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  • 1
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 9 (1978), S. 69-77 
    ISSN: 0091-7419
    Keywords: dexamethasone ; epidermal growth factor ; human diploid fibroblasts ; cell proliferation ; permissive effect ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: The addition of the glucocorticoid analog dexamethasone (DX) to serum-free cultures of human fibroblasts caused a twofold enhancement of the mitogenic response to epidermal growth factor (EGF), although DX by itself was not mitogenic. A basis for this effect was suggested by studies showing that DX also increased the cellular binding of 125I-EGF. DX increased the ability of the cells to bind 125I-EGF only at low physiological concentrations of this polypeptide. Thus, data from 125I-EGF binding to cells incubated without DX produced a linear Scatchard plot, whereas the data from 125I-EGF binding to DX-treated cells led to an upwardly curvilinear Scatchard plot. Measurements of 125I-EGF association with the cell surface and cytoplasm indicated that this binding change involved an alteration of cell surface EGF receptors. The binding change appeared not to involve negatively cooperative interactions between EGF receptors, nor a change in the number of receptors. The binding alteration could be explained by a model in which DX converted 25-30% of the cell surface EGF receptors to a form having a fourfold increased affinity.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    New York, N.Y. : Wiley-Blackwell
    Journal of Supramolecular Structure 9 (1978), S. 421-426 
    ISSN: 0091-7419
    Keywords: aldosterone ; dexamethasone ; dihydrotestosterone ; estrogen ; progesterone ; steroid hormone receptor ; Life Sciences ; Molecular Cell Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Binding of steroid hormones is inhibited by protease inhibitors and substrates. The protease inhibitors phenylmethyl sulphonylfluoride, tosyl-lysine chloromethyl ketone, and tosylamide-phenylethyl-chloromethyl ketone and the protease substrates tosyl arginine methyl ester and tryptophan methyl ester eliminate specific binding of aldosterone, dexamethasone, dihydrotestosterone, estrogen, and progesterone to their respective receptors. These protease inhibitors and substrates also inhibit binding of progesterone to the 20,000 molecular weight mero-receptor formed from the progesterone receptor in chick oviduct. The binding of estradiol to rat alpha-fetoprotein is inhibited by the protease inhibitors and substrates but not by tryptophan or tryptophan amide, indicating the importance of an ester structure in the inhibition of steroid binding. Our results suggest that all steroid hormone receptors have a site with both common structural features and a role in the regulation of steroid hormone binding.
    Additional Material: 5 Tab.
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  • 3
    Publication Date: 2016-06-07
    Description: The Cheney-Palouse tract of the channeled scabland is the largest continuous tract of scabland in eastern Washington. The tract is composed of a varied assortment of bedrock erosional forms, loess islands, and gravel bars. Prominent bedrock longitudinal grooves and inner channels formed by macroturbulent plucking erosion of the jointed rock. Loess island forms vary as a function of their position within the flow. The three major types (submerged, partially submerged, and subaerially exposed) created sedimentologic conditions and resulting bar forms distinct from one another. Other bar forms, notably expansion bars, account for most of the sedimentation in the tract.
    Keywords: GEOPHYSICS
    Type: Texas Univ. at Austin The Channeled Scabland; p 117-130
    Format: application/pdf
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  • 4
    Publication Date: 2016-06-07
    Description: The channeled scabland is a great anastomosing complex of highly overfit stand channels eroded into the basalt bedrock and overlying sediments of the Columbia Plateau. Both the erosional and depositional bed forms in these channels are described according to a simple hierarchical classification. The catastrophic flood flows produced macroforms (scale controlled by channel width) through the erosion of rock and sediment and by deposition (bars). Mesoforms (scale controlled by channel depth) are also erosional and depositional.
    Keywords: GEOPHYSICS
    Type: The Channeled Scabland; p 81-115
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  • 5
    Publication Date: 2016-06-07
    Description: The quaternary history of the channeled scabland is characterized by discrete episodes of catastrophic flooding and prolonged periods of loess accumulation and soil formation. The loess sequence was correlated with Richmond's Rocky Mountain glacial chronology. At least five major catastrophic flood events occurred in the general vicinity of the channeled scabland. The earliest episode occurred prior to the extensive deposition of the Palouse formation. The last major episode of flooding occurred between about 18,000 and 13,000 years ago. It probably consisted of two outbursts from glacial Lake Missoula.
    Keywords: GEOPHYSICS
    Type: The Channeled Scabland; p 17-35
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  • 6
    Publication Date: 2019-06-27
    Description: Properties of the energetic electron (E greater than or approximately equal to 200 keV) magnetopause layer along the distant magnetotail have been studied with Caltech instrumentation aboard IMP-8 for approximately 60 spacecraft orbits. The cross-sectional area of the layer appears to increase by a factor of approximately 5 with increasing geomagnetic activity, and the average unidirectional electron flux within the layer increases by a factor of approximately 4. The energy carried by electrons greater than or approximately equal to 200 keV ranges from approximately 10 to the 14th ergs per second to approximately 10 to the 15th ergs per second. Extrapolation to include all electrons greater than 1 keV suggests total energy flow ranging from approximately 3 x 10 to the 15th ergs per second at quiet times to approximately 5 x 10 to the 18th ergs per second at magnetically disturbed times.
    Keywords: GEOPHYSICS
    Type: Geophysical Research Letters; 4; Oct. 197
    Format: text
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  • 7
    Publication Date: 2019-06-27
    Description: Improved techniques for the analysis of Pioneer 10 Jupiter encounter data are used to obtain significantly more reliable values for energetic electron (Ee less than 21 MeV) intensities within the inner magnetosphere. The revised absolute intensities of electrons in the energy range 0.06-21 MeV are less than previous estimates by factors as great as 10 for L not exceeding 6. Previously published intensities at greater radial distances for Ee less than 21 MeV and at all radial distances for Ee greater than 21 MeV are not affected by the revisions.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Journal of Geophysical Research; 82; Feb. 1
    Format: text
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  • 8
    Publication Date: 2019-06-27
    Description: A simple rocket-borne system has been developed for deriving nitric oxide concentration in the mesosphere from measurements of resonantly scattered solar ultraviolet radiation in the NO gamma band near 2150 A. The NO signal is extracted from a background of Rayleigh-scattered light by a direct measurement of this scattered light by use of an NO absorption cell. This system was utilized to measure the NO concentration above White Sands, New Mexico, in the altitude range from 69 to 101 km. The derived NO profile shows a concentration of about 30 million per cu cm at 67 and 100 km with a deep valley (more than an order of magnitude less) at about 84 km. Comparison with model calculations indicates that the time constant for NO chemistry is smaller than or comparable with that for transport.
    Keywords: GEOPHYSICS
    Type: Journal of Geophysical Research; 82; Aug. 1
    Format: text
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  • 9
    Publication Date: 2019-07-13
    Description: Streamlined erosional forms in the Channeled Scabland are compared with streamline features recognized in the region of the Kasei Vallis on Mars shown in Viking imagery. The morphometric analysis considers three physical parameters, length, measured parallel to the suggested flow direction; width, taken as the maximum width of the streamlined form perpendicular to the flow direction; and area, measured with a grid placed over the surface. These parameters are used to calculate a dimensionless parameter k, defined as the square of the length multiplied by pi over four times the area. For the 137 Scabland forms studied k values range from 1.0 to 8.3 with an average of 3.2. The k values for 47 Martian streamlined forms range from 1.5 to 12.0 with an average of 3.8. The rough similarity of these results suggests that the terrestrial and Martian features were formed by similar processes. The forms appear to have developed an ideal shape, sufficiently elongated to reduce pressure drag in the fluid creating them, but not so long as to create excessive skin resistance.
    Keywords: LUNAR AND PLANETARY EXPLORATION
    Type: Lunar and Planetary Science Conference; Mar 13, 1978 - Mar 17, 1978; Houston, TX
    Format: text
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  • 10
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    In:  Other Sources
    Publication Date: 2019-06-27
    Description: The controversy over Bretz's hypothesis concerning the cataclysmic Spokane flood is discussed. Attention is directed to similarities between the Channeled Scabland of Washington and some Martian land features considered to be catastrophic flood channels. Characteristics of the enormous plexus of proglacial stream channels eroded into the loess and basalt of the Columbia Plateau in eastern Washington are described. The controversiality of the suggestion that a catastrophic flood is responsible for the Martian features is considered with respect to the Spokane flood controversy.
    Keywords: GEOPHYSICS
    Type: Science; 202; Dec. 22
    Format: text
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