ISSN:
1432-1041
Schlagwort(e):
nadolol
;
pharmacokinetics
;
plasma levels
;
urinary excretion
;
bioavailability
;
circadian rhythm
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Chemie und Pharmazie
,
Medizin
Notizen:
Summary In 7 healthy subjects (3 males and 4 females), the kinetics of nadolol was investigated after oral doses of 60 and 120 mg. The t1/2 was 14.0±1.8 h. The peak plasma level was doubled on doubling the dose (from 69±15 to 132±27 ng/ml, respectively) and the urinary excretion (13.5%) rose similarly. The half-life of elimination was longer at night than in the day, probably because of the slower nocturnal flow of urine.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00546720
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