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  • Articles  (202)
  • 1995-1999  (202)
  • 25
  • Chemistry and Pharmacology  (202)
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  • Articles  (202)
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  • 1
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    Bailout for drug research institute (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-05-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1998 Apr 17;280(5362):372.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9575079" target="_blank"〉PubMed〈/a〉
    Keywords: *Academies and Institutes/economics/organization & administration ; *Drug Industry/economics ; Hungary ; *Pharmaceutical Preparations ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    High-power directional emission from microlasers with chaotic resonators (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-11
    Description: High-power and highly directional semiconductor microcylinder lasers based on an optical resonator with deformed cross section are reported. In the favorable directions of the far-field, a power increase of up to three orders of magnitude over the conventional circularly symmetric lasers was obtained. A "bow-tie"-shaped resonance is responsible for the improved performance of the lasers in the higher range of deformations, in contrast to "whispering-gallery"-type modes of circular and weakly deformed lasers. This resonator design, although demonstrated here in midinfrared quantum-cascade lasers, should be applicable to any laser based on semiconductors or other high-refractive index materials.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gmachl -- Capasso -- Narimanov -- Nockel -- Stone -- Faist -- Sivco -- Cho -- New York, N.Y. -- Science. 1998 Jun 5;280(5369):1556-64.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉C. Gmachl, F. Capasso, J. Faist, D. L. Sivco, and A. Y. Cho are at Bell Laboratories, Lucent Technologies, 600 Mountain Avenue, Murray Hill, NJ 07974, USA. E. E. Narimanov and A. D. Stone are in the Department of Applied Physics, Yale University.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9616111" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    From shifting silt to solid stone: the manufacture of synthetic basalt in ancient mesopotamia (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-26
    Description: Slabs and fragments of gray-black vesicular "rock," superficially resembling natural basalt but distinctive in chemistry and mineralogy, were excavated at the second-millennium B.C. Mesopotamian city of Mashkan-shapir, about 80 kilometers south of Baghdad, Iraq. Most of this material appears to have been deliberately manufactured by the melting and slow cooling of local alluvial silts. The high temperatures (about 1200 degreesC) required and the large volume of material processed indicate an industry in which lithic materials were manufactured ("synthetic basalt") for grinding grain and construction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone -- Lindsley -- Pigott V -- Harbottle -- Ford -- New York, N.Y. -- Science. 1998 Jun 26;280(5372):2091-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉E. C. Stone, Department of Anthropology, State University of New York, Stony Brook, NY 11794-4364, USA. D. H. Lindsley, Department of Geosciences, State University of New York, Stony Brook, NY 11794-2100, USA. V. Pigott, MASCA (Museum Appl.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9641908" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Jumbo gene offers clue to Parkinson's (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-05-02
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, M -- New York, N.Y. -- Science. 1998 Apr 10;280(5361):203.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9565530" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; Chromosomes, Human, Pair 6/genetics ; Cloning, Molecular ; Humans ; *Ligases ; Mutation ; Parkinson Disease/*genetics/metabolism ; Proteins/chemistry/*genetics/physiology ; Substantia Nigra/metabolism ; *Ubiquitin-Protein Ligases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    A breakdown of Brassica self-incompatibility in ARC1 antisense transgenic plants (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-27
    Description: Self-incompatibility, the rejection of self pollen, is the most widespread mechanism by which flowering plants prevent inbreeding. In Brassica, the S receptor kinase (SRK) has been implicated in the self-incompatibility response, but the molecular mechanisms involving SRK are unknown. One putative downstream effector for SRK is ARC1, a protein that binds to the SRK kinase domain. Here it is shown that suppression of ARC1 messenger RNA levels in the self-incompatible Brassica napus W1 line is correlated with a partial breakdown of self-incompatibility, resulting in seed production. This provides strong evidence that ARC1 is a positive effector of the Brassica self-incompatibility response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, S L -- Arnoldo, M -- Goring, D R -- New York, N.Y. -- Science. 1999 Nov 26;286(5445):1729-31.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10576738" target="_blank"〉PubMed〈/a〉
    Keywords: Brassica/genetics/*physiology ; Carrier Proteins/*genetics/*physiology ; DNA, Antisense ; Germination ; Glycoproteins/genetics/metabolism ; Microscopy, Fluorescence ; Phenotype ; Plant Proteins/*genetics/metabolism/*physiology ; Plant Structures/genetics/physiology ; Plants, Genetically Modified ; Pollen/genetics/*physiology ; Protein Kinases/genetics/metabolism ; RNA, Messenger/genetics/metabolism ; RNA, Plant/genetics/metabolism ; Seeds/physiology ; Transgenes ; *Ubiquitin-Protein Ligases
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Paleontology. Siberian mammoth find raises hopes, questions (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-11-30
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1999 Oct 29;286(5441):876-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10577229" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Elephants/classification ; *Fossils ; History, Ancient ; Paleontology ; Siberia
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Permafrost comes alive for Siberian researchers (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-26
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, R -- New York, N.Y. -- Science. 1999 Oct 1;286(5437):36-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10532888" target="_blank"〉PubMed〈/a〉
    Keywords: Antarctic Regions ; Arctic Regions ; *Bacterial Physiological Phenomena ; Exobiology ; Freezing ; Geologic Sediments/*microbiology ; *Ice ; Planets ; Siberia ; *Virus Physiological Phenomena ; Water Microbiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-12-22
    Description: In late summer 1999, an outbreak of human encephalitis occurred in the northeastern United States that was concurrent with extensive mortality in crows (Corvus species) as well as the deaths of several exotic birds at a zoological park in the same area. Complete genome sequencing of a flavivirus isolated from the brain of a dead Chilean flamingo (Phoenicopterus chilensis), together with partial sequence analysis of envelope glycoprotein (E-glycoprotein) genes amplified from several other species including mosquitoes and two fatal human cases, revealed that West Nile (WN) virus circulated in natural transmission cycles and was responsible for the human disease. Antigenic mapping with E-glycoprotein-specific monoclonal antibodies and E-glycoprotein phylogenetic analysis confirmed these viruses as WN. This North American WN virus was most closely related to a WN virus isolated from a dead goose in Israel in 1998.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lanciotti, R S -- Roehrig, J T -- Deubel, V -- Smith, J -- Parker, M -- Steele, K -- Crise, B -- Volpe, K E -- Crabtree, M B -- Scherret, J H -- Hall, R A -- MacKenzie, J S -- Cropp, C B -- Panigrahy, B -- Ostlund, E -- Schmitt, B -- Malkinson, M -- Banet, C -- Weissman, J -- Komar, N -- Savage, H M -- Stone, W -- McNamara, T -- Gubler, D J -- New York, N.Y. -- Science. 1999 Dec 17;286(5448):2333-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80522, USA. rsl2@cdc.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10600742" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Monoclonal/immunology ; Antibodies, Viral/immunology ; Base Sequence ; Bird Diseases/epidemiology/virology ; Birds/virology ; *Disease Outbreaks ; Encephalitis Viruses, Japanese/classification/genetics ; Fluorescent Antibody Technique, Indirect ; Genome, Viral ; Humans ; Molecular Sequence Data ; New England/epidemiology ; New York City/epidemiology ; Phylogeny ; Songbirds/virology ; Viral Envelope Proteins/chemistry/genetics/immunology ; West Nile Fever/*epidemiology/veterinary/*virology ; West Nile virus/*classification/*genetics/immunology/isolation & purification
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Religion and science (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-07-03
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stone, E -- New York, N.Y. -- Science. 1999 Jun 11;284(5421):1773.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10391792" target="_blank"〉PubMed〈/a〉
    Keywords: Logic ; Religion and Medicine ; *Religion and Science ; Social Behavior
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Mutations in the SMAD4/DPC4 gene in juvenile polyposis (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-06-06
    Description: Familial juvenile polyposis is an autosomal dominant disease characterized by a predisposition to hamartomatous polyps and gastrointestinal cancer. Here it is shown that a subset of juvenile polyposis families carry germ line mutations in the gene SMAD4 (also known as DPC4), located on chromosome 18q21.1, that encodes a critical cytoplasmic mediator in the transforming growth factor-beta signaling pathway. The mutant SMAD4 proteins are predicted to be truncated at the carboxyl-terminus and lack sequences required for normal function. These results confirm an important role for SMAD4 in the development of gastrointestinal tumors.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Howe, J R -- Roth, S -- Ringold, J C -- Summers, R W -- Jarvinen, H J -- Sistonen, P -- Tomlinson, I P -- Houlston, R S -- Bevan, S -- Mitros, F A -- Stone, E M -- Aaltonen, L A -- New York, N.Y. -- Science. 1998 May 15;280(5366):1086-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Surgery, University of Iowa College of Medicine, Iowa City, IA 52242, USA. james-howe@uiowa.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9582123" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Membrane/metabolism ; Cell Nucleus/metabolism ; Chromosome Mapping ; Chromosomes, Human, Pair 18 ; Colorectal Neoplasms/*genetics ; *DNA-Binding Proteins ; Female ; Frameshift Mutation ; Gastrointestinal Neoplasms/*genetics ; Genes, DCC ; *Genes, Tumor Suppressor ; Genetic Predisposition to Disease ; Germ-Line Mutation ; Hamartoma Syndrome, Multiple/*genetics ; Humans ; Intestinal Polyps/*genetics ; Male ; Pedigree ; Polymerase Chain Reaction ; Sequence Deletion ; Signal Transduction ; Smad4 Protein ; Trans-Activators/chemistry/*genetics/metabolism ; Transforming Growth Factor beta/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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