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Pharmacokinetics of nadolol in healthy subjects (1984)

Schäfer-Korting, M. ; Bach, N. ; Knauf, H. ; [et al.]

Springer

European journal of clinical pharmacology 26 (1984), S. 125-127

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ISSN: 1432-1041

Keywords: nadolol ; pharmacokinetics ; plasma levels ; urinary excretion ; bioavailability ; circadian rhythm

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology , Medicine

Notes: Summary In 7 healthy subjects (3 males and 4 females), the kinetics of nadolol was investigated after oral doses of 60 and 120 mg. The t1/2 was 14.0±1.8 h. The peak plasma level was doubled on doubling the dose (from 69±15 to 132±27 ng/ml, respectively) and the urinary excretion (13.5%) rose similarly. The half-life of elimination was longer at night than in the day, probably because of the slower nocturnal flow of urine.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00546720

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