ISSN:
1432-1203
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary With an electro-immunodiffusion technique the authors immunologically titrated 10 deficient glucose-6-phosphate dehydrogenase variants in the leukocytes, platelets, and red blood cells. By comparison between the immunological reactivity and the enzymatic activity, the relative importance of the molecular instability, the decrease in molecular specific activity, and the post-translational modifications of the muted protein could be appreciated. The Gd(-) A, Gd(-) West Bengale, Gd(-) Seattle, and Gd(-) Worcester-like variants had a normal specific activity and were only unstable. The Gd(-) Mali, Gd(-) Fort de France, Gd(-) Ankara, Gd(-) Mediterranee, Gd(-) Matam, and Gd(-) Benevento-like variants were also unstable and they had a diminished molecular specific activity, which entirely or partly explained the leukocyte deficiency.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00283310
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