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  • 2020-2022  (131)
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  • 1
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    Concerted nonsyntenic allelic loss in human colorectal carcinoma (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-08-19
    Description: Familial polyposis coli (FPC) is caused by an autosomal dominant gene on chromosome 5, and it has been proposed that colorectal cancer in the general population arises from loss or inactivation of the FPC gene, analogous to recessive tumor genes in retinoblastoma and Wilms' tumor. Since allelic loss can be erroneously scored in nonhomogeneous samples, tumor cell populations were first microdissected from 24 colorectal carcinomas, an additional nine cancers were engrafted in nude mice, and nuclei were flow-sorted from an additional two. Of 31 cancers informative for chromosome 5 markers, only 6 (19%) showed loss of heterozygosity of chromosome 5 alleles, compared to 19 of 34 (56%) on chromosome 17, and 17 of 33 (52%) on chromosome 18. Therefore, it appears that (i) FPC is a true dominant for adenomatosis but not a common recessive gene for colon cancer; and (ii) simple Mendelian models involving loss of alleles at a single locus may be inappropriate for understanding common human solid tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Law, D J -- Olschwang, S -- Monpezat, J P -- Lefrancois, D -- Jagelman, D -- Petrelli, N J -- Thomas, G -- Feinberg, A P -- New York, N.Y. -- Science. 1988 Aug 19;241(4868):961-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor 48109.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2841761" target="_blank"〉PubMed〈/a〉
    Keywords: Adenocarcinoma/genetics ; Adenoma/genetics ; Adenomatous Polyposis Coli/*genetics ; *Alleles ; Animals ; Chromosomes, Human, Pair 17 ; Chromosomes, Human, Pair 18 ; Chromosomes, Human, Pair 5 ; Colonic Neoplasms/*genetics ; DNA, Neoplasm/analysis ; Genes, Dominant ; *Genetic Linkage ; Humans ; Mice ; Precancerous Conditions/genetics ; Rectal Neoplasms/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-09-30
    Description: Interleukin-3 (IL-3) is a member of a family of growth factors, each of which supports the proliferation and development of hematopoietic precursors in culture. Although the biologic effects of the different hematopoietic growth factors have been well documented in different culture systems, it has only recently become possible to study the activities of these molecules in vivo. In comparison with the later acting hematopoietic growth factors granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor, IL-3 elicited a delayed and relatively modest leukocytosis when continuously infused intravenously in primates. The IL-3 infusion, however, greatly potentiated the responsiveness of the animal to subsequent administration of a low dose of GM-CSF. These results suggest that IL-3 expands an early cell population in vivo that subsequently requires the action of a later acting factor such as GM-CSF to complete its development. Optimal stimulation of hematopoiesis may be achieved with combinations of hematopoietic growth factors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Donahue, R E -- Seehra, J -- Metzger, M -- Lefebvre, D -- Rock, B -- Carbone, S -- Nathan, D G -- Garnick, M -- Sehgal, P K -- Laston, D -- RR00168/RR/NCRR NIH HHS/ -- New York, N.Y. -- Science. 1988 Sep 30;241(4874):1820-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Genetics Institute, Cambridge, MA 02140.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3051378" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Colony-Stimulating Factors/*pharmacology ; Drug Synergism ; Granulocyte-Macrophage Colony-Stimulating Factor ; Growth Substances/*pharmacology ; Hematopoiesis/*drug effects ; Interleukin-3/*pharmacology ; Leukocyte Count ; Macaca fascicularis ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    The study on fishing and resource management of bony fisheries within southern Caspian Sea (2021)
    Iranian Fisheries Science Research Institute | Tehran, Iran
    In:  http://aquaticcommons.org/id/eprint/25444 | 18721 | 2018-09-23 17:01:05 | 25444 | Iranian Fisheries Science Research Institute
    Details
    Publication Date: 2021-07-16
    Description: The project of the Study on fishing and resource management of fisheries within Southern Caspian Sea was conducted on the base of an agreement made between fisheries organization (Shilat) and the Iranian fishery research organization (IFRO) signed in 2010. In this library-based study the current situation of bony fish fisheries and biology of these species has been surveyed in Iranian waters of the Caspian Sea . In this survey internal and external environmental factors of bony fishes activities were considered. Using SWOT analysis method, current situation of fisheries was investigated..One of the most important strategies for conserving anadromous species such as Caspian kutum , common carp, roach, bream and …. is rehabilitation of the natural spawning ground in rivers, coastal lagoon specially Anzali lagoon .By conducting this strategy not only restocks of bony fishes is done ,but also reduced the cost of artificial restocking programs and releasing fingerlings .In short term , it is nessesary to enhance the stocks of the species that have low catch is done by huge releasing of the fingerlings and study the qualification of the program.
    Keywords: Ecology ; Management ; Iran ; Caspian Sea ; Anzali lagoon ; Bony fishes ; Distribution ; Stocks ; Biology ; Fishing ; Species ; Caspian kutum ; Common carp ; Roach ; Bream ; Spawning ; Fingerlings
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 117
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  • 4
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    Stock assessment of the bony fishes in Iranian coastal waters of the Caspian Sea (2007-2010) (2021)
    Iranian Fisheries Science Research Institute | Tehran, Iran
    In:  http://aquaticcommons.org/id/eprint/25316 | 18721 | 2018-09-08 16:49:32 | 25316 | Iranian Fisheries Science Research Institute
    Details
    Publication Date: 2021-07-16
    Description: In the years 2007-2007, 2008-2009 and 2009-2010 the exploitation of bony fishes resources (by 131 beach seines) started on 12 October but finished on 9 April, 9 April and 13 April, respectively. During these periods the total catch of bony fishes were 23537.8, 20045.5 and 18664.8 tonnes, respevtively. During these periods, kutum predominated and represented the highest proportion of total catch at 73.1, 74.0 and 66.9% , followed by golden grey mullet at 18.3, 13.9 and 18.7%, respectively. K values calculated 0.22, 0.15 and 0.14 year-1 and L∞ were 66.0, 62.7 and 70.0 cm for kuttum, golden grey mullet and common carp, respectively. The instantaneous coefficient natural mortality were estimated as 0.386 and 0.35 year-1 for kutum and golden grey mullet, respectively. During three periods, the exploitation rates were 0.789, 0.584 and 0.614 for kutum and 0.71, 0.75 and 0.61 for golden grey mullet, respectively. In the years 2007-2007, 2008-2009 and 2009-2010, the total biomass, from the biomass-based cohort analysis were 56600, 62090 and 61590 tonnes for kutum and and MSY estimated about 24733.7 and 8550.4 tones for kuttum and 11040, 11900 and 14460 tonnes for golden grey mullet, respectively. The ABC (acceptable biological catch) were estimated as 8000 and 2200 tonnes.
    Keywords: Fisheries ; Iran ; Bony fishes ; Growth ; Mortality ; Biomass ; Acceptable biological catch ; Kutum ; Golden grey mullet ; Common carp ; Coastal waters
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 96
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  • 5
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    The feasibility study for culture of Salmo trutta caspius by brackish water (2021)
    Iranian Fisheries Science Research Institute | Tehran, Iran
    In:  http://aquaticcommons.org/id/eprint/25438 | 18721 | 2018-09-23 16:51:04 | 25438 | Iranian Fisheries Science Research Institute
    Details
    Publication Date: 2021-07-16
    Description: Caspian trout is valuable, Commercial, anadromous and endemic fish species in the Caspian Sea so that, researchers attention have been focused on this species. At the moment, only pay attention to stocks rehabilitation that fisheries organization releases more than 300,000 fingerlings to the rivers ends to the Caspian Sea. Importance of this study consist (1) introducing a new species to the aquaculture system and (2) provide breeders in this research. we used from 2 treatments that consist with density of 10 kg/m^3 and 20 kg/m3 with 3 replication. Results showed, culture of Caspian trout is suitable with density 10 kg/m^3, so that weight gain, SGR and Daily growth mean are better than treatment 2(15-20 kg/m^3 )
    Keywords: Aquaculture ; Iran ; Caspian Sea ; Salmo trutta caspius ; Growth factors ; Feasibility ; Culture ; Brackish water
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 116
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  • 6
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    Study of possibilities of replacement of fish meal by poultry by product in formulated diet of Huso huso (2021)
    Iranian Fisheries Science Research Institute | Tehran, Iran
    In:  http://aquaticcommons.org/id/eprint/25594 | 18721 | 2018-10-07 16:02:02 | 25594 | Iranian Fisheries Science Research Institute
    Details
    Publication Date: 2021-07-16
    Description: To regard to dramatic decreasing of pelagic fish and depending on fish meal for sturgeon Feeding a project with title on "Study of possibility of replacement of fish meal by poultry by product in formulated diet of Huso huso" in two faz (fingerling) and (Growth out) were carried out. In first faz, proximate composition of fish meal, poultry by product and diet ingredient were determined , thereafter Six test diets (contain 45% protein and 19 Mj kg^-1 energy) were prepared based on anchovy fish meal and poultry by-product substituted at levels of 20% (PBM_20), 40% (PBM_40), 60% (PBM_60), 80% (PBM_80) and 100% (PBM_100), respectively. Huso huso Fingerlings (28.42±0.17gr ± SD) were stocked in 18 fiberglass tanks and fed to satiation to eight week. Result indicated the highest final weight (FW), Weight gain (WG), Specific growth rate (SGR) and Protein efficiency ratio (PER) were belonged to control diet (350.52 ±21.86_gr),(1133.00 ±74.84%),(3.74±0.092 %per day) and (1.58 ±0.017) respectively. But No significant difference was detected between FM, PBM_20, PBM_40 and PBM_60 (P〉0.05), Also, there were not significant difference in treatments for Feed efficiency Ratio between (PBM_0), (PBM_20), (PBM_40), (PBM_60) (PBM_80) respectively (P〈0.05).But elimination of fish meal (PBM_100) led to significant increase in whole body protein (P〈0.05). In second faz (growth out period), Number of 180 Huso huso (107.89±5.19_gr ± SD) were stocked in 18 fiberglass tanks (volume 2000 lit) and fed by diets contain (40% protein and 20 Mj kg^-1 energy)that poultry by-product substituted at levels of 20% (PBM_20), 40% (PBM_40), 60% (PBM_60), 80% (PBM_80) and 100% (PBM_100) to satiation to 128 days. Biometry carried out one month interval. In the end of nutrition period highest final weight (FW) (844.2 ±2.44_gr), Weight gain (WG) (673.44 ±4.79 %) and Specific growth rate (SGR) (1.59 ±0.047% per day) were observed in fish fed control diet, but no significant differences were detected between (PBM_0), (PBM_20), (PBM_40), (PBM_60) and (PBM_80) respectively (P〉0.05).The best feed efficiency ratio belonged to fish fed PBM_40 that no significant differences with (PBM_20), (PBM_60) and (PBM_80) (P〉0.05).a significant decrease of body lipid observed by increasing of supplementation of poultry by product in diets that lowest body lipid (6.6±0.16) were stabilized in (PBM_80) (P〈0.05). the highest body protein belonged to fish fed PBM_20 (16.67±0.67) that significantly higher than body protein of fish fed PBM_60 (15.41±0.67) (P〈0.05), but no difference compare with other treatments (P〉0.05). also hepatosomatc index were significantly increase by increasing of poultry by product in diets respectively that highest were observed in fish fed PBM100 (4.2±0.63) (P〈0.05).Result of this investigation indicated that poultry by product had high potential for replacing of fish meal in fingerling and growth out Huso huso diet. Therefore suggested a investigation design for research about the effect of poultry by product on growth rate, body composition and immune system of Huso huso at long period for introduce a new replacer product Instead Of fish meal in sturgeon aquaculture industry.
    Keywords: Aquaculture ; Iran ; Huso huso ; Replacement ; Fish meal ; Poultry by product ; Growth index ; Feed efficiency ; Body composition ; Hepatosomatic index ; Visceral index
    Repository Name: AquaDocs
    Type: monograph
    Format: application/pdf
    Format: application/pdf
    Format: 76
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  • 7
    Electronic Resource
    Electronic Resource
    Two dimensional combined convection in vertical parallel plate ducts, including situations of flow reversal (1988)
    Chichester [u.a.] : Wiley-Blackwell
    International Journal for Numerical Methods in Engineering 26 (1988), S. 1645-1664 
    Details
    ISSN: 0029-5981
    Keywords: Engineering ; Engineering General
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mathematics , Technology
    Notes: Numerical solutions are presented for the problem of steady laminar combined convection flows in vertical parallel plate ducts. Axial diffusion is neglected in the analysis and the resulting governing equations, which are of a parabolic nature, are expressed in an implicit finite difference scheme using a vorticity-stream function formulation and are solved using a marching technique. A constant wall temperature boundary condition is used and investigations are restricted to the case Pr = 0.72. A large range of values of the ratio Gr/Re is considered, -300 ≤ Gr/Re ≤ 70, and comparisons are made with the case of pure forced convection. For large values of the ratio |Gr/Re| reverse flow occurs in the duct. A modification to the standard marching technique is introduced and complete solutions are achieved for these situations for the first time. Results are presented in terms of velocity profiles, Nusselt numbers, friction factors and temperature distributions.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/nme.1620260713
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  • 8
    Electronic Resource
    Electronic Resource
    Darstellung und Reaktionen von methylenverbrückten Phosphor(III)-Phosphor(V)-Verbindungen (1988)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 566 (1988), S. 90-102 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Preparation and Reactions of Methylene-bridged Phosphorus(III)-Phosphorus(V) CompoundsThe synthesis of methylene-bridged diphosphorus compounds of the type Y2PCH2P(S)X2 (with Y = F, Cl, OPri, NMe2, Ph) is reported. Reactions of these compounds with bicycloheptadiene-metaltetracarbonyls to form complexes of the type (L—L′)M(CO)4 and (L—L′)2M(CO)4, respectively, as well as some oxidation reactions and the conversion of the phosphine F2PCH2P(S)F2 to the cyclotetraphosphine [PCH2P(S)F2]4 are described.
    Notes: Über die Darstellung von methylenverbrückten Diphosphorverbindungen der Zusammensetzung Y2PCH2P(S)X2 (mit Y = F, Cl, OPri, NMe2, Ph; X = F, OPri, NMe2, Ph) wird berichtet. Umsetzungen der erhaltenen Verbindungen mit Bicycloheptadien-Metalltetracarbonylen zu Komplexen des Typs (L—L′)M(CO)4 bzw. (L—L′)2M(CO)4 (mit M = Cr, Mo, W), einige Oxidationsreaktionen und die Umwandlung des Phosphans F2PCH2P(S)F2 zum Cyclotetraphosphan [PCH2P(S)F2]4 werden beschrieben.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19885660113
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  • 9
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    A "selfish" B chromosome that enhances its transmission by eliminating the paternal genome (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-04-22
    Description: In the parasitic wasp, Nasonia vitripennis, males are haploid and usually develop from unfertilized eggs, whereas females are diploid and develop from fertilized eggs. Some individuals in this species carry a genetic element, termed psr (paternal sex ratio), which is transmitted through sperm and causes condensation and subsequent loss of paternal chromosomes in fertilized eggs, thus converting diploid females into haploid males. In this report the psr trait was shown to be caused by a supernumerary chromosome. This B chromosome contains at least three repetitive DNA sequences that do not cross-hybridize to each other or to the host genome. The psr chromosome apparently produces a trans-acting product responsible for condensation of the paternal chromosomes, but is itself insensitive to the effect. Because the psr chromosome enhances its transmission by eliminating the rest of the genome, it can be considered the most "selfish" genetic element yet described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Nur, U -- Werren, J H -- Eickbush, D G -- Burke, W D -- Eickbush, T H -- GM31867/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 1988 Apr 22;240(4851):512-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Rochester, NY 14627.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3358129" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Chromosomes/*physiology ; Cloning, Molecular ; DNA, Satellite ; Diploidy ; Haploidy ; Hymenoptera/*genetics ; Molecular Sequence Data ; Repetitive Sequences, Nucleic Acid ; Sex Determination Analysis ; *Sex Ratio ; Wasps/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Antisense RNA directed against the 3' noncoding region prevents dormant mRNA activation in mouse oocytes (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-08-05
    Description: Primary mouse oocytes contain untranslated stable messenger RNA for tissue plasminogen activator (t-PA). During meiotic maturation, this maternal mRNA undergoes a 3'-polyadenylation, is translated, and is degraded. Injections of maturing oocytes with different antisense RNA's complementary to both coding and noncoding portions of t-PA mRNA all selectively blocked t-PA synthesis. RNA blot analysis of t-PA mRNA in injected, matured oocytes suggested a cleavage of the RNA.RNA hybrid region, yielding a stable 5' portion, and an unstable 3' portion. In primary oocytes, the 3' noncoding region was susceptible to cleavage, while the other portions of the mRNA were blocked from hybrid formation until maturation occurred. Injection of antisense RNA complementary to 103 nucleotides of its extreme 3' untranslated region was sufficient to prevent the polyadenylation, translational activation, and destabilization of t-PA mRNA. These results demonstrate a critical role for the 3' noncoding region of a dormant mRNA in its translational recruitment during meiotic maturation of mouse oocytes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Strickland, S -- Huarte, J -- Belin, D -- Vassalli, A -- Rickles, R J -- Vassalli, J D -- HD-17875/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1988 Aug 5;241(4866):680-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Histology and Embryology, University of Geneva Medical School, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2456615" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Mice ; Nucleic Acid Hybridization ; Oocytes/*metabolism ; Poly A/metabolism ; Protein Biosynthesis/drug effects ; RNA/*pharmacology ; RNA, Antisense ; RNA, Messenger/*antagonists & inhibitors/metabolism ; Tissue Plasminogen Activator/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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