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  • ASTRONOMY  (235)
  • Chemical Engineering  (136)
  • Lunar and Planetary Science and Exploration
  • pharmacokinetics
  • 2000-2004
  • 1990-1994  (283)
  • 1980-1984  (149)
  • 1994  (283)
  • 1980  (149)
Collection
Publisher
Years
  • 2000-2004
  • 1990-1994  (283)
  • 1980-1984  (149)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 17 (1980), S. 111-116 
    ISSN: 1432-1041
    Keywords: zimelidine ; norzimelidine ; antidepressants ; pharmacokinetics ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The systemic availability of a new antidepressant, zimelidine, and of its pharmacologically active metabolite, norzimelidine, was studied in six healthy male volunteers. Three single doses of zimelidine (25 mg and 100 mg orally and 25 mg i.v.) and two single doses of norzimelidine (25 mg orally and i. v.) were given to each volunteer allowing at least seven days between administrations. Plasma concentrations of zimelidine and norzimelidine were determined in serial blood samples by HPLC. Following oral zimelidine peak plasma concentrations of the metabolite were attained about 3 h after dosing. Oral administration of norzimelidine itself resulted in a plasma concentration profile for this compound that was similar to that observed after oral zimelidine. Utilising the plasma concentration data following intravenous infusion of each compound, the elimination half-lives for zimelidine and norzimelidine were calculated to be 5.1 h (range 4.3–6.0) and 15.5 h (range 10.6–22.9) respectively. The total body clearances of the 2 compounds were similar at 0.52 l · min−1 (range 0.26–0.70) for zimelidine and 0.56 l · min−1 (range 0.28–0.83) for norzimelidine. The substantially longer elimination half-life of norzimelidine was apparently the result of a larger volume of distribution (9.4 l · kg−1; range 7.8–11.4) for this metabolite, as compared to zimelidine (3.21 · kg−1; range 1.6–4.9). The calculated bioavailability of zimelidine was 26% (range 9.1–39) after the 25 mg oral dose, and 29% (range 14–46) after the 100 mg dose. The bioavailability of norzimelidine was 66% (range 36–91). However, oral administration of zimelidine resulted in as much or more norzimelidine reaching the systemic circulation, as the oral administration of norzimelidine itself. This is important as a large part of the activity of the drug may be due to the metabolite.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2019-08-28
    Description: Gamma-ray observations of the nearby starburst galaxies NGC 253 and M82 over the energy range (0.05-10) MeV have been obtained with the Oriented Scintillation Spectrometer Experiment (OSSE) spectrometer on the Compton Gamma-Ray Observatory (CGRO). The priority of these galaxies as OSSE targets had been established on the grounds that the average supernova rate may be high in starbursts as indicated by infrared and radio observations, and at distances of approximately 3 Mpc a significant chance of supernova gamm-ray line detection exists. NGC 253 was detected in continuum emission up to 165 keV with a total significance of 4.4 sigma and an estimated luminosity of 3 x 10(exp 40) ergs/s. The spectrum is best fit by a power law of photon index approximately 2.5. We consider the possible contribution of different emission mechanisms, including inverse Compton scattering, bremsstrahlung, discrete sources, and Type Ia/Ib supernova continuum to the measured flux. No significant continuum flux was observed from M82. A search for the gamma-ray line from the decay of the most abundant radioactive element produced in supernovae (Ni-56 yields Co-56 yields Fe-56) yielded no significant detection: the 3 sigma upper limits to the line fluxes at 0.158, 0.812, 0.847, and 1.238 MeV for both galaxies are obtained.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 437; 1; p. 173-178
    Format: text
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  • 3
    ISSN: 1573-904X
    Keywords: fibrinogen receptor antagonist ; pharmacokinetics ; pharmacodynamics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The pharmacokinetics and pharmacodynamics of L-703,014, a fibrinogen receptor antagonist, have been examined in the dog. An analytical method which utilizes methanol precipitation of dog plasma proteins followed by HPLC with an automated column switching technique using the chemical analogue L-704,326 as internal standard was developed for the determination of L-703,014 in dog plasma. The compound was not metabolized in the dog and was eliminated in the kidneys and into bile. Of the administered dose, 68.9 ± 1.3% (i.v.) and 80.5 ± 11.9% (p.o.) were recovered in the feces; 20.3 ± 3% (i.v.) and 2.2 ± 0.2% (p.o.) were recovered in the urine by 72 hr. L-703,014 was 23 ± 3.4% bound in dog plasma protein and the mean ratio of plasma/whole blood was 1.22 ± 0.05. The mean terminal half-life was 118 ± 36 min, the mean steady-state volume of distribution was 0.61 ± 0.22 L/kg, and the mean plasma clearance was 8 ± 2 mL/min/kg. Ex vivo platelet aggregation measurements were made by inducing platelet aggregation with 10 µg/ mL collagen in the presence of 1 µM epinephrine as an agonist. The mean C 50 was 44.4 ± 6.0 ng/mL, and the mean Hill coefficient was 1.5 ± 0.3. The mean bioavailability was 4.9 ± 1.4% in dogs administered 2.0 mg/kg (p.o.).
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 34 (1994), S. 128-134 
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The method of normalization is used to develop the J-R curve fracture toughness characterization for polymeric materials. This method can develop J-R curves directly from load vs. displacement records without a need for an on-line crack monitoring system. It was used previously to develop J-R curves for metallic materials and is applied here for the first time to polymer materials. Single edge notched bend specimens of rubber toughened nylon 6/6 and rubber toughened amorphous nylon are used in this study. The J-R curves from the method of normalization are compared with the results obtained from the multiple specimen method of ASTM Standard E813. The results show that the method of normalization gives reasonable J-R curves; both methods show agreement over the early J-R curve region. In addition the JIc values are determined for each method and compared. Based on this work it is suggested that the method of normalization could be used as a general test method to develop J-R curves for polymeric materials.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
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  • 5
    Publication Date: 2019-01-25
    Description: The bright, peculiar elliptical galaxy Centaurus A (NGC 5128, PKS 1322-427) was one of the first extragalactic radio sources to be optically identified (Bolton et al. 1949). At a distance of 4 Mpc, Centaurus A is the closest active radio galaxy and affords the highest linear imaging resolution (1 mas approximately equal to 0.02 pc) and hence the best prospects for studying an active nucleus close to the central radio source. We present the results of multi-epoch, 8.4-GHz, very long baseline interferometry (VLBI), imaging observations of the nucleus made over the past three years. The nucleus possesses a core-jet structure where the inner portion of the jet shows apparent linear motion with a velocity substantially less than the speed of light.
    Keywords: ASTRONOMY
    Type: Australian Journal of Physics (ISSN 0004-9506); 47; 5; p. 619-624
    Format: text
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  • 6
    Publication Date: 2019-08-28
    Description: We present the first Extreme Ultraviolet Explorer (EUVE) satellite observation of the Jupiter system, obtained during the 2 day period 1993 March 30 through April 1, which shows a rich emission-line spectrum from the Io plasma torus spanning wavelengths 370 to 735 A. The emission features correspond primarily to known multiplets of oxygen and sulfur ions, but a blended feature near 372 A is a plausible Na II transition. The summed detected energy flux of (7.2 +/- 0.2) x 10(exp -11) ergs/sq cm(s) corresponds to a radiated power of approximately equal to 4 x 10(exp 11) W in this spectral range. All ansa emissions show a distinct dawn-dusk brightness asymmetry and the measured dusk/dawn ratio of the bright S III lambda-680 feature is 2.3 +/- 0.3, significantly larger than the ratio measured by the Voyager spacecraft ultraviolet (UV) instruments. A preliminary estimate of ion partitioning indicates that the oxygen/sulfur ion ratio is approximately equal to 2, compared to the value approximately equal to 1.3 measured by Voyager, and that (Na(+))/(e) greater than 0.01.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 426; 1; p. L51-L54
    Format: text
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  • 7
    Publication Date: 2019-08-28
    Description: We have used the Faint Object Spectrograph of the Hubble Space Telescope to observe interstellar linear polarization from 1300 to 3300 A in two stars with well-studied interstellar polarization at visible wavelenths. The wavelength dependence of linear polarization declines smoothly with decreasing wavelength and is devoid of structure associated with the prominent 2175 A absorption bump in the interstellar extinction curve. The data for one star (HD 161056) are consistent with an extrapolation based on the Serkowski formula of a fit to the ground-based polariztion; the other star (HD 7252) shows excess (super-Serkowski) polarization relative to the extrapolation. Out of a total of 10 stars now studied by means of spectropolarimetry in the satellite ultraviolet, including eight obseved with the Wisconsin Ultraviolet Photopolarimeter, five (those of longest lambda (sub max)) show Serkowski behavior, and four others show super-Serkowski behavior; only one (HD 197770) shows evidence for polarization associated with the 2175 A bump. These results place important constraints on the nature of the bump feature.
    Keywords: ASTRONOMY
    Type: Astrophysical Journal, Part 2 - Letters (ISSN 0004-637X); 427; 1; p. L47-L50
    Format: text
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  • 8
    Publication Date: 2011-08-17
    Description: The Voyager IR investigation is described, which uses a Michelson interferometer in the 180-2500/cm range, and a single-channel radiometer for the visible and near-IR, sharing a 50-cm diameter telescope. Emphasis is placed on the differences between the Voyager and the previous designs, including reductions in the field of view and in the noise equivalent spectral radiance of the instrument. Attention is given to the optical layout, the electronics module, power supply placement, thermal control heaters and flash heaters, data reduction, and calibration. A sample spectrum of Jupiter is also discussed.
    Keywords: ASTRONOMY
    Type: Applied Optics; 19; May 1
    Format: text
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  • 9
    Publication Date: 2019-06-28
    Description: We present the data and initial results from a combined HST/IUE/ground-based spectroscopic monitoring campaign on the Seyfert 1 galaxy NGC 5548 that was undertaken in order to address questions that require both higher temporal resolution and higher signal-to-noise ratios than were obtained in our previous multiwavelength monitoring of this galaxy in 1988-89. IUE spectra were obtained once every two days for a period of 74 days beginning on 14 March 1993. During the last 39 days of this campaign, spectroscopic observations were also made with the HST Faint Object Spectrograph (FOS) on a daily basis. Ground-based observations, consisting of 165 optical spectra and 77 photometric observations (both CCD imaging and aperture photometry), are reported for the period 1992 October to 1993 September, although much of the data are concentrated around the time of the satellite-based program. These data constitute a fifth year of intensive optical monitoring of this galaxy. In this contribution, we describe the acquisition and reduction of all of the satellite and ground-based data obtained in this program. We describe in detail various photometric problems with the FOS and explain how we identified and corrected for various anomalies. During the HST portion of the monitoring campaign, the 1350 A continuum flux is found to have varied by nearly a factor of two. In other wavebands, the continuum shows nearly identical behavior, except that the amplitude of variability is larger at shorter wavelengths, and the continuum light curves appear to show more short time-scale variability at shorter wavelengths. The broad emission lines also vary in flux, with amplitudes that are slightly smaller than the UV continuum variations and with a small time delay relative to the UV continuum. On the basis of simple time-series analysis of the UV and optical continuum and emission line light curves, we find (1) that the ultraviolet and optical continuum variations are virtually simultaneous, with any lag between the 1350 A continuum and the 5100 A continuum amounting to less than about one day; (2) that the variations in the highest ionization lines observed, He II lambda 1640 and N V lambda 1240, lag behind the continuum variations by somewhat less than 2 days, and (3) that the velocity field of the C IV-emitting region is not dominated by radial motion. The results on the C IV velocity field are preliminary and quite uncertain, but there are some weak indications that the emission-line (wings absolute value of Delta upsilon is greater than or equal to 3000 km/s) respond to continuum variations slightly more rapidly than does the core. The optical observations show that the variations in the broad H beta line flux follow the continuum variations with a time lag of around two weeks, about twice the lag for Ly alpha and C IV, as in our previous monitoring campaign on this same galaxy. However, the lags measured for Ly alpha, C IV, and H Beta are each slightly smaller than previously determined. We confirm two trends reported earlier, namely (1) that the UV/optical continuum becomes 'harder' as it gets brighter, and (2) that the highest ionization emission lines have the shortest lags, thus indicating radial ionization stratificatin of a broad-line region that spans over an order of magnitude range in radius.
    Keywords: ASTRONOMY
    Type: NASA-CR-199341 , NAS 1.26:199341
    Format: application/pdf
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  • 10
    Publication Date: 2019-06-28
    Description: During the all sky survey (May 1991 - Nov. 1992) of the Compton Gamma Ray Observatory the Vela pulsar PSR0833-45 was in the field of view of the Energetic Gamma Ray Experiment Telescope (EGRET) in ten separate viewing periods. The pulsar was detected in each one. The average intensity from 100 MeV to 2 GeV was (7.8 +/- 1.0) x 10 (exp -6) photons cm(exp -2) s(exp -1), which indicates that the pulsar in the years 1991/92 was in a state comparable to the low fluxes observed in 1977-1980. No significant changes in intensity were detected during the EGRET observations. The total spectrum of PSR0833-45 measured by EGRET can be described by a power law with index -(1.70 +/- 0.02) over the range 30 MeV to 2 GeV. The extrapolation of this spectrum into the 3 to 30 MeV range agrees with the observations by COMPTEL. Above 2 to 4 GeV EGRET detects a strong spectral break. The lightcurves obtained show a familar structure in the phase histogram: two peaks separated by 0.424 +/- 0.002 in phase with considerable emission in the phase interval between the peaks. The first gamma ray peak maximum trails the single radio peak maximum by 10.54 +/- 0.09 ms (= 0.118 +/- 0.001 in phase). The widths of the emission peaks (FWHM) are 2.7 ms for the first peak (0.03 phase) and 4.1 ms for the second peak (0.05 phase). The widths are approximately constant below a GeV, but show a tendency to become narrower at higher energies. On Jul. 20 1991 a glitch of the Vela period was registered in monitor radio observations. No significant differences between the pre- and post-glitch gamma ray lightcurves were found. The statistics available for the Vela observations allow for a division of the lightcurve into eight phase intervals. The emission peak cores (central FWHM) with leading and trailing wings and two interval regions were defined and spectra were derived for all parts of the lightcurve. The energy spectra for the eight phase intervals show significant differences: the first peak (approximately E(exp -1.81 +/- 0.04)) is somewhat softer than the second peak (approximately E(exp -1.71 +/- 0.03)); the wings attached to each peak show softer spectra than the code of the peaks; the interval emission has the hardest spectrum (approximately E(exp -1.52 +/- 0.03)).
    Keywords: ASTRONOMY
    Type: NASA-CR-197959 , NAS 1.26:197959 , MPE-PREPRINT-289
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