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  • Springer  (13)
  • Periodicals Archive Online (PAO)
  • 1985-1989
  • 1975-1979  (13)
  • 1976  (13)
Collection
Publisher
Years
  • 1985-1989
  • 1975-1979  (13)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Einfluß von Coffein auf den Seruminsulinspiegel während des i. v. Glucosetoleranztestes bei einigen Patienten mit chemischem Diabetes (1976)
    Springer
    European journal of nutrition 15 (1976), S. 151-155 
    Details
    ISSN: 1436-6215
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary Nine mild male diabetic patients were studied by intravenous glucose tolerance tests with and without pretreatment with caffeine. The dose of caffeine was 90 mg given as 195 mg of caffeine citrate. The parameters measured were blood glucose and serum insulin. Caffeine given 2 hours previously did not affect the mean glucose disappearance rate of the group, however, those with the highest rates did show a reduced rate after caffeine. Insulin levels showed a decrease Particularly during the first five minutes after glucose. This finding was present Particularly in those patients who exhibited the larger first peak. It is possible that a relationship exists between the magnitude of the caffeine effect upon early insulin secretion and the glucose disappearance rate.
    Notes: Zusammenfassung Bei 9 Patienten mit chemischem Diabetes wurde der Einfluß von 90 mg Coffein p.o. auf Blutzucker und Seruminsulin während eines intravenösen Glucosetoleranztestes untersucht. Im Durchschnitt wiesen die mit Coffein-Tabletten behandelten Patienten während des intravenösen Glucosetoleranztests einen geringfügig höheren Blutzuckerspiegel auf als bei Gabe von Placebo. Die Eliminationskonstante K für Glucose wurde bei den Patienten, deren K über 1,0 lag, geringfügig erniedrigt, bei solchen mit niedrigerem Ausgangs-K nicht verändert oder geringfügig erhöht. Bei den Patienten, bei denen während des intravenösen Glucosetoleranztests noch eine deutliche Zweigipfligkeit der Seruminsulinkurve zu erkennen war, fehlte der 1. Gipfel, wenn sie mit Coffein vorbehandelt waren. Bei den Patienten, die auf den intravenösen Glucosetoleranztest praktisch nicht mehr mit einer Insulinsekretion reagierten, wurde letztere durch Coffein nicht beeinflußt. Unsere Ergebnisse lassen vermuten, daß 90 mg Coffein p.o. während des intravenösen Glucosetoleranztests die 1. Phase der Insulinsekretion hemmt und daß damit die Sofortreaktion des Organismus gegenüber der Glucosezufuhr vermindert wird. Dagegen wird bei bereits stark eingeschränkter Insulinsekretion diese durch Coffein weder verbessert noch verschlechtert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02018435
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  • 2
    Electronic Resource
    Electronic Resource
    Hereditary hemolytic anemia with erythrocyte phosphofructokinase deficiency (1976)
    Springer
    Human genetics 〈Berlin〉 31 (1976), S. 83-91 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A case of hereditary nonspherocytic hemolytic anemia associated with partial erythrocyte PFK deficiency without muscular symptoms is reported: erythrocyte enzyme activity in the propositus was 60% of normal. Kinetic studies of erythrocyte PFK revealed increased sensitivity to ATP inhibition and decreased sensitivity to citrate inhibition. Muscle PFK from the patient had a normal enzymatic activity, but was highly unstable to heat, dilution without stabilizer and urea; furthermore its starch gel electrophoretic mobility was markedly faster than the one of a normal control. The results suggested that a muscle type's subunit was deficient in the erythrocyte PFK. The authors hypothesize that there was no PFK deficiency in the patient's muscle because of the active synthesis of proteins by this tissue. In contrast, the deficiency of PFK would be easily detected in erythrocytes, because of the absence of protein synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270403
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  • 3
    Electronic Resource
    Electronic Resource
    GD (-) Aachen, a new variant of deficient glucose-6-phosphate dehydrogenase (1976)
    Springer
    Human genetics 〈Berlin〉 32 (1976), S. 171-180 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A deficient G-6PD variant was discovered in 4 males of one family from north-western Germany. Five generations of this family could be studied. The deficient G-6PD was a new variant, called “Gd (-) Aachen”. Its main characteristics are the following: severe enzyme deficiency in erythrocytes (3% of normal), contrasting with an almost normal activity in leukocytes; normal molecular specific activity (i.e., normal ratio enzyme activity/cross-reacting material); slow mobility in starch gel electrophoresis (92–94% of normal); increased Michaelis constant for glucose-6-phosphate (60–70 μM) and NADP+ (20–25 μM); decreased inhibition constant by NADPH with respect to NADP+ (7 μM); increased inhibition by ATP; normal utilization of the substrate analogues; slightly biphasic pH curve; thermal instability, and normal activation energy of the enzymatic reaction. The relationships between the hematologic disorders (severe and frequent hemolytic crises) and the unfavorable kinetic modifications are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00291500
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  • 4
    Electronic Resource
    Electronic Resource
    Pyruvate kinase isozymes in man (1976)
    Springer
    Human genetics 〈Berlin〉 33 (1976), S. 35-46 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary By focusing in sucrose, gradient L-type pyruvate kinase from human liver could be separated into 2 major forms (pI 6.28±0.03 and 5.85±0.09) and a minor more acid form (pI≙5). These different forms could also be detected by focusing in acrylamide-ampholine slab gel. The major forms were interconvertible, the equilibrium being shifted toward the acid form by fructose 1,6-diphosphate and SH reagents, and toward the alkaline form by proteinic factors extracted by ammonium sulphate fractionation from liver extracts and from hemolysates. These factors seemed to be responsible for the stabilization of the liver crude extract enzyme in its alkaline conformation. By acrylamide slab gel electrofocusing, erythrocyte pyruvate kinase from whole hemolysates exhibited a complex pattern composed of at least 3 interconvertible forms. The in vitro aging of the red blood cells and the storage of the hemolysates resulted in a progressive disappearance of the acid forms and in a strengthening of the alkaline form. Partially purified erythrocyte enzyme focused in 2 major bands, interconvertible under the influence of the same factors as those described for L-type pyruvate kinase. Although closely related, the focusing patterns of L-type and erythrocyte-type were never exactly identical. Double immunodiffusion against antihuman L-type serum showed a complete identity reaction between erythrocyte-and L-type pyruvate kinases. Moreover, antihuman M2-type serum was unable to neutralize erythrocyte pyruvate kinase as well as to change its electrophoretic mobility. Consequently, we conclude that both human erythrocyte-and liver L-type pyruvate kinases existed under several conformers interconvertible under the influence of the same ligands or proteinic factors; erythrocyte-type enzyme seems to include L-type subunit and not M1- or M2-type subunits. The erythrocyte- and L-type enzymes, however, are not identical and the nature of the differences between them is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00447284
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  • 5
    Electronic Resource
    Electronic Resource
    Pyruvate kinase isozymes in man (1976)
    Springer
    Human genetics 〈Berlin〉 31 (1976), S. 35-45 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Anti human M2 type and anti human L type pyruvate kinase sera allowed us to distinguish two groups of pyruvate kinase in man. Erythrocyte and liver (L type) enzymes on the one hand were inhibited by anti L and not at all by anti M2 serum; pyruvate kinase from all the other tissues on the other hand were inhibited by anti M2 and not at all by anti L serum. This latter group represent the M type pyruvate kinase isozymes. The M type isozymes have been studied by electrofocusing in thin layer acrylamideampholine gel. In adult tissues 4 types of isozymes were found, designated, from acid to alkaline pH, as M2 (predominant form in spleen, leukocytes, lung...), M3, M4 and M1 (predominant form in muscle and brain). In foetal tissues an extra band M2, called M2f, more anodic than M2, was added to the previously described isozymes. Except in brain (in which the isozymes M2, M3, M4 and M1 were found), the most anodic bands (M2f, M2 and M3) were predominant in all the foetal tissues. The isozymes M2f and M2 seem therefore to be the original M type pyruvate kinase forms from which the other isozymes issue. The rate of each isozyme seems to depend on tissue factors characterizing the state of differentiation of some tissues, as indicated by the ability of adult muscle extracts to change the isozymes M2 and M3 into more cathodic forms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00270397
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  • 6
    Electronic Resource
    Electronic Resource
    Realization problems for the group of homotopy classes of self-equivalences (1976)
    Springer
    Mathematische Annalen 220 (1976), S. 37-46 
    Details
    ISSN: 1432-1807
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01354527
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  • 7
    Electronic Resource
    Electronic Resource
    Raft cultures (1976)
    Springer
    Methods in cell science 2 (1976), S. 409-410 
    Details
    ISSN: 1573-0603
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00918296
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  • 8
    Electronic Resource
    Electronic Resource
    Optimal multiprogramming (1976)
    Springer
    Acta informatica 7 (1976), S. 197-216 
    Details
    ISSN: 1432-0525
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Summary Three heuristics for controlling the multiprogramming load to maximize system work capacity are studied. Each allows the highest load possible subject to a given constraint. The knee criterion constrains the memory policy so that program resident sets average near the knees of their inter page fault lifetime curves. The L=S criterion constrains the memory policy or load so that the system inter page fault lifetime L is at least as large as page swap time S. The 50 % criterion constrains the load so that the paging device is busy approximately half the time. Numerical evaluations of queueing networks show that the knee criterion, which is the most difficult to implement, is the most robust, while the easily implemented 50 % criterion is the least robust. These evaluations also circumscribe the conditions under which the criteria are expected to work reliably. Examples from practical systems further validate the criteria. Stability problems are examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00265771
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  • 9
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    Einfluß von Coffein auf den Seruminsulinspiegel während des i. v. Glucosetoleranztestes bei einigen Patienten mit chemischem Diabetes (1976)
    Springer
    Details
    Publication Date: 1976-06-01
    Print ISSN: 0044-264X
    Electronic ISSN: 1435-1293
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Published by Springer
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  • 10
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    Hereditary hemolytic anemia with erythrocyte phosphofructokinase deficiency (1976)
    Springer
    Details
    Publication Date: 1976-01-01
    Print ISSN: 0340-6717
    Electronic ISSN: 1432-1203
    Topics: Biology , Medicine
    Published by Springer
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