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  • American Association for the Advancement of Science (AAAS)  (3)
  • Annual Reviews  (2)
  • 2015-2019
  • 2000-2004  (5)
  • 1960-1964
  • 1920-1924
  • 2000  (5)
  • 1924
  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Materials Research 30 (2000), S. 451-474 
    ISSN: 0084-6600
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract We review the recent progress in the study of layered magnetic manganites La2-2xSr1+2xMn2O7, which have many unique features of charge transport and magnetism inherent to the quasi-two-dimensional electronic structure. The system shows a wide variety of magnetic-field-induced phenomena due to the layered crystal and magnetic structure, such as the highly anisotropic ferromagnetic metallic ground state, the colossal magnetoresistance (CMR) effect, and the tunneling-type magnetoresistance (TMR). The charge transport properties, as well as the magnetic ones, strongly depend on the carrier-doping level and the applied pressure, which reflects the variation of the orbital-dependent occupancy of itinerant eg-like electrons. Although the layered manganite is one of a new class of CMR materials, the study of this system may also reveal some of the key issues for understanding the CMR effect in mixed-valent manganese oxide.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2000-03-17
    Description: Allergic asthma is caused by the aberrant expansion in the lung of T helper cells that produce type 2 (TH2) cytokines and is characterized by infiltration of eosinophils and bronchial hyperreactivity. This disease is often triggered by mast cells activated by immunoglobulin E (IgE)-mediated allergic challenge. Activated mast cells release various chemical mediators, including prostaglandin D2 (PGD2), whose role in allergic asthma has now been investigated by the generation of mice deficient in the PGD receptor (DP). Sensitization and aerosol challenge of the homozygous mutant (DP-/-) mice with ovalbumin (OVA) induced increases in the serum concentration of IgE similar to those in wild-type mice subjected to this model of asthma. However, the concentrations of TH2 cytokines and the extent of lymphocyte accumulation in the lung of OVA-challenged DP-/- mice were greatly reduced compared with those in wild-type animals. Moreover, DP-/- mice showed only marginal infiltration of eosinophils and failed to develop airway hyperreactivity. Thus, PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matsuoka, T -- Hirata, M -- Tanaka, H -- Takahashi, Y -- Murata, T -- Kabashima, K -- Sugimoto, Y -- Kobayashi, T -- Ushikubi, F -- Aze, Y -- Eguchi, N -- Urade, Y -- Yoshida, N -- Kimura, K -- Mizoguchi, A -- Honda, Y -- Nagai, H -- Narumiya, S -- New York, N.Y. -- Science. 2000 Mar 17;287(5460):2013-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto 606-8501, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10720327" target="_blank"〉PubMed〈/a〉
    Keywords: Allergens/immunology ; Animals ; Asthma/immunology/metabolism/pathology/*physiopathology ; Bronchial Hyperreactivity ; Bronchoalveolar Lavage Fluid/cytology/immunology ; Crosses, Genetic ; Female ; Gene Targeting ; Humans ; Immunoglobulin E/blood ; Interferon-gamma/metabolism ; Interleukins/metabolism ; Lung/immunology/metabolism/pathology ; Lymphocytes/immunology ; Male ; Mast Cells/metabolism ; Mice ; Mice, Inbred C57BL ; Mucus/secretion ; Ovalbumin/immunology ; Prostaglandin D2/metabolism/*physiology ; *Receptors, Immunologic ; Receptors, Prostaglandin/genetics/metabolism/*physiology ; Respiratory Mucosa/secretion
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2000-10-06
    Description: An insulinlike signaling pathway controls Caenorhabditis elegans aging, metabolism, and development. Mutations in the daf-2 insulin receptor-like gene or the downstream age-1 phosphoinositide 3-kinase gene extend adult life-span by two- to threefold. To identify tissues where this pathway regulates aging and metabolism, we restored daf-2 pathway signaling to only neurons, muscle, or intestine. Insulinlike signaling in neurons alone was sufficient to specify wild-type life-span, but muscle or intestinal signaling was not. However, restoring daf-2 pathway signaling to muscle rescued metabolic defects, thus decoupling regulation of life-span and metabolism. These findings point to the nervous system as a central regulator of animal longevity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wolkow, C A -- Kimura, K D -- Lee, M S -- Ruvkun, G -- AG14161/AG/NIA NIH HHS/ -- New York, N.Y. -- Science. 2000 Oct 6;290(5489):147-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11021802" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/genetics/*physiology ; Animals ; Caenorhabditis elegans/genetics/*physiology ; *Caenorhabditis elegans Proteins ; Catalase/genetics/metabolism ; Gene Expression Regulation ; Genes, Helminth ; Helminth Proteins/genetics/metabolism ; Intestines/cytology/physiology ; Larva/physiology ; Longevity ; Muscles/cytology/physiology ; Nervous System Physiological Phenomena ; Neurons/*physiology ; Phenotype ; *Phosphatidylinositol 3-Kinases ; Promoter Regions, Genetic ; Receptor, Insulin/genetics/*metabolism ; Recombinant Fusion Proteins/metabolism ; *Signal Transduction ; Superoxide Dismutase/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2000-08-05
    Description: Ferromagnetic (FM) spin fluctuations are believed to mediate the spin-triplet pairing for the p-wave superconductivity in Sr(2)RuO(4). Our experiments show that, at the surface, a bulk soft-phonon mode freezes into a static lattice distortion associated with an in-plane rotation of the RuO(6) octahedron. First-principle calculations confirm this structure and predict a FM ground state at the surface. This coupling between structure and magnetism in the environment of broken symmetry at the surface allows a reconsideration of the coupling mechanism in the bulk.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Matzdorf -- Fang -- Ismail -- Zhang -- Kimura -- Tokura -- Terakura -- Plummer -- New York, N.Y. -- Science. 2000 Aug 4;289(5480):746-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics and Astronomy, The University of Tennessee, Knoxville, TN 37996-1200, and Oak Ridge National Laboratory (ORNL), Oak Ridge, TN 37831-6057, USA. Department of Physics, Florida International University, Miami, FL 33199, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10926529" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2000-08-01
    Print ISSN: 0084-6600
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Published by Annual Reviews
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