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  • Articles  (7)
  • Time Factors  (7)
  • American Association for the Advancement of Science (AAAS)  (7)
  • Blackwell Publishing Ltd
  • 1975-1979  (7)
  • 1978  (7)
  • Physics  (7)
  • 1
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    Rebound insomnia: a new clinical syndrome (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-15
    Description: Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of sleep is attributed to the short duration of the action of these drugs. A hypothesis involving benzodiazepine receptors in the brain is proposed in which there is a delay or lag in replacement of endogenous benzodiazepine-like molecules after the abrupt withdrawal of exogenous drugs.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kales, A -- Scharf, M B -- Kales, J D -- New York, N.Y. -- Science. 1978 Sep 15;201(4360):1039-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684426" target="_blank"〉PubMed〈/a〉
    Keywords: Benzodiazepines/*adverse effects/metabolism ; Brain/metabolism ; Flunitrazepam/adverse effects/metabolism ; Humans ; Hypnotics and Sedatives/*adverse effects/metabolism ; Nitrazepam/adverse effects/metabolism ; Receptors, Drug/drug effects/metabolism ; Sleep Initiation and Maintenance Disorders/*etiology/metabolism ; *Substance Withdrawal Syndrome/metabolism ; Syndrome ; Time Factors ; Triazolam/adverse effects/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Inhibition of bone formation during space flight (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: Parameters of bone formation and resorption were measured in rats orbited for 19.5 days aboard the Soviet Cosmos 782 biological satellite. The most striking effects were on bone formation. During flight, rats formed significantly less periosteal bone than did control rats on the ground. An arrest line at both the periosteum and the endosteum of flight animals suggest that a complete cessation of bone growth occurred. During a 26-day postflight period, the defect in bone formation was corrected. No significant changes in bone resorption were observed.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Morey, E R -- Baylink, D J -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1138-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/150643" target="_blank"〉PubMed〈/a〉
    Keywords: *Aerospace Medicine ; Animals ; *Bone Development ; Bone Matrix/physiology ; Bone Resorption ; Male ; Periosteum/physiology ; Rats ; *Space Flight ; Specific Pathogen-Free Organisms ; Tetracycline ; Tibia/cytology/growth & development/physiology ; Time Factors ; Weightlessness
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Activity patterns of human skeletal muscles: relation to muscle fiber type composition (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-21
    Description: The muscle activity of normal ambulatory individuals was recorded continuously for 8-hour (working day) periods. Parameters of activity patterns were defined and numerical outcomes for these parameters were compared across a diverse population of muscles. Several pattern parameters, such as the average percentage of time active, were highly correlated with the percentage of type I fibers of a muscle.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Monster, A W -- Chan, H -- O'Connor, D -- New York, N.Y. -- Science. 1978 Apr 21;200(4339):314-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/635587" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Electromyography ; Humans ; Male ; *Muscle Contraction ; Muscles/anatomy & histology/*physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Potency in male rhesus monkeys: effects of continuously receptive females (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: Ejaculations decreased and mount latencies increased when intact males were paired regularly over a 3.5-year period (3180 tests) with ovariectomized females made constantly receptive by daily injections of estradiol. The deterioration in potency was abruptly and completely reversed by substituting a group of new but similarly treated females for the original ones.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michael, R P -- Zumpe, D -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):451-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/417398" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ejaculation ; Female ; Haplorhini ; Macaca/*physiology ; Macaca mulatta/*physiology ; Male ; Pair Bond ; Periodicity ; Seasons ; Sexual Behavior, Animal/*physiology ; Testosterone/blood ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Effects of naloxone on schizophrenia: reduction in hallucinations in a subpopulation of subjects (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: Endogenous opiate-like peptides (endorphins) are putative neuroregulators located throughout the mammalian brainstem. There is some evidence for their role in pain, stress, and affect. We report that the opiate antagonist, naloxone, alters some schizophrenic symptoms. In a double-blind, cross-over study, naloxone produced decreases in auditory hallucinations in some schizophrenic patients. This finding supports the hypothesis that the endorphins may play a roll in modulating hallucinations in a highly selected subgroup of chronically hallucinating schizophrenic patients.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Watson, S J -- Berger, P A -- Akil, H -- Mills, M J -- Barchas, J D -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):73-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/351804" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Chronic Disease ; Clinical Trials as Topic ; Dose-Response Relationship, Drug ; Double-Blind Method ; Endorphins/physiology ; Hallucinations/*drug therapy ; Humans ; Male ; Naloxone/administration & dosage/*therapeutic use ; Schizophrenia/*drug therapy/physiopathology ; Schizophrenia, Paranoid/drug therapy ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Effect of prolonged illumination (phototherapy) on concentrations of luteinizing hormone in human infants (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-17
    Description: Concentrations of luteinizing hormone in the serums of human neonates were altered when the neonates were exposed to prolonged, intense illumination (phototherapy) with their eyes covered. Concentrations decreased after 48 to 72 hours of exposure, increased 6 to 9 days after phototherapy, and subsequently returned to levels similar to those of controls. These data suggest that light may affect pituitary-gonadal function in the human neonate.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dacou-Voutetakis, C -- Anagnostakis, D -- Matsaniotis, N -- New York, N.Y. -- Science. 1978 Mar 17;199(4334):1229-31.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/628840" target="_blank"〉PubMed〈/a〉
    Keywords: Humans ; *Infant, Newborn ; Jaundice, Neonatal/blood/*therapy ; Luteinizing Hormone/*blood ; *Phototherapy ; Time Factors ; Vision, Ocular
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Human flicker sensitivity: two stages of retinal diffusion (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-11-24
    Description: A well-known solution of the diffusion equation gives an exponential square-root function as the frequency response for a one-dimensional diffusion or transmission process. When two or more such processes are cascaded, the result is still an exponential square-root characteristic, but with a longer time constant. This seems to explain why flicker thresholds obey the Kelly-Veringa diffusion model at high frequencies, even though the psychophysically inferred diffusion process is much slower than the first stage of visual transduction measured by, for example, late receptor potentials. Two such stages in tandem are sufficient to account for the psychophysical data, because the psychophysical time constant is proportional to the square of the number of stages involved. In addition, the nonlinear behavior of flicker thresholds under intense light adaptation can be explained if the loss factor in the first stage is proportional to the amount of the photopigment bleached. Apparently the flicker thresholds are governed by first- and second-order retinal neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kelly, D H -- Wilson, H R -- New York, N.Y. -- Science. 1978 Nov 24;202(4370):896-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715449" target="_blank"〉PubMed〈/a〉
    Keywords: Adaptation, Physiological ; Diffusion ; Flicker Fusion/*physiology ; Humans ; Light ; Models, Biological ; Photoreceptor Cells/physiology ; Retina/*physiology ; Retinal Pigments/physiology ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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