent of the total cellular protein was found to be an insoluble and stable chimeric protein. The purified chimeric protein competed equally on a molar basis with VP3 for specific antibodies to foot-and-mouth disease virus. When inoculated into six cattle and two swine, this protein elicited high levels of neutralizing antibody and protection against challenge with foot-and-mouth disease virus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kleid, D G -- Yansura, D -- Small, B -- Dowbenko, D -- Moore, D M -- Grubman, M J -- McKercher, P D -- Morgan, D O -- Robertson, B H -- Bachrach, H L -- New York, N.Y. -- Science. 1981 Dec 4;214(4525):1125-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6272395" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Animals ; Antibody Formation ; Base Sequence ; Cattle ; Cattle Diseases/*prevention & control ; *Cloning, Molecular ; DNA Restriction Enzymes ; DNA, Recombinant/metabolism ; Foot-and-Mouth Disease/*prevention & control ; Immunity, Cellular ; Protein Biosynthesis ; Swine ; Swine Diseases/*prevention & control ; Transcription, Genetic ; *Vaccines ; Viral Proteins/genetics/*therapeutic use
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 2
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    Hyperkeratosis induced by sunlight degradation products of the major polybrominated biphenyl in Firemaster (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-08-21
    Beschreibung: Sunlight photodegradation of 2,2', 4,4', 5,5' -hexabromobiphenyl, the major component of Firemaster, gave a mixture that produces severe hyperkeratosis of the rabbit ear. This component in its pure state does not cause hyperkeratosis. One or more of the four major photolysis products must be responsible for this activity. A similar photodegradation pattern was observed for 2,2', 3,4,4', 5,5' -heptabromobiphenyl, the second largest component of Firemaster.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Patterson, D G -- Hill, R H -- Needham, L L -- Orti, D L -- Kimbrough, R D -- Liddle, J A -- New York, N.Y. -- Science. 1981 Aug 21;213(4510):901-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6266016" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; *Biphenyl Compounds/radiation effects ; Chemical Industry ; Disease Models, Animal ; Environmental Exposure ; Keratosis/*chemically induced ; Michigan ; Photochemistry ; *Polybrominated Biphenyls/radiation effects ; Rabbits ; Sunlight
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 3
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    Sustained intracerebroventricular infusion of brain fuels reduces body weight and food intake in rats (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-04-03
    Beschreibung: Long-term infusion of glucose, beta-hydroxybutyrate, and glycerol into the third ventricle of the rat brain caused a stabilization of body weight at a lower than normal level. Among the glucose- and glycerol-treated animals this weight loss was caused in part by temporary hypophagia. Among the animals treated with beta-hydroxybutyrate the weight loss was unaccompanied by a reduction in food intake. The results are consistent with the view that the systems controlling food intake and body weight are sensitive to the availability of brain fuels. They are not consistent however, with the view that these control systems monitor calories independently of their source.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Davis, J D -- Wirtshafter, D -- Asin, K E -- Brief, D -- AM 26030/AM/NIADDK NIH HHS/ -- New York, N.Y. -- Science. 1981 Apr 3;212(4490):81-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7193909" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): 3-Hydroxybutyric Acid ; Animals ; *Appetite Regulation/drug effects ; *Body Weight/drug effects ; Brain/drug effects/*physiology ; Circadian Rhythm ; Drinking/drug effects ; *Eating/drug effects ; Glucose/*pharmacology ; Glycerol/*pharmacology ; Hydroxybutyrates/administration & dosage/*pharmacology ; Hypothalamus/drug effects ; Injections, Intraventricular ; Male ; Rats
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 4
    Digitale Medien
    Digitale Medien
    Propellanes. LXII. The endo- and exo-adducts of 11-cyano-1,6-methano[10] annulene with 4-methyl-1,2,4-triazoline-3,5-dionePart LXI: see [1].Dedicated to the memory of Professor Frantisek Šorm (1981)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 64 (1981), S. 579-581 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The title compounds have been isolated and their structures determined by X-ray crystallography. Their relative stability is discussed in terms of theory and experiment. The endo-adduct is the thermodynamically more stable one.
    Zusätzliches Material: 2 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19810640222
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  • 5
    Digitale Medien
    Digitale Medien
    Structure Determination of Brominated Morphinan-6-ones by 13C-NMR. Spectroscopy: A novel closure of the oxygen bridge using 4-acetoxymorphinan-6-onesDedicated to Professor George H. Büchi on the occasion of his 60th birthday (1981)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 64 (1981), S. 1672-1681 
    Details
    ISSN: 0018-019X
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Bromination of (-)-4-hydroxy-N-methylmorphinan-6-one (3), prepared from natural morphine, with 1 mol of bromine in acetic acid, afforded the 1-bromo ketone 5. The structure of 5 was assigned by 13C-NMR.spectroscopy, and confirmed by X-ray diffraction analysis of its hydrobromide salt. It is suggested that monobromination of synthetic (±)-2,4-dihydroxy-N-formylmorphinan-6-one (7) takes in principle a similar course, although the 13C-NMR.spectrum of the primary reaction product 9 could not be measured because of insolubility in commonly used solvents. Monobromination of (-)-4-acetoxy-N-formylmorphinan-6-one (12) of the natural series, and of (±)-2,4-diacetoxy-N-formylmorphinan-6-one (8) of the synthetic series, followed by treatment of the monobrominated ketones with potassium carbonate in methanol resulted in closure of the O-bridge, and afforded after acid hydrolysis, the corresponding 4,5-epoxy-morphinan-6-ones (-)-16 and (±)-17 respectively. This variation of the ring closure reaction represents a novel and convenient method to convert 4-hydroxymorphinan-6-ones into their corresponding 4,5-epoxymorphinan-6-ones, without involving aromatic bromination and with only 1 mol of bromine.
    Zusätzliches Material: 1 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/hlca.19810640545
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  • 6
    Digitale Medien
    Digitale Medien
    Über die Si—N-Bindung. XXXIX [1]. Kinetische Untersuchungen zur spontanen Hydrolyse, Alkoholyse und Phenolyse von AminosilanenHerrn Prof. Dr. Günter Schott zum 60. Geburtstag gewidmet (1981)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 323 (1981), S. 721-728 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Silicon-Nitrogen Bonds. XXXIX. Kinetic Studies on the Spontaneous Hydrolysis, Alcoholysis, and Phenolysis of SilylaminesIt could be shown by polarimetric and DC-metric methods that hydrolysis, alcoholysis, and phenolysis of silylamines are of second order and lead to equilibria.The rate of equilibrium establishment is determined by the position of a preceding protonation equilibrium and by steric effects. The position of the equilibria depends on inductive and steric effects. The enthalpy of activation for the ethanolysis of Me3SiNHPh was determined to 27,2 kJ/mol and the entropy of activation to -231 J/K · mol. The mechanism of the reactions is given.
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19813230504
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  • 7
    Digitale Medien
    Digitale Medien
    Stereochemistry of Diastereomeric 3-Dialkylaminopropanols and O-Derivatives (1981)
    New York, NY : Wiley-Blackwell
    Journal für Praktische Chemie/Chemiker-Zeitung 323 (1981), S. 793-800 
    Details
    ISSN: 0021-8383
    Schlagwort(e): Chemistry ; Organic Chemistry
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Stereochemie von diastereomeren 3-Dialkylaminopropanolen und entsprechenden O-DerivatenErythro- und threo-3-Dialkylamino-1-phenyl(1-ethyl)-2-methyl-1-propanole 1a-c, 2a, b wurden durch fraktionierte Umkristallisation bzw. Säulenchromatographie über Kieselgel oder Aluminiumoxid isoliert. Weiterhin wurden die diastereomeren O-Derivate 3-8 erhalten. Eine erythro-threo-Isomerisation wurde mit Säuren durchgeführt. Die relativen Konfigurationen und bevorzugten Konformationen wurden durch 1H-NMR- und IR-Spektroskopie bestimmt.
    Zusätzliches Material: 3 Tab.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/prac.19813230511
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  • 8
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    Persistent behavior at high rates maintained by intravenous self-administration of nicotine (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-10-30
    Beschreibung: Squirrel monkeys pressed a level at high rates under a second-order schedule of reinforcement in which level pressing produced a brief visual stimulus that was occasionally contiguous with an intravenous injection of nicotine. The rate of lever pressing could be markedly reduced either by substituting saline for nicotine injections or by blocking the effects of nicotine with mecamylamine. The rate of level pressing could be reduced by eliminating the brief visual stimulus. These results show that nicotine can function as an effective reinforcer under a second-order schedule of drug self-administration and that an environmental stimulus associated with nicotine intake can contribute to the maintenance of persistent drug-seeking behavior.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Goldberg, S R -- Spealman, R D -- Goldberg, D M -- DA00499/DA/NIDA NIH HHS/ -- DA02658/DA/NIDA NIH HHS/ -- MH07658/MH/NIMH NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Oct 30;214(4520):573-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7291998" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Behavior, Animal/drug effects ; Humans ; Injections, Intravenous ; Nicotine/administration & dosage/*pharmacology ; Reinforcement (Psychology)/drug effects ; Saimiri ; Self Administration
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Tonic immobility produces hyperalgesia and antagonizes morphine analgesia (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-07-17
    Beschreibung: Hyperalgesia was demonstrated during and immediately after termination of tonic immobility in the lizard Anolis carolinensis. Additionally, tonic immobility antagonized morphine-induced analgesia. In conjunction with other research, these data suggest that the response is accompanied by a reduced availability of serotonin, possibly at postsynaptic receptors of raphe neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mauk, M D -- Olson, R D -- LaHoste, G J -- Olson, G A -- New York, N.Y. -- Science. 1981 Jul 17;213(4505):353-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7244620" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): *Analgesia ; Animals ; Brain/physiology ; Evoked Potentials/drug effects ; Lizards ; Morphine/*pharmacology ; Pain/*physiopathology ; *Restraint, Physical ; Serotonin/physiology
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 10
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    Genetically determined deficiency of the third component of complement in the dog (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1981-06-05
    Beschreibung: A genetically determined deficiency of the third component of complement (C3) has been identified in a colony of Brittany spaniels. Immunochemical methods show no detectable C3 in the serum of the affected dogs, and there is no evidence of an inhibitor of C3 in the serum. The C3 deficiency appears to be transmitted as an autosomal recessive trait.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Winkelstein, J A -- Cork, L C -- Griffin, D E -- Griffin, J W -- Adams, R J -- Price, D L -- AI-11637/AI/NIAID NIH HHS/ -- NS-10580/NS/NINDS NIH HHS/ -- RR-00130/RR/NCRR NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1981 Jun 5;212(4499):1169-70.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233211" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Complement C3/deficiency/*genetics ; Dog Diseases/genetics ; Dogs ; Female ; Genes, Recessive ; Heterozygote Detection ; Homozygote ; Male ; Muscular Atrophy/genetics/veterinary ; Pedigree
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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