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The structure of FMNL2–Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation (2015)

Sonja Kühn; Constanze Erdmann; Frieda Kage; Jennifer Block; Lisa Schwenkmezger; Anika Steffen; Klemens Rottner; Matthias Geyer

Springer Nature

In: Nature Communications

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Publication Date: 2015-05-14

Description: Article FMNL formins polymerize actin filaments to generate cellular protrusions such as lamellipodia and filopodia at the leading edge of a cell. Here the authors provide detailed mechanistic insights into the formation of actin-based protrusions through GTPase dependent activation and membrane localization of FMNL1 and FMNL2. Nature Communications doi: 10.1038/ncomms8088 Authors: Sonja Kühn, Constanze Erdmann, Frieda Kage, Jennifer Block, Lisa Schwenkmezger, Anika Steffen, Klemens Rottner, Matthias Geyer

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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The structure and substrate specificity of human Cdk12/Cyclin K (2014)

Christian A. Bösken; Lucas Farnung; Corinna Hintermair; Miriam Merzel Schachter; Karin Vogel-Bachmayr; Dalibor Blazek; Kanchan Anand; Robert P. Fisher; Dirk Eick; Matthias Geyer

Springer Nature

In: Nature Communications

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Publication Date: 2014-03-26

Description: Article Cyclin-dependent kinase 12 (Cdk12) phosphorylates the C-terminal domain (CTD) of RNA polymerase II to regulate transcription. Here, the authors solve the crystal structure of the Cdk12 kinase domain and show that Cdk12 has its highest activity on a CTD substrate that carries a serine 7 phosphorylation. Nature Communications doi: 10.1038/ncomms4505 Authors: Christian A. Bösken, Lucas Farnung, Corinna Hintermair, Miriam Merzel Schachter, Karin Vogel-Bachmayr, Dalibor Blazek, Kanchan Anand, Robert P. Fisher, Dirk Eick, Matthias Geyer

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Alarmin S100A8/S100A9 as a biomarker for molecular imaging of local inflammatory activity (2014)

Thomas Vogl; Michel Eisenblätter; Tom Völler; Stefanie Zenker; Sven Hermann; Peter van Lent; Andreas Faust; Christiane Geyer; Beatrix Petersen; Kirsten Roebrock; Michael Schäfers; Christoph Bremer; Johannes Roth

Springer Nature

In: Nature Communications

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Publication Date: 2014-08-08

Description: Article Alarmins are locally released during inflammation and are early amplifiers of inflammation. Here Vogl et al. show that the alarmin S100A8/S100A9 can be used as a sensitive marker to detect subclinical inflammation and follow disease progression in a variety of disease models. Nature Communications doi: 10.1038/ncomms5593 Authors: Thomas Vogl, Michel Eisenblätter, Tom Völler, Stefanie Zenker, Sven Hermann, Peter van Lent, Andreas Faust, Christiane Geyer, Beatrix Petersen, Kirsten Roebrock, Michael Schäfers, Christoph Bremer, Johannes Roth

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Nuclear lamina dysfunction triggers a germline stem cell checkpoint (2018)

Lacy J. Barton; Tingting Duan; Wenfan Ke; Amy Luttinger; Kaylee E. Lovander; Alexey A. Soshnev; Pamela K. Geyer

Springer Nature

In: Nature Communications

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Publication Date: 2018-09-28

Description: Nuclear lamina dysfunction triggers a germline stem cell checkpoint Nuclear lamina dysfunction triggers a germline stem cell checkpoint, Published online: 27 September 2018; doi:10.1038/s41467-018-06277-z Otefin is a nuclear lamina protein required for survival of Drosophila germ stem cells. Here the authors show that nuclear lamina dysfunction resulting from loss of Otefin activates a DNA damage-independent germ stem cell-specific checkpoint, mediated by the ATR and Chk2 kinases, which ensures that healthy gametes are passed on to the next generation.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail (2017)

Coen M. Adema; La; Deana W. Hillier; Catherine S. Jones; Eric S. Loker; Matty Knight; Patrick Minx; Guilherme Oliveira; Nithya Raghavan; Andrew Shedlock; Laurence Rodrigues do Amaral; Halime D. Arican-Goktas; Juliana G. Assis; Elio Hideo Baba; Olga L. Baron; Christopher J. Bayne; Utibe Bickham-Wright; Kyle K. Biggar; Michael Blouin; Bryony C. Bonning; Chris Botka; Joanna M. Bridger; Katherine M. Buckley; Sarah K. Buddenborg; Roberta Lima Caldeira; Julia Carleton; Omar S. Carvalho; Maria G. Castillo; Iain W. Chalmers; Mikkel Christensens; Sandra Clifton; Celine Cosseau; Christine Coustau; Richard M. Cripps; Yesid Cuesta-Astroz; Scott F. Cummins; Leon Di Stefano; Nathalie Dinguirard; David Duval; Scott Emrich; Cédric Feschotte; Rene Feyereisen; Peter Fitz; Gerald; Catrina Fronick; Lucinda Fulton; Richard Galinier; Sandra G. Gava; Michael Geusz; Kathrin K. Geyer; Gloria I. Giraldo-Calderón; Matheus de Souza Gomes; Michelle A. Gordy; Benjamin Gourbal; Christoph Grunau; Patrick C. Hanington; Karl F. Hoffmann; Daniel Hughes; Judith Humphries; Daniel J. Jackson; Liana K. Jannotti-Passos; Wander de Jesus Jeremias; Susan Jobling; Bishoy Kamel; Aurélie Kapusta; Satwant Kaur; Joris M. Koene; Andrea B. Kohn; Dan Lawson; Scott P. Lawton; Di Liang; Yanin Limpanont; Sijun Liu; Anne E. Lockyer; Ty Anna L. Lovato; Fernanda Ludolf; Vince Magrini; Donald P. McManus; Monica Medina; Milind Misra; Guillaume Mitta; Gerald M. Mkoji; Michael J. Montague; Cesar Montelongo; Leonid L. Moroz; Monica C. Munoz-Torres; Umar Niazi; Leslie R. Noble; Francislon S. Oliveira; Fabiano S. Pais; Anthony T. Papenfuss; Rob Peace; Janeth J. Pena; Emmanuel A. Pila; Titouan Quelais; Brian J. Raney; Jonathan P. Rast; David Rollinson; Izinara C. Rosse; Bronwyn Rotgans; Edwin J. Routledge; Kathryn M. Ryan; Wesley C. Warren; Min Zhao; Timothy P. Yoshino; Xiao-Jun Wu; Si-Ming Zhang; Mohammed Yusuf; Tianfang Wang; Richard K. Wilson; Jacob A. Tennessen; Anthony J. Walker; Chad Tomlinson; Martin Swain; Ittiprasert Wannaporn; Kenneth B. Storey; Larissa L. S. Scholte; Damian L. Trujillo; Emanuela V. Volpi

Springer Nature

In: Nature Communications

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Publication Date: 2017-08-24

Description: Corrigendum: Whole genome analysis of a schistosomiasis-transmitting freshwater snail Nature Communications, Published online: 23 August 2017; doi:10.1038/ncomms16153

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3 (2017)

Santiago Manrique; Daniel Sauter; Florian A. Horenkamp; Sebastian Lülf; Hangxing Yu; Dominik Hotter; Kanchan Anand; Frank Kirchhoff; Matthias Geyer

Springer Nature

In: Nature Communications

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Publication Date: 2017-09-06

Description: Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3 Nature Communications, Published online: 5 September 2017; doi:10.1038/s41467-017-00481-z HIV and simian immunodeficiency virus (SIV) Nef proteins both stimulate the clathrin-mediated endocytosis of CD4 but differ in downmodulation of the immune receptor CD3. Here, the authors present the structure of SIV Nef bound to the ExxxLM motif of another Nef molecule, which allows them to propose a model how Nef recognizes these motifs in CD3 and CD4.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Genetic loci associated with heart rate variability and their effects on cardiac disease risk (2017)

Springer Nature

In: Nature Communications

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Publication Date: 2017-06-15

Description: Genetic loci associated with heart rate variability and their effects on cardiac disease risk Nature Communications, Published online: 14 June 2017; doi:10.1038/ncomms15805 Heart rate variability (HRV) describes the individual variation in cardiac cycle duration and is a measure of vagal control of heart rate. Here, the authors identify seventeen single-nucleotide polymorphisms associated with HRV, lending new insight into the vagal regulation of heart rhythm.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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FMNL formins boost lamellipodial force generation (2017)

Frieda Kage; Moritz Winterhoff; Vanessa Dimchev; Jan Mueller; Tobias Thalheim; Anika Freise; Stefan Brühmann; Jana Kollasser; Jennifer Block; Georgi Dimchev; Matthias Geyer; Hans-Joachim Schnittler; Cord Brakebusch; Theresia E. B. Stradal; Marie-France Carlier; Michael Sixt; Josef Käs; Jan Faix; Klemens Rottner

Springer Nature

In: Nature Communications

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Publication Date: 2017-03-23

Description: FMNL formins boost lamellipodial force generation Nature Communications, Published online: 22 March 2017; doi:10.1038/ncomms14832 Actin polymerization in lamellipodia of cells is regulated by the Arp2/3 complex and FMNL family formins. Here the authors show that both FMNL2 and FMNL3 contribute to lamellipodium protrusion and structure, and abolishing FMNL2/3 reduces protrusion force generation and migration, without affecting Arp2/3 incorporation.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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