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Digitale Medien

Determination of chlorpromazine and its major metabolites by gas chromatography/mass spectrometry: Application to biological fluids (1985)

Gruenke, L. D. ; Craig, J. Cymerman ; Klein, F. D. ; [weitere]

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 12 (1985), S. 707-713

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ISSN: 1052-9306

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A method for the quantitative determination of chlorpromazine and five of its major metabolites in a single sample of biological fluid in the ng/ml range has been developed utilizing gas chromatography/mass spectrometry with selected ion recording. The assay is highly specific and quantification is accomplished by an inverse stable isotope dilution technique, using deuterium-labeled variants of the compounds as internal standards. In this way the concentrations of chlorpromazine and five of its major metabolites (the sulfoxide, the N-oxide, the monodemethylated, the didemethylated, and the 7-hydroxylated compounds) can be determined in biological fluids. Levels in humans have been measured both in plasma and in red blood cells and are compared to those found in related in vitro studies.

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bms.1200121207

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2

Digitale Medien

Two-dimensional proton NMR studies on poly(VPGVG) and its cyclic conformational correlate, cyclo(VPGVG)3 (1989)

Urry, D. W. ; Chang, D. K. ; Krishna, N. R. ; [weitere]

New York : Wiley-Blackwell

Biopolymers 28 (1989), S. 819-833

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ISSN: 0006-3525

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Two-dimensional nuclear Overhauser enhancement (2D NOESY) data are reported for the polypentapeptide of elastin, poly(VPGVG), and the cyclopentadecapeptide, cyclo(VPGVG)3. In both, the repeating type II Pro2-Gly3 β-turn can be derived from the NOE data, providing confirmation of many previous studies. In addition, other through-space connectivities are detailed that also compare favorably with previously determined crystal and solution structures for cyclo(VPGVG)3. Also, near identical data for the cyclopentadecapeptide and the polypentapeptide demonstrate the cyclic conformation-linear (helical) conformational correlate relationship between the two molecules. The 2D NOESY experiment is seen to be an effective means of establishing the presence or absence of a conformational relationship between a cyclic repeating sequence and its higher molecular weight linear counterpart. This is an approach of substantial practical value when developing the conformation of sequential polypeptides and when attempting to identify the presence of the conformation of a repeating peptide sequence within a more complex primary structure.Having established the basic conformational relationship between a cyclic conformation and its linear helical counterpart, cross peaks present in the linear helical structure that are not present in the cyclic conformational correlate can provide information on the interactions between adjacent turns of the helix. In this connection, a ValγCH3 ↔ ProβCH2 interaction is reported that can be the basis for determining the number of pentamers per turn of helix once it is determined whether it is dominantly the Val1 or Val4γCH3 that is interacting with the Pro2βCH2.

Zusätzliches Material: 7 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bip.360280404

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3

Digitale Medien

Laboratory studies on the suitability of a fertilizer-tap water medium for mass culture of algae (1985)

Geldenhuys, D. J. ; Walmsley, R. D. ; Toerien, D. F.

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 27 (1985), S. 1572-1576

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ISSN: 0006-3592

Schlagwort(e): Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bit.260271108

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4

Digitale Medien

Gram-Scale purification of arginine, formylmethionione, glutamic acid and phenylalanine transfer ribonucleic acids from E. coli K-12 MO7Research sponsored by the National Institute of General Medical Sciences, National Institutes of Health under contract with the United States Atomic Energy Commission and Union Carbide Corporation, Nuclear Division. (1970)

Weeren, H. O. ; Ryon, A. D. ; Heatherly, D. E. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 12 (1970), S. 889-912

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ISSN: 0006-3592

Schlagwort(e): Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: Gram-sized quantities of purified arginine, formylmethionine, glutamic acid, and phenylalanine-2 tRNAs have been prepared from pools of E. coli K-12 MO7 mixed tRNAs by reversed-phase chromatography after preliminary fractionation on DEAE-cellulose. Purified formylmethionine tRNA and partially purified arginine tRNA and glutamie acid tRNA were obtained from large-scale RPC-3 runs (4 × 36 in. column). The arginine tRNA was further purified by rechromatography on RPC-4 columns, and the gluatmic acid tRNA by rechromatography on an RPC-3 column. Two phenylalanine tRNAs were resolved on large-scale (2 × 96 in. column) RPC-3 runs; only the second phenylalanine tRNA reached a satisfactory degree of activity. About 0.88 g of arginine tRNA, 70% activity; 3.32 g of formylmethionine tRNA, 97% activity; 0.80 g of glutamic acid tRNA, 83% activity and O.92 g of phenylalanine-2 tRNA, 78% activity, were produced. The processing steps employed are reliable and reproducible and the procedure is amenable to routine production of these tRNAs.

Zusätzliches Material: 9 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bit.260120604

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5

Digitale Medien

Enhanced sedimentation of mammalian cells following acoustic aggregation (1989)

Kilburn, D. G. ; Clarke, D. J. ; Coakley, W. T. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Biotechnology and Bioengineering 34 (1989), S. 559-562

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ISSN: 0006-3592

Schlagwort(e): Chemistry ; Biochemistry and Biotechnology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Zusätzliches Material: 5 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/bit.260340415

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6

Digitale Medien

Low temperature deposition of a CaF2 insulator layer on GaAs (1989)

Vere, A. W. ; Mackey, K. J. ; Rodway, D. C. ; [weitere]

Weinheim : Wiley-Blackwell

Advanced Materials 1 (1989), S. 399-400

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ISSN: 0935-9648

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Maschinenbau , Physik

Zusätzliches Material: 2 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/adma.19890011109

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7

Digitale Medien

Pharmacological profile of the substituted beta-lactam L-659,286: A member of a new class of human PMN elastase inhibitors (1989)

Bonney, R. J. ; Ashe, B. ; Maycock, A. ; [weitere]

New York, N.Y. : Wiley-Blackwell

Journal of Cellular Biochemistry 39 (1989), S. 47-53

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ISSN: 0730-2312

Schlagwort(e): elastase inhibitors ; β-lactams ; lung damage ; Life and Medical Sciences ; Cell & Developmental Biology

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Biologie , Chemie und Pharmazie , Medizin

Notizen: Human polymorphonuclear leukocyte elastase (PMN elastase) is inhibited by L-659, 286 (7α-methoxy-8-oxo-3-[[(1,2,5,6-tetrahydro-2-methyl-5,6-dioxo-1,2,4-triaz-in-3-yl)thio]methyl]-5-thia-1-aza-6R-bicyclo [4.2.O]oct-2-ene-2-pyrrolidine carboxamide-5,-dioxide) with a Ki of 0.4 μM. This inhibition is time-dependent, rapid, and only slowly reversible, with a t1/2 of 〉 3 days at 25°C. L-659, 286 is also highly selective for PMN elastase, as it does not inhibit thrombin, trypsin, papain, plasmin, chymotrypsin, or cathepsin G. L-659, 286 administered intratracheally inhibits lung damage caused by administration via the same route of human PMN elastase into hamsters. In marmosets, L-659, 286 is cleared from blood very rapidly after an intravenous injection but is recovered in bronchoalveolar lavage fluid for several hours after intratracheal administration.

Zusätzliches Material: 4 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/jcb.240390106

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8

Digitale Medien

Test methodology for the determination of optimum fusion welding conditions of polyethylene (1989)

Saint-Royre, D. ; Gueugnaut, D. ; Reveret, D.

New York, NY [u.a.] : Wiley-Blackwell

Journal of Applied Polymer Science 38 (1989), S. 147-162

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ISSN: 0021-8995

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Maschinenbau , Physik

Notizen: The fusion welding behavior of a medium density polyethylene resin has been studied for a wide range of heating rates using a recently developed test methodology. With this method, the thermal and physical phenomena occurring at the interface of two thin polyethylene pieces assembled by fusion can be studied. It consists of a thermal welding phase and a phase of mechanical separation of the welded assembly. For the mechanical phase, an adaptation of the T-peel test was used. These conditions make it possible to determine the thermal welding parameters (temperature, time) for optimal mechanical quality of the joint, according to a criterion established by optimization of the peel test used. The variations in minimum temperature required for an optimum weld, as a function of heating rate, can be simulated with a numerical model based on the concept of macromolecular interdiffusion. Consistent with the experimental behavior, the numerical model involves two parameters characteristic of the diffusion behavior of the polyethylene resin. Thus, these parameters characterize the weldability of the polyethylene resin under study.

Zusätzliches Material: 8 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/app.1989.070380114

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9

Digitale Medien

Separation, detection, and identification of inositol triphosphate and phytic acid derivatives by supercritical fluid chromatography and SFC-mass spectrometry (1989)

Chester, T. L. ; Pinkston, J. D. ; Innis, D. P. ; [weitere]

New York, NY [u.a.] : Wiley-Blackwell

Journal of Microcolumn Separations 1 (1989), S. 182-189

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ISSN: 1040-7685

Schlagwort(e): supercrirical fluid chromatography ; mass spectrometry ; capillary column ; inositol ; phosphate ; phytic acid ; silyl derivatives ; Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: Capillary supercritical fluid chromatography with flame ionization detection appears promising for the separation and detection of silylated inositol phosphates. Inositol triphosphate and phytic acid, following ion exchange to their fully protonated forms, were silylated in one step with the addition of 9 and 12 trimethylsilyl groups, respectively. The resulting derivatives are well behaved in open-tubular chromatography columns with methyl-silicone stationary phase when CO2 is used as the mobile phase. Both flow-splitting and directinjection methods were evaluated. The identities of the derivatives were confirmed by supercritical fluid chromatography-mass spectrometry using chemical ionization with both ammonia and isobutane, and using electron ionization - CO2 charge exchange.

Zusätzliches Material: 9 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/mcs.1220010405

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10

Digitale Medien

Mixing studies in the single screw extruder (1985)

Bigio, D. I. ; Boyd, J. D. ; Erwin, L. ; [weitere]

Stamford, Conn. [u.a.] : Wiley-Blackwell

Polymer Engineering and Science 25 (1985), S. 305-310

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ISSN: 0032-3888

Schlagwort(e): Chemistry ; Chemical Engineering

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Maschinenbau , Physik

Notizen: Laminar mixing in a single screw extruder between two miscible liquids is considered. Studies are presented which examine the mixing performance in single screw extruders with mixing sections, variable geometry screws, and multi-viscosity mixtures. Model extruders, set up on engine lathes, were used to mix colored silicone rubber which eventually cured in the screw channel. The cured silicone was then removed and sliced to measure the mixing. Results show mixing as a function of both down channel location and total average strain. For the mixing section study, results support the theory of interfacial area reorientation as the key mechanism in mixing section performance. Increasing viscosity ratio for the multi-viscosity study showed a decrease in mixing rate.

Zusätzliches Material: 13 Ill.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1002/pen.760250510

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