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  • LUNAR AND PLANETARY EXPLORATION  (169)
  • Life and Medical Sciences  (127)
  • 1990-1994  (290)
  • 1960-1964  (6)
  • 1955-1959
  • 1993  (290)
  • 1963  (6)
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  • 1990-1994  (290)
  • 1960-1964  (6)
  • 1955-1959
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  • 1
    ISSN: 1059-910X
    Schlagwort(e): STEM ; PEELS ; HAADFI ; Nanolithography ; Super-resolution ; STM ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Allgemeine Naturwissenschaft
    Notizen: The Microstructural Physics group at the Cavendish Laboratory is actively involved in a considerable number of research projects which cover a broad range of materials science. In this paper, we describe briefly several such projects, with particular emphasis given to the application of parallel-detection electron energy loss spectroscopy (PEELS) on a scanning transmission electron microscope (STEM) to the analysis of materials such as stainless steels, catalysts, and high temperature superconductors. In addition, we describe a number of related projects that are currently being carried out in the group, particularly those which utilise and develop novel STEM imaging and analytical techniques. © 1993 Wiley-Liss, Inc.
    Zusätzliches Material: 19 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    ISSN: 0021-9541
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: In the present study, we have sought to determine whether a given signal transduction pathway can have diverse effects on subpopulations of cells of a lineage depending upon the stage of differentiation. To test this hypothesis, we selected the cyclic adenosine monophosphate (cAMP) signal transduction pathway because of its recognized importance in mediating the actions of many hormones, e.g., parathyroid hormone which acts on the bone-forming cells, the osteoblasts. Subpopulations of human osteosarcoma SaOS-2 cells with low (LSaOS) and high (HSaOS) alkaline phosphatase (ALP) content were chosen as model systems for preosteoblasts (pre-OB) and osteoblasts (OB), respectively. Dibutyryl cyclic AMP (DBcAMP) treatment of serum free cultures produced a differential effect on the proliferation of LSaOS cells (40 ± 5% of control at 1 mM DBcAMP, P 〈 0.001) compared with HSaOS cells (no statistically significant effect). The finding supports the hypothesis. Next, we sought evidence for mediation, at least in part, by the insulin-like growth factor (IGF)-II regulatory system. We report that the basal expression of IGF-II, IGF binding protein (IGFBP)-3, and IGFBP-4 was higher in LSaOS cells than in HSaOS cells with the opposite true for type I IGF receptor. DBcAMP treatment of LSaOS cells decreased IGF-II and IGFBP-3 but increased IGFBP-4 and type I IGF receptor; no effect was observed for the type II IGF receptors. DBcAMP treatment of HSaOS cells had no detectable effect on IGF-II; IGFBP-3, or type I and type II IGF receptor expression; only IGFBP-4 expression increased with DBcAMP. These observations suggest that the differential regulation of cell proliferation by the cAMP signal transduction pathway may be mediated, at least in part, by the IGF-II regulatory system. © 1993 Wiley-Liss, Inc.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    New York, NY : Wiley-Blackwell
    BioEssays 15 (1993), S. 695-697 
    ISSN: 0265-9247
    Schlagwort(e): Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The male gametes of most organisms lack cytoplasm. Consequently, most cytoplasmic genetic elements are maternally inherited: they cannot be transmitted patrilinnearly. The evolutionary interests of cytoplasmic elements therefore lie in transmission through the female. These elements may thus be in evolutionary conflict with nuclear genes which are transmitted by both sexes. This conflict is manifested in observations of cytoplasmically induced biased sex-ratios. Some cytoplasmic genes avoid this fate by biasing the primary sex ratio towards females, or by inducing parthenogenesis. Others kill male hosts, and either achieve transmission via dispersal, or benefit their clonal relatives in the dead male's female siblings. Still others cause the failure of zygotes resulting from pairings between males carrying specific microbes and females lacking them, causing an increase in the microbes through the sterilisation of non-bearing females. Many, but not all, of these ‘ultra-selfish’ microbes are closely related. Investigations of the significance of their phylogenetic affinities, or lack of them, their adaptability in terms of the methods by which they avoid, or ameliorate, the adverse effects of being in male hosts, and their importance as selective agents in the evolution of invertebrate sex determination systems, provide fertile spheres for future research.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 2019-06-28
    Beschreibung: The flyby of Voyager 1 at Saturn resulted in the detection of a large variety of plasma waves, e.g., chorus, hiss, and electron cyclotron harmonics. Just before the outbound equator crossing, at about 6.1 R(sub s), the Voyager 1 plasma wave instrument detected a strong, well-defined low-frequency enhancement. Initially it was suggested that plasma waves might be responsible for the spectral feature but more recently dust was suggested as at least a partial contributor to the enhancement. In this report we present evidence which supports the conclusion that dust contributes to the low-frequency enhancement. A new method has been used to derive the dust impact rate. The method relies mainly on the 16-channel spectrum analyzer data. The few wide band waveform observations available (which have been used to study dust impacts during the Voyager 2 ring plane crossing) were useful for calibrating the impact rate from the spectrum analyzer data. The mass and, hence, the size of the dust particles were also obtained by analyzing the response of the plasma wave spectrum analyzer. The results show that the region sampled by Voyager 1 is populated by dust particles that have rms masses of up to few times 10(exp -11) g and sizes of up to a few microns. The dust particle number density is on the order of 10(exp -3) m(exp 3). The optical depth of the region sampled by the spacecraft is 1.04 x 10(exp -6). The particle population is centered about 2500 km south of the equatorial plane and has a north-south thickness of about 4000 km. Possible sources of these particles are the moons Enceladus and Tethys whose orbits lie within the E-ring radial extent. These results are in reasonable agreement with photometric studies and numerical simulations.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: NASA-CR-194694 , NAS 1.26:194694 , U-OF-IOWA-93-19
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2013-08-31
    Beschreibung: We determined concentration profiles of Ne-21, Ne-22, and Ar-38 produced by solar protons as a function of depth in oriented lunar rock 68815. A comparison with model predictions indicate a solar proton flux J(4(pi)(r); E greater than 10 MeV) of 100-125 p/sq. cm/s and a rigidity, R sub 0, of 85-100 MV, assuming an erosion rate of 1-2 mm/Myr. These results for 68815 and similar results on 61016 define the integrated solar proton energy spectrum at the moon over the past approximately 2 Myr.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: Lunar and Planetary Inst., Twenty-Fourth Lunar and Planetary Science Conference. Part 2: G-M; p 521-522
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Publikationsdatum: 2019-01-25
    Beschreibung: The NASA/GISS Mars General Circulation Model (GCM) is an adapted version of the GISS Global Climate/Middle Atmosphere Model, specifically developed for the diagnostic validation and objective analysis of measured atmospheric temperatures from the Mars Observer Pressure Modulator Infrared Radiometer (PMIRR) experiment. The GISS Mars GCM has 23 vertical layers extending from the surface to approximately 80 km altitude, representing a vertical resolution of about 0.3 scale heights. The primitive (vertically hydrostatic) equations are solved in finite difference form on the Krakawa B grid, with a horizontal resolution of 8 deg x 10 deg (latitude-longitude). The model includes a diurnal solar cycle, heat transport within a two-layer ground, and a high-order 'slopes-scheme' for the advection of heat in the upper atmosphere. The radiative transfer scheme is based on the correlated k distribution method for the treatment of nongray gaseous absorption thermal emission, and multiple scattering, including options for suspended dust. A special feature of the model of particular importance for Mars is a parameterization of gravity-wave-induced drag incorporating orographic forcing, wind shear, convection, and radiative damping. The implementation of the GISS Mars model includes global maps of topography, roughness, and albedo.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: Lunar and Planetary Inst., Workshop on Atmospheric Transport on Mars; p 5
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Publikationsdatum: 2019-01-25
    Beschreibung: Lunar granite 12033,576 is a subsample of the 'large' (approximately 1 g) felsite 12033,507 which was identified from a collection of 4-10 mm particles from the 12033 soil sampled from the north rim of Head Crater in the eastern part of Oceanus Procellarum. Discordant ages of approximately 3.6, approximately 0.8, approximately 3.9, and approximately 2.2 Ga for this lunar granite were obtained, respectively, by the K-Ca, Ar-39/Ar-40, and U-Pb zircon methods in previous studies and by the Rb-Sr method is this study. Assuming the granite crystallized approximately 3.9 Ga ago (zircon age) and was shocked by meteoritic impacts at 0.8 Ga ago (Ar-39-Ar-40 age), the intermediate apparent ages by the Rb-Sr and K-Ca methods can be interpreted as reset by diffusion of the parent and daughter nuclides. The Rb-Sr age is less resistant to resetting than the K-Ca age, but more resistant that the Ar-39/Ar-40 age.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: Lunar and Planetary Inst., Twenty-Fourth Lunar and Planetary Science Conference. Part 3: N-Z; p 1295-1296
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Publikationsdatum: 2019-07-13
    Beschreibung: Roosevelt County (RC) 075 was recovered in 1990 as a single 258-gram stone. Classification of this meteorite is complicated by its highly unequilibrated nature and its severe terrestrial weathering, but we favor H classification. This is supported by O isotopes and estimates of the original Fe, Ni metal content. The O isotopic composition is similar to that of a number of reduced ordinary chondrites (e.g., Cerro los Calvos, Willaroy), although RC 075 exhibits no evidence of reduced mineral compositions. Chondrule diameters are consistent with classification as an L chondrite, but large uncertainties in chondrule diameters of RC 075 and poorly constrained means of H, L and LL chondrites prevent use of this parameter for reliable classification. Other parameters are compromised by severe weathering (e.g., siderophile element abundances) or unsuitable for discrimination between unequilibrated H, L and LL chondrites (e.g., Co in kamacite delta C-13). Petrologic subtype 3.2 +/- 0.1 is suggested by the degree of olivine heterogeneity, the compositions of chondrule olivines, the thermoluminescence sensitivity, the abundances and types of chondrules mapped on cathodoluminescence mosaics, and the amount of presolar SiC. The meteorite is very weakly shocked (S2), with some chondrules essentially unshocked and, thus, is classified as an H3.2(S2) chondrite. Weathering is evident by a LREE enrichment due to clay contamination, reduced levels of many siderophile elements, the almost total loss of Fe, Ni metal and troilite, and the reduced concentrations of noble gases. Some components of the meteorite (e.g., type IA chondrules, SiC) appear to preserve their nebular states, with little modification from thermal metamorphism. We conclude that RC 075 is the most equilibrated H chondrite yet recovered and may provide additional insights into the origin of primitive materials in the solar nebula.
    Schlagwort(e): LUNAR AND PLANETARY EXPLORATION
    Materialart: Meteoritics (ISSN 0026-1114); 28; 5; p. 681-691
    Format: text
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 26 (1993), S. 49-65 
    ISSN: 0886-1544
    Schlagwort(e): fatty acid ; MHC ; MLC ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: The fatty acid 12(S)-HETE may be a new second messenger capable of activating PKC. In tumor cells 12(S)-HETE stimulates cytoskeleton-dependent cellular responses such as adhesion and spreading. Analysis of 12(S)-HETE effects on B16a melanoma cell cytoskeleton revealed reversible rearrangement of microtubules, microfilaments, the actin-binding proteins, vinculin, myosin heavy (MHC) and light chains (MLC), as well as bundling of vimentin intermediate filaments. The alterations in microfilaments and intermediate filaments occurred very rapidly, i.e., 5 min after exposure of tumor cells to 12(S)-HETE. The 12(S)-HETE-induced cytoskeletal alterations were accompanied by centrifugal organelle-translocation. Interestingly, MLC exhibited clear association with the cytoplasmic organelles. Biochemical analysis of the 12(S)-HETE effect indicated a PKC-mediated reversible hyperphosphorylation of MLC, vimentin, and a 130 kD cytoskeletal-associated protein. Optimal effects were obtained after 5 min treatment with 12(S)-HETE at 0.1 μM concentration. 12(S)-HETE pretreatment induced tumor cell spreading on a fibronectin matrix which required the intactness of all three major cytoskeletal components. The spreading process was dependent upon the activity of PKC. Our data suggest that 12(S)-HETE is a physiological stimulant of PKC. Further, it induces rearrangement of the cytoskeleton of tumor cells in interphase resulting in the stimulation of cytoskeleton-dependent cell activity such as spreading. © 1993 Wiley-Liss, Inc.
    Zusätzliches Material: 9 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    New York, NY : Wiley-Blackwell
    Cell Motility and the Cytoskeleton 24 (1993), S. 245-255 
    ISSN: 0886-1544
    Schlagwort(e): tubulin ; microtubule-associated proteins ; membranous organelles ; interaction ; Life and Medical Sciences ; Cell & Developmental Biology
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Biologie , Medizin
    Notizen: To explore the behaviour of microtubule-associated proteins, MAP2 and TAU in the interactions of mitochondria with microtubules, an homologous acellular system has been reconstituted with organelles isolated from rat brain. We have established a quantitative in vitro binding assay based on the cosedimentation of 125I-labeled microtubules with mitochondria. We found that binding of microtubules to mitochondria was concentration dependent and saturable. Binding was insensitive to ATP. A comparison of taxol-stabilized microtubules prepared from MAP-free tubulin or tubulin coated with TAU or MAP2 showed that the microtubule-associated proteins diminished, or reduced to background levels, the formation of complexes with mitochondria. In contrast, the amount of MAP-free taxol microtubules that cosedimented with mitochondria increased two- and six-fold when mitochondria were coated with MAP2 or TAU. These studies suggest that the two major brain MAPs could have a crosslinking or a spacing role, depending on their organelle localization. © 1993 Wiley-Liss, Inc.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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