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  • 1
    Electronic Resource
    Electronic Resource
    Glucocorticoid-mediated alteration in growth factor binding and action: Analysis of the binding change (1978)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 9 (1978), S. 69-77 
    Details
    ISSN: 0091-7419
    Keywords: dexamethasone ; epidermal growth factor ; human diploid fibroblasts ; cell proliferation ; permissive effect ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The addition of the glucocorticoid analog dexamethasone (DX) to serum-free cultures of human fibroblasts caused a twofold enhancement of the mitogenic response to epidermal growth factor (EGF), although DX by itself was not mitogenic. A basis for this effect was suggested by studies showing that DX also increased the cellular binding of 125I-EGF. DX increased the ability of the cells to bind 125I-EGF only at low physiological concentrations of this polypeptide. Thus, data from 125I-EGF binding to cells incubated without DX produced a linear Scatchard plot, whereas the data from 125I-EGF binding to DX-treated cells led to an upwardly curvilinear Scatchard plot. Measurements of 125I-EGF association with the cell surface and cytoplasm indicated that this binding change involved an alteration of cell surface EGF receptors. The binding change appeared not to involve negatively cooperative interactions between EGF receptors, nor a change in the number of receptors. The binding alteration could be explained by a model in which DX converted 25-30% of the cell surface EGF receptors to a form having a fourfold increased affinity.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400090108
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Inhibition by protease inhibitors of binding of adrenal and sex steroid hormones (1978)
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 9 (1978), S. 421-426 
    Details
    ISSN: 0091-7419
    Keywords: aldosterone ; dexamethasone ; dihydrotestosterone ; estrogen ; progesterone ; steroid hormone receptor ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Binding of steroid hormones is inhibited by protease inhibitors and substrates. The protease inhibitors phenylmethyl sulphonylfluoride, tosyl-lysine chloromethyl ketone, and tosylamide-phenylethyl-chloromethyl ketone and the protease substrates tosyl arginine methyl ester and tryptophan methyl ester eliminate specific binding of aldosterone, dexamethasone, dihydrotestosterone, estrogen, and progesterone to their respective receptors. These protease inhibitors and substrates also inhibit binding of progesterone to the 20,000 molecular weight mero-receptor formed from the progesterone receptor in chick oviduct. The binding of estradiol to rat alpha-fetoprotein is inhibited by the protease inhibitors and substrates but not by tryptophan or tryptophan amide, indicating the importance of an ester structure in the inhibition of steroid binding. Our results suggest that all steroid hormone receptors have a site with both common structural features and a role in the regulation of steroid hormone binding.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jss.400090312
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    Paper (German National Licenses)
    Fulltext
  • 3
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    Origin of the Cheney-Palouse Scabland tract (1978)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The Cheney-Palouse tract of the channeled scabland is the largest continuous tract of scabland in eastern Washington. The tract is composed of a varied assortment of bedrock erosional forms, loess islands, and gravel bars. Prominent bedrock longitudinal grooves and inner channels formed by macroturbulent plucking erosion of the jointed rock. Loess island forms vary as a function of their position within the flow. The three major types (submerged, partially submerged, and subaerially exposed) created sedimentologic conditions and resulting bar forms distinct from one another. Other bar forms, notably expansion bars, account for most of the sedimentation in the tract.
    Keywords: GEOPHYSICS
    Type: Texas Univ. at Austin The Channeled Scabland; p 117-130
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 4
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    Large-scale erosional and depositional features of the Channeled Scabland (1978)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The channeled scabland is a great anastomosing complex of highly overfit stand channels eroded into the basalt bedrock and overlying sediments of the Columbia Plateau. Both the erosional and depositional bed forms in these channels are described according to a simple hierarchical classification. The catastrophic flood flows produced macroforms (scale controlled by channel width) through the erosion of rock and sediment and by deposition (bars). Mesoforms (scale controlled by channel depth) are also erosional and depositional.
    Keywords: GEOPHYSICS
    Type: The Channeled Scabland; p 81-115
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 5
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    Paleohydraulics and hydrodynamics of Scabland floods (1978)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The last major episode of scabland flooding (approx. 18,000-13,000 years B.P.) left considerable high-water mark evidence in the form of: (1) eroded channel margins; (2) depositional features; (3) ice-rafter erratics; and (4) divide crossings. These were used to reconstruct maximum flood stages and water-surface gradients. Engineering hydraulic calculation procedures allowed the analyses of flood discharges and mean velocities from these data. Secondary flow phenomena, including various forms of vortices and flow separations, are considered to have been the principal erosive processes. The intense pressure and velocity gradients of vortices along the irregular channel boundaries produced the plucking-type erosion.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The Channeled Scabland; p 59-79
    Format: application/pdf
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    NASA TECHNICAL REPORTS
  • 6
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    Quaternary geology of the Channeled Scabland and adjacent areas (1978)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: The quaternary history of the channeled scabland is characterized by discrete episodes of catastrophic flooding and prolonged periods of loess accumulation and soil formation. The loess sequence was correlated with Richmond's Rocky Mountain glacial chronology. At least five major catastrophic flood events occurred in the general vicinity of the channeled scabland. The earliest episode occurred prior to the extensive deposition of the Palouse formation. The last major episode of flooding occurred between about 18,000 and 13,000 years ago. It probably consisted of two outbursts from glacial Lake Missoula.
    Keywords: GEOPHYSICS
    Type: The Channeled Scabland; p 17-35
    Format: application/pdf
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  • 7
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    The Spokane flood controversy (1978)
    In:  CASI
    Details
    Publication Date: 2016-06-07
    Description: An enormous plexus of proglacial channels that eroded into the loess and basalt of the Columbia Plateau, eastern Washington is studied. This channeled scabland contained erosional and depositional features that were unique among fluvial phenomena. Documentation of the field relationships of the region explains the landforms as the product of a relatively brief, but enormous flood, then so-called the Spokane flood.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: The Channeled Scabland; p 3-15
    Format: application/pdf
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  • 8
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    Development of a winter wheat adjustable crop calendar model. Volume 2: Appendices (1978)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: There are no author-identified significant results in this report.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: E78-10089 , NASA-CR-151643
    Format: application/pdf
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  • 9
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    Development of a winter wheat adjustable crop calendar model (1978)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The author has identified the following significant results. After parameter estimation, tests were conducted with variances from the fits, and on independent data. From these tests, it was generally concluded that exponential functions have little advantage over polynomials. Precipitation was not found to significantly affect the fits. The Robertson's triquadratic form, in general use for spring wheat, was found to show promise for winter wheat, but special techniques and care were required for its use. In most instances, equations with nonlinear effects were found to yield erratic results when utilized with daily environmental values as independent variables.
    Keywords: EARTH RESOURCES AND REMOTE SENSING
    Type: E78-10088 , NASA-CR-151644
    Format: application/pdf
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  • 10
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    Particle acceleration in pulsar magnetospheres (1978)
    In:  CASI
    Details
    Publication Date: 2019-06-27
    Description: The structure of pulsar magnetospheres and the acceleration mechanism for charged particles in the magnetosphere was studied using a pulsar model which required large acceleration of the particles near the surface of the star. A theorem was developed which showed that particle acceleration cannot be expected when the angle between the magnetic field lines and the rotation axis is constant (e.g. radial field lines). If this angle is not constant, however, acceleration must occur. The more realistic model of an axisymmetric neutron star with a strong dipole magnetic field aligned with the rotation axis was investigated. In this case, acceleration occurred at large distances from the surface of the star. The magnitude of the current can be determined using the model presented. In the case of nonaxisymmetric systems, the acceleration is expected to occur nearer to the surface of the star.
    Keywords: ASTROPHYSICS
    Type: NASA-CR-157768 , SUIPR-762
    Format: application/pdf
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