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Land–atmosphere feedbacks amplify aridity increase over land under global warming (2016)

Alexis Berg; Kirsten Findell; Benjamin Lintner; Alessandra Giannini; Sonia I. Seneviratne; Bart van den Hurk; Ruth Lorenz; Andy Pitman; Stefan Hagemann; Arndt Meier; Frédérique Cheruy; Agnès Ducharne; Sergey Malyshev; P. C. D. Milly

Springer Nature

In: Nature Climate Change

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Publication Date: 2016-08-26

Description: Aridity is expected to increase globally in a warmer world. Research now suggests that this is substantially amplified by land–atmosphere feedbacks associated with the land surface’s response to climate and plant responses to increased atmospheric CO2. Nature Climate Change 6 869 doi: 10.1038/nclimate3029

Print ISSN: 1758-678X

Electronic ISSN: 1758-6798

Topics: Geosciences

Published by Springer Nature

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ADAM8 as a drug target in pancreatic cancer (2015)

Uwe Schlomann; Garrit Koller; Catharina Conrad; Taheera Ferdous; Panagiota Golfi; Adolfo Molejon Garcia; Sabrina Höfling; Maddy Parsons; Patricia Costa; Robin Soper; Maud Bossard; Thorsten Hagemann; Rozita Roshani; Norbert Sewald; Randal R. Ketchem; Marcia L. Moss; Fred H. Rasmussen; Miles A. Miller; Douglas A. Lauffenburger; David A. Tuveson; Christopher Nimsky; Jörg W. Bartsch

Springer Nature

In: Nature Communications

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Publication Date: 2015-01-30

Description: Article Expression of ADAM8, a metalloprotease disintegrin, correlates with worse prognosis in pancreatic adenocarcinoma (PDAC). Here Schlomann et al . show that ADAM8 promotes PDAC invasiveness, and develop a peptide inhibitor that blocks ADAM8 function and impedes PDAC progression in mouse models. Nature Communications doi: 10.1038/ncomms7175 Authors: Uwe Schlomann, Garrit Koller, Catharina Conrad, Taheera Ferdous, Panagiota Golfi, Adolfo Molejon Garcia, Sabrina Höfling, Maddy Parsons, Patricia Costa, Robin Soper, Maud Bossard, Thorsten Hagemann, Rozita Roshani, Norbert Sewald, Randal R. Ketchem, Marcia L. Moss, Fred H. Rasmussen, Miles A. Miller, Douglas A. Lauffenburger, David A. Tuveson, Christopher Nimsky, Jörg W. Bartsch

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Nitric oxide mediates glial-induced neurodegeneration in Alexander disease (2015)

Liqun Wang; Tracy L. Hagemann; Hermann Kalwa; Thomas Michel; Albee Messing; Mel B. Feany

Springer Nature

In: Nature Communications

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Publication Date: 2015-11-28

Description: Article Alexander disease is a rare neurological disorder caused by mutations in GFAP, yet it is unclear how glial disruptions lead to neural death. Here, Wang et al . identify a mechanism by which glial-derived nitric oxide leads to neuronal degeneration in fly and mouse models of the disease. Nature Communications doi: 10.1038/ncomms9966 Authors: Liqun Wang, Tracy L. Hagemann, Hermann Kalwa, Thomas Michel, Albee Messing, Mel B. Feany

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

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Towards process-informed bias correction of climate change simulations (2017)

Douglas Maraun; Theodore G. Shepherd; Martin Widmann; Giuseppe Zappa; Daniel Walton; José M. Gutiérrez; Stefan Hagemann; Ingo Richter; Pedro M. M. Soares; Alex Hall; Linda O. Mearns

Springer Nature

In: Nature Climate Change

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Publication Date: 2017-11-03

Description: Towards process-informed bias correction of climate change simulations Towards process-informed bias correction of climate change simulations, Published online: 02 November 2017; doi:10.1038/nclimate3418 NatureArticleSnippet(type=short-summary, markup= Bias correction methods aim to remove introduced bias for climate model simulations; however, improper use can result in spurious climate signals. This Perspective considers the issues of bias correction and makes recommendations for research to overcome model biases. , isJats=true)

Print ISSN: 1758-678X

Electronic ISSN: 1758-6798

Topics: Geosciences

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Filopodia-based Wnt transport during vertebrate tissue patterning (2015)

Eliana Stanganello; Anja I. H. Hagemann; Benjamin Mattes; Claude Sinner; Dana Meyen; Sabrina Weber; Alexander Schug; Erez Raz; Steffen Scholpp

Springer Nature

In: Nature Communications

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Publication Date: 2015-01-07

Description: Article Distribution of Wnt morphogens in tissues is often graded, but it is unclear how these secreted factors move to form concentration gradients. Here, the authors show that Wnt8a is transported on actin-based filopodia, known also as cytonemes, that contact the signal-receiving cells during zebrafish gastrulation. Nature Communications doi: 10.1038/ncomms6846 Authors: Eliana Stanganello, Anja I. H. Hagemann, Benjamin Mattes, Claude Sinner, Dana Meyen, Sabrina Weber, Alexander Schug, Erez Raz, Steffen Scholpp

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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