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  • Analytical Chemistry and Spectroscopy  (59)
  • Humans
  • SPACE RADIATION
  • Wiley-Blackwell  (59)
  • 1975-1979  (59)
  • 1975  (59)
  • 1
    Electronic Resource
    Electronic Resource
    The identification of 6-methoxy 8-aminoquionoline as a metabolite of primaquine in man (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 304-306 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The identification of 6-methoxy 8-aminoquinoline as a metabolite of Primaquine, an important antimalarial drug, is described. The metabolite is present in urine, plasma and erythrocytes following drug ingestion. It was identified by mass fragmentography of its 1H and 2H acetate and the acetate produced from authentic material. No evidence of further metabolites was obtained.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020605
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of carotenoids by field desorption mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1975), S. 1102-1110 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of a variety of authentic carotenoids covering a range of structural types have been studied using the field desorption technique. All the compounds examined show the molecular ion as the base peak, even where this ion is of very low intensity in the electron-impact spectra. Little fragmentation is observed, but thermal decomposition can be induced in certain cases by using higher emitter currents. Application to a simple mixture of authentic compounds and a more complex mixture of sedimentary origin shows the potential of the method in the rapid qualitative screening of carotenoids in crude extracts.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210101207
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  • 3
    Electronic Resource
    Electronic Resource
    Nuclear magnetic resonance and the conformation of some derivatives of Michler's ketone (1975)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 7 (1975), S. 154-159 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 1H NMR spectra are reported for Michler's ketone and twenty of its derivatives, along with 13C chemical shifts for five of the compounds. 1H chemical shifts show only small changes with increasing substitution at the sterically hindered 2-position. Estimates of the dihedral angle between the benzene ring and C—CO—C planes have been obtained from the chemical shifts of C=O and 4-C for ketones 1, 3, 5, 15 and 16. These angles are both internally consistent and very similar to dihedral angles determined by other methods for corresponding compounds in the benzophenone series.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270070403
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  • 4
    Electronic Resource
    Electronic Resource
    The atomic number dependence of the X-ray continuum intensity and the practical calculation of background in energy dispersive electron microprobe analysis (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 4 (1975), S. 149-156 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: Computer fitting techniques have been used to derive a new expression for the relationship between X-ray continuum intensity and atomic number for a range of electron acelerating potentials up to 25 kV, continuum energies up to 10 keV and average atomic numbers up to thirty. A practical approach to background corrections in energy dispersive electron microprobe analysis, which utilizes this expression, is outlined. The procedure should lead to significant improvements in both accuracy and detection limits in this method of X-ray analysis.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300040311
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  • 5
    Electronic Resource
    Electronic Resource
    The rapid identification of a new metabolite of warfarin via a chemical ionization mass spectrometry ion doublet technique (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 23-30 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: An ion doublet chemical ionization mass spectrometry technique was utilized for the rapid detection and elucidation of the structure of a new hydroxylated metabolite of the oral anticoagulant warfarin. This technique involves the use of a 50:50 mixture of stable isotope labeled and unlabeled drug. With this procedure ions found in the mass spectrum which are associated with the administered drug can be identified unambiguously. The unknown metabolite from rat liver microsomal preparations was identified as benzylic hydroxywarfarin by reincubating the microsomes with warfarin specifically labeled in the benzylic position and observing the subsequent loss of label in the product. The ion doublet technique was also employed in a single human study, and benzylic hydroxywarfarin was detected and identified.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020106
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  • 6
    Electronic Resource
    Electronic Resource
    A microtechnique for the identification of diterpene ester inflammatory toxins (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 126-130 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method is described for the micro-identification of both mono- and diesters of 12-deoxyphorbol based upon a combination of thin-layer chromatography and mass spectrometry. The technique may be used on as little as 5 ml of fresh plant latex. Nine thin-layer systems are described, six of which are adsorption systems based on silica gel or alumina as adsorbent, and three are partition systems using diethyleneglycol as stationary phase. The migration by means of thin-layer chromatography is dependent upon the chain length of the C-13 esterifying acid and on the presence or absence of a free primary hydroxyl group at C-20. By means of mass spectrometry it was possible to confirm the identity of the esterifying moiety at both the C-13 and C-20 positions of 12-deoxy-4βOH-phorbol.
    Additional Material: 4 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020304
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  • 7
    Electronic Resource
    Electronic Resource
    Analysis of organochlorine metabolites in crude extracts by high resolution photoplate mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 201-203 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: High resolution photoplate mass spectrometry has been used to examine crude goat urine extracts to determine the fate of organochlorine xenobiotics in these animals. Using a direct introduction temperature controlled probe the crude urine extracts were analyzed and the presence of oxygenated metabolites of 4-chlorobiphenyl and 4,4′-dichlorobiphenyl were confirmed in goats; analyses of urine extracts from goats injected with the commercial Aroclor mixtures 1254 and 5460 confirmed the formation of oxygenated penta-, tetra- and monochlorobiphenyl metabolites and an oxygenated dichloroterphenyl metabolite, respectively. This technique was particularly useful in the analysis of complex mixtures of metabolites.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020407
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  • 8
    Electronic Resource
    Electronic Resource
    Quantification of phencyclidine in body fluids by gas chromatography chemical ionization mass spectrometry and identification of two metabolitesPresented in part at the American Society for Mass Spectrometry, 23rd Annual Conference on Mass Spectrometry, Houston, Texas, May, 1975.Abbreviation: PCP = phencyclidine. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 206-214 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: A method has been developed for quantification of phencyclidine [1-(1-phenylcyclohexyl)piperidine] in body fluids using gas chromatography chemical ionization mass spectrometry with selected ion recording. Pentadeuterated phencyclidine was synthesized and used as the internal standard. In developing the method it was discovered that phencyclidine thermally fragments to 1-phenylcyclohexene at elevated temperatures. The sensitivity and specificity of the method permits determination of 1 ng of phencyclidine in 1 ml of body fluid. The concentrations of the drug in blood samples from five individuals, who ingested unknown quantities of phencyclidine, were found to range from 50 ng/ml to 2.7 μg/ml. Following intravenous administration of 1 mg of phencyclidine hydrochloride to a 12.5 kg dog, the blood concentration of the drug peaked at 17.6 ng/ml and exhibited a half-life of approximately one hour. Two metabolities of phencyclidine were detected in human and dog urine after enzymatic hydrolysis. The metabolities were tentatively identified as 4-phenyl-4-piperidinocyclohexanol and 1-(1-phenylcyclohexyl)-4-hydroxy-piperidine by electron impact and chemical ionization mass spectral analysis of the metabolites and their trimethylsilyl derivatives. Structural confirmation was achieved by synthesis of the metabolities. A third metabolite was found in urine from rhesus monkeys and was tentatively identified as 1-(1-phenyl-4-hydroxycyclohexyl)-4-hydroxypiperidine.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020409
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  • 9
    Electronic Resource
    Electronic Resource
    Mass spectrometry in toxicology: I - calculation of theoretical isotopic abundances and optimum ion dwell time for a 2,3,7,8-tetrachlorodibenzo-p-dioxin pharmacokinetic studyAbbreviation: TCDD = 2,3,7,8-tetrachlorodibenzo-p-dioxin. (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 276-278 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: 2,3,7,8-Tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin-13C12 parent ion isotope cluster abundances are calculated on a multinomial probability basis for all possible isotope combinations. Parent negative ions \documentclass{article}\pagestyle{empty}\begin{document}$ \left[{\rm M} \right]^{\mathop - \limits_. } $\end{document} at m/e 322 and m/e 334 were selected for dual ion monitoring in the isotope dilution technique. Calculations, according to the Jaech's Method, are given for optimizing dual ion monitoring dwell time in the pulse counting mode at the femtogram level.
    Additional Material: 3 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020507
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  • 10
    Electronic Resource
    Electronic Resource
    The application of quadrupole mass filters in field desorption mass spectrometry (1975)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1975), S. 31-35 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The advantages and limitations which quadrupole mass filters afford to the field desorption technique with respect to use for routine work are discussed and experimentally confirmed by the analyses of some drugs using a field desorption quadrupole mass spectrometer. The possibility of fast identification of drug intoxication is demonstrated by the analysis of the chloroform extract of urine in a case of overdose of hypnotics.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200020107
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