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  • Time Factors  (19)
  • Cells, Cultured  (17)
  • American Association for the Advancement of Science (AAAS)  (36)
  • Cambridge University Press
  • International Union of Crystallography (IUCr)
  • Springer
  • 1980-1984  (36)
  • 1940-1944
  • 1981  (17)
  • 1980  (19)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (36)
  • Cambridge University Press
  • International Union of Crystallography (IUCr)
  • Springer
Years
  • 1980-1984  (36)
  • 1940-1944
Year
  • 1
    Publication Date: 1980-11-07
    Description: An analog of luteinizing hormone-releasing hormone containing a gamma-lactam as a conformational constraint has been prepared with the use of a novel cyclization of a methionine sulfonium salt. The analog is more active as a luteinizing hormone-releasing hormone agonist that the parent hormone, and provides evidence for a bioactive conformation containing a beta-turn.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Freidinger, R M -- Veber, D F -- Perlow, D S -- Brooks, J R -- Saperstein, R -- New York, N.Y. -- Science. 1980 Nov 7;210(4470):656-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7001627" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Biological Assay ; Cells, Cultured ; Female ; *Gonadotropin-Releasing Hormone/analogs & derivatives ; Hydrogen Bonding ; Lactams ; Protein Conformation ; Rats ; Structure-Activity Relationship
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1981-03-27
    Description: Two rhesus monkeys, exposed continuously to realistic patterns and levels of noise for 9 months, exhibited sustained elevations in blood pressure that did not return to baseline values after the noise ended. Auditory brainstem responses, measured before and after exposure, indicated no change in auditory sensitivity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peterson, E A -- Augenstein, J S -- Tanis, D C -- Augenstein, D G -- New York, N.Y. -- Science. 1981 Mar 27;211(4489):1450-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7466404" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Blood Pressure ; Evoked Potentials, Auditory ; Female ; *Noise ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1981-01-23
    Description: The use of tanning booths as a substitute for natural sunlight is becoming increasingly popular. However, unless careful attention is paid to proper design and maintenance, the radiation field inside a tanning booth can be highly anisotropic. The use of simple, inexpensive ultraviolet radiation meters to measure dosage can lead to serious overexposure. Since the ultraviolet radiation inside a tanning booth has a greater proportion of short wavelengths (less than 300 nanometers) than natural sunlight, the amount of skin cancer-inducing radiation received for a tan may be twice that received for a natural suntan.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nachtwey, D S -- Rundel, R D -- New York, N.Y. -- Science. 1981 Jan 23;211(4480):405-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7221547" target="_blank"〉PubMed〈/a〉
    Keywords: Dose-Response Relationship, Radiation ; Erythema/etiology ; Humans ; *Light ; Photometry ; Skin/*radiation effects ; Sunburn/*etiology ; Time Factors ; *Ultraviolet Rays
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 1980-08-08
    Description: Quantitative neurohistological techniques were used to examine the hippocampal complex of laboratory rats maintained on ethanol-containing or control diets for 5 months followed by a 2-month alcohol-free period. Chronic ethanol consumption resulted in a significant loss of hippocampal pyramidal and dentate gyrus granule cells. This study provides direct evidence that long-term ethanol consumption, in the absence of malnutrition, produces neuronal loss in the central nervous system.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Walker, D W -- Barnes, D E -- Zornetzer, S F -- Hunter, B E -- Kubanis, P -- New York, N.Y. -- Science. 1980 Aug 8;209(4457):711-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7394532" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ethanol/*pharmacology ; Hippocampus/drug effects/*physiology ; Male ; Neurons/drug effects/*physiology ; Pyramidal Tracts/drug effects/physiology ; Rats ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1980-11-21
    Description: A hormonally defined medium was used to isolate a homogeneous epithelioid cell population from canine kidney. Monolayers of these cells form domes, an indication of active ion transport, and this process is inhibited by ouabain. This technique allows the isolation of primary cultures of renal epithelial cells, free of fibroblasts, for the characterization of biochemical and physiological properties related to renal function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jefferson, D M -- Cobb, M H -- Gennaro, J F Jr -- Scott, W N -- New York, N.Y. -- Science. 1980 Nov 21;210(4472):912-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7434005" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Biological Transport, Active ; Cell Adhesion ; Cells, Cultured ; Culture Media ; Dogs ; Epithelium/metabolism ; Female ; Kidney/*cytology ; Male ; Sodium/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 1980-10-01
    Description: Contrast thresholds for sine-wave gratings of spatial frequencies of 2, 4, 12, and 16 cycles per degree were determined for normal and disabled readers at a range of stimulus durations. Normal readers demonstrated monotonically decreasing sensitivity with increasing spatial frequency at exposure durations between 40 and 100 milliseconds. At exposure durations of 150 to 1000 milliseconds, they showed peak sensitivity at 4 cycles per degree. In comparison, disabled readers showed monotonically decreasing sensitivity with increasing spatial frequency at all stimulus durations. The difference in sensitivity pattern across spatial frequencies was greatest at stimulus durations approximately equal to fixation durations during reading.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lovegrove, W J -- Bowling, A -- Badcock, D -- Blackwood, M -- New York, N.Y. -- Science. 1980 Oct;210(4468):439-40.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7433985" target="_blank"〉PubMed〈/a〉
    Keywords: Afterimage/physiology ; Dyslexia/*physiopathology ; Humans ; Space Perception/physiology ; Time Factors ; Visual Perception/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-07-25
    Description: Intracellular recordings from voltage-clamped mouse spinal neurons in tissue culture were used to study the membrane mechanisms underlying inhibitory responses to gamma-aminobutyric acid and the (-) isomer of pentobarbital. Fluctuation analysis suggested that both substances activated ion channels in the membranes. However, the channels activated by pentobarbital remained open five times longer than those activated by gamma-aminobutyric acid.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mathers, D A -- Barker, J L -- New York, N.Y. -- Science. 1980 Jul 25;209(4455):507-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6248961" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Membrane/drug effects/physiology ; Cells, Cultured ; Ion Channels/drug effects/*physiology ; Membrane Potentials/drug effects ; Mice ; Neurons/drug effects/*physiology ; Pentobarbital/*pharmacology ; Spinal Cord/*physiology ; gamma-Aminobutyric Acid/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-08-29
    Description: Noradrenergic neurons in the hypothalamus involved in feeding and satiety are activated by gastrointestinal receptors. In the unrestrained rat, sites were first identified at which norepinephrine injected in the medial hypothalamus caused spontaneous feeding, or in the lateral hypothalamus caused no response. The activity of in vivo norepinephrine at these two sites was characterized by localized push-pull perfusion. When a nutrient was infused directly into the rat's duodenum, the synaptic release of hypothalamic norepinephrine was enhanced at lateral sites insensitive to norepinephrine, but suppressed at medial sites reactive to norepinephrine. Thus, signals from duodenal receptors are conceivably sent to the rat's brain to end feeding by way of noradrenergic inhibitory neurons in the hypothalamus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Myers, R D -- McCaleb, M L -- New York, N.Y. -- Science. 1980 Aug 29;209(4460):1035-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7403866" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Duodenum/innervation/*physiology ; Feeding Behavior/physiology ; Glucose ; Hypothalamus/*physiology ; Norepinephrine/*physiology ; Rats ; Satiation/*physiology ; Satiety Response/*physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-09-19
    Description: Mutants of animal viruses can be isolated in bacteria by recombinant DNA methods. Since no viral functions are required for propagation of recombinants in bacteria, viral mutants with lethal changes in cis- or trans-acting elements can be isolated, as well as partially or conditionally defective mutants. In the cases of viruses with small DNA genomes, such as the tumorigenic simian virus 40 (SV40), the entire viral DNA can be inserted into the bacterial plasmid pBR322 and cloned in Escherichia coli. Recombinant plasmids with a single copy of SV40 DNA cause morphological transformation of mouse cells in culture with the same efficiency as SV40 DNA isolated from virus-infected monkey cells, but the recombinant DNA is noninfectious and replicates poorly in permissive cells. However, SV40 DNA excised from the plasmid replicates as well as authentic viral DNA and is fully infectious. SV40 mutants with small deletions or base substitutions have been isolated by in vitro site-specific or random local mutagenesis of recombinant DNA followed by cloning in E. coli. Many of the mutants thus isolated are defective in specific viral functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Peden, K W -- Pipas, J M -- Pearson-White, S -- Nathans, D -- New York, N.Y. -- Science. 1980 Sep 19;209(4463):1392-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6251547" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Neoplasm/*genetics ; Antigens, Viral/genetics ; Cell Transformation, Viral ; Cells, Cultured ; Chromosome Deletion ; DNA, Recombinant ; DNA, Viral/*genetics ; Escherichia coli ; *Mutation ; Simian virus 40/*genetics ; Viral Proteins/*genetics ; Virus Replication
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1980-04-11
    Description: The activities of cyclic nucleotide phosphohydrolase, an enzyme marker for oligodendrocytes, and glutamine synthetase, an enzyme marker for astrocytes, were studied at early (21 to 26) and late (82 to 88) cell passages. The activity of cyclic nucleotide phosphohydrolase was markedly high and that of glutamine synthetase was low in the early passages, but this relation was reversed in the late passages. These findings suggest a "transdifferentiation" of C6 glial cells with passage in culture.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parker, K K -- Norenberg, M D -- Vernadakis, A -- New York, N.Y. -- Science. 1980 Apr 11;208(4440):179-81.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6102413" target="_blank"〉PubMed〈/a〉
    Keywords: 2',3'-Cyclic-Nucleotide Phosphodiesterases/metabolism ; Animals ; Astrocytes/enzymology ; *Cell Differentiation ; Cells, Cultured ; Glutamate-Ammonia Ligase/metabolism ; Neuroglia/*enzymology ; Oligodendroglia/enzymology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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